Construct: sgRNA BRDN0001487060
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- CTGCCCACCTAAGCTTACTG
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- MST1R (4486)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000003.12 | 3 | 49898523 | - | MST1R | NNNCCCACCTAAGCTTACTG | NGG | 0 | 1.0 | Tier I |
2 | NC_000018.10 | 18 | 79472307 | - | NFATC1 | NNNCCCAGCTGAGCTTACTG | NGG | 2 | 0.4179 | Tier II |
3 | NC_000012.12 | 12 | 39746462 | + | REDIC1 | NNNCCCACCTCAGCTCACTG | NGG | 2 | 0.2667 | Tier II |
4 | NC_000010.11 | 10 | 116757168 | - | HSPA12A | NNNCCCAGCTAAGCCTACTG | NGG | 2 | 0.1753 | Tier II |
5 | NC_000003.12 | 3 | 9768605 | + | OGG1 | NNNCCCAGCTAAGCTTGCTG | NGG | 2 | 0.1134 | Tier II |
6 | NC_000003.12 | 3 | 9768605 | + | CAMK1 | NNNCCCAGCTAAGCTTGCTG | NGG | 2 | 0.1134 | Tier II |
7 | NC_000007.14 | 7 | 98396193 | + | BAIAP2L1 | NNNCCCACCTCAGCCTACTG | NGG | 2 | 0.1091 | Tier II |
8 | NC_000006.12 | 6 | 143716597 | + | PHACTR2 | NNNCCCACCTCAGCTTACTG | NAG | 2 | 0.1037 | Tier II |
9 | NC_000002.12 | 2 | 61103260 | + | SANBR | NNNCCCACCTCAGCTTCCTG | NGG | 2 | 0.0706 | Tier II |
10 | NC_000003.12 | 3 | 155618769 | + | PLCH1 | NNNCCCACCTCAGCTTCCTG | NGG | 2 | 0.0706 | Tier II |
11 | NC_000006.12 | 6 | 27460062 | - | ZNF184 | NNNCCCACCTCAGCTTCCTG | NGG | 2 | 0.0706 | Tier II |
12 | NC_000010.11 | 10 | 12636451 | + | CAMK1D | NNNCCCACCTCAGCTTCCTG | NGG | 2 | 0.0706 | Tier II |
13 | NC_000010.11 | 10 | 74192650 | + | ADK | NNNCCCACCTCAGCTTCCTG | NGG | 2 | 0.0706 | Tier II |
14 | NC_000012.12 | 12 | 122365904 | - | CLIP1 | NNNCCCACCTCAGCTTCCTG | NGG | 2 | 0.0706 | Tier II |
15 | NC_000013.11 | 13 | 30563504 | - | HMGB1 | NNNCCCACCTCAGCTTCCTG | NGG | 2 | 0.0706 | Tier II |
16 | NC_000013.11 | 13 | 92102982 | + | GPC5 | NNNCCCACCTCAGCTTCCTG | NGG | 2 | 0.0706 | Tier II |
17 | NC_000014.9 | 14 | 62107328 | - | SYT16 | NNNCCCACCTCAGCTTCCTG | NGG | 2 | 0.0706 | Tier II |
18 | NC_000015.10 | 15 | 68976295 | + | SPESP1-NOX5 | NNNCCCACCTCAGCTTCCTG | NGG | 2 | 0.0706 | Tier II |
19 | NC_000019.10 | 19 | 47207758 | + | SAE1 | NNNCCCACCTCAGCTTCCTG | NGG | 2 | 0.0706 | Tier II |
20 | NC_000022.11 | 22 | 33209769 | + | LARGE1 | NNNCCCACCTCAGCTTCCTG | NGG | 2 | 0.0706 | Tier II |
21 | NC_000010.11 | 10 | 25420273 | + | GPR158 | NNNCCCACCTCAGCTTTCTG | NGG | 2 | 0.0533 | Tier II |
22 | NC_000011.10 | 11 | 11892711 | - | USP47 | NNNCCCACCTAAGCCTCCTG | NGG | 2 | 0.0481 | Tier II |
23 | NC_000009.12 | 9 | 36121008 | - | RECK | NNNCCCACCTATGCTTACTG | NGC | 2 | 0.0074 | Tier II |
24 | NC_000003.12 | 3 | 13119532 | - | IQSEC1 | NNNCCCACCTAACCTTACTG | NGT | 2 | 0.0068 | Tier II |
25 | NC_000002.12 | 2 | 73868769 | - | STAMBP | NNNCCCACCTCAGCTTACTG | NGT | 2 | 0.0065 | Tier II |
26 | NC_000010.11 | 10 | 104704291 | + | SORCS3 | NNNCCCACCTCAGCTTACTG | NGT | 2 | 0.0065 | Tier II |
27 | NC_000012.12 | 12 | 11147311 | + | PRH1 | NNNCCCACCTCAGCTTACTG | NGT | 2 | 0.0065 | Tier II |
28 | NC_000012.12 | 12 | 11147311 | + | PRH1-TAS2R14 | NNNCCCACCTCAGCTTACTG | NGT | 2 | 0.0065 | Tier II |
29 | NC_000015.10 | 15 | 42463695 | - | ZNF106 | NNNCCCACCTCAGCTTACTG | NGT | 2 | 0.0065 | Tier II |
30 | NC_000015.10 | 15 | 51845652 | - | TMOD3 | NNNCCCACCTCAGCTTACTG | NGT | 2 | 0.0065 | Tier II |
31 | NC_000023.11 | X | 53119171 | + | KANTR | NNNCCCACCTCAGCTTACTG | NGT | 2 | 0.0065 | Tier II |
32 | NC_000003.12 | 3 | 81631099 | - | GBE1 | NNNCCCACCTAAGCCTACTG | NGT | 2 | 0.0044 | Tier II |
33 | NC_000014.9 | 14 | 20347997 | + | PARP2 | NNNCCCACCTAAGCTTCCTG | NGT | 2 | 0.0028 | Tier II |
34 | NC_000017.11 | 17 | 74691350 | - | RAB37 | NNNCCCATCTAAGGTTACTG | NGG | 2 | 0.0 | Tier II |
35 | NC_000018.10 | 18 | 79472307 | - | LOC107985162 | NNNCCCAGCTGAGCTTACTG | NGG | 2 | 0.4179 | Tier III |
36 | NC_000006.12 | 6 | 29331766 | + | LOC105375005 | NNNCCCACCTCAGCATACTG | NGG | 2 | 0.2316 | Tier III |
37 | NC_000006.12 | 6 | 131429785 | - | LOC105378005 | NNNCCCACCTCAGCCTACTG | NGG | 2 | 0.1091 | Tier III |
38 | NC_000004.12 | 4 | 121957958 | - | LOC102724158 | NNNCCCACCTCAGCTTCCTG | NGG | 2 | 0.0706 | Tier III |
39 | NC_000008.11 | 8 | 85229701 | - | LOC105375936 | NNNCCCACCTCAGCTTCCTG | NGG | 2 | 0.0706 | Tier III |
40 | NC_000008.11 | 8 | 85229701 | - | LOC124901969 | NNNCCCACCTCAGCTTCCTG | NGG | 2 | 0.0706 | Tier III |
41 | NC_000012.12 | 12 | 87790607 | - | LINC02258 | NNNCCCACCTAACCTTACTG | NGT | 2 | 0.0068 | Tier III |
42 | NC_000012.12 | 12 | 11147311 | + | PRH1-PRR4 | NNNCCCACCTCAGCTTACTG | NGT | 2 | 0.0065 | Tier III |
43 | NC_000003.12 | 3 | 66713446 | - | LOC105377142 | NNNCCCACCTAAGCTTCCTG | NGT | 2 | 0.0028 | Tier III |
44 | NC_000004.12 | 4 | 84536561 | - | LOC102723338 | NNNCCCACCTAAGCTTCCTG | NGT | 2 | 0.0028 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000077.6 | 11 | 61157036 | - | Usp22 | NNNCTTACCTAAGCTTACTG | NGG | 2 | 0.5909 | Tier II |
2 | NC_000079.6 | 13 | 85198023 | - | Ccnh | NNNCCCACCTAAACTTCCTG | NGG | 2 | 0.1629 | Tier II |
3 | NC_000068.7 | 2 | 179761330 | + | Cdh4 | NNNCCCCCCTAAGCTGACTG | NGG | 2 | 0.1514 | Tier II |
4 | NC_000073.6 | 7 | 145252959 | + | Tpcn2 | NNNCCCACCTACCCTTACTG | NGG | 2 | 0.1108 | Tier II |
5 | NC_000069.6 | 3 | 83913199 | + | Tmem131l | NNNCCCACCTAAGCCTACAG | NGG | 2 | 0.0779 | Tier II |
6 | NC_000076.6 | 10 | 118556114 | + | Ifngas1 | NNNTCCACCAAAGCTTACTG | NGG | 2 | 0.6857 | Tier III |