Construct: sgRNA BRDN0001162514
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- AAGAGGCCATCTCCCATGAG
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- CAMKV (79012)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000003.12 | 3 | 49860476 | - | CAMKV | NNNAGGCCATCTCCCATGAG | NGG | 0 | 1.0 | Tier I |
2 | NC_000001.11 | 1 | 222628967 | - | MIA3 | NNNTGGTCATCTCCCATGAG | NGG | 2 | 0.517 | Tier I |
3 | NC_000009.12 | 9 | 135791051 | + | KCNT1 | NNNAGGCTGTCTCCCATGAG | NGG | 2 | 0.5833 | Tier II |
4 | NC_000002.12 | 2 | 42767973 | - | HAAO | NNNAGACCATCTCCCATGTG | NGG | 2 | 0.5385 | Tier II |
5 | NC_000005.10 | 5 | 15844536 | + | FBXL7 | NNNAGGCCATCTCTCATGAT | NGG | 2 | 0.5133 | Tier II |
6 | NC_000008.11 | 8 | 6475361 | - | MCPH1 | NNNAGCACATCTCCCATGAG | NGG | 2 | 0.5114 | Tier II |
7 | NC_000005.10 | 5 | 172898827 | - | ERGIC1 | NNNTGGCCATCTCCCATTAG | NGG | 2 | 0.4242 | Tier II |
8 | NC_000010.11 | 10 | 418922 | + | DIP2C | NNNAGGCCACCTTCCATGAG | NGG | 2 | 0.3733 | Tier II |
9 | NC_000003.12 | 3 | 196308711 | + | DYNLT2B | NNNAGGCAATCTCCCATGTG | NGG | 2 | 0.35 | Tier II |
10 | NC_000002.12 | 2 | 70728695 | - | ADD2 | NNNAGGGCTTCTCCCATGAG | NGG | 2 | 0.2824 | Tier II |
11 | NC_000001.11 | 1 | 153172125 | + | SPRR2G | NNNAAGCCATGTCCCATGAG | NGG | 2 | 0.2167 | Tier II |
12 | NC_000002.12 | 2 | 49633946 | - | LOC124906005 | NNNAGTCCATTTCCCATGAG | NGG | 2 | 0.2051 | Tier II |
13 | NC_000004.12 | 4 | 76771569 | + | SHROOM3 | NNNAGGGCATCTCACATGAG | NGG | 2 | 0.1647 | Tier II |
14 | NC_000020.11 | 20 | 62419858 | - | RBBP8NL | NNNAGGCCACCTCCCATGAG | NAG | 2 | 0.1383 | Tier II |
15 | NC_000004.12 | 4 | 102251847 | + | SLC39A8 | NNNAGGCCATCTCCCATGTG | NGA | 2 | 0.0374 | Tier II |
16 | NC_000005.10 | 5 | 149030705 | - | SH3TC2 | NNNAGGCCATCTCCCAGGAG | NAG | 2 | 0.0305 | Tier II |
17 | NC_000022.11 | 22 | 38244890 | + | TMEM184B | NNNAGGCCAGCTCCCATGAG | NGC | 2 | 0.0111 | Tier II |
18 | NC_000001.11 | 1 | 44890127 | - | EIF2B3 | NNNAGCCCATCTCCCATGAG | NGT | 2 | 0.011 | Tier II |
19 | NC_000005.10 | 5 | 73697538 | + | ARHGEF28 | NNNAGGCCATCTCACCTGAG | NGG | 2 | 0.0 | Tier II |
20 | NC_000005.10 | 5 | 5414739 | + | LOC101929200 | NNNAGTCCATCTCCCATGAG | NGG | 1 | 0.6667 | Tier III |
21 | NC_000009.12 | 9 | 135791051 | + | LOC107987140 | NNNAGGCTGTCTCCCATGAG | NGG | 2 | 0.5833 | Tier III |
22 | NC_000008.11 | 8 | 6475361 | - | LOC101928016 | NNNAGCACATCTCCCATGAG | NGG | 2 | 0.5114 | Tier III |
23 | NC_000009.12 | 9 | 2472809 | - | LOC101930053 | NNNAGCCCATCTCCCATGAT | NGG | 2 | 0.4773 | Tier III |
24 | NC_000004.12 | 4 | 76771569 | + | SHROOM3-AS1 | NNNAGGGCATCTCACATGAG | NGG | 2 | 0.1647 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000075.6 | 9 | 107947156 | + | Camkv | NNNAGGCCATCTCCCACGAA | NGG | 2 | 0.6618 | Tier I |
2 | NC_000068.7 | 2 | 26387258 | + | Entr1 | NNNAGGCCATATCCCATGAG | NTG | 2 | 0.0292 | Tier I |
3 | NC_000067.6 | 1 | 3397000 | - | Xkr4 | NNNACTCCATCTCCCATGAG | NGG | 2 | 0.5238 | Tier II |
4 | NC_000075.6 | 9 | 44266455 | + | Nlrx1 | NNNGGGCCATCTCCCAAGAG | NGG | 2 | 0.3333 | Tier II |
5 | NC_000081.6 | 15 | 7137394 | + | Lifr | NNNAGGCCAACTCCCAGGAG | NGG | 2 | 0.1008 | Tier II |
6 | NC_000085.6 | 19 | 10796539 | + | Cd6 | NNNAGGCCACCTGCCATGAG | NGG | 2 | 0.0727 | Tier II |
7 | NC_000080.6 | 14 | 33121563 | - | Wdfy4 | NNNAGGCCATCTCCCATGAG | NGA | 1 | 0.0694 | Tier II |
8 | NC_000085.6 | 19 | 34808674 | + | Pank1 | NNNAGGCCATTTCCAATGAG | NGG | 2 | 0.0684 | Tier II |
9 | NC_000067.6 | 1 | 127225740 | + | Mgat5 | NNNAGGCCATATCCCATGAG | NGA | 2 | 0.0521 | Tier II |
10 | NC_000073.6 | 7 | 46260576 | + | Otog | NNNAGGCCATTTCCCATGAG | NTG | 2 | 0.012 | Tier II |
11 | NC_000077.6 | 11 | 78975263 | - | Lgals9 | NNNAGCCCATCTCCCATGAG | NGT | 2 | 0.011 | Tier II |
12 | NC_000067.6 | 1 | 156289811 | + | Tdrd5 | NNNAGGCCATCGCCCATGAG | NGT | 2 | 0.0081 | Tier II |
13 | NC_000082.6 | 16 | 42249846 | + | Gap43 | NNNAGGCAATCTCCCTTGAG | NGG | 2 | 0.0 | Tier II |
14 | NC_000074.6 | 8 | 18800147 | - | Mcph1 | NNNAGGCCATCTCCCATGAG | NCA | 2 | 0.0 | Tier II |
15 | NC_000073.6 | 7 | 144612794 | - | Ano1 | NNNAGGCCATGTCCCCTGAG | NGG | 2 | 0.0 | Tier II |
16 | NC_000075.6 | 9 | 48418692 | - | Gm32131 | NNNTGGCCATCTCCCATGAG | NTG | 2 | 0.0248 | Tier III |