Construct: sgRNA BRDN0001487068
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- CTTGTTGTAAATGTAACAGT
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- BRD2 (6046)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000006.12 | 6 | 32975505 | - | BRD2 | NNNGTTGTAAATGTAACAGT | NGG | 0 | 1.0 | Tier I |
2 | NC_000009.12 | 9 | 129071920 | + | MIGA2 | NNNGCTGTGAATGTAACAGT | NGG | 2 | 0.6667 | Tier II |
3 | NC_000005.10 | 5 | 22604788 | + | CDH12 | NNNGTTGCAAATGTAACAGA | NGG | 2 | 0.5625 | Tier II |
4 | NC_000006.12 | 6 | 148436885 | + | SASH1 | NNNGTAGTAAATGAAACAGT | NGG | 2 | 0.5365 | Tier II |
5 | NC_000003.12 | 3 | 179385334 | - | MFN1 | NNNGGTCTAAATGTAACAGT | NGG | 2 | 0.44 | Tier II |
6 | NC_000002.12 | 2 | 113632143 | + | RABL2A | NNNGTTGTAAAGGTAACATT | NGG | 2 | 0.3333 | Tier II |
7 | NC_000022.11 | 22 | 50778754 | - | RABL2B | NNNGTTGTAAAGGTAACATT | NGG | 2 | 0.3333 | Tier II |
8 | NC_000005.10 | 5 | 98899207 | - | CHD1 | NNNGTTGTAAATGTAAAATT | NGG | 2 | 0.3111 | Tier II |
9 | NC_000003.12 | 3 | 130996302 | + | ATP2C1 | NNNGTTGTAAATGTAACAGT | NAG | 1 | 0.2593 | Tier II |
10 | NC_000017.11 | 17 | 8521577 | - | MYH10 | NNNATTGTAAATGTAACAGT | NAG | 2 | 0.2333 | Tier II |
11 | NC_000001.11 | 1 | 65345050 | + | DNAJC6 | NNNGTTGTAAATGTAACAGA | NAG | 2 | 0.1458 | Tier II |
12 | NC_000003.12 | 3 | 173860556 | + | NLGN1 | NNNGGTGTAAATGTTACAGT | NGG | 2 | 0.128 | Tier II |
13 | NC_000006.12 | 6 | 148880607 | - | UST | NNNGTTGTAAATGTAACATG | NGG | 2 | 0.1176 | Tier II |
14 | NC_000002.12 | 2 | 31371495 | - | XDH | NNNGTTGTAACTGCAACAGT | NGG | 2 | 0.1143 | Tier II |
15 | NC_000007.14 | 7 | 116997816 | - | ST7 | NNNTTTGTAAATGTAACAGT | NAG | 2 | 0.0943 | Tier II |
16 | NC_000022.11 | 22 | 40437824 | - | MRTFA | NNNGTTGTAAATGTAAACGT | NGG | 2 | 0.0889 | Tier II |
17 | NC_000010.11 | 10 | 47985636 | - | ANXA8 | NNNGTTGTAAATCTTACAGT | NGG | 2 | 0.0842 | Tier II |
18 | NC_000013.11 | 13 | 98910325 | - | DOCK9 | NNNATTGTAAATGTAACAGT | NTG | 2 | 0.0351 | Tier II |
19 | NC_000009.12 | 9 | 71367473 | + | TRPM3 | NNNTTTGTAAATGTAACAGT | NTG | 2 | 0.0142 | Tier II |
20 | NC_000013.11 | 13 | 112827058 | - | ATP11A | NNNGTTGTAAATGTAACAGC | NCG | 2 | 0.0097 | Tier II |
21 | NC_000005.10 | 5 | 122997008 | + | SNX24 | NNNGTTGTAAATGGAACAGT | NGT | 2 | 0.0 | Tier II |
22 | NC_000009.12 | 9 | 91752419 | - | ROR2 | NNNGTTGTACATGTATCAGT | NGG | 2 | 0.0 | Tier II |
23 | NC_000003.12 | 3 | 164148386 | + | LOC102724419 | NNNGTGGGAAATGTAACAGT | NGG | 2 | 0.419 | Tier III |
24 | NC_000022.11 | 22 | 50778754 | - | RPL23AP82 | NNNGTTGTAAAGGTAACATT | NGG | 2 | 0.3333 | Tier III |
25 | NC_000010.11 | 10 | 46399017 | + | LINC00842 | NNNGTTGTAAATCTTACAGT | NGG | 2 | 0.0842 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000083.6 | 17 | 34116215 | + | Brd2 | NNNGTTATAAATGTAACAGT | NGG | 1 | 1.0 | Tier I |
2 | NC_000072.6 | 6 | 61759061 | + | Ccser1 | NNNATTGTAAATGTAACAGT | NGG | 1 | 0.9 | Tier II |
3 | NC_000071.6 | 5 | 35087801 | - | Dok7 | NNNGTTAAAAATGTAACAGT | NGG | 2 | 0.8 | Tier II |
4 | NC_000071.6 | 5 | 128837499 | - | Rimbp2 | NNNGGTGTAAATGTAACAGT | NGG | 1 | 0.64 | Tier II |
5 | NC_000069.6 | 3 | 154675082 | + | Erich3 | NNNATTGTAAGTGTAACAGT | NGG | 2 | 0.585 | Tier II |
6 | NC_000078.6 | 12 | 98862003 | - | Eml5 | NNNGTTGTAGATGTAACAGT | NGG | 1 | 0.5556 | Tier II |
7 | NC_000069.6 | 3 | 121774546 | - | Abcd3 | NNNGTTTTATATGTAACAGT | NGG | 2 | 0.5042 | Tier II |
8 | NC_000080.6 | 14 | 124041951 | + | Fgf14 | NNNGTTATAAATGTAACTGT | NGG | 2 | 0.5 | Tier II |
9 | NC_000082.6 | 16 | 41747049 | + | Lsamp | NNNGTTGAAAATGTAACAGA | NGG | 2 | 0.45 | Tier II |
10 | NC_000075.6 | 9 | 28439451 | + | Opcml | NNNGTTGTAAATGTAACACT | NGG | 1 | 0.4483 | Tier II |
11 | NC_000068.7 | 2 | 155164598 | + | Itch | NNNGTTGTAGATGTAACAAT | NGG | 2 | 0.3968 | Tier II |
12 | NC_000086.7 | X | 147421704 | + | Il13ra2 | NNNGGTGTAGATGTAACAGT | NGG | 2 | 0.3556 | Tier II |
13 | NC_000084.6 | 18 | 59062858 | - | Minar2 | NNNTTTGAAAATGTAACAGT | NGG | 2 | 0.2909 | Tier II |
14 | NC_000070.6 | 4 | 45307349 | + | Trmt10b | NNNCTTGTAAAGGTAACAGT | NGG | 2 | 0.2647 | Tier II |
15 | NC_000071.6 | 5 | 130551879 | + | Caln1 | NNNGATGTAAAGGTAACAGT | NGG | 2 | 0.25 | Tier II |
16 | NC_000074.6 | 8 | 65739548 | - | Marchf1 | NNNGTTGTAAATGTAACATT | NAG | 2 | 0.1728 | Tier II |
17 | NC_000068.7 | 2 | 68954406 | - | Cers6 | NNNGTTGTAATTCTAACAGT | NGG | 2 | 0.1296 | Tier II |
18 | NC_000085.6 | 19 | 22260318 | - | Trpm3 | NNNGTTGTAAATGTAACCTT | NGG | 2 | 0.127 | Tier II |
19 | NC_000071.6 | 5 | 138088859 | + | Zkscan1 | NNNGTTGTAGATGTAGCAGT | NGG | 2 | 0.1068 | Tier II |
20 | NC_000076.6 | 10 | 88351246 | + | Dram1 | NNNGTTGTAAATTTAAGAGT | NGG | 2 | 0.0176 | Tier II |
21 | NC_000067.6 | 1 | 162210787 | - | Dnm3 | NNNGTTGTAAATGTAACAGT | NGT | 1 | 0.0161 | Tier II |
22 | NC_000069.6 | 3 | 145368748 | + | Col24a1 | NNNGCTGTAAATGTATCAGT | NGG | 2 | 0.0 | Tier II |
23 | NC_000074.6 | 8 | 24952220 | - | Adam9 | NNNGTTGTAAATGAATCAGT | NGG | 2 | 0.0 | Tier II |
24 | NC_000070.6 | 4 | 121179301 | - | Rlf | NNNGTTGTAAATGGATCAGT | NGG | 2 | 0.0 | Tier II |
25 | NC_000076.6 | 10 | 31572793 | - | Rnf217 | NNNGTTGTAAATGTATCATT | NGG | 2 | 0.0 | Tier II |
26 | NC_000067.6 | 1 | 61846479 | + | Pard3b | NNNGTTGTAAATTTATCAGT | NGG | 2 | 0.0 | Tier II |
27 | NC_000072.6 | 6 | 54182975 | - | Chn2 | NNNGTTGTAATTGTATCAGT | NGG | 2 | 0.0 | Tier II |
28 | NC_000070.6 | 4 | 77945065 | - | Ptprd | NNNGTTGTACATGTATCAGT | NGG | 2 | 0.0 | Tier II |
29 | NC_000085.6 | 19 | 17459173 | - | Pcsk5 | NNNGTTGTAGATGTACCAGT | NGG | 2 | 0.0 | Tier II |
30 | NC_000069.6 | 3 | 100614545 | - | Man1a2 | NNNGTTGTAGATGTATCAGT | NGG | 2 | 0.0 | Tier II |
31 | NC_000071.6 | 5 | 102787277 | + | Arhgap24 | NNNGTTGTAGATGTATCAGT | NGG | 2 | 0.0 | Tier II |
32 | NC_000074.6 | 8 | 17438975 | - | C030002A05Rik | NNNGTTGTAGATGTATCAGT | NGG | 2 | 0.0 | Tier II |
33 | NC_000074.6 | 8 | 17438975 | - | Csmd1 | NNNGTTGTAGATGTATCAGT | NGG | 2 | 0.0 | Tier II |
34 | NC_000074.6 | 8 | 65724154 | - | Marchf1 | NNNGTTGTAGATGTATCAGT | NGG | 2 | 0.0 | Tier II |
35 | NC_000074.6 | 8 | 85832229 | - | Itfg1 | NNNGTTGTAGATGTATCAGT | NGG | 2 | 0.0 | Tier II |
36 | NC_000075.6 | 9 | 64879313 | + | Dennd4a | NNNGTTGTAGATGTATCAGT | NGG | 2 | 0.0 | Tier II |
37 | NC_000076.6 | 10 | 20482760 | - | Pde7b | NNNGTTGTAGATGTATCAGT | NGG | 2 | 0.0 | Tier II |
38 | NC_000076.6 | 10 | 76109557 | - | Slc5a4b | NNNGTTGTAGATGTATCAGT | NGG | 2 | 0.0 | Tier II |
39 | NC_000077.6 | 11 | 58284392 | + | 4930438A08Rik | NNNGTTGTAGATGTATCAGT | NGG | 2 | 0.0 | Tier II |
40 | NC_000081.6 | 15 | 72940219 | - | Trappc9 | NNNGTTGTAGATGTATCAGT | NGG | 2 | 0.0 | Tier II |
41 | NC_000084.6 | 18 | 89392821 | + | Dok6 | NNNGTTGTAGATGTATCAGT | NGG | 2 | 0.0 | Tier II |
42 | NC_000085.6 | 19 | 50412339 | + | Sorcs1 | NNNGTTGTAGATGTATCAGT | NGG | 2 | 0.0 | Tier II |
43 | NC_000086.7 | X | 42964128 | + | Tenm1 | NNNGTTGTAGATGTATCAGT | NGG | 2 | 0.0 | Tier II |
44 | NC_000069.6 | 3 | 101023556 | - | Cd101 | NNNGTTGTGAATGTATCAGT | NGG | 2 | 0.0 | Tier II |
45 | NC_000079.6 | 13 | 23933483 | - | Gm33516 | NNNGCTGGAAATGTAACAGT | NGG | 2 | 0.7333 | Tier III |
46 | NC_000067.6 | 1 | 41778027 | + | Gm29260 | NNNGTTGTAGATGTGACAGT | NGG | 2 | 0.3611 | Tier III |
47 | NC_000071.6 | 5 | 86375441 | - | Gm35367 | NNNGTTGTAAATGAAACAGA | NGG | 2 | 0.3482 | Tier III |
48 | NC_000076.6 | 10 | 27784445 | + | Gm30228 | NNNGTTGTAAATGTAACCGT | NGG | 1 | 0.1905 | Tier III |
49 | NC_000085.6 | 19 | 22260318 | - | Gm33755 | NNNGTTGTAAATGTAACCTT | NGG | 2 | 0.127 | Tier III |
50 | NC_000067.6 | 1 | 96615759 | + | 4930533P14Rik | NNNGTTGTAAATGTAGCTGT | NGG | 2 | 0.0962 | Tier III |
51 | NC_000072.6 | 6 | 134341212 | - | 4933406J09Rik | NNNGCTGTAAATGTATCAGT | NGG | 2 | 0.0 | Tier III |
52 | NC_000080.6 | 14 | 46665578 | - | D330046F09Rik | NNNGTTGTAAAAGTACCAGT | NGG | 2 | 0.0 | Tier III |
53 | NC_000086.7 | X | 153047211 | - | 9530051G07Rik | NNNGTTGTAAATATATCAGT | NGG | 2 | 0.0 | Tier III |
54 | NC_000072.6 | 6 | 92978188 | - | 9530026P05Rik | NNNGTTGTAAATGTATCAAT | NGG | 2 | 0.0 | Tier III |
55 | NC_000068.7 | 2 | 144777239 | - | Gm39951 | NNNGTTGTAAATGTATCAGT | NGC | 2 | 0.0 | Tier III |
56 | NC_000080.6 | 14 | 53711352 | - | Tcra | NNNGTTGTAAATGTATCAGT | NTG | 2 | 0.0 | Tier III |
57 | NC_000067.6 | 1 | 61846479 | + | Pard3bos1 | NNNGTTGTAAATTTATCAGT | NGG | 2 | 0.0 | Tier III |
58 | NC_000067.6 | 1 | 79789828 | - | Gm39666 | NNNGTTGTAGATGTATCAGT | NGG | 2 | 0.0 | Tier III |
59 | NC_000077.6 | 11 | 58284392 | + | Gm39827 | NNNGTTGTAGATGTATCAGT | NGG | 2 | 0.0 | Tier III |