Construct: sgRNA BRDN0001145947
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- AGCAGTGTGAAAATGGTGCA
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- SCYL2 (55681)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000012.12 | 12 | 100311088 | + | SCYL2 | NNNAGTGTGAAAATGGTGCA | NGG | 0 | 1.0 | Tier I |
2 | NC_000002.12 | 2 | 201412789 | - | TRAK2 | NNNAGTGTGAAAATGGTACA | NGG | 1 | 0.6923 | Tier II |
3 | NC_000011.10 | 11 | 43439976 | + | TTC17 | NNNAGTGTGAAAATGGTGCT | NGG | 1 | 0.6 | Tier II |
4 | NC_000017.11 | 17 | 76938163 | - | MGAT5B | NNNAGTGTGAGAATGGTGCG | NGG | 2 | 0.4971 | Tier II |
5 | NC_000010.11 | 10 | 98507583 | - | HPSE2 | NNNAGTCTGAAAATGGTACA | NGG | 2 | 0.476 | Tier II |
6 | NC_000022.11 | 22 | 19475350 | - | UFD1 | NNNACTGTGAAAATGGTGCT | NGG | 2 | 0.4714 | Tier II |
7 | NC_000001.11 | 1 | 172358895 | + | DNM3 | NNNACTGTGGAAATGGTGCA | NGG | 2 | 0.4365 | Tier II |
8 | NC_000009.12 | 9 | 120689500 | + | MEGF9 | NNNAGTGTGAAAATGGACCA | NGG | 2 | 0.254 | Tier II |
9 | NC_000001.11 | 1 | 167773981 | + | MPZL1 | NNNAGTGTGATGATGGTGCA | NGG | 2 | 0.2222 | Tier II |
10 | NC_000004.12 | 4 | 88733209 | + | FAM13A | NNNAGTGTGCAAATGGTTCA | NGG | 2 | 0.2222 | Tier II |
11 | NC_000001.11 | 1 | 53642368 | - | GLIS1 | NNNAGTGTGAAATAGGTGCA | NGG | 2 | 0.1857 | Tier II |
12 | NC_000015.10 | 15 | 33055481 | + | FMN1 | NNNAGTGTGAAACTGGTACA | NGG | 2 | 0.1457 | Tier II |
13 | NC_000010.11 | 10 | 82908045 | + | NRG3 | NNNAGTGTCAAAATGGTGCC | NGG | 2 | 0.1224 | Tier II |
14 | NC_000004.12 | 4 | 141008771 | - | RNF150 | NNNAGTGTGATATTGGTGCA | NGG | 2 | 0.0923 | Tier II |
15 | NC_000007.14 | 7 | 139922982 | - | TBXAS1 | NNNAGTGTGATATTGGTGCA | NGG | 2 | 0.0923 | Tier II |
16 | NC_000012.12 | 12 | 51430065 | + | SLC4A8 | NNNAGGGTGAAAATGGTGGA | NGG | 2 | 0.0714 | Tier II |
17 | NC_000023.11 | X | 7140234 | - | PUDP | NNNAGTGTTAAAATGGTGGA | NGG | 2 | 0.0667 | Tier II |
18 | NC_000013.11 | 13 | 32038454 | - | FRY | NNNAGTGTGCAAATGGTGGA | NGG | 2 | 0.0417 | Tier II |
19 | NC_000019.10 | 19 | 38923554 | + | SARS2 | NNNAGTGTGAAAATGGGGCC | NGG | 2 | 0.0267 | Tier II |
20 | NC_000008.11 | 8 | 98360300 | - | STK3 | NNNAGTGTGCAAATGGTGCA | NGA | 2 | 0.0231 | Tier II |
21 | NC_000006.12 | 6 | 39914680 | - | MOCS1 | NNNAGTCTGAAAATGCTGCA | NGG | 2 | 0.0 | Tier II |
22 | NC_000001.11 | 1 | 174228818 | + | RABGAP1L | NNNAGTCTGAAAATGTTGCA | NGG | 2 | 0.0 | Tier II |
23 | NC_000009.12 | 9 | 4367278 | - | GLIS3 | NNNAGTGTGAAAATGCTGAA | NGG | 2 | 0.0 | Tier II |
24 | NC_000001.11 | 1 | 154048040 | - | NUP210L | NNNAGTGTGAAAATGTTCCA | NGG | 2 | 0.0 | Tier II |
25 | NC_000003.12 | 3 | 131947076 | - | CPNE4 | NNNAGTGTGAAATTGTTGCA | NGG | 2 | 0.0 | Tier II |
26 | NC_000009.12 | 9 | 97934756 | - | HEMGN | NNNAGTGTTAAAATGTTGCA | NGG | 2 | 0.0 | Tier II |
27 | NC_000002.12 | 2 | 113339507 | + | LINC02966 | NNNACTGTGAAAATAGTGCA | NGG | 2 | 0.7395 | Tier III |
28 | NC_000002.12 | 2 | 201412789 | - | SCYL2P1 | NNNAGTGTGAAAATGGTACA | NGG | 1 | 0.6923 | Tier III |
29 | NC_000001.11 | 1 | 165564285 | - | LRRC52-AS1 | NNNAGTGTGAAGATGGTACA | NGG | 2 | 0.5 | Tier III |
30 | NC_000010.11 | 10 | 129813656 | + | LOC107984281 | NNNTGTGTTAAAATGGTGCA | NGG | 2 | 0.3394 | Tier III |
31 | NC_000012.12 | 12 | 74232312 | + | LINC02882 | NNNTGTGTGAAAATGGTGAA | NGG | 2 | 0.2727 | Tier III |
32 | NC_000012.12 | 12 | 48301460 | - | LOC105369753 | NNNAGTGAGAAAATGGTGCA | NAG | 2 | 0.2074 | Tier III |
33 | NC_000004.12 | 4 | 23069418 | + | LOC105374524 | NNNAGTGTGAAAATTGTGCA | NGG | 1 | 0.1429 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000076.6 | 10 | 89662422 | - | Scyl2 | NNNAGTGTAAAAATGGTTCA | NGG | 2 | 0.4286 | Tier I |
2 | NC_000081.6 | 15 | 94283833 | - | Adamts20 | NNNAGTGGGAAAATGGAGCA | NGG | 2 | 0.3911 | Tier I |
3 | NC_000082.6 | 16 | 11601862 | + | Snx29 | NNNAGTGCTAAAATGGTGCA | NGG | 2 | 0.5333 | Tier II |
4 | NC_000079.6 | 13 | 73474017 | + | Lpcat1 | NNNAATGTGAAAATGGTGCT | NGG | 2 | 0.52 | Tier II |
5 | NC_000072.6 | 6 | 58650704 | - | Abcg2 | NNNAATGTGAAAATGGTGAA | NGG | 2 | 0.3714 | Tier II |
6 | NC_000081.6 | 15 | 65892733 | + | Oc90 | NNNAGTGTAAAAATGGTCCA | NGG | 2 | 0.3061 | Tier II |
7 | NC_000074.6 | 8 | 119075256 | + | Cdh13 | NNNAGTGTGAAAATGGACCA | NGG | 2 | 0.254 | Tier II |
8 | NC_000080.6 | 14 | 30853014 | + | Stimate | NNNAGTGTGAAATTGGTTCA | NGG | 2 | 0.2 | Tier II |
9 | NC_000075.6 | 9 | 76290870 | - | Hcrtr2 | NNNATTGTGAAAATGGAGCA | NGG | 2 | 0.16 | Tier II |
10 | NC_000067.6 | 1 | 25652375 | - | Adgrb3 | NNNAGTGTGAAAATGGAGCA | NAG | 2 | 0.1383 | Tier II |
11 | NC_000068.7 | 2 | 106135686 | - | Dcdc5 | NNNAGTGTGATCATGGTGCA | NGG | 2 | 0.081 | Tier II |
12 | NC_000068.7 | 2 | 164484483 | + | Dbndd2 | NNNAGTTTGAAAATGGGGCA | NGG | 2 | 0.0672 | Tier II |
13 | NC_000086.7 | X | 7739747 | - | Ccdc120 | NNNAGTGTGAAAATGGGGAA | NGG | 2 | 0.0504 | Tier II |
14 | NC_000067.6 | 1 | 180948966 | + | Tmem63a | NNNAGTGTGAATATTGTGCA | NGG | 2 | 0.0476 | Tier II |
15 | NC_000086.7 | X | 113631040 | - | Dach2 | NNNAGTGTGAAAATGATGCA | NGT | 2 | 0.0161 | Tier II |
16 | NC_000071.6 | 5 | 131987183 | + | Auts2 | NNNAGTGTTAAAATGGTGCA | NGT | 2 | 0.0086 | Tier II |
17 | NC_000069.6 | 3 | 60020822 | - | Aadacl2 | NNNAGTGTGAAATTGGTGCA | NGT | 2 | 0.0048 | Tier II |
18 | NC_000068.7 | 2 | 120304514 | + | Pla2g4f | NNNAGTGTGAAAAGGGAGCA | NGG | 2 | 0.0 | Tier II |
19 | NC_000067.6 | 1 | 152583526 | - | Rgl1 | NNNAGTGTGTAAAGGGTGCA | NGG | 2 | 0.0 | Tier II |
20 | NC_000082.6 | 16 | 5403788 | - | Gm41414 | NNNACTGTGTAAATGGTGCA | NGG | 2 | 0.6933 | Tier III |
21 | NC_000069.6 | 3 | 143480882 | - | Gm33604 | NNNAGTGTGAAAATGGTAAA | NGG | 2 | 0.2967 | Tier III |
22 | NC_000074.6 | 8 | 90739578 | - | Gm35850 | NNNAGTGTGAAAATGGAGCA | NAG | 2 | 0.1383 | Tier III |
23 | NC_000069.6 | 3 | 60020822 | - | Gm18427 | NNNAGTGTGAAATTGGTGCA | NGT | 2 | 0.0048 | Tier III |