Construct: sgRNA BRDN0001144724
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- TGTGCATGATTCCCTTGCTG
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- CSNK2A2 (1459)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 75586
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000016.10 |
16 |
58168674 |
+ |
CSNK2A2 |
NNNGCATGATTCCCTTGCTG |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000005.10 |
5 |
6378093 |
+ |
MED10 |
NNNGCATGATTCCCTTGATA |
NGG |
2 |
0.5048 |
Tier II |
3 |
NC_000017.11 |
17 |
58301350 |
- |
TSPOAP1 |
NNNGCATGTTTCCTTTGCTG |
NGG |
2 |
0.44 |
Tier II |
4 |
NC_000011.10 |
11 |
2714820 |
- |
KCNQ1 |
NNNGCATCATTCCCTTGCTT |
NGG |
2 |
0.4308 |
Tier II |
5 |
NC_000001.11 |
1 |
14964232 |
+ |
KAZN |
NNNCCATGATTCCTTTGCTG |
NGG |
2 |
0.3882 |
Tier II |
6 |
NC_000011.10 |
11 |
132198252 |
+ |
NTM |
NNNCCATGATGCCCTTGCTG |
NGG |
2 |
0.2118 |
Tier II |
7 |
NC_000005.10 |
5 |
114212322 |
+ |
KCNN2 |
NNNGCATAATTCCCTTGGTG |
NGG |
2 |
0.1333 |
Tier II |
8 |
NC_000005.10 |
5 |
170022576 |
+ |
DOCK2 |
NNNACATGATTCCCTTGGTG |
NGG |
2 |
0.12 |
Tier II |
9 |
NC_000012.12 |
12 |
103773146 |
- |
NT5DC3 |
NNNGCAAGATTCCCTTGCTG |
NGA |
2 |
0.0608 |
Tier II |
10 |
NC_000001.11 |
1 |
44264522 |
- |
ERI3 |
NNNGCATGATTACCTTGCTG |
NGA |
2 |
0.0496 |
Tier II |
11 |
NC_000011.10 |
11 |
33515589 |
- |
KIAA1549L |
NNNTCATGATTCCCTTGCTG |
NCG |
2 |
0.039 |
Tier II |
12 |
NC_000006.12 |
6 |
5990992 |
- |
LOC105374898 |
NNNGAATGAATCCCTTGCTG |
NGG |
2 |
0.4898 |
Tier III |
13 |
NC_000017.11 |
17 |
81343109 |
+ |
RENO1 |
NNNGCATGATACCCTGGCTG |
NGG |
2 |
0.2596 |
Tier III |
14 |
NC_000012.12 |
12 |
67541106 |
- |
LINC02408 |
NNNGCATGATTCCCTTTCTA |
NGG |
2 |
0.2344 |
Tier III |
15 |
NC_000021.9 |
21 |
41640719 |
+ |
LOC105372812 |
NNNGAATGATGCCCTTGCTG |
NGG |
2 |
0.2286 |
Tier III |
16 |
NC_000009.12 |
9 |
40952217 |
- |
LOC107986997 |
NNNGCATGATCCCCCTGCTG |
NGG |
2 |
0.1818 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000074.6 |
8 |
95461610 |
+ |
Csnk2a2 |
NNNGCATGATTCCCTTGCTG |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000072.6 |
6 |
70893114 |
- |
Eif2ak3 |
NNNGCATGAGTCCCTTGCTG |
NGC |
2 |
0.0111 |
Tier I |
3 |
NC_000071.6 |
5 |
119824969 |
+ |
Tbx5 |
NNNGCTTGATTCCCTTGCTG |
NGG |
1 |
0.7143 |
Tier II |
4 |
NC_000074.6 |
8 |
118226711 |
- |
Cdh13 |
NNNGCATGATTCCTTTGCTA |
NGG |
2 |
0.6875 |
Tier II |
5 |
NC_000076.6 |
10 |
87885130 |
- |
Igf1 |
NNNGCAGAATTCCCTTGCTG |
NGG |
2 |
0.5882 |
Tier II |
6 |
NC_000077.6 |
11 |
36457438 |
- |
Tenm2 |
NNNGAATGATTCCCTTGTTG |
NGG |
2 |
0.3673 |
Tier II |
7 |
NC_000077.6 |
11 |
21644437 |
+ |
Wdpcp |
NNNGCATGAGTCCTTTGCTG |
NGG |
2 |
0.3667 |
Tier II |
8 |
NC_000086.7 |
X |
168275220 |
- |
Frmpd4 |
NNNCCATGATTTCCTTGCTG |
NGG |
2 |
0.2851 |
Tier II |
9 |
NC_000076.6 |
10 |
120017798 |
+ |
Grip1 |
NNNTCATGATTCCCTTGTTG |
NGG |
2 |
0.2338 |
Tier II |
10 |
NC_000079.6 |
13 |
30204716 |
+ |
Mboat1 |
NNNGTATGATTCCATTGCTG |
NGG |
2 |
0.2227 |
Tier II |
11 |
NC_000079.6 |
13 |
48605803 |
- |
Ptpdc1 |
NNNGCATCATTCCATTGCTG |
NGG |
2 |
0.2154 |
Tier II |
12 |
NC_000077.6 |
11 |
52866390 |
- |
Fstl4 |
NNNGCATCATTCCCTGGCTG |
NGG |
2 |
0.213 |
Tier II |
13 |
NC_000082.6 |
16 |
4660380 |
+ |
Coro7 |
NNNGCATGATTCTCTTGCAG |
NGG |
2 |
0.2 |
Tier II |
14 |
NC_000067.6 |
1 |
106559386 |
- |
Bcl2 |
NNNGCATGATTGCATTGCTG |
NGG |
2 |
0.1556 |
Tier II |
15 |
NC_000069.6 |
3 |
145376952 |
+ |
Col24a1 |
NNNGCATGTTTCCCTTGCTG |
NAG |
2 |
0.1556 |
Tier II |
16 |
NC_000086.7 |
X |
37876373 |
+ |
Rhox8 |
NNNGCATCATTCCCTTTCTG |
NGG |
2 |
0.1538 |
Tier II |
17 |
NC_000070.6 |
4 |
117634281 |
+ |
Eri3 |
NNNGCATGATTACCTTGCTG |
NGA |
2 |
0.0496 |
Tier II |
18 |
NC_000073.6 |
7 |
136953823 |
+ |
Mgmt |
NNNGCATGATTCCCTGGCTG |
NGA |
2 |
0.024 |
Tier II |
19 |
NC_000084.6 |
18 |
62184537 |
+ |
Gm9949 |
NNNGCATGATTCTCTTGCTG |
NGT |
2 |
0.0113 |
Tier II |
20 |
NC_000069.6 |
3 |
127365981 |
- |
Ank2 |
NNNGCATGATGCCCTTGCTG |
NGT |
2 |
0.0065 |
Tier II |
21 |
NC_000071.6 |
5 |
119824969 |
+ |
Gm5563 |
NNNGCTTGATTCCCTTGCTG |
NGG |
1 |
0.7143 |
Tier III |
22 |
NC_000071.6 |
5 |
138894486 |
- |
Gm31891 |
NNNGCATGATTGCCTTGTTG |
NGG |
2 |
0.2857 |
Tier III |
23 |
NC_000068.7 |
2 |
16980560 |
- |
4930515L03Rik |
NNNCCATGATTTCCTTGCTG |
NGG |
2 |
0.2851 |
Tier III |
24 |
NC_000069.6 |
3 |
98351585 |
+ |
Gm31420 |
NNNGCATGCTTGCCTTGCTG |
NGG |
2 |
0.254 |
Tier III |
25 |
NC_000078.6 |
12 |
43735701 |
- |
Gm33384 |
NNNACATGATTCCCTTTCTG |
NGG |
2 |
0.225 |
Tier III |
26 |
NC_000078.6 |
12 |
29007193 |
- |
Gm31508 |
NNNGCATCATTCCCTGGCTG |
NGG |
2 |
0.213 |
Tier III |
27 |
NC_000074.6 |
8 |
50297366 |
- |
1700019L22Rik |
NNNTCATGATTCCCTTGCTG |
NGA |
2 |
0.0253 |
Tier III |
28 |
NC_000080.6 |
14 |
104896821 |
- |
D130009I18Rik |
NNNGCATGATTCCCTTCCTG |
NTG |
2 |
0.0092 |
Tier III |
29 |
NC_000067.6 |
1 |
152221316 |
+ |
Gm36920 |
NNNGCATGATTCACTTGCTG |
NGC |
2 |
0.0085 |
Tier III |
Other clones with same target sequence:
(none)