Construct: sgRNA BRDN0001162560
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- CGTCCTCAAAGTACACATCC
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- EEF2K (29904)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 77856
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000016.10 |
16 |
22251241 |
- |
EEF2K |
NNNCCTCAAAGTACACATCC |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000002.12 |
2 |
223998183 |
+ |
SERPINE2 |
NNNCCTCAAAGTTCACATTC |
NGG |
2 |
0.1385 |
Tier I |
3 |
NC_000011.10 |
11 |
8618931 |
+ |
TRIM66 |
NNNCCTCAAAGAACACTTCC |
NGG |
2 |
0.1067 |
Tier I |
4 |
NC_000020.11 |
20 |
49233315 |
- |
DDX27 |
NNNCCTCAAAGTACTCATCC |
NGC |
2 |
0.0044 |
Tier I |
5 |
NC_000001.11 |
1 |
207909796 |
+ |
CD34 |
NNNCCCCAAAGCACACATCC |
NGG |
2 |
0.8612 |
Tier II |
6 |
NC_000007.14 |
7 |
29159709 |
+ |
CHN2 |
NNNCCTCACAGCACACATCC |
NGG |
2 |
0.5414 |
Tier II |
7 |
NC_000007.14 |
7 |
29159709 |
+ |
CPVL |
NNNCCTCACAGCACACATCC |
NGG |
2 |
0.5414 |
Tier II |
8 |
NC_000011.10 |
11 |
16973143 |
- |
PLEKHA7 |
NNNCATAAAAGTACACATCC |
NGG |
2 |
0.4286 |
Tier II |
9 |
NC_000007.14 |
7 |
2816029 |
+ |
GNA12 |
NNNCGTCTAAGTACACATCC |
NGG |
2 |
0.2571 |
Tier II |
10 |
NC_000011.10 |
11 |
133381523 |
- |
OPCML |
NNNCCTCAAGCTACACATCC |
NGG |
2 |
0.2381 |
Tier II |
11 |
NC_000018.10 |
18 |
35051638 |
+ |
MAPRE2 |
NNNCCTCAAAGTGCACAGCC |
NGG |
2 |
0.2174 |
Tier II |
12 |
NC_000009.12 |
9 |
15191559 |
+ |
TTC39B |
NNNCCTCAAAGCCCACATCC |
NGG |
2 |
0.1994 |
Tier II |
13 |
NC_000009.12 |
9 |
132455867 |
- |
CFAP77 |
NNNCCTCAAAGCCCACATCC |
NGG |
2 |
0.1994 |
Tier II |
14 |
NC_000018.10 |
18 |
48556513 |
+ |
CTIF |
NNNCCTCAAAGTACACACTC |
NGG |
2 |
0.1978 |
Tier II |
15 |
NC_000005.10 |
5 |
45687794 |
+ |
HCN1 |
NNNCCTCAATGTACACATGC |
NGG |
2 |
0.1103 |
Tier II |
16 |
NC_000016.10 |
16 |
6968967 |
- |
RBFOX1 |
NNNCCTCAAAGTACACATCC |
NGA |
1 |
0.0694 |
Tier II |
17 |
NC_000007.14 |
7 |
70401336 |
- |
AUTS2 |
NNNCCTCAAACTACACATGC |
NGG |
2 |
0.0536 |
Tier II |
18 |
NC_000004.12 |
4 |
65245471 |
+ |
LOC124900852 |
NNNCCTCAAAGAATACATCC |
NGG |
2 |
0.5867 |
Tier III |
19 |
NC_000014.9 |
14 |
50962242 |
+ |
LOC400212 |
NNNCCTCAAGATACACATCC |
NGG |
2 |
0.5556 |
Tier III |
20 |
NC_000002.12 |
2 |
104403308 |
+ |
LOC100287010 |
NNNCACCAAAGTACACATCC |
NGG |
2 |
0.5195 |
Tier III |
21 |
NC_000001.11 |
1 |
94820105 |
+ |
SLC44A3-AS1 |
NNNCGTCAAAGTGCACATCC |
NGG |
2 |
0.3913 |
Tier III |
22 |
NC_000020.11 |
20 |
48558340 |
- |
LOC105372646 |
NNNCCTCAAAGTGCACATTC |
NGG |
2 |
0.301 |
Tier III |
23 |
NC_000002.12 |
2 |
39936394 |
+ |
SLC8A1-AS1 |
NNNCCTCAAAGTACAAATCC |
NAG |
2 |
0.2593 |
Tier III |
24 |
NC_000014.9 |
14 |
97743933 |
+ |
LOC105370651 |
NNNCCTCAAAGTACACATCA |
NGC |
2 |
0.0111 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000081.6 |
15 |
7254445 |
+ |
Egflam |
NNNCCTCAAAGGATACATCC |
NGG |
2 |
0.3667 |
Tier I |
2 |
NC_000067.6 |
1 |
75491011 |
+ |
Obsl1 |
NNNCCTCAAGGTGCACATCC |
NGG |
2 |
0.3623 |
Tier I |
3 |
NC_000070.6 |
4 |
128604354 |
- |
Zscan20 |
NNNCCTCAAAGAACAGATCC |
NGG |
2 |
0.1231 |
Tier I |
4 |
NC_000067.6 |
1 |
90931523 |
- |
Mlph |
NNNCCTCAAAGTCCACATCT |
NGG |
2 |
0.0632 |
Tier I |
5 |
NC_000086.7 |
X |
159366692 |
- |
Rps6ka3 |
NNNGCTCAAAGTATACATCC |
NGG |
2 |
0.3667 |
Tier II |
6 |
NC_000076.6 |
10 |
3823976 |
+ |
Plekhg1 |
NNNCCCCAAATTACACATCC |
NGG |
2 |
0.3497 |
Tier II |
7 |
NC_000075.6 |
9 |
9180944 |
+ |
Arhgap42 |
NNNCCTCACAGTACACATCA |
NGG |
2 |
0.2857 |
Tier II |
8 |
NC_000084.6 |
18 |
44538297 |
- |
Mcc |
NNNCCTCAGAGTACACACCC |
NGG |
2 |
0.2857 |
Tier II |
9 |
NC_000075.6 |
9 |
13570312 |
+ |
Maml2 |
NNNCCTCAAAGCTCACATCC |
NGG |
2 |
0.2842 |
Tier II |
10 |
NC_000067.6 |
1 |
74775942 |
- |
Wnt6 |
NNNCATCAAAGTACACATTC |
NGG |
2 |
0.2637 |
Tier II |
11 |
NC_000069.6 |
3 |
142819543 |
- |
Pkn2 |
NNNCTTCAAAGTAAACATCC |
NGG |
2 |
0.2227 |
Tier II |
12 |
NC_000079.6 |
13 |
47210653 |
+ |
Rnf144b |
NNNCCTCAAAGTACACACCA |
NGG |
2 |
0.2143 |
Tier II |
13 |
NC_000077.6 |
11 |
97217743 |
+ |
Npepps |
NNNCCTCTAAGTACACATCC |
NAG |
2 |
0.1111 |
Tier II |
14 |
NC_000069.6 |
3 |
142740110 |
+ |
Kyat3 |
NNNCCTCAAAGGACAGATCC |
NGG |
2 |
0.0769 |
Tier II |
15 |
NC_000074.6 |
8 |
113734236 |
+ |
Adamts18 |
NNNCCTCAAAGTCCATATCC |
NGG |
2 |
0.0648 |
Tier II |
16 |
NC_000076.6 |
10 |
73397125 |
- |
Pcdh15 |
NNNCCTCAAAGTAAACTTCC |
NGG |
2 |
0.0467 |
Tier II |
17 |
NC_000081.6 |
15 |
82931547 |
- |
Tcf20 |
NNNCCTCAAAGTTCACTTCC |
NGG |
2 |
0.04 |
Tier II |
18 |
NC_000085.6 |
19 |
10972834 |
+ |
Ms4a10 |
NNNCCTCAAAGTCCACCTCC |
NGG |
2 |
0.0372 |
Tier II |
19 |
NC_000076.6 |
10 |
43247179 |
- |
Pdss2 |
NNNCCTCAAAGTCCACTTCC |
NGG |
2 |
0.0281 |
Tier II |
20 |
NC_000081.6 |
15 |
30186333 |
+ |
Ctnnd2 |
NNNCCTCAAAGTACACATTC |
NGT |
2 |
0.0074 |
Tier II |
21 |
NC_000082.6 |
16 |
14103276 |
+ |
Bmerb1 |
NNNCCTCAAAGTCCACATCC |
NGT |
2 |
0.0034 |
Tier II |
22 |
NC_000077.6 |
11 |
82857807 |
+ |
Rffl |
NNNCCTCAAAGTACACATCC |
NAA |
2 |
0.0 |
Tier II |
23 |
NC_000080.6 |
14 |
120362464 |
+ |
Mbnl2 |
NNNCCTGAAAGTAGACATCC |
NGG |
2 |
0.0 |
Tier II |
24 |
NC_000069.6 |
3 |
64739279 |
+ |
Vmn2r-ps11 |
NNNCCTAAAAGGACACATCC |
NGG |
2 |
0.375 |
Tier III |
25 |
NC_000076.6 |
10 |
127842929 |
- |
Rdh18-ps |
NNNCCTAAAAGTACACATTC |
NGG |
2 |
0.3462 |
Tier III |
26 |
NC_000084.6 |
18 |
44538297 |
- |
Gm52347 |
NNNCCTCAGAGTACACACCC |
NGG |
2 |
0.2857 |
Tier III |
27 |
NC_000067.6 |
1 |
74775942 |
- |
Gm29539 |
NNNCATCAAAGTACACATTC |
NGG |
2 |
0.2637 |
Tier III |
28 |
NC_000067.6 |
1 |
73145784 |
- |
Gm31197 |
NNNCCTCAAAGTTAACATCC |
NGG |
2 |
0.105 |
Tier III |
29 |
NC_000067.6 |
1 |
73145784 |
- |
Gm29185 |
NNNCCTCAAAGTTAACATCC |
NGG |
2 |
0.105 |
Tier III |
30 |
NC_000081.6 |
15 |
30186333 |
+ |
Gm31953 |
NNNCCTCAAAGTACACATTC |
NGT |
2 |
0.0074 |
Tier III |
31 |
NC_000073.6 |
7 |
120841794 |
+ |
Gm36449 |
NNNCCTCAAAGTACACATGC |
NTG |
2 |
0.0049 |
Tier III |
32 |
NC_000070.6 |
4 |
56712426 |
+ |
Gm34687 |
NNNCCTCAAAGTTCACATCC |
NGT |
2 |
0.0048 |
Tier III |
33 |
NC_000080.6 |
14 |
120362464 |
+ |
Gm26679 |
NNNCCTGAAAGTAGACATCC |
NGG |
2 |
0.0 |
Tier III |
Other clones with same target sequence:
(none)