Construct: sgRNA BRDN0001147019
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- GAAGGGCAGAAGCTGCATGT
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- PIP4K2B (8396)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000017.11 | 17 | 38777742 | - | PIP4K2B | NNNGGGCAGAAGCTGCATGT | NGG | 0 | 1.0 | Tier I |
2 | NC_000019.10 | 19 | 38838900 | - | HNRNPL | NNNGGGCAGAAGCTGAATGT | NTG | 2 | 0.039 | Tier I |
3 | NC_000003.12 | 3 | 13034865 | - | IQSEC1 | NNNGGACAGGAGCTGCATGT | NGG | 2 | 0.5556 | Tier II |
4 | NC_000007.14 | 7 | 45715821 | + | ADCY1 | NNNGGGTAGAGGCTGCATGT | NGG | 2 | 0.5281 | Tier II |
5 | NC_000006.12 | 6 | 68854982 | - | ADGRB3 | NNNGGTAAGAAGCTGCATGT | NGG | 2 | 0.5 | Tier II |
6 | NC_000014.9 | 14 | 23173255 | + | SLC7A8 | NNNGAGCAGAAGCTGCATGA | NGG | 2 | 0.4875 | Tier II |
7 | NC_000001.11 | 1 | 237802816 | - | RYR2 | NNNGGGCAGAAGCTGCATCT | NGG | 1 | 0.4483 | Tier II |
8 | NC_000010.11 | 10 | 72069218 | - | SPOCK2 | NNNGGGCAGAGGCTGCATTT | NGG | 2 | 0.4333 | Tier II |
9 | NC_000002.12 | 2 | 69596839 | + | AAK1 | NNNAGGCTGAAGCTGCATGT | NGG | 2 | 0.3857 | Tier II |
10 | NC_000014.9 | 14 | 68593431 | + | RAD51B | NNNGGGCAGAAGCTGCAGGT | NGG | 1 | 0.3333 | Tier II |
11 | NC_000006.12 | 6 | 5303408 | + | FARS2 | NNNGGGCTGAAGCTGCACGT | NGG | 2 | 0.1837 | Tier II |
12 | NC_000009.12 | 9 | 127762718 | - | SH2D3C | NNNGGGCAGAAGCTGACTGT | NGG | 2 | 0.1765 | Tier II |
13 | NC_000011.10 | 11 | 133918071 | + | IGSF9B | NNNGGGCAGAAGCTGCAGCT | NGG | 2 | 0.1494 | Tier II |
14 | NC_000019.10 | 19 | 3386726 | - | NFIC | NNNAGGCAGAAGCTGCTTGT | NGG | 2 | 0.12 | Tier II |
15 | NC_000007.14 | 7 | 23745530 | + | STK31 | NNNGGGCAGCAGCTGCAGGT | NGG | 2 | 0.1111 | Tier II |
16 | NC_000022.11 | 22 | 33806081 | - | LARGE1 | NNNGGGCAGAAGCTGCCTGA | NGG | 2 | 0.0993 | Tier II |
17 | NC_000001.11 | 1 | 241655599 | - | WDR64 | NNNGGGCAGAAGGTGCATGA | NGG | 2 | 0.0767 | Tier II |
18 | NC_000020.11 | 20 | 34190854 | - | ASIP | NNNGGGCAGAAGTTGCATGC | NGG | 2 | 0.0636 | Tier II |
19 | NC_000006.12 | 6 | 69073282 | + | ADGRB3 | NNNGGGCAGAAGCTGCAGGG | NGG | 2 | 0.0588 | Tier II |
20 | NC_000009.12 | 9 | 129850624 | - | USP20 | NNNAGGCAGAAGCTGCATGT | NTG | 2 | 0.0351 | Tier II |
21 | NC_000020.11 | 20 | 53325422 | + | TSHZ2 | NNNGGGAAGAAGCTGCATGT | NTG | 2 | 0.0292 | Tier II |
22 | NC_000003.12 | 3 | 53074185 | + | RFT1 | NNNGGGCAGAAGCTGGGTGT | NGG | 2 | 0.0271 | Tier II |
23 | NC_000012.12 | 12 | 131786874 | - | SFSWAP | NNNGGGCAGCAGCTGCATGT | NGA | 2 | 0.0231 | Tier II |
24 | NC_000006.12 | 6 | 161140759 | + | AGPAT4 | NNNGGGCAGAAGCTGCCTGC | NGG | 2 | 0.016 | Tier II |
25 | NC_000015.10 | 15 | 42546536 | - | LRRC57 | NNNGGCCAGAAGCTGCATGT | NGT | 2 | 0.011 | Tier II |
26 | NC_000010.11 | 10 | 58615533 | - | BICC1 | NNNGGGCACAAGCTGCATGT | NGT | 2 | 0.0087 | Tier II |
27 | NC_000016.10 | 16 | 67331049 | + | LRRC36 | NNNGGGCAGAAGGTGCATGT | NTG | 2 | 0.0053 | Tier II |
28 | NC_000005.10 | 5 | 122722974 | + | LINC02201 | NNNAGGTAGAAGCTGCATGT | NGG | 2 | 0.7313 | Tier III |
29 | NC_000001.11 | 1 | 29459134 | + | LOC107984933 | NNNGGGCAGTAGCAGCATGT | NGG | 2 | 0.5462 | Tier III |
30 | NC_000001.11 | 1 | 193351906 | - | LINC01031 | NNNGGGCAGAAGCTGCAATT | NGG | 2 | 0.4444 | Tier III |
31 | NC_000006.12 | 6 | 7481508 | - | HNRNPLP1 | NNNGGGCAGAAGCTGAATGT | NTG | 2 | 0.039 | Tier III |
32 | NC_000007.14 | 7 | 77530068 | - | LOC124901681 | NNNGGGCAGAAGCTGAATGT | NTG | 2 | 0.039 | Tier III |
33 | NC_000015.10 | 15 | 34489419 | - | HNRNPLP2 | NNNGGGCAGAAGCTGAATGT | NTG | 2 | 0.039 | Tier III |
34 | NC_000019.10 | 19 | 38838900 | - | LOC124904712 | NNNGGGCAGAAGCTGAATGT | NTG | 2 | 0.039 | Tier III |
35 | NC_000015.10 | 15 | 93372208 | + | LOC105370982 | NNNGGGCAGAAGCTGCTTGG | NGG | 2 | 0.0235 | Tier III |
36 | NC_000006.12 | 6 | 161140759 | + | LOC124901455 | NNNGGGCAGAAGCTGCCTGC | NGG | 2 | 0.016 | Tier III |
37 | NC_000004.12 | 4 | 142946018 | - | USP38-DT | NNNGGGCAGAAGCTGCATCT | NGC | 2 | 0.01 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000070.6 | 4 | 43545667 | + | Tln1 | NNNGGGCAGAGGCTGCATGT | NGG | 1 | 0.65 | Tier I |
2 | NC_000077.6 | 11 | 97722417 | - | Pip4k2b | NNNGGGCAGAAGCTGCACGT | NGG | 1 | 0.4286 | Tier I |
3 | NC_000082.6 | 16 | 38004628 | - | Gpr156 | NNNGGGCAGAGGCTGCATCT | NGG | 2 | 0.2914 | Tier I |
4 | NC_000072.6 | 6 | 86959250 | - | Aak1 | NNNGGGCAGCAGCTGCCTGT | NGG | 2 | 0.0588 | Tier I |
5 | NC_000074.6 | 8 | 122333868 | - | Zfpm1 | NNNGGGCAGCAGCTGGATGT | NGG | 2 | 0.0513 | Tier I |
6 | NC_000075.6 | 9 | 78087536 | - | Fbxo9 | NNNGGGCAGAAGCTGCATGA | NGC | 2 | 0.0125 | Tier I |
7 | NC_000068.7 | 2 | 21425169 | + | Gpr158 | NNNGGGAAGAAGCTGAATGT | NGG | 2 | 0.75 | Tier II |
8 | NC_000075.6 | 9 | 64566101 | - | Megf11 | NNNAGGCAAAAGCTGCATGT | NGG | 2 | 0.5786 | Tier II |
9 | NC_000084.6 | 18 | 68322243 | - | Rnmt | NNNGGGCAGGAGCTGCATGT | NGG | 1 | 0.5556 | Tier II |
10 | NC_000068.7 | 2 | 68348617 | - | Stk39 | NNNGGGGAGAAGCTGAATGT | NGG | 2 | 0.4706 | Tier II |
11 | NC_000068.7 | 2 | 9950635 | - | Taf3 | NNNGGGCAGAGGCTGCACGT | NGG | 2 | 0.2786 | Tier II |
12 | NC_000080.6 | 14 | 86763557 | + | Diaph3 | NNNGGGCAGAAGCTGCCTGT | NGG | 1 | 0.1765 | Tier II |
13 | NC_000074.6 | 8 | 45552808 | - | Sorbs2 | NNNGGACAGAAGCTGCTTGT | NGG | 2 | 0.1333 | Tier II |
14 | NC_000075.6 | 9 | 96870923 | - | Pxylp1 | NNNAGGCAGAAGCTGCTTGT | NGG | 2 | 0.12 | Tier II |
15 | NC_000075.6 | 9 | 42579281 | + | Grik4 | NNNGGGCAGGAGCTGCCTGT | NGG | 2 | 0.098 | Tier II |
16 | NC_000072.6 | 6 | 113861543 | - | Atp2b2 | NNNGGGCACAAGCTGCCTGT | NGG | 2 | 0.095 | Tier II |
17 | NC_000080.6 | 14 | 117049743 | - | Gpc6 | NNNGGGCAGAAGCTGCAGGT | NAG | 2 | 0.0864 | Tier II |
18 | NC_000074.6 | 8 | 108573174 | - | Zfhx3 | NNNGGGCAGAAGCTACATGT | NGA | 2 | 0.0654 | Tier II |
19 | NC_000079.6 | 13 | 12486447 | + | Edaradd | NNNGTGCAGAAGCTGCGTGT | NGG | 2 | 0.0529 | Tier II |
20 | NC_000077.6 | 11 | 83895873 | + | Hnf1b | NNNGGGCAGATGCTTCATGT | NGG | 2 | 0.044 | Tier II |
21 | NC_000080.6 | 14 | 35129633 | + | Grid1 | NNNGGGCAGAAGCTGAATGT | NTG | 2 | 0.039 | Tier II |
22 | NC_000084.6 | 18 | 35275421 | - | Sil1 | NNNGGGCAGAAGCTTCATGC | NGG | 2 | 0.013 | Tier II |
23 | NC_000085.6 | 19 | 7358688 | - | Spindoc | NNNGGGCAGAAGCTGCATTT | NGT | 2 | 0.0108 | Tier II |
24 | NC_000076.6 | 10 | 118523256 | + | Ifngas1 | NNNGGGGAGAAGCTGAATGT | NGG | 2 | 0.4706 | Tier III |
25 | NC_000078.6 | 12 | 112221269 | + | Gm36894 | NNNGGGCACAGGCTGCATGT | NGG | 2 | 0.35 | Tier III |
26 | NC_000075.6 | 9 | 100320502 | - | Gm28167 | NNNGAGCAGAAGCTTCATGT | NGG | 2 | 0.1238 | Tier III |
27 | NC_000074.6 | 8 | 108573174 | - | Lncbate1 | NNNGGGCAGAAGCTACATGT | NGA | 2 | 0.0654 | Tier III |
28 | NC_000074.6 | 8 | 108573174 | - | Gm51548 | NNNGGGCAGAAGCTACATGT | NGA | 2 | 0.0654 | Tier III |
29 | NC_000077.6 | 11 | 39687024 | - | Gm33963 | NNNGGACAGAAGCTGCATGT | NTG | 2 | 0.039 | Tier III |