Construct: sgRNA BRDN0001145059
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- GGCTCCCAGCAAAGCATCAG
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- CDK15 (65061)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000002.12 | 2 | 201835718 | - | CDK15 | NNNTCCCAGCAAAGCATCAG | NGG | 0 | 1.0 | Tier I |
2 | NC_000013.11 | 13 | 112876541 | - | ATP11A | NNNTCCCAGTAAAGCAGCAG | NGG | 2 | 0.1107 | Tier I |
3 | NC_000017.11 | 17 | 21700089 | + | KCNJ18 | NNNTCCCAGCACAGCCTCAG | NGG | 2 | 0.0 | Tier I |
4 | NC_000017.11 | 17 | 78702269 | - | CYTH1 | NNNTCCCAGCAAAGCATCAT | NGG | 1 | 0.7 | Tier II |
5 | NC_000001.11 | 1 | 177019004 | + | ASTN1 | NNNTAACAGCAAAGCATCAG | NGG | 2 | 0.5306 | Tier II |
6 | NC_000019.10 | 19 | 44636625 | + | IGSF23 | NNNTGCAAGCAAAGCATCAG | NGG | 2 | 0.45 | Tier II |
7 | NC_000019.10 | 19 | 368431 | - | SPMAP2 | NNNTTCCAGCAAAGCATAAG | NGG | 2 | 0.3427 | Tier II |
8 | NC_000012.12 | 12 | 69646655 | + | BEST3 | NNNTCCCTGCAGAGCATCAG | NGG | 2 | 0.3095 | Tier II |
9 | NC_000001.11 | 1 | 111497617 | + | TMIGD3 | NNNTCCCAGCAAGCCATCAG | NGG | 2 | 0.2795 | Tier II |
10 | NC_000004.12 | 4 | 84959778 | + | WDFY3 | NNNTCCCAGCAAAAAATCAG | NGG | 2 | 0.1667 | Tier II |
11 | NC_000010.11 | 10 | 1333269 | - | ADARB2 | NNNTCCCAGCAAAGCATCAC | NAG | 2 | 0.1111 | Tier II |
12 | NC_000015.10 | 15 | 27375446 | + | GABRG3 | NNNTCCCAGCAAAGCATCAG | NCG | 1 | 0.1071 | Tier II |
13 | NC_000013.11 | 13 | 110538762 | + | RAB20 | NNNTCCCAGCAAGGCAGCAG | NGG | 2 | 0.0767 | Tier II |
14 | NC_000012.12 | 12 | 99558508 | + | ANKS1B | NNNTGCCAGCAAAGCAGCAG | NGG | 2 | 0.0706 | Tier II |
15 | NC_000012.12 | 12 | 117237046 | - | NOS1 | NNNTCCCAGCAAAGCATCAA | NGA | 2 | 0.0651 | Tier II |
16 | NC_000009.12 | 9 | 77432251 | + | GNA14 | NNNTCCCAGCACCGCATCAG | NGG | 2 | 0.0554 | Tier II |
17 | NC_000011.10 | 11 | 47681911 | - | AGBL2 | NNNTCCAAGCAAAGCATCAG | NGA | 2 | 0.0521 | Tier II |
18 | NC_000021.9 | 21 | 21344279 | - | NCAM2 | NNNACCCAGCAAAGTATCAG | NGG | 2 | 0.0317 | Tier II |
19 | NC_000001.11 | 1 | 35553344 | + | KIAA0319L | NNNTCCCAGCAAAGCATCAT | NTG | 2 | 0.0273 | Tier II |
20 | NC_000001.11 | 1 | 185221695 | - | SWT1 | NNNTCCCAGAAAAGCATCAG | NGC | 2 | 0.0193 | Tier II |
21 | NC_000016.10 | 16 | 5450722 | - | RBFOX1 | NNNTCCCAGCAAGGCATCAG | NGC | 2 | 0.0145 | Tier II |
22 | NC_000010.11 | 10 | 24106203 | - | KIAA1217 | NNNTCCCAGCCAAGCATCAG | NGT | 2 | 0.0065 | Tier II |
23 | NC_000015.10 | 15 | 26565541 | + | GABRB3 | NNNTCCCAGCAAAGCCACAG | NGG | 2 | 0.0 | Tier II |
24 | NC_000003.12 | 3 | 141095470 | - | SPSB4 | NNNTCCCAGCAAAGTCTCAG | NGG | 2 | 0.0 | Tier II |
25 | NC_000017.11 | 17 | 21412626 | + | KCNJ12 | NNNTCCCAGCACAGCCTCAG | NGG | 2 | 0.0 | Tier II |
26 | NC_000004.12 | 4 | 122673376 | + | IL21-AS1 | NNNTCTCAGCAAAGCAACAG | NGG | 2 | 0.4952 | Tier III |
27 | NC_000020.11 | 20 | 46740259 | - | LOC124904918 | NNNTCCCAGCGAAACATCAG | NGG | 2 | 0.4875 | Tier III |
28 | NC_000012.12 | 12 | 69646655 | + | LOC105369823 | NNNTCCCTGCAGAGCATCAG | NGG | 2 | 0.3095 | Tier III |
29 | NC_000006.12 | 6 | 139443361 | + | LOC107986651 | NNNTCCAAGCATAGCATCAG | NGG | 2 | 0.25 | Tier III |
30 | NC_000007.14 | 7 | 92851928 | + | CDK6-AS1 | NNNTCCCAGCAATGAATCAG | NGG | 2 | 0.0667 | Tier III |
31 | NC_000002.12 | 2 | 71712616 | - | LOC124907827 | NNNTCCCAGCAAAGCTTCAG | NGC | 2 | 0.0 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000067.6 | 1 | 177860019 | - | Catspere1 | NNNTCCCAGCTAAGCATCAA | NGG | 2 | 0.2885 | Tier I |
2 | NC_000067.6 | 1 | 178098565 | - | Catspere2 | NNNTCCCAGCTAAGCATCAA | NGG | 2 | 0.2885 | Tier I |
3 | NC_000067.6 | 1 | 59289734 | - | Cdk15 | NNNTCCCAGCAAAGCGTCAG | NTG | 2 | 0.0075 | Tier I |
4 | NC_000076.6 | 10 | 60831121 | + | Unc5b | NNNTCCCAGCAAAGCAGCAG | NGC | 2 | 0.0026 | Tier I |
5 | NC_000069.6 | 3 | 99294696 | - | Tbx15 | NNNTCTCAGTAAAGCATCAG | NGG | 2 | 0.8739 | Tier II |
6 | NC_000067.6 | 1 | 21524489 | - | Kcnq5 | NNNTCCCAGTAAAACATCAG | NGG | 2 | 0.7059 | Tier II |
7 | NC_000071.6 | 5 | 74450794 | + | Scfd2 | NNNTCCCAGAAGAGCATCAG | NGG | 2 | 0.6259 | Tier II |
8 | NC_000072.6 | 6 | 115610878 | + | Mkrn2 | NNNGCCCAGCAAAGCATCAG | NGG | 1 | 0.625 | Tier II |
9 | NC_000072.6 | 6 | 121401200 | + | Iqsec3 | NNNTCCCAGCGGAGCATCAG | NGG | 2 | 0.4694 | Tier II |
10 | NC_000084.6 | 18 | 63293077 | - | Piezo2 | NNNCCCCAGCAAAGCATCAT | NGG | 2 | 0.4529 | Tier II |
11 | NC_000073.6 | 7 | 143592173 | + | Cars | NNNTCCCATCAAAGCATTAG | NGG | 2 | 0.3429 | Tier II |
12 | NC_000081.6 | 15 | 96266260 | - | Gm38469 | NNNTCCCAGCACAGCATCAG | NGG | 1 | 0.2632 | Tier II |
13 | NC_000067.6 | 1 | 164158973 | + | F5 | NNNTCCCATCAAACCATCAG | NGG | 2 | 0.2286 | Tier II |
14 | NC_000074.6 | 8 | 123256273 | - | Zfp276 | NNNACCCTGCAAAGCATCAG | NGG | 2 | 0.2041 | Tier II |
15 | NC_000080.6 | 14 | 60037829 | + | Atp8a2 | NNNTCTCAGCAAAGCATCCG | NGG | 2 | 0.1921 | Tier II |
16 | NC_000076.6 | 10 | 108214158 | - | Ppp1r12a | NNNTCCCAGCACAGCATCAT | NGG | 2 | 0.1842 | Tier II |
17 | NC_000075.6 | 9 | 25487893 | - | Eepd1 | NNNTCCCATCAAAGCAGCAG | NGG | 2 | 0.0627 | Tier II |
18 | NC_000076.6 | 10 | 52069532 | + | Ros1 | NNNTCCCAGCAAAACATCAG | NGA | 2 | 0.0521 | Tier II |
19 | NC_000070.6 | 4 | 155872751 | - | Ints11 | NNNCCCCAGCAAAGGATCAG | NGG | 2 | 0.0324 | Tier II |
20 | NC_000079.6 | 13 | 30694773 | + | Dusp22 | NNNTCCCAGCAAAGCATGAG | NTG | 2 | 0.0052 | Tier II |
21 | NC_000072.6 | 6 | 39422800 | - | Mkrn1 | NNNTCCCAGCAAAGCAGCAG | NGC | 2 | 0.0026 | Tier II |
22 | NC_000078.6 | 12 | 13381143 | + | Nbas | NNNTCACAGCAAAGCCTCAG | NGG | 2 | 0.0 | Tier II |
23 | NC_000069.6 | 3 | 55707070 | - | Nbea | NNNTCCCAGCACAGCTTCAG | NGG | 2 | 0.0 | Tier II |
24 | NC_000068.7 | 2 | 168361290 | + | Gm33262 | NNNTCCCAGCAAGCCATCAG | NGG | 2 | 0.2795 | Tier III |
25 | NC_000079.6 | 13 | 33434333 | - | Gm19155 | NNNTCCCAGCAAAGCATCAG | NAG | 1 | 0.2593 | Tier III |
26 | NC_000078.6 | 12 | 8451037 | - | Gm51967 | NNNTCCCAGCAGAGGATCAG | NGG | 2 | 0.0361 | Tier III |