Construct: sgRNA BRDN0001487138
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- AGCGCTCTGGTTGCATCCCT
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- NO_SITE control
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 80227
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000003.12 |
3 |
193301281 |
- |
ATP13A5 |
NNNGCTCTGGTTTCATCCTT |
NGG |
2 |
0.1385 |
Tier I |
2 |
NC_000020.11 |
20 |
46949831 |
+ |
EYA2 |
NNNGCTTTGGTTGCAACCCT |
NGG |
2 |
0.7386 |
Tier II |
3 |
NC_000001.11 |
1 |
108881026 |
+ |
GPSM2 |
NNNGCTCTGATTGCATACCT |
NGG |
2 |
0.4356 |
Tier II |
4 |
NC_000022.11 |
22 |
47066522 |
+ |
TBC1D22A |
NNNCCTCTGTTTGCATCCCT |
NGG |
2 |
0.4301 |
Tier II |
5 |
NC_000001.11 |
1 |
2088424 |
+ |
PRKCZ |
NNNGCCCTGGTTGCATCCTT |
NGG |
2 |
0.4196 |
Tier II |
6 |
NC_000001.11 |
1 |
7676199 |
- |
CAMTA1 |
NNNGCTCTGTTGGCATCCCT |
NGG |
2 |
0.4063 |
Tier II |
7 |
NC_000005.10 |
5 |
176528310 |
+ |
RNF44 |
NNNGGTCTGGCTGCATCCCT |
NGG |
2 |
0.4 |
Tier II |
8 |
NC_000017.11 |
17 |
74338254 |
+ |
KIF19 |
NNNGTTCTGGTTGCATCCCA |
NGG |
2 |
0.358 |
Tier II |
9 |
NC_000001.11 |
1 |
231028164 |
+ |
FAM89A |
NNNCCTCTGGCTGCATCCCT |
NGG |
2 |
0.3529 |
Tier II |
10 |
NC_000017.11 |
17 |
20949507 |
+ |
LOC124900389 |
NNNGCTCTGTTTGCATCCAT |
NGG |
2 |
0.3482 |
Tier II |
11 |
NC_000002.12 |
2 |
73092927 |
- |
RAB11FIP5 |
NNNGCTCTGGTTGAGTCCCT |
NGG |
2 |
0.2275 |
Tier II |
12 |
NC_000017.11 |
17 |
45672702 |
+ |
LINC02210-CRHR1 |
NNNGCTCTGGTTGCTTCCTT |
NGG |
2 |
0.0923 |
Tier II |
13 |
NC_000005.10 |
5 |
78542473 |
+ |
LHFPL2 |
NNNGCTCTGCTTGCATCCCG |
NGG |
2 |
0.0706 |
Tier II |
14 |
NC_000005.10 |
5 |
42649942 |
- |
GHR |
NNNGCTCTGGTTTCTTCCCT |
NGG |
2 |
0.06 |
Tier II |
15 |
NC_000006.12 |
6 |
13974242 |
- |
RNF182 |
NNNGCTCTGGTAGCATCCCT |
NGA |
2 |
0.0556 |
Tier II |
16 |
NC_000008.11 |
8 |
23399079 |
+ |
LOXL2 |
NNNGCTCTGGTTGCATCTCT |
NTG |
2 |
0.025 |
Tier II |
17 |
NC_000019.10 |
19 |
17645630 |
+ |
UNC13A |
NNNGCTCTGGCTGGATCCCT |
NGG |
2 |
0.0 |
Tier II |
18 |
NC_000017.11 |
17 |
74338254 |
+ |
LOC107985078 |
NNNGTTCTGGTTGCATCCCA |
NGG |
2 |
0.358 |
Tier III |
19 |
NC_000017.11 |
17 |
20949507 |
+ |
LOC339260 |
NNNGCTCTGTTTGCATCCAT |
NGG |
2 |
0.3482 |
Tier III |
20 |
NC_000003.12 |
3 |
13680373 |
+ |
LINC00620 |
NNNGCTCAGGTTGCTTCCCT |
NGG |
2 |
0.16 |
Tier III |
21 |
NC_000017.11 |
17 |
6865214 |
+ |
ALOX12P2 |
NNNGCTCTGGTTCCATCCCT |
NGA |
2 |
0.0292 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000067.6 |
1 |
135998580 |
- |
Igfn1 |
NNNGCTCTGGTGACATCCCT |
NGG |
2 |
0.4615 |
Tier I |
2 |
NC_000085.6 |
19 |
6994749 |
- |
Nudt22 |
NNNGCTCTGGTGGCATCCCC |
NGG |
2 |
0.0455 |
Tier I |
3 |
NC_000068.7 |
2 |
7389408 |
- |
Celf2 |
NNNGCTCTGGTTATATCCCT |
NGG |
2 |
0.6769 |
Tier II |
4 |
NC_000081.6 |
15 |
11877492 |
- |
Npr3 |
NNNGCTCTGGCAGCATCCCT |
NGG |
2 |
0.5333 |
Tier II |
5 |
NC_000069.6 |
3 |
8518126 |
+ |
Stmn2 |
NNNGCACTGGTTGCATTCCT |
NGG |
2 |
0.4044 |
Tier II |
6 |
NC_000076.6 |
10 |
85408243 |
- |
Btbd11 |
NNNGCTCTCGTTGTATCCCT |
NGG |
2 |
0.3949 |
Tier II |
7 |
NC_000067.6 |
1 |
91025034 |
- |
Lrrfip1 |
NNNGATCTGGCTGCATCCCT |
NGG |
2 |
0.381 |
Tier II |
8 |
NC_000070.6 |
4 |
147919045 |
- |
Plod1 |
NNNTCTCTGATTGCATCCCT |
NGG |
2 |
0.3394 |
Tier II |
9 |
NC_000084.6 |
18 |
25102159 |
+ |
Fhod3 |
NNNGCCCTGGTTTCATCCCT |
NGG |
2 |
0.2727 |
Tier II |
10 |
NC_000077.6 |
11 |
85358128 |
+ |
Bcas3 |
NNNGCTCTGGGTCCATCCCT |
NGG |
2 |
0.1684 |
Tier II |
11 |
NC_000077.6 |
11 |
32667115 |
+ |
Fbxw11 |
NNNGCTCTGGTTGCATCTCT |
NGC |
2 |
0.0143 |
Tier II |
12 |
NC_000067.6 |
1 |
193158589 |
+ |
Irf6 |
NNNGGTCTGGTTGCATCCCT |
NGC |
2 |
0.0133 |
Tier II |
13 |
NC_000079.6 |
13 |
111795964 |
- |
Map3k1 |
NNNGCTCTGGTTCCATCCCT |
NGC |
2 |
0.0094 |
Tier II |
14 |
NC_000081.6 |
15 |
35408530 |
- |
Vps13b |
NNNGCTCTGGCTGGATCCCT |
NGG |
2 |
0.0 |
Tier II |
15 |
NC_000071.6 |
5 |
89539118 |
- |
Npffr2 |
NNNGCTCTGGTTGCATCCCT |
NAT |
2 |
0.0 |
Tier II |
16 |
NC_000084.6 |
18 |
23633178 |
+ |
Dtna |
NNNGCTCTGGTTGGAACCCT |
NGG |
2 |
0.0 |
Tier II |
17 |
NC_000069.6 |
3 |
153086429 |
+ |
Gm52620 |
NNNGCTCTGGTTACATCCAT |
NGG |
2 |
0.3956 |
Tier III |
18 |
NC_000083.6 |
17 |
39896395 |
- |
AY036118 |
NNNGCTCTGGTTGCAGACCT |
NGG |
2 |
0.1615 |
Tier III |
19 |
NC_000070.6 |
4 |
95105954 |
- |
Junos |
NNNGCTCTGGTTGCATCCAT |
NAG |
2 |
0.1111 |
Tier III |
Other clones with same target sequence:
(none)