Construct: sgRNA BRDN0001144777
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- CCGCAGCTCAGGAATATAGG
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- CDC42BPG (55561)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000011.10 | 11 | 64838725 | + | CDC42BPG | NNNCAGCTCAGGAATATAGG | NGG | 0 | 1.0 | Tier I |
2 | NC_000005.10 | 5 | 45293561 | + | HCN1 | NNNTAGCACAGGAATATAGG | NGG | 2 | 0.64 | Tier II |
3 | NC_000001.11 | 1 | 76343386 | + | ST6GALNAC3 | NNNCAGTTCAGGAATATAAG | NGG | 2 | 0.5804 | Tier II |
4 | NC_000009.12 | 9 | 113955544 | - | ZNF618 | NNNCAGCCCAGGAAAATAGG | NGG | 2 | 0.5789 | Tier II |
5 | NC_000002.12 | 2 | 165554226 | - | CSRNP3 | NNNCAGCACAGGAATATAAG | NGG | 2 | 0.5714 | Tier II |
6 | NC_000001.11 | 1 | 24788764 | - | CLIC4 | NNNCAAGTCAGGAATATAGG | NGG | 2 | 0.4706 | Tier II |
7 | NC_000006.12 | 6 | 130223523 | - | SAMD3 | NNNCAGCTGAGCAATATAGG | NGG | 2 | 0.3277 | Tier II |
8 | NC_000002.12 | 2 | 232620930 | + | EFHD1 | NNNCTGCTTAGGAATATAGG | NGG | 2 | 0.3182 | Tier II |
9 | NC_000017.11 | 17 | 77409122 | - | SEPTIN9 | NNNCAGCTCAGGAAAATGGG | NGG | 2 | 0.2316 | Tier II |
10 | NC_000011.10 | 11 | 64114937 | + | FLRT1 | NNNCAGCTCAGGAATAGAGA | NGG | 2 | 0.1103 | Tier II |
11 | NC_000011.10 | 11 | 64114937 | + | MACROD1 | NNNCAGCTCAGGAATAGAGA | NGG | 2 | 0.1103 | Tier II |
12 | NC_000007.14 | 7 | 139963820 | + | TBXAS1 | NNNCAGCTCAGGAATAGATG | NGG | 2 | 0.0784 | Tier II |
13 | NC_000012.12 | 12 | 11804983 | - | ETV6 | NNNCAGCTCTGGAATATAGG | NGA | 2 | 0.0613 | Tier II |
14 | NC_000006.12 | 6 | 42030075 | + | CCND3 | NNNCAGCTCAGGAATACAGG | NGT | 2 | 0.0114 | Tier II |
15 | NC_000015.10 | 15 | 42562060 | - | HAUS2 | NNNCAGCTCAGGAATACAGG | NGT | 2 | 0.0114 | Tier II |
16 | NC_000001.11 | 1 | 69643144 | + | LRRC7 | NNNCAGCTCAGGAAGATAGG | NGA | 2 | 0.0035 | Tier II |
17 | NC_000017.11 | 17 | 1621327 | - | SLC43A2 | NNNCAGCTCAGGAATTTAGA | NGG | 2 | 0.0 | Tier II |
18 | NC_000006.12 | 6 | 156285457 | + | LOC101928923 | NNNTATCTCAGGAATATAGG | NGG | 2 | 0.5333 | Tier III |
19 | NC_000013.11 | 13 | 44147055 | + | SMIM2 | NNNCAGCTCAGGAAAATGGG | NGG | 2 | 0.2316 | Tier III |
20 | NC_000013.11 | 13 | 44147055 | + | SMIM2-IT1 | NNNCAGCTCAGGAAAATGGG | NGG | 2 | 0.2316 | Tier III |
21 | NC_000013.11 | 13 | 44147055 | + | SMIM2-AS1 | NNNCAGCTCAGGAAAATGGG | NGG | 2 | 0.2316 | Tier III |
22 | NC_000013.11 | 13 | 44147055 | + | LINC00390 | NNNCAGCTCAGGAAAATGGG | NGG | 2 | 0.2316 | Tier III |
23 | NC_000017.11 | 17 | 72523937 | + | LINC00673 | NNNCTGGTCAGGAATATAGG | NGG | 2 | 0.1711 | Tier III |
24 | NC_000012.12 | 12 | 27152133 | - | LOC124902904 | NNNCAGCTCCCGAATATAGG | NGG | 2 | 0.1429 | Tier III |
25 | NC_000007.14 | 7 | 34521815 | - | NPSR1-AS1 | NNNCAGCTCAGGAGCATAGG | NGG | 2 | 0.1273 | Tier III |
26 | NC_000003.12 | 3 | 66933305 | + | LOC105377144 | NNNAAGCTCAGGAATATAGG | NGA | 2 | 0.0585 | Tier III |
27 | NC_000005.10 | 5 | 89128339 | - | MEF2C-AS1 | NNNCAGCTCAGGCAGATAGG | NGG | 2 | 0.0105 | Tier III |
28 | NC_000021.9 | 21 | 37531075 | + | KCNJ6-AS1 | NNNCAGCTCAGGAATCTAGG | NGG | 1 | 0.0 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000075.6 | 9 | 7994096 | + | Yap1 | NNNAAGCCCAGGAATATAGG | NGG | 2 | 0.8421 | Tier II |
2 | NC_000072.6 | 6 | 67458597 | - | Il23r | NNNCAGCTCAAGAATATATG | NGG | 2 | 0.6667 | Tier II |
3 | NC_000070.6 | 4 | 86129059 | - | Adamtsl1 | NNNCAGATTAGGAATATAGG | NGG | 2 | 0.6563 | Tier II |
4 | NC_000085.6 | 19 | 55074021 | - | Gpam | NNNCAACTCAGGAATATTGG | NGG | 2 | 0.5 | Tier II |
5 | NC_000073.6 | 7 | 63485811 | + | Otud7a | NNNCAGCTCAGGAATATTGG | NGG | 1 | 0.5 | Tier II |
6 | NC_000074.6 | 8 | 113832595 | + | Adamts18 | NNNGAGCCCAGGAATATAGG | NGG | 2 | 0.5 | Tier II |
7 | NC_000078.6 | 12 | 79434728 | + | Rad51b | NNNCAGCTCAGGAATATATT | NGG | 2 | 0.4667 | Tier II |
8 | NC_000077.6 | 11 | 110511939 | + | Map2k6 | NNNCAGCTAAGCAATATAGG | NGG | 2 | 0.4538 | Tier II |
9 | NC_000071.6 | 5 | 8807943 | - | Abcb1b | NNNCAACTCAGGAATATGGG | NGG | 2 | 0.4 | Tier II |
10 | NC_000080.6 | 14 | 79414180 | + | Mtrf1 | NNNTAGCTCAGGAATATTGG | NGG | 2 | 0.4 | Tier II |
11 | NC_000081.6 | 15 | 76445548 | - | Mroh1 | NNNCAGCTCAGAAATATGGG | NGG | 2 | 0.3733 | Tier II |
12 | NC_000074.6 | 8 | 84388248 | - | Cacna1a | NNNCAGCTCATGAATATAGT | NGG | 2 | 0.2692 | Tier II |
13 | NC_000077.6 | 11 | 29417225 | + | Ccdc88a | NNNCAGCTCAGGAACATAGA | NGG | 2 | 0.2557 | Tier II |
14 | NC_000083.6 | 17 | 47771943 | + | Tfeb | NNNCAGCTCAGGAAGATAGA | NGG | 2 | 0.0469 | Tier II |
15 | NC_000071.6 | 5 | 136293315 | + | Cux1 | NNNCAGCTAAGGAAGATAGG | NGG | 2 | 0.0429 | Tier II |
16 | NC_000083.6 | 17 | 67305458 | - | Ptprm | NNNCAGCTCAGGTAGATAGG | NGG | 2 | 0.015 | Tier II |
17 | NC_000078.6 | 12 | 30289982 | - | Sntg2 | NNNCAGCACAGGAATATAGG | NGT | 2 | 0.0129 | Tier II |
18 | NC_000079.6 | 13 | 107497542 | - | Gm31803 | NNNCAGCCCAGGAATATAGG | NAG | 2 | 0.2593 | Tier III |
19 | NC_000071.6 | 5 | 39273593 | + | Gm40293 | NNNCAGCTCAGGAATATGGC | NGG | 2 | 0.1714 | Tier III |
20 | NC_000069.6 | 3 | 155996853 | + | 9330178D15Rik | NNNCAGCTCAGGAATATAGA | NGT | 2 | 0.0151 | Tier III |
21 | NC_000079.6 | 13 | 50325296 | - | Gm46385 | NNNCAGCTCAGGAAACTAGG | NGG | 2 | 0.0 | Tier III |
22 | NC_000079.6 | 13 | 50762776 | + | 4930518P08Rik | NNNCAGCTCAGGAAACTAGG | NGG | 2 | 0.0 | Tier III |