Construct: sgRNA BRDN0001144760
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- GATAGCAAGTGATCCACACT
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- STK31 (56164)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 77376
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000007.14 |
7 |
23772189 |
- |
STK31 |
NNNAGCAAGTGATCCACACT |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000019.10 |
19 |
41716659 |
+ |
CEACAM5 |
NNNAGCAAGTGACCCACACT |
NGG |
1 |
0.7895 |
Tier II |
3 |
NC_000019.10 |
19 |
42520227 |
- |
CEACAM1 |
NNNAGCGAGTGACCCACACT |
NGG |
2 |
0.5573 |
Tier II |
4 |
NC_000004.12 |
4 |
2343174 |
- |
ZFYVE28 |
NNNAGGAAGTAATCCACACT |
NGG |
2 |
0.5 |
Tier II |
5 |
NC_000004.12 |
4 |
92341329 |
- |
GRID2 |
NNNAGCAAGTGATCCACATT |
NGG |
1 |
0.4615 |
Tier II |
6 |
NC_000010.11 |
10 |
120567016 |
- |
PLPP4 |
NNNAGCCAGAGATCCACACT |
NGG |
2 |
0.375 |
Tier II |
7 |
NC_000020.11 |
20 |
47730922 |
+ |
SULF2 |
NNNAGCAGGTGATCCACGCT |
NGG |
2 |
0.2933 |
Tier II |
8 |
NC_000011.10 |
11 |
19567268 |
+ |
NAV2 |
NNNGGCCAGTGATCCACACT |
NGG |
2 |
0.2734 |
Tier II |
9 |
NC_000003.12 |
3 |
37565834 |
- |
ITGA9 |
NNNAGCAAGGGTTCCACACT |
NGG |
2 |
0.1667 |
Tier II |
10 |
NC_000009.12 |
9 |
16630009 |
+ |
BNC2 |
NNNAGCATGTTATCCACACT |
NGG |
2 |
0.1648 |
Tier II |
11 |
NC_000016.10 |
16 |
73180636 |
- |
ZFHX3 |
NNNAGCAAGTGATACACACT |
NAG |
2 |
0.0907 |
Tier II |
12 |
NC_000012.12 |
12 |
104025889 |
+ |
GLT8D2 |
NNNAGCAAGTGATCCACACA |
NGT |
2 |
0.0091 |
Tier II |
13 |
NC_000007.14 |
7 |
140041520 |
+ |
PARP12 |
NNNAGCAAGTGAGCCACACT |
NGC |
2 |
0.0058 |
Tier II |
14 |
NC_000019.10 |
19 |
41762999 |
+ |
CEACAM6 |
NNNAGCAAGTGACGCACACT |
NGG |
2 |
0.0 |
Tier II |
15 |
NC_000010.11 |
10 |
69941661 |
+ |
COL13A1 |
NNNAGCAAGTGAGGCACACT |
NGG |
2 |
0.0 |
Tier II |
16 |
NC_000018.10 |
18 |
80173216 |
+ |
PARD6G |
NNNAGCATGTGATGCACACT |
NGG |
2 |
0.0 |
Tier II |
17 |
NC_000019.10 |
19 |
42520227 |
- |
LIPE-AS1 |
NNNAGCGAGTGACCCACACT |
NGG |
2 |
0.5573 |
Tier III |
18 |
NC_000004.12 |
4 |
2343174 |
- |
LOC105374352 |
NNNAGGAAGTAATCCACACT |
NGG |
2 |
0.5 |
Tier III |
19 |
NC_000004.12 |
4 |
2343174 |
- |
LOC124900649 |
NNNAGGAAGTAATCCACACT |
NGG |
2 |
0.5 |
Tier III |
20 |
NC_000005.10 |
5 |
163099136 |
+ |
LOC105377700 |
NNNAGCAAGTGATCCAAACT |
NAG |
2 |
0.121 |
Tier III |
21 |
NC_000007.14 |
7 |
66860140 |
- |
GTF2IP23 |
NNNAGCAAGTGATCCACAGA |
NGG |
2 |
0.0703 |
Tier III |
22 |
NC_000018.10 |
18 |
80173216 |
+ |
PARD6G-AS1 |
NNNAGCATGTGATGCACACT |
NGG |
2 |
0.0 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000072.6 |
6 |
49439141 |
- |
Stk31 |
NNNAGCAAGTAATCCACATT |
NGG |
2 |
0.4615 |
Tier I |
2 |
NC_000077.6 |
11 |
76190891 |
+ |
Tlcd3a |
NNNACCAAGTGATTCACACT |
NGG |
2 |
0.5762 |
Tier II |
3 |
NC_000067.6 |
1 |
172348391 |
+ |
Kcnj10 |
NNNAGCAAGTGACCCATACT |
NGG |
2 |
0.3684 |
Tier II |
4 |
NC_000073.6 |
7 |
66013791 |
- |
Pcsk6 |
NNNAGCAAGAGTTCCACACT |
NGG |
2 |
0.2857 |
Tier II |
5 |
NC_000075.6 |
9 |
41026741 |
- |
Ubash3b |
NNNAGGAAGTGATCCACACA |
NGG |
2 |
0.2813 |
Tier II |
6 |
NC_000081.6 |
15 |
80196685 |
+ |
Mgat3 |
NNNAGCAAGTGAGCCACACT |
NGG |
1 |
0.2609 |
Tier II |
7 |
NC_000069.6 |
3 |
146656223 |
+ |
4930503B20Rik |
NNNAGCAAATGTTCCACACT |
NGG |
2 |
0.2143 |
Tier II |
8 |
NC_000083.6 |
17 |
67746234 |
- |
Lama1 |
NNNAGCAATTGATACACACT |
NGG |
2 |
0.1867 |
Tier II |
9 |
NC_000076.6 |
10 |
7163163 |
- |
Cnksr3 |
NNNAGCATGTGAGCCACACT |
NGG |
2 |
0.1118 |
Tier II |
10 |
NC_000079.6 |
13 |
24964115 |
+ |
Gpld1 |
NNNAGCAAGTGTTCCACCCT |
NGG |
2 |
0.0635 |
Tier II |
11 |
NC_000069.6 |
3 |
157569924 |
+ |
Ptger3 |
NNNAGCAAGTGATCCAAACT |
NCG |
2 |
0.05 |
Tier II |
12 |
NC_000078.6 |
12 |
53791086 |
- |
Npas3 |
NNNAGCAACTGATCCACACC |
NGG |
2 |
0.049 |
Tier II |
13 |
NC_000080.6 |
14 |
56555337 |
- |
Cenpj |
NNNGGCAAGTGATCTACACT |
NGG |
2 |
0.0417 |
Tier II |
14 |
NC_000069.6 |
3 |
123079582 |
+ |
Synpo2 |
NNNAGGAAGTGATCCACACT |
NGT |
2 |
0.0081 |
Tier II |
15 |
NC_000068.7 |
2 |
119193662 |
+ |
Dnajc17 |
NNNAGCAAGTGAACCTCACT |
NGG |
2 |
0.0 |
Tier II |
16 |
NC_000077.6 |
11 |
68042687 |
+ |
Stx8 |
NNNAGCAAGTGATCCTCTCT |
NGG |
2 |
0.0 |
Tier II |
17 |
NC_000073.6 |
7 |
10805716 |
+ |
Gm18781 |
NNNAGAATGTGATCCACACT |
NGG |
2 |
0.398 |
Tier III |
18 |
NC_000076.6 |
10 |
69312192 |
+ |
Gm40685 |
NNNAGCAAGTGTTCCTCACT |
NGG |
2 |
0.0 |
Tier III |
Other clones with same target sequence:
(none)