Construct: sgRNA BRDN0001146987
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- GAAAAACAAGTATATCACAT
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- STYK1 (55359)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000012.12 | 12 | 10627669 | - | STYK1 | NNNAAACAAGTATATCACAT | NGG | 0 | 1.0 | Tier I |
2 | NC_000023.11 | X | 150663813 | - | MTM1 | NNNAAACAATTATATCACAT | NGG | 1 | 0.8125 | Tier II |
3 | NC_000013.11 | 13 | 78627892 | - | OBI1 | NNNAAACAAGTAAATAACAT | NGG | 2 | 0.6923 | Tier II |
4 | NC_000007.14 | 7 | 133832889 | + | EXOC4 | NNNAAACAAGTATATCACAA | NGG | 1 | 0.5625 | Tier II |
5 | NC_000003.12 | 3 | 178669158 | + | KCNMB2 | NNNAAAAAAGTAAATCACAT | NGG | 2 | 0.5192 | Tier II |
6 | NC_000002.12 | 2 | 60770431 | - | PAPOLG | NNNAAACAATTATAACACAT | NGG | 2 | 0.4704 | Tier II |
7 | NC_000008.11 | 8 | 91211306 | + | SLC26A7 | NNNAAAAAAGTATATCACAA | NGG | 2 | 0.4219 | Tier II |
8 | NC_000008.11 | 8 | 91211306 | + | LRRC69 | NNNAAAAAAGTATATCACAA | NGG | 2 | 0.4219 | Tier II |
9 | NC_000002.12 | 2 | 72506765 | - | EXOC6B | NNNAACCAATTATATCACAT | NGG | 2 | 0.3693 | Tier II |
10 | NC_000014.9 | 14 | 92729573 | + | LGMN | NNNTAACAAGTATAACACAT | NGG | 2 | 0.3684 | Tier II |
11 | NC_000003.12 | 3 | 188857119 | + | LPP | NNNAAAATAGTATATCACAT | NGG | 2 | 0.3214 | Tier II |
12 | NC_000007.14 | 7 | 140576228 | - | DENND2A | NNNATACAAGTAAATCACAT | NGG | 2 | 0.2517 | Tier II |
13 | NC_000016.10 | 16 | 22020858 | - | MOSMO | NNNGAACAACTATATCACAT | NGG | 2 | 0.25 | Tier II |
14 | NC_000010.11 | 10 | 63406076 | + | JMJD1C | NNNAAACAAGAATATTACAT | NGG | 2 | 0.2308 | Tier II |
15 | NC_000004.12 | 4 | 53382851 | - | FIP1L1 | NNNAAATAAGTAGATCACAT | NGG | 2 | 0.212 | Tier II |
16 | NC_000005.10 | 5 | 52953134 | + | ITGA1 | NNNAAACAAGTATATTAAAT | NGG | 2 | 0.1657 | Tier II |
17 | NC_000001.11 | 1 | 171317792 | - | FMO4 | NNNAAACAAGGATATTACAT | NGG | 2 | 0.1231 | Tier II |
18 | NC_000010.11 | 10 | 73048086 | + | P4HA1 | NNNAAACAAGTATGTCACAT | NAG | 2 | 0.121 | Tier II |
19 | NC_000010.11 | 10 | 106946165 | + | SORCS1 | NNNAAACAAGTGTATGACAT | NGG | 2 | 0.1111 | Tier II |
20 | NC_000004.12 | 4 | 86335348 | + | MAPK10 | NNNAAACAAGTATAAGACAT | NGG | 2 | 0.0891 | Tier II |
21 | NC_000001.11 | 1 | 58049534 | + | DAB1 | NNNAACCAAGTATATGACAT | NGG | 2 | 0.0699 | Tier II |
22 | NC_000007.14 | 7 | 43781346 | - | BLVRA | NNNAAAAAAGTATATCACAC | NGG | 2 | 0.0682 | Tier II |
23 | NC_000001.11 | 1 | 159187362 | + | CADM3 | NNNAAACAAGTAAATCACAC | NGG | 2 | 0.0629 | Tier II |
24 | NC_000011.10 | 11 | 9183281 | - | DENND5A | NNNAAACAAGTCTATGACAT | NGG | 2 | 0.0405 | Tier II |
25 | NC_000023.11 | X | 53668642 | + | HUWE1 | NNNAAACAAGTCTATCTCAT | NGG | 2 | 0.0351 | Tier II |
26 | NC_000018.10 | 18 | 9285459 | + | ANKRD12 | NNNAAAAAAGTATATCACAT | NTG | 2 | 0.0292 | Tier II |
27 | NC_000003.12 | 3 | 12488627 | - | TSEN2 | NNNAAACAAGTATATAACAT | NGC | 2 | 0.0222 | Tier II |
28 | NC_000002.12 | 2 | 233430504 | - | DGKD | NNNAAACATGTATATCACAT | NGT | 2 | 0.0097 | Tier II |
29 | NC_000004.12 | 4 | 80335357 | - | CFAP299 | NNNAAACAAGTATATCAAAT | NGT | 2 | 0.0087 | Tier II |
30 | NC_000005.10 | 5 | 125238806 | - | LOC101927421 | NNNAAACAATCATATCACAT | NGG | 2 | 0.5417 | Tier III |
31 | NC_000003.12 | 3 | 34879055 | - | LOC101928135 | NNNAAACAAATATAACACAT | NGG | 2 | 0.5404 | Tier III |
32 | NC_000009.12 | 9 | 21734128 | - | LOC107987026 | NNNAAGAAAGTATATCACAT | NGG | 2 | 0.5357 | Tier III |
33 | NC_000003.12 | 3 | 178669158 | + | KCNMB2-AS1 | NNNAAAAAAGTAAATCACAT | NGG | 2 | 0.5192 | Tier III |
34 | NC_000010.11 | 10 | 23562049 | + | LOC105376454 | NNNAAACAAGTATATCAATT | NGG | 2 | 0.2899 | Tier III |
35 | NC_000004.12 | 4 | 157814773 | + | LOC105377509 | NNNAAACTAGTATATCAAAT | NGG | 2 | 0.2308 | Tier III |
36 | NC_000005.10 | 5 | 52953134 | + | ITGA2-AS1 | NNNAAACAAGTATATTAAAT | NGG | 2 | 0.1657 | Tier III |
37 | NC_000022.11 | 22 | 23655823 | - | GUSBP11 | NNNAAACAAGGCTATCACAT | NGG | 2 | 0.1053 | Tier III |
38 | NC_000010.11 | 10 | 57390172 | - | LOC105378313 | NNNAAATAAGTATAGCACAT | NGG | 2 | 0.0406 | Tier III |
39 | NC_000002.12 | 2 | 8033351 | + | LINC00299 | NNNAAACATGTATATCACAT | NGC | 2 | 0.0133 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000072.6 | 6 | 131307099 | - | Styk1 | NNNAAACAAATATATCACAT | NGG | 1 | 0.9333 | Tier I |
2 | NC_000081.6 | 15 | 76596425 | - | Cpsf1 | NNNAAACAAGCATATCACAT | NGT | 2 | 0.0108 | Tier I |
3 | NC_000067.6 | 1 | 159890210 | + | Tnr | NNNAAGCAAGTATATCACAT | NGG | 1 | 0.7143 | Tier II |
4 | NC_000067.6 | 1 | 32616332 | - | Khdrbs2 | NNNAAAAAAGTATATCACTT | NGG | 2 | 0.4038 | Tier II |
5 | NC_000068.7 | 2 | 90763913 | - | Fnbp4 | NNNAGACAAGTATTTCACAT | NGG | 2 | 0.384 | Tier II |
6 | NC_000068.7 | 2 | 59636120 | + | Tanc1 | NNNACACATGTATATCACAT | NGG | 2 | 0.3 | Tier II |
7 | NC_000071.6 | 5 | 67957308 | - | Gm5108 | NNNAAACCAGTAAATCACAT | NGG | 2 | 0.2967 | Tier II |
8 | NC_000069.6 | 3 | 139484901 | + | Stpg2 | NNNAAACAAGTATATTATAT | NGG | 2 | 0.1978 | Tier II |
9 | NC_000076.6 | 10 | 64000035 | + | Lrrtm3 | NNNGAACAAGTCTATCACAT | NGG | 2 | 0.1645 | Tier II |
10 | NC_000076.6 | 10 | 64000035 | + | Ctnna3 | NNNGAACAAGTCTATCACAT | NGG | 2 | 0.1645 | Tier II |
11 | NC_000084.6 | 18 | 5051058 | - | Svil | NNNAAACAAGTGTATCACAG | NGG | 2 | 0.1275 | Tier II |
12 | NC_000080.6 | 14 | 39297433 | - | Nrg3 | NNNAAACAAGCATATCACAG | NGG | 2 | 0.1176 | Tier II |
13 | NC_000073.6 | 7 | 57295038 | + | Gabrg3 | NNNAAAGAAGTATATCTCAT | NGG | 2 | 0.0627 | Tier II |
14 | NC_000071.6 | 5 | 150799719 | + | Pds5b | NNNAAACATGTATATCACAT | NGT | 2 | 0.0097 | Tier II |
15 | NC_000069.6 | 3 | 97736871 | + | Pde4dip | NNNAAACAAGTATATCACTT | NGT | 2 | 0.0087 | Tier II |
16 | NC_000078.6 | 12 | 70855330 | - | Frmd6 | NNNAAACAAGTATGTCACAT | NGT | 2 | 0.0075 | Tier II |
17 | NC_000073.6 | 7 | 57295038 | + | Gm39017 | NNNAAAGAAGTATATCTCAT | NGG | 2 | 0.0627 | Tier III |
18 | NC_000072.6 | 6 | 6678973 | + | Gm20618 | NNNAAACAACTATATCACAC | NGG | 2 | 0.0364 | Tier III |
19 | NC_000069.6 | 3 | 97736871 | + | Gm31305 | NNNAAACAAGTATATCACTT | NGT | 2 | 0.0087 | Tier III |