Construct: sgRNA BRDN0001145494
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- CTGGTCTTAGGCAAACCCCT
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- FGFR1 (2260)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 76067
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000008.11 |
8 |
38417974 |
- |
FGFR1 |
NNNGTCTTAGGCAAACCCCT |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000023.11 |
X |
123189016 |
- |
GRIA3 |
NNNGTCTTAAGCAAACCTCT |
NGG |
2 |
0.6 |
Tier II |
3 |
NC_000007.14 |
7 |
127066973 |
- |
GRM8 |
NNNGTTTTAGGCAAACCACT |
NGG |
2 |
0.5 |
Tier II |
4 |
NC_000017.11 |
17 |
15336830 |
- |
TEKT3 |
NNNGTCTTAGGCATACCCAT |
NGG |
2 |
0.2286 |
Tier II |
5 |
NC_000005.10 |
5 |
107669274 |
+ |
EFNA5 |
NNNCTCTTAGGCTAACCCCT |
NGG |
2 |
0.1588 |
Tier II |
6 |
NC_000020.11 |
20 |
43116382 |
- |
PTPRT |
NNNGTCTAAGGCAAAGCCCT |
NGG |
2 |
0.1231 |
Tier II |
7 |
NC_000007.14 |
7 |
71783974 |
- |
CALN1 |
NNNGTCTTAGGCAAACCCAG |
NGG |
2 |
0.0756 |
Tier II |
8 |
NC_000004.12 |
4 |
165427192 |
+ |
CPE |
NNNGTCTTAGGCAAGCCCCT |
NGT |
2 |
0.0105 |
Tier II |
9 |
NC_000009.12 |
9 |
118009266 |
+ |
LOC105376246 |
NNNGTATTAGGCAAACTCCT |
NGG |
2 |
0.4333 |
Tier III |
10 |
NC_000021.9 |
21 |
39529416 |
+ |
JCADP1 |
NNNGTCTCAGGCTAACCCCT |
NGG |
2 |
0.3 |
Tier III |
11 |
NC_000023.11 |
X |
22664016 |
- |
PTCHD1-AS |
NNNGGCTTAGGCCAACCCCT |
NGG |
2 |
0.1347 |
Tier III |
12 |
NC_000003.12 |
3 |
6763378 |
- |
GRM7-AS3 |
NNNGTCTTAGGCAACCTCCT |
NGG |
2 |
0.1273 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000074.6 |
8 |
25569657 |
+ |
Fgfr1 |
NNNGTCTTAGGCAAACCACT |
NGG |
1 |
0.5385 |
Tier I |
2 |
NC_000080.6 |
14 |
77714457 |
+ |
Enox1 |
NNNGTCTTAGGCAAACCCCA |
NGG |
1 |
0.5625 |
Tier II |
3 |
NC_000070.6 |
4 |
14605175 |
+ |
Slc26a7 |
NNNGTATTTGGCAAACCCCT |
NGG |
2 |
0.5571 |
Tier II |
4 |
NC_000078.6 |
12 |
105218468 |
- |
Tcl1 |
NNNGTCTTAGCCAAACCCCT |
NGG |
1 |
0.4286 |
Tier II |
5 |
NC_000069.6 |
3 |
152526461 |
+ |
Ak5 |
NNNGTCATAGGCAAACTCCT |
NGG |
2 |
0.4083 |
Tier II |
6 |
NC_000069.6 |
3 |
26770675 |
- |
Spata16 |
NNNGTCTTAGGAAAACACCT |
NGG |
2 |
0.3333 |
Tier II |
7 |
NC_000068.7 |
2 |
4508084 |
+ |
Frmd4a |
NNNGTCTTAGGCAAGCCCTT |
NGG |
2 |
0.3 |
Tier II |
8 |
NC_000073.6 |
7 |
35510168 |
- |
Tdrd12 |
NNNTTCTTAGGTAAACCCCT |
NGG |
2 |
0.1958 |
Tier II |
9 |
NC_000075.6 |
9 |
71518651 |
+ |
Myzap |
NNNGTCTTAGGCAAACCCCG |
NGG |
1 |
0.1765 |
Tier II |
10 |
NC_000071.6 |
5 |
149682747 |
+ |
B3glct |
NNNGTCTTAGGCAACCCCCA |
NGG |
2 |
0.1534 |
Tier II |
11 |
NC_000075.6 |
9 |
89604078 |
- |
Minar1 |
NNNGTCTTAGGCAACCCCCA |
NGG |
2 |
0.1534 |
Tier II |
12 |
NC_000073.6 |
7 |
87693585 |
+ |
Grm5 |
NNNGTCTTAGGCAACTCCCT |
NGG |
2 |
0.0839 |
Tier II |
13 |
NC_000071.6 |
5 |
128864906 |
- |
Rimbp2 |
NNNGTCTTAGGCAAACCCTG |
NGG |
2 |
0.0814 |
Tier II |
14 |
NC_000072.6 |
6 |
94215677 |
+ |
Magi1 |
NNNTTCTTAGGCACACCCCT |
NGG |
2 |
0.0779 |
Tier II |
15 |
NC_000068.7 |
2 |
7068368 |
- |
Celf2 |
NNNGTCTTAGGCAAAGCCCT |
NAG |
2 |
0.0399 |
Tier II |
16 |
NC_000068.7 |
2 |
80423062 |
+ |
Frzb |
NNNGTCTTAAGCAAACCCCT |
NTG |
2 |
0.0364 |
Tier II |
17 |
NC_000074.6 |
8 |
120618541 |
- |
1190005I06Rik |
NNNGTCTTAGGCGAACCCCT |
NTG |
2 |
0.0254 |
Tier II |
18 |
NC_000074.6 |
8 |
120618541 |
- |
Gm27021 |
NNNGTCTTAGGCGAACCCCT |
NTG |
2 |
0.0254 |
Tier II |
19 |
NC_000075.6 |
9 |
62365756 |
+ |
Anp32a |
NNNGTCTTAGGCAGACCCCT |
NTG |
2 |
0.0182 |
Tier II |
20 |
NC_000076.6 |
10 |
14532892 |
- |
Adgrg6 |
NNNGTCTTAGGCAAACCCCG |
NGA |
2 |
0.0123 |
Tier II |
21 |
NC_000067.6 |
1 |
170435177 |
- |
Nos1ap |
NNNGTCTTAGGCAACCCCCT |
NTG |
2 |
0.0106 |
Tier II |
22 |
NC_000073.6 |
7 |
27993034 |
+ |
Zfp850 |
NNNGTCTTAGGCAACCCCCT |
NTG |
2 |
0.0106 |
Tier II |
23 |
NC_000078.6 |
12 |
70871762 |
- |
Frmd6 |
NNNGTCTTAGGCAACCCCCT |
NTG |
2 |
0.0106 |
Tier II |
24 |
NC_000068.7 |
2 |
4508084 |
+ |
Gm39751 |
NNNGTCTTAGGCAAGCCCTT |
NGG |
2 |
0.3 |
Tier III |
25 |
NC_000072.6 |
6 |
94215677 |
+ |
4930511A08Rik |
NNNTTCTTAGGCACACCCCT |
NGG |
2 |
0.0779 |
Tier III |
26 |
NC_000072.6 |
6 |
94215677 |
+ |
Gm52867 |
NNNTTCTTAGGCACACCCCT |
NGG |
2 |
0.0779 |
Tier III |
27 |
NC_000077.6 |
11 |
54215793 |
+ |
Gm12223 |
NNNGTCTTTGGCAAACCCCT |
NGT |
2 |
0.0097 |
Tier III |
Other clones with same target sequence:
(none)