Construct: sgRNA BRDN0001162220
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- TGGGTTTCCCAACAGCAACA
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- XYLB (9942)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000003.12 | 3 | 38365201 | + | XYLB | NNNGTTTCCCAACAGCAACA | NGG | 0 | 1.0 | Tier I |
2 | NC_000014.9 | 14 | 73206388 | + | PSEN1 | NNNCTTTCCCAACAGCAACA | NTG | 2 | 0.0206 | Tier I |
3 | NC_000022.11 | 22 | 46184550 | - | PPARA | NNNATTTTCCAACAGCAACA | NGG | 2 | 0.7875 | Tier II |
4 | NC_000016.10 | 16 | 12274256 | - | SNX29 | NNNGTTTCTAAACAGCAACA | NGG | 2 | 0.7583 | Tier II |
5 | NC_000016.10 | 16 | 519651 | - | RAB11FIP3 | NNNGTCTCCCAACAGCAACG | NGG | 2 | 0.6952 | Tier II |
6 | NC_000004.12 | 4 | 153294563 | + | TRIM2 | NNNGTTTCCTAATAGCAACA | NGG | 2 | 0.6588 | Tier II |
7 | NC_000008.11 | 8 | 66754973 | + | SGK3 | NNNGTTTAACAACAGCAACA | NGG | 2 | 0.5571 | Tier II |
8 | NC_000008.11 | 8 | 66754973 | + | C8orf44-SGK3 | NNNGTTTAACAACAGCAACA | NGG | 2 | 0.5571 | Tier II |
9 | NC_000010.11 | 10 | 25496834 | - | GPR158 | NNNGTTACCCAACTGCAACA | NGG | 2 | 0.4667 | Tier II |
10 | NC_000003.12 | 3 | 156491006 | + | KCNAB1 | NNNGATTCTCAACAGCAACA | NGG | 2 | 0.4375 | Tier II |
11 | NC_000003.12 | 3 | 31566250 | - | STT3B | NNNGATTCCAAACAGCAACA | NGG | 2 | 0.4333 | Tier II |
12 | NC_000009.12 | 9 | 4311647 | + | GLIS3 | NNNCTTCCCCAACAGCAACA | NGG | 2 | 0.364 | Tier II |
13 | NC_000002.12 | 2 | 167426979 | + | B3GALT1 | NNNGTTCCCCAACAGCAAAA | NGG | 2 | 0.2946 | Tier II |
14 | NC_000002.12 | 2 | 69027144 | - | ANTXR1 | NNNGATGCCCAACAGCAACA | NGG | 2 | 0.2941 | Tier II |
15 | NC_000015.10 | 15 | 50014127 | + | ATP8B4 | NNNATTTCCCACCAGCAACA | NGG | 2 | 0.2368 | Tier II |
16 | NC_000023.11 | X | 114889311 | - | HTR2C | NNNGTGTCCCAACAGCAACA | NAG | 2 | 0.1481 | Tier II |
17 | NC_000011.10 | 11 | 126588115 | + | KIRREL3 | NNNGTTTCCCATCAGCAAAA | NGG | 2 | 0.1429 | Tier II |
18 | NC_000014.9 | 14 | 79634498 | - | NRXN3 | NNNTTTTCCCAAAAGCAACA | NGG | 2 | 0.1399 | Tier II |
19 | NC_000018.10 | 18 | 58578666 | - | ALPK2 | NNNGTTTCCCAACACCATCA | NGG | 2 | 0.1364 | Tier II |
20 | NC_000015.10 | 15 | 80576065 | - | ARNT2 | NNNGTTTCCCAACAGAAAGA | NGG | 2 | 0.125 | Tier II |
21 | NC_000005.10 | 5 | 31992726 | - | PDZD2 | NNNCTTTCCCAAGAGCAACA | NGG | 2 | 0.0722 | Tier II |
22 | NC_000001.11 | 1 | 25652300 | - | MAN1C1 | NNNGTTTCCCAACAGCAACC | NAG | 2 | 0.0589 | Tier II |
23 | NC_000001.11 | 1 | 197586177 | + | DENND1B | NNNGTTTCCCAAAAGCTACA | NGG | 2 | 0.0513 | Tier II |
24 | NC_000001.11 | 1 | 20078560 | + | PLA2G5 | NNNGTTTCCCACCAGCCACA | NGG | 2 | 0.0464 | Tier II |
25 | NC_000001.11 | 1 | 244502603 | - | CATSPERE | NNNGTTTCCTAACAGCAACA | NTG | 2 | 0.0367 | Tier II |
26 | NC_000010.11 | 10 | 68102638 | - | MYPN | NNNATTTCCCAACAGCAACA | NTG | 2 | 0.0351 | Tier II |
27 | NC_000008.11 | 8 | 105570061 | - | ZFPM2 | NNNGTTTCCCAAGAGGAACA | NGG | 2 | 0.021 | Tier II |
28 | NC_000013.11 | 13 | 42915573 | + | EPSTI1 | NNNGTTTCCCAACAACAACA | NGT | 2 | 0.0152 | Tier II |
29 | NC_000014.9 | 14 | 39651207 | - | LOC105370461 | NNNGTTTCTCAACAGCATCA | NGG | 2 | 0.4375 | Tier III |
30 | NC_000009.12 | 9 | 7315021 | - | LOC105375970 | NNNTTTTCCCAGCAGCAACA | NGG | 2 | 0.2626 | Tier III |
31 | NC_000011.10 | 11 | 126588115 | + | KIRREL3-AS1 | NNNGTTTCCCATCAGCAAAA | NGG | 2 | 0.1429 | Tier III |
32 | NC_000008.11 | 8 | 7893770 | + | LOC124901865 | NNNGTTTCCCATCACCAACA | NGG | 2 | 0.0909 | Tier III |
33 | NC_000015.10 | 15 | 25067083 | - | SNHG14 | NNNGTTTCCCAACAGCACAA | NGG | 2 | 0.0816 | Tier III |
34 | NC_000015.10 | 15 | 25067083 | - | LOC128966705 | NNNGTTTCCCAACAGCACAA | NGG | 2 | 0.0816 | Tier III |
35 | NC_000008.11 | 8 | 5912649 | + | LOC105377795 | NNNCTTTCCCAACATCAACA | NGG | 2 | 0.0756 | Tier III |
36 | NC_000021.9 | 21 | 14038055 | - | LOC105377134 | NNNGTTTCCCAAAATCAACA | NGG | 2 | 0.0549 | Tier III |
37 | NC_000008.11 | 8 | 88531669 | + | LOC105375629 | NNNGTTTCCCCACAGCAAGA | NGG | 2 | 0.05 | Tier III |
38 | NC_000008.11 | 8 | 88531669 | + | LOC105375630 | NNNGTTTCCCCACAGCAAGA | NGG | 2 | 0.05 | Tier III |
39 | NC_000013.11 | 13 | 42915573 | + | LOC124903165 | NNNGTTTCCCAACAACAACA | NGT | 2 | 0.0152 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000082.6 | 16 | 4038010 | - | Dnase1 | NNNGCTTCCCAACAGCAACC | NGG | 2 | 0.2273 | Tier I |
2 | NC_000072.6 | 6 | 8630722 | + | Ica1 | NNNTTTTCCCAACAGCATCA | NGG | 2 | 0.1818 | Tier I |
3 | NC_000073.6 | 7 | 45800560 | + | Lmtk3 | NNNGTTTCCCAACAGCGACA | NCG | 2 | 0.0189 | Tier I |
4 | NC_000071.6 | 5 | 131185314 | + | Galnt17 | NNNGTATCCCAACAGAAACA | NGG | 2 | 0.8667 | Tier II |
5 | NC_000068.7 | 2 | 157011270 | - | Soga1 | NNNGTTTGCCAACAGCAACA | NGG | 1 | 0.6429 | Tier II |
6 | NC_000068.7 | 2 | 27678693 | - | Rxra | NNNGTTTCTCAACTGCAACA | NGG | 2 | 0.4667 | Tier II |
7 | NC_000068.7 | 2 | 18853405 | - | Pip4k2a | NNNCTTACCCAACAGCAACA | NGG | 2 | 0.4632 | Tier II |
8 | NC_000067.6 | 1 | 5102274 | - | Atp6v1h | NNNAATTCCCAACAGCAACA | NGG | 2 | 0.45 | Tier II |
9 | NC_000076.6 | 10 | 69544671 | + | Ank3 | NNNATTTCCCAACAGCATCA | NGG | 2 | 0.45 | Tier II |
10 | NC_000069.6 | 3 | 117618557 | + | Plppr5 | NNNGCTTCCCCACAGCAACA | NGG | 2 | 0.4 | Tier II |
11 | NC_000072.6 | 6 | 128298901 | + | Tead4 | NNNGTTTCCCCACAGAAACA | NGG | 2 | 0.4 | Tier II |
12 | NC_000083.6 | 17 | 90699644 | - | Nrxn1 | NNNGTTTTCCAACAGCAAAA | NGG | 2 | 0.375 | Tier II |
13 | NC_000085.6 | 19 | 30678248 | - | Prkg1 | NNNTTTTCCCAACAGCAACA | NGG | 1 | 0.3636 | Tier II |
14 | NC_000084.6 | 18 | 67980153 | - | Ldlrad4 | NNNGATTCCCAGCAGCAACA | NGG | 2 | 0.3611 | Tier II |
15 | NC_000081.6 | 15 | 91529006 | + | Slc2a13 | NNNATTTCCCCACAGCAACA | NGG | 2 | 0.36 | Tier II |
16 | NC_000074.6 | 8 | 58350680 | - | Galntl6 | NNNCTTGCCCAACAGCAACA | NGG | 2 | 0.3114 | Tier II |
17 | NC_000071.6 | 5 | 51537820 | + | Ppargc1a | NNNGTTTCCCAACAACAACA | NAG | 2 | 0.244 | Tier II |
18 | NC_000083.6 | 17 | 33703314 | - | Marchf2 | NNNTTTTCCCAACAGCAACT | NGG | 2 | 0.2182 | Tier II |
19 | NC_000070.6 | 4 | 145698562 | - | Zfp980 | NNNGTTTCCCAGCACCAACA | NGG | 2 | 0.197 | Tier II |
20 | NC_000070.6 | 4 | 146192625 | - | Zfp600 | NNNGTTTCCCAGCACCAACA | NGG | 2 | 0.197 | Tier II |
21 | NC_000070.6 | 4 | 146715250 | - | Zfp993 | NNNGTTTCCCAGCACCAACA | NGG | 2 | 0.197 | Tier II |
22 | NC_000070.6 | 4 | 147054919 | - | Rex2 | NNNGTTTCCCAGCACCAACA | NGG | 2 | 0.197 | Tier II |
23 | NC_000070.6 | 4 | 147387641 | - | Zfp978 | NNNGTTTCCCAGCACCAACA | NGG | 2 | 0.197 | Tier II |
24 | NC_000070.6 | 4 | 147616093 | + | Zfp979 | NNNGTTTCCCAGCACCAACA | NGG | 2 | 0.197 | Tier II |
25 | NC_000075.6 | 9 | 65466303 | - | Spg21 | NNNGTTTCCCAACAGCACCA | NGG | 1 | 0.1905 | Tier II |
26 | NC_000067.6 | 1 | 181040369 | - | 9130409I23Rik | NNNTATTCCCAACAGCAACA | NGG | 2 | 0.1818 | Tier II |
27 | NC_000078.6 | 12 | 108417252 | - | Eml1 | NNNCTTTCCCATCAGCAACA | NGG | 2 | 0.1765 | Tier II |
28 | NC_000068.7 | 2 | 144406249 | + | Kat14 | NNNGGTTCCCAACACCAACA | NGG | 2 | 0.1745 | Tier II |
29 | NC_000069.6 | 3 | 87129266 | - | Kirrel | NNNGTCTCCCAACAGCACCA | NGG | 2 | 0.1732 | Tier II |
30 | NC_000077.6 | 11 | 118655578 | - | Rbfox3 | NNNGTGTCCCAACACCAACA | NGG | 2 | 0.1558 | Tier II |
31 | NC_000076.6 | 10 | 74090915 | + | Pcdh15 | NNNGTTTTCCAACAGCCACA | NGG | 2 | 0.1544 | Tier II |
32 | NC_000081.6 | 15 | 55432552 | - | Col14a1 | NNNGATTCCCAACAGTAACA | NGG | 2 | 0.1538 | Tier II |
33 | NC_000075.6 | 9 | 67300685 | + | Tln2 | NNNGTTTCCCATCAGCAAAA | NGG | 2 | 0.1429 | Tier II |
34 | NC_000081.6 | 15 | 91308621 | + | Slc2a13 | NNNGTTTCCCAGCAGCCACA | NGG | 2 | 0.1275 | Tier II |
35 | NC_000082.6 | 16 | 13794633 | - | Rrn3 | NNNATTTCCCAACAGCTACA | NGG | 2 | 0.12 | Tier II |
36 | NC_000071.6 | 5 | 112374372 | - | Hps4 | NNNGTTTCCCAACACCAGCA | NGG | 2 | 0.1091 | Tier II |
37 | NC_000074.6 | 8 | 4337704 | + | Ccl25 | NNNGGTTCCCAACATCAACA | NGG | 2 | 0.0914 | Tier II |
38 | NC_000076.6 | 10 | 122925881 | + | Ppm1h | NNNGATTCCCAACAGCCACA | NGG | 2 | 0.0882 | Tier II |
39 | NC_000077.6 | 11 | 119999536 | + | Baiap2 | NNNCTTTCCCAAGAGCAACA | NGG | 2 | 0.0722 | Tier II |
40 | NC_000079.6 | 13 | 55558847 | + | Fam193b | NNNGATTCCCAACAGCTACA | NGG | 2 | 0.0667 | Tier II |
41 | NC_000082.6 | 16 | 43993307 | + | Gramd1c | NNNGATTCCCAACAGCTACA | NGG | 2 | 0.0667 | Tier II |
42 | NC_000083.6 | 17 | 29620850 | - | Rnf8 | NNNTTTTCCCAACAGCCACA | NGG | 2 | 0.0642 | Tier II |
43 | NC_000067.6 | 1 | 58746852 | - | Cflar | NNNGTTTCCCAAAAGCAAGA | NGG | 2 | 0.0481 | Tier II |
44 | NC_000074.6 | 8 | 107305035 | + | Nfat5 | NNNGTTTCCCAACACCCACA | NGG | 2 | 0.0481 | Tier II |
45 | NC_000076.6 | 10 | 60042453 | - | Ascc1 | NNNGTTTCCCAACACCTACA | NGG | 2 | 0.0364 | Tier II |
46 | NC_000071.6 | 5 | 144852172 | + | Trrap | NNNGTTTCCCAACATCCACA | NGG | 2 | 0.0252 | Tier II |
47 | NC_000071.6 | 5 | 19888687 | + | Magi2 | NNNGTTTCCCAACAGGAAGA | NGG | 2 | 0.0192 | Tier II |
48 | NC_000076.6 | 10 | 69544671 | + | Gm33464 | NNNATTTCCCAACAGCATCA | NGG | 2 | 0.45 | Tier III |
49 | NC_000076.6 | 10 | 69544671 | + | Gm51806 | NNNATTTCCCAACAGCATCA | NGG | 2 | 0.45 | Tier III |
50 | NC_000075.6 | 9 | 43608993 | + | Gm29909 | NNNGTCTCCCAAAAGCAACA | NGG | 2 | 0.3497 | Tier III |
51 | NC_000070.6 | 4 | 146192625 | - | Vmn2r-ps17 | NNNGTTTCCCAGCACCAACA | NGG | 2 | 0.197 | Tier III |
52 | NC_000070.6 | 4 | 146192625 | - | Gm13165 | NNNGTTTCCCAGCACCAACA | NGG | 2 | 0.197 | Tier III |
53 | NC_000073.6 | 7 | 61182262 | - | A230006K03Rik | NNNGTTTCCAAACAGCCACA | NGG | 2 | 0.1529 | Tier III |
54 | NC_000071.6 | 5 | 112374372 | - | Gm20636 | NNNGTTTCCCAACACCAGCA | NGG | 2 | 0.1091 | Tier III |
55 | NC_000073.6 | 7 | 36076388 | - | Gm38991 | NNNGTTTCCCACCAGCAGCA | NGG | 2 | 0.1053 | Tier III |
56 | NC_000074.6 | 8 | 4337704 | + | LOC108167518 | NNNGGTTCCCAACATCAACA | NGG | 2 | 0.0914 | Tier III |
57 | NC_000083.6 | 17 | 29620850 | - | Gm28043 | NNNTTTTCCCAACAGCCACA | NGG | 2 | 0.0642 | Tier III |