Construct: sgRNA BRDN0001145134
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- AAAGCTGTTCATGTGAACCA
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- FLT3 (2322)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 77350
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000013.11 |
13 |
28049684 |
- |
FLT3 |
NNNGCTGTTCATGTGAACCA |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000013.11 |
13 |
23332702 |
+ |
SACS |
NNNGCTGTTCTTGTGGACCA |
NGG |
2 |
0.0592 |
Tier I |
3 |
NC_000004.12 |
4 |
25007784 |
- |
LGI2 |
NNNGCTGTCCATGTGCACCA |
NGG |
2 |
0.0 |
Tier I |
4 |
NC_000003.12 |
3 |
17245893 |
- |
TBC1D5 |
NNNGCTGCTCGTGTGAACCA |
NGG |
2 |
0.65 |
Tier II |
5 |
NC_000008.11 |
8 |
134611260 |
- |
ZFAT |
NNNGCTTTTTATGTGAACCA |
NGG |
2 |
0.5378 |
Tier II |
6 |
NC_000001.11 |
1 |
15039499 |
+ |
KAZN |
NNNGCTGTCCCTGTGAACCA |
NGG |
2 |
0.3692 |
Tier II |
7 |
NC_000021.9 |
21 |
25642083 |
+ |
JAM2 |
NNNGCTGTTGATGTGAACCT |
NGG |
2 |
0.2333 |
Tier II |
8 |
NC_000007.14 |
7 |
96484429 |
+ |
SEM1 |
NNNGCTCTTCATGTGAACCA |
NAG |
2 |
0.1782 |
Tier II |
9 |
NC_000009.12 |
9 |
92966682 |
+ |
FGD3 |
NNNGCTGTGCATGTGGACCA |
NGG |
2 |
0.119 |
Tier II |
10 |
NC_000008.11 |
8 |
25822353 |
- |
LOC107986933 |
NNNGCTGTTCATGAAAACCA |
NGG |
2 |
0.5826 |
Tier III |
11 |
NC_000017.11 |
17 |
3977562 |
- |
LINC01975 |
NNNGCAGTTCGTGTGAACCA |
NGG |
2 |
0.5633 |
Tier III |
12 |
NC_000012.12 |
12 |
55580716 |
- |
LOC100418940 |
NNNGCTGTTCAAGTGAACCT |
NGG |
2 |
0.48 |
Tier III |
13 |
NC_000012.12 |
12 |
22926085 |
- |
LINC02955 |
NNNGCTCTGCATGTGAACCA |
NGG |
2 |
0.4256 |
Tier III |
14 |
NC_000007.14 |
7 |
96484429 |
+ |
LOC105375411 |
NNNGCTCTTCATGTGAACCA |
NAG |
2 |
0.1782 |
Tier III |
15 |
NC_000021.9 |
21 |
22294750 |
+ |
LOC107985508 |
NNNGGTGTTCATGTGACCCA |
NGG |
2 |
0.1059 |
Tier III |
16 |
NC_000021.9 |
21 |
42050295 |
+ |
LOC107985502 |
NNNGCTGTTCATGTGGTCCA |
NGG |
2 |
0.0256 |
Tier III |
17 |
NC_000004.12 |
4 |
25007784 |
- |
LOC102723675 |
NNNGCTGTCCATGTGCACCA |
NGG |
2 |
0.0 |
Tier III |
18 |
NC_000018.10 |
18 |
52208359 |
- |
LOC105372121 |
NNNGCTGTTCATATGCACCA |
NGG |
2 |
0.0 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000068.7 |
2 |
181653241 |
- |
Prpf6 |
NNNGCAGTTCATATGAACCA |
NGG |
2 |
0.8 |
Tier II |
2 |
NC_000072.6 |
6 |
127929890 |
+ |
Tspan11 |
NNNGATGGTCATGTGAACCA |
NGG |
2 |
0.419 |
Tier II |
3 |
NC_000071.6 |
5 |
96999183 |
- |
Bmp2k |
NNNGCTGTTAATGTGAACAA |
NGG |
2 |
0.3714 |
Tier II |
4 |
NC_000071.6 |
5 |
128254352 |
+ |
Tmem132d |
NNNACTGTTCATTTGAACCA |
NGG |
2 |
0.27 |
Tier II |
5 |
NC_000072.6 |
6 |
24858028 |
- |
Hyal5 |
NNNTGTGTTCATGTGAACCA |
NGG |
2 |
0.2182 |
Tier II |
6 |
NC_000077.6 |
11 |
22091776 |
+ |
Ehbp1 |
NNNGCTGTACATGTGAGCCA |
NGG |
2 |
0.1639 |
Tier II |
7 |
NC_000068.7 |
2 |
14608308 |
+ |
Cacnb2 |
NNNGCTGTTCATGTGAAACA |
NAG |
2 |
0.1396 |
Tier II |
8 |
NC_000081.6 |
15 |
100707048 |
- |
Galnt6 |
NNNGCTGTGCATGTGAGCCA |
NGG |
2 |
0.1092 |
Tier II |
9 |
NC_000081.6 |
15 |
100707130 |
- |
Galnt6 |
NNNGCTGTGCATGTGAGCCA |
NGG |
2 |
0.1092 |
Tier II |
10 |
NC_000081.6 |
15 |
100707422 |
- |
Galnt6 |
NNNGCTGTGCATGTGAGCCA |
NGG |
2 |
0.1092 |
Tier II |
11 |
NC_000071.6 |
5 |
86713515 |
- |
Tmprss11e |
NNNGCTGTTCATGTGAACTC |
NGG |
2 |
0.1049 |
Tier II |
12 |
NC_000071.6 |
5 |
53124270 |
+ |
Sel1l3 |
NNNGCTGCTCATGTGAACCA |
NGA |
2 |
0.0694 |
Tier II |
13 |
NC_000074.6 |
8 |
28770643 |
- |
Unc5d |
NNNGCTGTTCATCTGAAGCA |
NGG |
2 |
0.0561 |
Tier II |
14 |
NC_000079.6 |
13 |
30834477 |
- |
Exoc2 |
NNNGCTGTTGATGTGATCCA |
NGG |
2 |
0.0519 |
Tier II |
15 |
NC_000069.6 |
3 |
37364883 |
- |
Fgf2 |
NNNGCTGTTCATGTGAAGCC |
NGG |
2 |
0.0303 |
Tier II |
16 |
NC_000071.6 |
5 |
144203208 |
- |
Tecpr1 |
NNNGGTGTTCATGTGAACCA |
NGC |
2 |
0.0133 |
Tier II |
17 |
NC_000081.6 |
15 |
96218063 |
+ |
Gm38469 |
NNNGCTGTTCTTGTGAACCA |
NTG |
2 |
0.012 |
Tier II |
18 |
NC_000067.6 |
1 |
165436326 |
+ |
Dcaf6 |
NNNGCTGTTCATGTGAACCA |
NTC |
2 |
0.0 |
Tier II |
19 |
NC_000075.6 |
9 |
119576159 |
- |
Scn5a |
NNNGCTGTTCATTGGAACCA |
NGG |
2 |
0.0 |
Tier II |
20 |
NC_000072.6 |
6 |
127929890 |
+ |
Gm38903 |
NNNGATGGTCATGTGAACCA |
NGG |
2 |
0.419 |
Tier III |
21 |
NC_000068.7 |
2 |
21914770 |
- |
Gm39767 |
NNNGCTTGTCATGTGAACCA |
NGG |
2 |
0.419 |
Tier III |
22 |
NC_000081.6 |
15 |
10788449 |
+ |
4930556M19Rik |
NNNACTGTTGATGTGAACCA |
NGG |
2 |
0.35 |
Tier III |
23 |
NC_000083.6 |
17 |
94831572 |
- |
Gm1976 |
NNNGATGTTCATGTGAAGCA |
NGG |
2 |
0.0762 |
Tier III |
Other clones with same target sequence:
(none)