Construct: sgRNA BRDN0001162233
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- TACTCAAAAAGCATGCACAC
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- ROR1 (4919)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000001.11 | 1 | 64177686 | - | ROR1 | NNNTCAAAAAGCATGCACAC | NGG | 0 | 1.0 | Tier I |
2 | NC_000002.12 | 2 | 74170923 | + | MOB1A | NNNTCAAGAAGCATACACAC | NGG | 2 | 0.6902 | Tier II |
3 | NC_000002.12 | 2 | 57942599 | - | VRK2 | NNNTTAAAAAGCATACACAC | NGG | 2 | 0.5989 | Tier II |
4 | NC_000003.12 | 3 | 196490698 | + | RNF168 | NNNACAAAAAACATGCACAC | NGG | 2 | 0.4762 | Tier II |
5 | NC_000021.9 | 21 | 40399486 | - | DSCAM | NNNTCAGATAGCATGCACAC | NGG | 2 | 0.4235 | Tier II |
6 | NC_000008.11 | 8 | 39658271 | - | ADAM18 | NNNTGAAATAGCATGCACAC | NGG | 2 | 0.36 | Tier II |
7 | NC_000001.11 | 1 | 217526007 | - | GPATCH2 | NNNTCAAAAAGTATGCACAA | NGG | 2 | 0.2692 | Tier II |
8 | NC_000003.12 | 3 | 152351821 | + | MBNL1 | NNNACAAAAAGCATGCAAAC | NGG | 2 | 0.2564 | Tier II |
9 | NC_000002.12 | 2 | 63191506 | - | WDPCP | NNNTCAAAAAGCCTGAACAC | NGG | 2 | 0.2105 | Tier II |
10 | NC_000008.11 | 8 | 68004500 | - | PREX2 | NNNTCAATAAGGATGCACAC | NGG | 2 | 0.1905 | Tier II |
11 | NC_000010.11 | 10 | 6107138 | + | RBM17 | NNNTCAAAATGCATGGACAC | NGG | 2 | 0.1357 | Tier II |
12 | NC_000001.11 | 1 | 204839085 | - | NFASC | NNNTCAAAAAGCATGCATCC | NGG | 2 | 0.133 | Tier II |
13 | NC_000018.10 | 18 | 44786273 | - | SETBP1 | NNNTCAATAAGCATGTACAC | NGG | 2 | 0.1319 | Tier II |
14 | NC_000019.10 | 19 | 48042982 | + | CABP5 | NNNTTAAAAAGCATGCCCAC | NGG | 2 | 0.1123 | Tier II |
15 | NC_000001.11 | 1 | 165639310 | + | MGST3 | NNNGCAAAAAGCATGGACAC | NGG | 2 | 0.0962 | Tier II |
16 | NC_000002.12 | 2 | 74267263 | - | SLC4A5 | NNNTCAAAAGGCATGCACAC | NGA | 2 | 0.0386 | Tier II |
17 | NC_000003.12 | 3 | 183408127 | - | MCF2L2 | NNNTCAAAAATCATGCACAC | NGA | 2 | 0.0267 | Tier II |
18 | NC_000005.10 | 5 | 5451865 | + | ICE1 | NNNTCAAATAGCATGCACAC | NTG | 2 | 0.0234 | Tier II |
19 | NC_000013.11 | 13 | 28005688 | + | FLT3 | NNNTCAAAAAGGATGCACAC | NTG | 2 | 0.0173 | Tier II |
20 | NC_000010.11 | 10 | 78665361 | - | LOC105378379 | NNNTCAAAAGGCATGCAAAC | NGG | 2 | 0.2991 | Tier III |
21 | NC_000023.11 | X | 131025551 | - | LINC01201 | NNNTCACAAAGCAAGCACAC | NGG | 2 | 0.2708 | Tier III |
22 | NC_000011.10 | 11 | 125683336 | - | LOC105369551 | NNNTCAACAATCATGCACAC | NGG | 2 | 0.1648 | Tier III |
23 | NC_000008.11 | 8 | 133163599 | - | LOC105375769 | NNNTCAAAAAACATGCAGAC | NGG | 2 | 0.1333 | Tier III |
24 | NC_000002.12 | 2 | 66015352 | - | LINC02934 | NNNCCAAAAAGCATGCACAC | NGA | 2 | 0.0449 | Tier III |
25 | NC_000006.12 | 6 | 139825709 | - | FILNC1 | NNNTCATAAAGCATGCACAC | NTG | 2 | 0.017 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000070.6 | 4 | 100441076 | - | Ror1 | NNNTCAAAGAGCATACACAC | NGG | 2 | 0.6275 | Tier I |
2 | NC_000080.6 | 14 | 4863939 | - | Gm3264 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier I |
3 | NC_000080.6 | 14 | 7650271 | + | Gm38418 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier I |
4 | NC_000073.6 | 7 | 29507430 | + | Sipa1l3 | NNNTCAAAAAGCATGCACAC | NGG | 0 | 1.0 | Tier II |
5 | NC_000072.6 | 6 | 61228697 | - | Ccser1 | NNNTCAAGAAGCATACACAC | NGG | 2 | 0.6902 | Tier II |
6 | NC_000075.6 | 9 | 27010728 | - | Vps26b | NNNTCAGAAAGCATACACAC | NGG | 2 | 0.6644 | Tier II |
7 | NC_000078.6 | 12 | 4892080 | + | Ubxn2a | NNNTCAAAAAGCAAACACAC | NGG | 2 | 0.5826 | Tier II |
8 | NC_000086.7 | X | 161085511 | - | Scml2 | NNNCCAAAATGCATGCACAC | NGG | 2 | 0.5709 | Tier II |
9 | NC_000086.7 | X | 161119637 | - | Scml2 | NNNCCAAAATGCATGCACAC | NGG | 2 | 0.5709 | Tier II |
10 | NC_000086.7 | X | 161152391 | - | Scml2 | NNNCCAAAATGCATGCACAC | NGG | 2 | 0.5709 | Tier II |
11 | NC_000067.6 | 1 | 52815513 | - | Inpp1 | NNNTCCAAATGCATGCACAC | NGG | 2 | 0.4011 | Tier II |
12 | NC_000083.6 | 17 | 34620169 | + | Ppt2 | NNNTTAAAAAGCAAGCACAC | NGG | 2 | 0.3939 | Tier II |
13 | NC_000077.6 | 11 | 50694099 | - | Adamts2 | NNNTTAAAAAGCATGCAAAC | NGG | 2 | 0.3427 | Tier II |
14 | NC_000080.6 | 14 | 54408055 | - | Slc7a7 | NNNTCAAAAAGCAAGCAAAC | NGG | 2 | 0.3333 | Tier II |
15 | NC_000068.7 | 2 | 139748916 | - | Ism1 | NNNTCAGAAAGGATGCACAC | NGG | 2 | 0.3137 | Tier II |
16 | NC_000086.7 | X | 36003721 | - | Dock11 | NNNTCTATAAGCATGCACAC | NGG | 2 | 0.3061 | Tier II |
17 | NC_000082.6 | 16 | 38543826 | + | Poglut1 | NNNAGAAAAAGCATGCACAC | NGG | 2 | 0.2857 | Tier II |
18 | NC_000074.6 | 8 | 39022172 | - | Tusc3 | NNNTCCAAAAGCAAGCACAC | NGG | 2 | 0.2814 | Tier II |
19 | NC_000079.6 | 13 | 108922967 | + | Pde4d | NNNTCAGAAATCATGCACAC | NGG | 2 | 0.2715 | Tier II |
20 | NC_000082.6 | 16 | 34063241 | + | Kalrn | NNNGCAAAAACCATGCACAC | NGG | 2 | 0.2679 | Tier II |
21 | NC_000080.6 | 14 | 23881112 | + | Kcnma1 | NNNTCAATAAGTATGCACAC | NGG | 2 | 0.2308 | Tier II |
22 | NC_000070.6 | 4 | 86838125 | - | Dennd4c | NNNCCAAAACGCATGCACAC | NGG | 2 | 0.2157 | Tier II |
23 | NC_000071.6 | 5 | 93141040 | - | Septin11 | NNNTCAAAAGGCTTGCACAC | NGG | 2 | 0.1667 | Tier II |
24 | NC_000084.6 | 18 | 77344295 | - | Loxhd1 | NNNCCAAAAAGCATGCCCAC | NGG | 2 | 0.1142 | Tier II |
25 | NC_000067.6 | 1 | 188583118 | - | Ush2a | NNNACAAAAAGCATGCACCC | NGG | 2 | 0.0985 | Tier II |
26 | NC_000077.6 | 11 | 68515281 | + | Pik3r6 | NNNTCAAAAAGAATGCACAG | NGG | 2 | 0.042 | Tier II |
27 | NC_000067.6 | 1 | 88229251 | + | Mroh2a | NNNTCAAAAAGCATTCACAC | NAG | 2 | 0.037 | Tier II |
28 | NC_000073.6 | 7 | 16580984 | + | Arhgap35 | NNNTCAAAATGCATGCACAC | NTG | 2 | 0.0344 | Tier II |
29 | NC_000074.6 | 8 | 9214846 | - | Fam155a | NNNTAAAAAAGCATGCACAC | NTG | 2 | 0.0223 | Tier II |
30 | NC_000075.6 | 9 | 104928478 | - | Cpne4 | NNNTCAAAAAGCATGGTCAC | NGG | 2 | 0.0205 | Tier II |
31 | NC_000071.6 | 5 | 7023932 | - | Zfp804b | NNNTCAAAAACCATGCACAC | NTG | 2 | 0.0167 | Tier II |
32 | NC_000078.6 | 12 | 79402907 | - | Rad51b | NNNTCAACAAGCATGCACAC | NTG | 2 | 0.0167 | Tier II |
33 | NC_000078.6 | 12 | 117700948 | - | Rapgef5 | NNNTCAAACAGCATGCACAC | NGT | 2 | 0.0092 | Tier II |
34 | NC_000075.6 | 9 | 74884508 | + | Onecut1 | NNNTCAAAAAGCATGCACAC | NCA | 2 | 0.0 | Tier II |
35 | NC_000080.6 | 14 | 3218080 | - | D830030K20Rik | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier II |
36 | NC_000080.6 | 14 | 3218080 | - | Gm38690 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier II |
37 | NC_000080.6 | 14 | 3957270 | - | Gm3095 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier II |
38 | NC_000080.6 | 14 | 4027463 | - | Gm5796 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier II |
39 | NC_000080.6 | 14 | 4027463 | - | Gm32966 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier II |
40 | NC_000080.6 | 14 | 4118860 | - | Gm8108 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier II |
41 | NC_000080.6 | 14 | 4118860 | - | Gm32966 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier II |
42 | NC_000080.6 | 14 | 4191004 | - | Gm2974 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier II |
43 | NC_000080.6 | 14 | 4341671 | - | 2610042L04Rik | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier II |
44 | NC_000080.6 | 14 | 4507541 | - | Gm3173 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier II |
45 | NC_000080.6 | 14 | 4657899 | - | Gm3239 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier II |
46 | NC_000080.6 | 14 | 4863939 | - | Gm26650 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier II |
47 | NC_000080.6 | 14 | 5157409 | - | Gm3317 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier II |
48 | NC_000080.6 | 14 | 5379706 | + | Gm3500 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier II |
49 | NC_000080.6 | 14 | 5451950 | + | Gm3194 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier II |
50 | NC_000080.6 | 14 | 5510050 | - | Gm3488 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier II |
51 | NC_000080.6 | 14 | 5732242 | + | Gm3373 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier II |
52 | NC_000080.6 | 14 | 5804441 | + | Gm3383 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier II |
53 | NC_000080.6 | 14 | 5952198 | + | Gm3248 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier II |
54 | NC_000080.6 | 14 | 6273806 | + | Gm3411 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier II |
55 | NC_000080.6 | 14 | 6418736 | + | Lamtor3-ps | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier II |
56 | NC_000080.6 | 14 | 6596858 | + | Gm33933 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier II |
57 | NC_000080.6 | 14 | 7019081 | + | Gm10406 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier II |
58 | NC_000080.6 | 14 | 7097101 | + | Gm3696 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier II |
59 | NC_000080.6 | 14 | 7097101 | + | Gm31035 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier II |
60 | NC_000080.6 | 14 | 7480285 | + | Gm3752 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier II |
61 | NC_000080.6 | 14 | 7559036 | + | Gm3558 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier II |
62 | NC_000080.6 | 14 | 19576742 | + | Gm2237 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier II |
63 | NC_000067.6 | 1 | 192931923 | + | Syt14 | NNNTCAACAAGCAGGCACAC | NGG | 2 | 0.0 | Tier II |
64 | NC_000083.6 | 17 | 3263572 | + | Gm34035 | NNNTCAAAATGCATGCACAA | NGG | 2 | 0.4412 | Tier III |
65 | NC_000067.6 | 1 | 188583118 | - | Gm36456 | NNNACAAAAAGCATGCACCC | NGG | 2 | 0.0985 | Tier III |
66 | NC_000078.6 | 12 | 8147506 | - | Gm33037 | NNNTGAAAAAGCATGGACAC | NGG | 2 | 0.0923 | Tier III |
67 | NC_000078.6 | 12 | 109535901 | - | Gm34081 | NNNTCAACAAGCATGCACAC | NCG | 2 | 0.0459 | Tier III |
68 | NC_000080.6 | 14 | 3420997 | - | Gm10409 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier III |
69 | NC_000080.6 | 14 | 3660413 | - | Gm3020 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier III |
70 | NC_000080.6 | 14 | 3818491 | - | Gm3002 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier III |
71 | NC_000080.6 | 14 | 4423822 | - | Gm3164 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier III |
72 | NC_000080.6 | 14 | 4734554 | - | Gm3252 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier III |
73 | NC_000080.6 | 14 | 5079419 | - | Gm8281 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier III |
74 | NC_000080.6 | 14 | 5157409 | - | Gm26552 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier III |
75 | NC_000080.6 | 14 | 5379706 | + | Gm41087 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier III |
76 | NC_000080.6 | 14 | 5732242 | + | Gm36476 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier III |
77 | NC_000080.6 | 14 | 5952198 | + | Gm51421 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier III |
78 | NC_000080.6 | 14 | 6418736 | + | Gm26630 | NNNTCAAAAAGCATGCACAC | NCT | 2 | 0.0 | Tier III |