Construct: sgRNA BRDN0001149393
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- TGTCTTTACGGGTGAAAAGG
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- SNRK (54861)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000003.12 | 3 | 43303325 | + | SNRK | NNNCTTTACGGGTGAAAAGG | NGG | 0 | 1.0 | Tier I |
2 | NC_000018.10 | 18 | 50044438 | + | MYO5B | NNNCTTTAGAGGTGAAAAGG | NGG | 2 | 0.5778 | Tier II |
3 | NC_000009.12 | 9 | 5879491 | - | BRD10 | NNNCTTTAGGGATGAAAAGG | NGG | 2 | 0.5778 | Tier II |
4 | NC_000002.12 | 2 | 134606974 | + | TMEM163 | NNNCTGTACTGGTGAAAAGG | NGG | 2 | 0.4643 | Tier II |
5 | NC_000002.12 | 2 | 134607355 | + | TMEM163 | NNNCTGTACTGGTGAAAAGG | NGG | 2 | 0.4643 | Tier II |
6 | NC_000002.12 | 2 | 134607798 | + | TMEM163 | NNNCTGTACTGGTGAAAAGG | NGG | 2 | 0.4643 | Tier II |
7 | NC_000002.12 | 2 | 134608610 | + | TMEM163 | NNNCTGTACTGGTGAAAAGG | NGG | 2 | 0.4643 | Tier II |
8 | NC_000002.12 | 2 | 134608898 | + | TMEM163 | NNNCTGTACTGGTGAAAAGG | NGG | 2 | 0.4643 | Tier II |
9 | NC_000002.12 | 2 | 134608963 | + | TMEM163 | NNNCTGTACTGGTGAAAAGG | NGG | 2 | 0.4643 | Tier II |
10 | NC_000002.12 | 2 | 134609090 | + | TMEM163 | NNNCTGTACTGGTGAAAAGG | NGG | 2 | 0.4643 | Tier II |
11 | NC_000002.12 | 2 | 134609248 | + | TMEM163 | NNNCTGTACTGGTGAAAAGG | NGG | 2 | 0.4643 | Tier II |
12 | NC_000002.12 | 2 | 134609313 | + | TMEM163 | NNNCTGTACTGGTGAAAAGG | NGG | 2 | 0.4643 | Tier II |
13 | NC_000002.12 | 2 | 134609378 | + | TMEM163 | NNNCTGTACTGGTGAAAAGG | NGG | 2 | 0.4643 | Tier II |
14 | NC_000002.12 | 2 | 134609446 | + | TMEM163 | NNNCTGTACTGGTGAAAAGG | NGG | 2 | 0.4643 | Tier II |
15 | NC_000002.12 | 2 | 134609511 | + | TMEM163 | NNNCTGTACTGGTGAAAAGG | NGG | 2 | 0.4643 | Tier II |
16 | NC_000002.12 | 2 | 134609579 | + | TMEM163 | NNNCTGTACTGGTGAAAAGG | NGG | 2 | 0.4643 | Tier II |
17 | NC_000002.12 | 2 | 134609613 | + | TMEM163 | NNNCTGTACTGGTGAAAAGG | NGG | 2 | 0.4643 | Tier II |
18 | NC_000002.12 | 2 | 134609647 | + | TMEM163 | NNNCTGTACTGGTGAAAAGG | NGG | 2 | 0.4643 | Tier II |
19 | NC_000002.12 | 2 | 134609681 | + | TMEM163 | NNNCTGTACTGGTGAAAAGG | NGG | 2 | 0.4643 | Tier II |
20 | NC_000002.12 | 2 | 134609715 | + | TMEM163 | NNNCTGTACTGGTGAAAAGG | NGG | 2 | 0.4643 | Tier II |
21 | NC_000002.12 | 2 | 134609749 | + | TMEM163 | NNNCTGTACTGGTGAAAAGG | NGG | 2 | 0.4643 | Tier II |
22 | NC_000002.12 | 2 | 134609783 | + | TMEM163 | NNNCTGTACTGGTGAAAAGG | NGG | 2 | 0.4643 | Tier II |
23 | NC_000002.12 | 2 | 134609817 | + | TMEM163 | NNNCTGTACTGGTGAAAAGG | NGG | 2 | 0.4643 | Tier II |
24 | NC_000002.12 | 2 | 134609851 | + | TMEM163 | NNNCTGTACTGGTGAAAAGG | NGG | 2 | 0.4643 | Tier II |
25 | NC_000002.12 | 2 | 134609885 | + | TMEM163 | NNNCTGTACTGGTGAAAAGG | NGG | 2 | 0.4643 | Tier II |
26 | NC_000009.12 | 9 | 21853303 | + | MTAP | NNNCTTTAGGGGGGAAAAGG | NGG | 2 | 0.1615 | Tier II |
27 | NC_000020.11 | 20 | 31640493 | + | COX4I2 | NNNCTTTAAGGGTGAAGAGG | NGG | 2 | 0.1513 | Tier II |
28 | NC_000002.12 | 2 | 216672378 | - | IGFBP5 | NNNCTTTACTGGTGAAAAGG | NTG | 2 | 0.0317 | Tier II |
29 | NC_000008.11 | 8 | 141472464 | + | MROH5 | NNNCTTTACAGGTGAAAAGC | NGG | 2 | 0.4 | Tier III |
30 | NC_000014.9 | 14 | 39486967 | + | LOC105370460 | NNNCTTATCGGGTGAAAAGG | NGG | 2 | 0.375 | Tier III |
31 | NC_000014.9 | 14 | 39486967 | + | LOC105370461 | NNNCTTATCGGGTGAAAAGG | NGG | 2 | 0.375 | Tier III |
32 | NC_000014.9 | 14 | 39486967 | + | LOC112267899 | NNNCTTATCGGGTGAAAAGG | NGG | 2 | 0.375 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000072.6 | 6 | 39805365 | - | Mrps33 | NNNCTTTACAGGTGATAAGG | NGG | 2 | 0.0 | Tier I |
2 | NC_000069.6 | 3 | 87658591 | + | Arhgef11 | NNNCTTTACAAGTGAAAAGG | NGG | 2 | 0.9333 | Tier II |
3 | NC_000081.6 | 15 | 37630122 | - | Ncald | NNNCTATATGGGTGAAAAGG | NGG | 2 | 0.7583 | Tier II |
4 | NC_000081.6 | 15 | 20628933 | - | Cdh12 | NNNATTTACTGGTGAAAAGG | NGG | 2 | 0.6842 | Tier II |
5 | NC_000068.7 | 2 | 120006784 | + | Mapkbp1 | NNNCTTTACGGATGAGAAGG | NGG | 2 | 0.1795 | Tier II |
6 | NC_000077.6 | 11 | 60639685 | - | Gm12625 | NNNTTTTACGGATGAAAAGG | NGG | 2 | 0.7467 | Tier III |