Construct: sgRNA BRDN0001146668
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- AGCCGGAAGAAGGACTGGGT
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- UCKL1 (54963)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000020.11 | 20 | 63945806 | - | UCKL1 | NNNCGGAAGAAGGACTGGGT | NGG | 0 | 1.0 | Tier I |
2 | NC_000006.12 | 6 | 30189513 | - | TRIM26 | NNNCGGAAGAAGTTCTGGGT | NGG | 2 | 0.16 | Tier I |
3 | NC_000009.12 | 9 | 127944884 | - | EEIG1 | NNNCGGAAGAAGGACTCGGT | NGA | 2 | 0.0163 | Tier I |
4 | NC_000015.10 | 15 | 38034967 | - | TMCO5A | NNNAGGAAGAAGGACTGTGT | NGG | 2 | 0.5614 | Tier II |
5 | NC_000001.11 | 1 | 50574370 | + | FAF1 | NNNTGGAAGAGGGACTGGGT | NGG | 2 | 0.52 | Tier II |
6 | NC_000014.9 | 14 | 24405529 | + | NYNRIN | NNNAGGAAGAAGGTCTGGGT | NGG | 2 | 0.4491 | Tier II |
7 | NC_000019.10 | 19 | 33441545 | - | PEPD | NNNGGGAAGGAGGACTGGGT | NGG | 2 | 0.2778 | Tier II |
8 | NC_000002.12 | 2 | 237728813 | - | LRRFIP1 | NNNGGGAAGAAGGTCTGGGT | NGG | 2 | 0.2667 | Tier II |
9 | NC_000001.11 | 1 | 151709403 | - | CELF3 | NNNCGGAAGAAGGGCTGGGA | NGG | 2 | 0.2625 | Tier II |
10 | NC_000001.11 | 1 | 68172997 | + | WLS | NNNCGGAAGACGGACTGGGA | NGG | 2 | 0.225 | Tier II |
11 | NC_000001.11 | 1 | 53672132 | - | GLIS1 | NNNCGGAAGAATGGCTGGGT | NGG | 2 | 0.1795 | Tier II |
12 | NC_000011.10 | 11 | 72580556 | + | PDE2A | NNNGGGAAGAAGGACGGGGT | NGG | 2 | 0.1731 | Tier II |
13 | NC_000001.11 | 1 | 15445529 | - | CTRC | NNNGGGAAGCAGGACTGGGT | NGG | 2 | 0.1667 | Tier II |
14 | NC_000023.11 | X | 9804030 | + | SHROOM2 | NNNGGGAAGATGGACTGGGT | NGG | 2 | 0.1538 | Tier II |
15 | NC_000003.12 | 3 | 49889160 | - | MST1R | NNNGGGAAGAAGGACTGGGC | NGG | 2 | 0.0455 | Tier II |
16 | NC_000007.14 | 7 | 51026500 | + | COBL | NNNCGGAAGAAGGGGTGGGT | NGG | 2 | 0.0233 | Tier II |
17 | NC_000012.12 | 12 | 10855083 | - | PRH1-PRR4 | NNNCAGGAGAAGGACTGGGT | NGG | 2 | 0.6118 | Tier III |
18 | NC_000012.12 | 12 | 116487232 | + | LOC105370007 | NNNAGGAAGGAGGACTGGGT | NGG | 2 | 0.4678 | Tier III |
19 | NC_000004.12 | 4 | 9686837 | + | LOC124900660 | NNNCGGAAAAAGGACTGAGT | NGG | 2 | 0.4451 | Tier III |
20 | NC_000001.11 | 1 | 38092761 | + | MIR3659HG | NNNGGGAGGAAGGACTGGGT | NGG | 2 | 0.3667 | Tier III |
21 | NC_000022.11 | 22 | 18064703 | + | LOC105372853 | NNNGGGAATAAGGACTGGGT | NGG | 2 | 0.2667 | Tier III |
22 | NC_000001.11 | 1 | 68172997 | + | GNG12-AS1 | NNNCGGAAGACGGACTGGGA | NGG | 2 | 0.225 | Tier III |
23 | NC_000011.10 | 11 | 57211380 | + | LOC105369309 | NNNCAGAAGAAGGCCTGGGT | NGG | 2 | 0.1857 | Tier III |
24 | NC_000011.10 | 11 | 25555753 | + | LINC02699 | NNNCGGAAGAAGGACCTGGT | NGG | 2 | 0.1667 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000083.6 | 17 | 24628943 | - | Tsc2 | NNNTGGAAGAAGAACTGGGT | NGG | 2 | 0.7385 | Tier I |
2 | NC_000068.7 | 2 | 181574370 | - | Uckl1 | NNNCGGAAAAAGGACTGGGT | NGG | 1 | 0.6429 | Tier I |
3 | NC_000082.6 | 16 | 46045290 | - | Cd96 | NNNAGGAAGAAGGACTAGGT | NGG | 2 | 0.786 | Tier II |
4 | NC_000087.7 | Y | 2123786 | + | Zfy2 | NNNAGGAAGTAGGACTGGGT | NGG | 2 | 0.743 | Tier II |
5 | NC_000076.6 | 10 | 89458434 | + | Nr1h4 | NNNCAGAAGAAGGACTGGTT | NGG | 2 | 0.5778 | Tier II |
6 | NC_000084.6 | 18 | 5674777 | - | Zeb1 | NNNAGGAAGAAGGACTGTGT | NGG | 2 | 0.5614 | Tier II |
7 | NC_000073.6 | 7 | 56899257 | + | Gabrg3 | NNNAGGAAGAGGGACTGGGT | NGG | 2 | 0.5474 | Tier II |
8 | NC_000081.6 | 15 | 78953402 | + | Triobp | NNNCGGAAGGAGAACTGGGT | NGG | 2 | 0.5128 | Tier II |
9 | NC_000085.6 | 19 | 46268659 | + | Gbf1 | NNNCAGAAGAAGGACTGGGA | NGG | 2 | 0.4875 | Tier II |
10 | NC_000073.6 | 7 | 47054370 | + | Tmem86a | NNNTGGTAGAAGGACTGGGT | NGG | 2 | 0.35 | Tier II |
11 | NC_000082.6 | 16 | 8411906 | - | Tmem114 | NNNAGGAAGAAGGACGGGGT | NGG | 2 | 0.2915 | Tier II |
12 | NC_000067.6 | 1 | 175992389 | + | Pld5 | NNNAGGAAGCAGGACTGGGT | NGG | 2 | 0.2807 | Tier II |
13 | NC_000068.7 | 2 | 141846066 | + | Macrod2 | NNNAGGAAGCAGGACTGGGT | NGG | 2 | 0.2807 | Tier II |
14 | NC_000069.6 | 3 | 145446856 | - | Col24a1 | NNNAGGAAGCAGGACTGGGT | NGG | 2 | 0.2807 | Tier II |
15 | NC_000072.6 | 6 | 106479301 | + | Cntn4 | NNNAGGAAGCAGGACTGGGT | NGG | 2 | 0.2807 | Tier II |
16 | NC_000073.6 | 7 | 57493407 | - | Gabra5 | NNNAGGAAGCAGGACTGGGT | NGG | 2 | 0.2807 | Tier II |
17 | NC_000076.6 | 10 | 53684803 | - | Fam184a | NNNAGGAAGCAGGACTGGGT | NGG | 2 | 0.2807 | Tier II |
18 | NC_000078.6 | 12 | 37998187 | - | Dgkb | NNNAGGAAGCAGGACTGGGT | NGG | 2 | 0.2807 | Tier II |
19 | NC_000078.6 | 12 | 41697684 | - | Immp2l | NNNAGGAAGCAGGACTGGGT | NGG | 2 | 0.2807 | Tier II |
20 | NC_000079.6 | 13 | 9737210 | - | Zmynd11 | NNNAGGAAGCAGGACTGGGT | NGG | 2 | 0.2807 | Tier II |
21 | NC_000079.6 | 13 | 62989479 | + | Aopep | NNNAGGAAGCAGGACTGGGT | NGG | 2 | 0.2807 | Tier II |
22 | NC_000079.6 | 13 | 63007918 | + | Aopep | NNNAGGAAGCAGGACTGGGT | NGG | 2 | 0.2807 | Tier II |
23 | NC_000080.6 | 14 | 4823977 | + | Gm26650 | NNNAGGAAGCAGGACTGGGT | NGG | 2 | 0.2807 | Tier II |
24 | NC_000081.6 | 15 | 30535886 | - | Ctnnd2 | NNNAGGAAGCAGGACTGGGT | NGG | 2 | 0.2807 | Tier II |
25 | NC_000083.6 | 17 | 42443909 | - | Ptchd4 | NNNAGGAAGCAGGACTGGGT | NGG | 2 | 0.2807 | Tier II |
26 | NC_000086.7 | X | 42163376 | - | Stag2 | NNNAGGAAGCAGGACTGGGT | NGG | 2 | 0.2807 | Tier II |
27 | NC_000086.7 | X | 84170167 | + | Dmd | NNNAGGAAGCAGGACTGGGT | NGG | 2 | 0.2807 | Tier II |
28 | NC_000074.6 | 8 | 25536235 | - | Fgfr1 | NNNCGGGAGAAGGACGGGGT | NGG | 2 | 0.2443 | Tier II |
29 | NC_000069.6 | 3 | 102826275 | + | Sycp1 | NNNGGGAAGCAGGACTGGGT | NGG | 2 | 0.1667 | Tier II |
30 | NC_000078.6 | 12 | 99394624 | - | Foxn3 | NNNAGGAAGAAGGACTGGGG | NGG | 2 | 0.1486 | Tier II |
31 | NC_000074.6 | 8 | 75216506 | + | Rasd2 | NNNCTGCAGAAGGACTGGGT | NGG | 2 | 0.1313 | Tier II |
32 | NC_000077.6 | 11 | 5151487 | - | Emid1 | NNNCGGAGGAAGGACTGGGG | NGG | 2 | 0.1294 | Tier II |
33 | NC_000071.6 | 5 | 124829511 | - | Dnah10 | NNNCTGAAGAAGGACTGGGT | NAG | 2 | 0.0778 | Tier II |
34 | NC_000072.6 | 6 | 90334291 | + | Uroc1 | NNNCGGTAGAAGGACTGGGG | NGG | 2 | 0.0772 | Tier II |
35 | NC_000075.6 | 9 | 123462675 | - | Lars2 | NNNAGGAAGAAGGACTGGGT | NGA | 2 | 0.0585 | Tier II |
36 | NC_000086.7 | X | 161146286 | - | Scml2 | NNNAGGAAGAAGGATTGGGT | NGG | 2 | 0.0561 | Tier II |
37 | NC_000067.6 | 1 | 16480463 | + | Stau2 | NNNAGGAAGAAGGAGTGGGT | NGG | 2 | 0.0421 | Tier II |
38 | NC_000068.7 | 2 | 105278913 | + | Them7 | NNNAGGAAGAAGGAGTGGGT | NGG | 2 | 0.0421 | Tier II |
39 | NC_000069.6 | 3 | 102850261 | + | Sycp1 | NNNAGGAAGAAGGAGTGGGT | NGG | 2 | 0.0421 | Tier II |
40 | NC_000074.6 | 8 | 11225267 | - | Col4a1 | NNNAGGAAGAAGGAGTGGGT | NGG | 2 | 0.0421 | Tier II |
41 | NC_000074.6 | 8 | 129052628 | - | Ccdc7a | NNNAGGAAGAAGGAGTGGGT | NGG | 2 | 0.0421 | Tier II |
42 | NC_000075.6 | 9 | 4775579 | + | Gria4 | NNNAGGAAGAAGGAGTGGGT | NGG | 2 | 0.0421 | Tier II |
43 | NC_000075.6 | 9 | 24736764 | + | Tbx20 | NNNAGGAAGAAGGAGTGGGT | NGG | 2 | 0.0421 | Tier II |
44 | NC_000076.6 | 10 | 27349572 | + | Lama2 | NNNAGGAAGAAGGAGTGGGT | NGG | 2 | 0.0421 | Tier II |
45 | NC_000080.6 | 14 | 4815834 | - | Gm26650 | NNNAGGAAGAAGGAGTGGGT | NGG | 2 | 0.0421 | Tier II |
46 | NC_000080.6 | 14 | 124451699 | - | Fgf14 | NNNAGGAAGAAGGAGTGGGT | NGG | 2 | 0.0421 | Tier II |
47 | NC_000082.6 | 16 | 74382933 | - | Robo2 | NNNAGGAAGAAGGAGTGGGT | NGG | 2 | 0.0421 | Tier II |
48 | NC_000085.6 | 19 | 57753842 | - | Atrnl1 | NNNAGGAAGAAGGAGTGGGT | NGG | 2 | 0.0421 | Tier II |
49 | NC_000086.7 | X | 20929150 | + | Cfp | NNNAGGAAGAAGGAGTGGGT | NGG | 2 | 0.0421 | Tier II |
50 | NC_000086.7 | X | 95546005 | - | Asb12 | NNNAGGAAGAAGGAGTGGGT | NGG | 2 | 0.0421 | Tier II |
51 | NC_000086.7 | X | 137701264 | - | Il1rapl2 | NNNAGGAAGAAGGAGTGGGT | NGG | 2 | 0.0421 | Tier II |
52 | NC_000075.6 | 9 | 92542787 | - | Plod2 | NNNCGGAAGGAGGAGTGGGT | NGG | 2 | 0.0278 | Tier II |
53 | NC_000080.6 | 14 | 41002569 | - | Prxl2a | NNNCTGAAGAAGGACTGGGC | NGG | 2 | 0.0273 | Tier II |
54 | NC_000068.7 | 2 | 77722843 | + | Zfp385b | NNNGGGAAGAAGGAGTGGGT | NGG | 2 | 0.025 | Tier II |
55 | NC_000083.6 | 17 | 14284945 | - | Smoc2 | NNNCGGAAGAAGGATTGGGT | NAG | 2 | 0.0173 | Tier II |
56 | NC_000072.6 | 6 | 40746769 | - | Mgam | NNNCGGAAGCAGGAGTGGGT | NGG | 2 | 0.0167 | Tier II |
57 | NC_000083.6 | 17 | 57472513 | + | Adgre1 | NNNCGGAAGCAGGAGTGGGT | NGG | 2 | 0.0167 | Tier II |
58 | NC_000072.6 | 6 | 15145921 | - | Foxp2 | NNNCGGAAGAAGGAGTGGGT | NGA | 2 | 0.0035 | Tier II |
59 | NC_000067.6 | 1 | 80463792 | - | 1700016L21Rik | NNNAGGAAGAGGGACTGGGT | NGG | 2 | 0.5474 | Tier III |
60 | NC_000067.6 | 1 | 80463792 | - | Gm38673 | NNNAGGAAGAGGGACTGGGT | NGG | 2 | 0.5474 | Tier III |
61 | NC_000074.6 | 8 | 50250246 | - | 1700019L22Rik | NNNGGGAAGAAGGACTGGGA | NGG | 2 | 0.2813 | Tier III |
62 | NC_000076.6 | 10 | 57148388 | + | Gm40652 | NNNAGGAAGCAGGACTGGGT | NGG | 2 | 0.2807 | Tier III |
63 | NC_000078.6 | 12 | 15035190 | - | 4930448C13Rik | NNNAGGAAGCAGGACTGGGT | NGG | 2 | 0.2807 | Tier III |
64 | NC_000078.6 | 12 | 86236374 | - | Gm40481 | NNNAGGAAGCAGGACTGGGT | NGG | 2 | 0.2807 | Tier III |
65 | NC_000080.6 | 14 | 6458673 | - | Gm26630 | NNNAGGAAGCAGGACTGGGT | NGG | 2 | 0.2807 | Tier III |
66 | NC_000080.6 | 14 | 6793776 | - | Gm26680 | NNNAGGAAGCAGGACTGGGT | NGG | 2 | 0.2807 | Tier III |
67 | NC_000080.6 | 14 | 6926260 | - | Gm32041 | NNNAGGAAGCAGGACTGGGT | NGG | 2 | 0.2807 | Tier III |
68 | NC_000078.6 | 12 | 60200107 | - | Gm40431 | NNNGGGAAGGAGGACTGGGT | NGG | 2 | 0.2778 | Tier III |
69 | NC_000074.6 | 8 | 25536235 | - | Gm31288 | NNNCGGGAGAAGGACGGGGT | NGG | 2 | 0.2443 | Tier III |
70 | NC_000080.6 | 14 | 6780672 | + | Gm26680 | NNNAGGAAGAAGGAATGGGT | NGG | 2 | 0.1871 | Tier III |
71 | NC_000080.6 | 14 | 6913735 | + | Gm32041 | NNNAGGAAGAAGGAATGGGT | NGG | 2 | 0.1871 | Tier III |
72 | NC_000072.6 | 6 | 41348754 | + | Tcrb | NNNGGGAAGCAGGACTGGGT | NGG | 2 | 0.1667 | Tier III |
73 | NC_000073.6 | 7 | 94911097 | + | Gm32647 | NNNAGGAAGAAGGAGTGGGT | NGG | 2 | 0.0421 | Tier III |
74 | NC_000075.6 | 9 | 72232321 | + | Gm27188 | NNNAGGAAGAAGGAGTGGGT | NGG | 2 | 0.0421 | Tier III |
75 | NC_000077.6 | 11 | 41899198 | - | A230004M16Rik | NNNAGGAAGAAGGAGTGGGT | NGG | 2 | 0.0421 | Tier III |
76 | NC_000078.6 | 12 | 14238534 | - | Gm36007 | NNNAGGAAGAAGGAGTGGGT | NGG | 2 | 0.0421 | Tier III |
77 | NC_000080.6 | 14 | 6466780 | + | Gm26630 | NNNAGGAAGAAGGAGTGGGT | NGG | 2 | 0.0421 | Tier III |
78 | NC_000080.6 | 14 | 6934312 | + | Gm32041 | NNNAGGAAGAAGGAGTGGGT | NGG | 2 | 0.0421 | Tier III |
79 | NC_000085.6 | 19 | 8540213 | - | Gm8189 | NNNAGGAAGAAGGAGTGGGT | NGG | 2 | 0.0421 | Tier III |
80 | NC_000075.6 | 9 | 92542787 | - | B430319G15Rik | NNNCGGAAGGAGGAGTGGGT | NGG | 2 | 0.0278 | Tier III |
81 | NC_000069.6 | 3 | 106864830 | - | Gm35507 | NNNGGGAAGAAGGAGTGGGT | NGG | 2 | 0.025 | Tier III |
82 | NC_000080.6 | 14 | 53735268 | - | Tcra | NNNCGGAAGCAGGAGTGGGT | NGG | 2 | 0.0167 | Tier III |