Construct: sgRNA BRDN0001147093
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- CTCTGGTGTCCCACAAAATG
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- C8orf44-SGK3 (100533105)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000008.11 | 8 | 66841094 | - | SGK3 | NNNTGGTGTCCCACAAAATG | NGG | 0 | 1.0 | Tier I |
2 | NC_000008.11 | 8 | 66841094 | - | C8orf44-SGK3 | NNNTGGTGTCCCACAAAATG | NGG | 0 | 1.0 | Tier I |
3 | NC_000007.14 | 7 | 147605345 | + | CNTNAP2 | NNNTGGAGTCCCACAAAATA | NGG | 2 | 0.8203 | Tier II |
4 | NC_000001.11 | 1 | 22524091 | + | ZBTB40 | NNNTCGTGTCCCACAAAATG | NGG | 1 | 0.7857 | Tier II |
5 | NC_000009.12 | 9 | 39190074 | - | CNTNAP3 | NNNTGGTGTCCCACAAATTA | NGG | 2 | 0.4688 | Tier II |
6 | NC_000009.12 | 9 | 61428904 | + | CNTNAP3C | NNNTGGTGTCCCACAAATTA | NGG | 2 | 0.4688 | Tier II |
7 | NC_000008.11 | 8 | 4638591 | + | CSMD1 | NNNAGGTGTACCACAAAATG | NGG | 2 | 0.4127 | Tier II |
8 | NC_000015.10 | 15 | 53762849 | + | WDR72 | NNNTGGGGGCCCACAAAATG | NGG | 2 | 0.3641 | Tier II |
9 | NC_000012.12 | 12 | 124553926 | + | NCOR2 | NNNTGGTGTCCCTCAAAATG | NGG | 1 | 0.3 | Tier II |
10 | NC_000003.12 | 3 | 171164272 | + | TNIK | NNNTTGTGCCCCACAAAATG | NGG | 2 | 0.2769 | Tier II |
11 | NC_000012.12 | 12 | 112052374 | + | NAA25 | NNNTGCTGTGCCACAAAATG | NGG | 2 | 0.2652 | Tier II |
12 | NC_000004.12 | 4 | 153758637 | - | RNF175 | NNNTTGTGTACCACAAAATG | NGG | 2 | 0.26 | Tier II |
13 | NC_000012.12 | 12 | 107442453 | + | ABTB3 | NNNTTGTGTACCACAAAATG | NGG | 2 | 0.26 | Tier II |
14 | NC_000017.11 | 17 | 33801119 | + | ASIC2 | NNNTGGTGTCCATCAAAATG | NGG | 2 | 0.2143 | Tier II |
15 | NC_000019.10 | 19 | 39385724 | - | PAF1 | NNNTGGTTTCCCACAAAATG | NAG | 2 | 0.162 | Tier II |
16 | NC_000019.10 | 19 | 39385724 | - | SAMD4B | NNNTGGTTTCCCACAAAATG | NAG | 2 | 0.162 | Tier II |
17 | NC_000007.14 | 7 | 117731657 | + | CTTNBP2 | NNNTGGTGTGCCACAAAGTG | NGG | 2 | 0.1556 | Tier II |
18 | NC_000009.12 | 9 | 136070554 | - | NACC2 | NNNTGGTGTCCCACAAACTT | NGG | 2 | 0.1333 | Tier II |
19 | NC_000002.12 | 2 | 219300833 | + | PTPRN | NNNTGGTTTCCCCCAAAATG | NGG | 2 | 0.1316 | Tier II |
20 | NC_000023.11 | X | 102285207 | - | NXF2 | NNNTGGTGTCCCACAAAGAG | NGG | 2 | 0.1143 | Tier II |
21 | NC_000023.11 | X | 102401911 | + | NXF2B | NNNTGGTGTCCCACAAAGAG | NGG | 2 | 0.1143 | Tier II |
22 | NC_000001.11 | 1 | 6076287 | - | KCNAB2 | NNNTGGTGTCCTACAAACTG | NGG | 2 | 0.1026 | Tier II |
23 | NC_000009.12 | 9 | 109999770 | + | PALM2AKAP2 | NNNTTGTGTCCCACTAAATG | NGG | 2 | 0.06 | Tier II |
24 | NC_000007.14 | 7 | 1062027 | - | C7orf50 | NNNTGGTGTCTCACAAACTG | NGG | 2 | 0.0586 | Tier II |
25 | NC_000002.12 | 2 | 217979428 | - | TNS1 | NNNTGGTGTCCCACAAAATT | NTG | 2 | 0.0273 | Tier II |
26 | NC_000013.11 | 13 | 100487687 | - | PCCA | NNNTGGTATCCCACAAAATG | NGC | 2 | 0.0222 | Tier II |
27 | NC_000004.12 | 4 | 3479372 | - | DOK7 | NNNTGGTGGCCCACAAAATG | NGT | 2 | 0.01 | Tier II |
28 | NC_000004.12 | 4 | 3479372 | - | LOC105374355 | NNNTGGTGGCCCACAAAATG | NGT | 2 | 0.01 | Tier II |
29 | NC_000012.12 | 12 | 103066883 | - | C12orf42 | NNNTGGTGTCCCACAGAATG | NGT | 2 | 0.0031 | Tier II |
30 | NC_000018.10 | 18 | 42793913 | - | RIT2 | NNNGGGTGTCCCAGAAAATG | NGG | 2 | 0.0 | Tier II |
31 | NC_000023.11 | X | 7332488 | + | STS | NNNTTGTGTCCCAGAAAATG | NGG | 2 | 0.0 | Tier II |
32 | NC_000007.14 | 7 | 142557646 | - | TRB | NNNGGGTGCCCCACAAAATG | NGG | 2 | 0.5769 | Tier III |
33 | NC_000022.11 | 22 | 47689657 | - | EPIC1 | NNNTGGTGTATCACAAAATG | NGG | 2 | 0.2667 | Tier III |
34 | NC_000012.12 | 12 | 112052374 | + | LOC124903022 | NNNTGCTGTGCCACAAAATG | NGG | 2 | 0.2652 | Tier III |
35 | NC_000002.12 | 2 | 122988547 | + | LOC105373596 | NNNTGCTGTCCCACAAAAAG | NGG | 2 | 0.1948 | Tier III |
36 | NC_000003.12 | 3 | 25896970 | - | LOC124909357 | NNNTAGTGTCCCACAAAATG | NGA | 2 | 0.0602 | Tier III |
37 | NC_000002.12 | 2 | 217979428 | - | TNS1-AS1 | NNNTGGTGTCCCACAAAATT | NTG | 2 | 0.0273 | Tier III |
38 | NC_000015.10 | 15 | 87459985 | + | LOC102724465 | NNNTTGTGTCCCACAAAATG | NTG | 2 | 0.0117 | Tier III |
39 | NC_000014.9 | 14 | 21783257 | - | TRA | NNNTGGGGTCCCAGAAAATG | NGG | 2 | 0.0 | Tier III |
40 | NC_000014.9 | 14 | 21783257 | - | TRAV7 | NNNTGGGGTCCCAGAAAATG | NGG | 2 | 0.0 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000085.6 | 19 | 6542670 | + | Slc22a12 | NNNTGGTGACCCACAAAATG | NGG | 1 | 0.9286 | Tier I |
2 | NC_000067.6 | 1 | 156091911 | - | Fam163a | NNNTGGTCTCCCACAAAATG | NGG | 1 | 0.6154 | Tier II |
3 | NC_000067.6 | 1 | 151985355 | + | 1700025G04Rik | NNNTGGTCTCCCACAAAATA | NGG | 2 | 0.5769 | Tier II |
4 | NC_000081.6 | 15 | 43044996 | + | Rspo2 | NNNTCGTGTCCAACAAAATG | NGG | 2 | 0.5612 | Tier II |
5 | NC_000068.7 | 2 | 139841155 | + | Tasp1 | NNNAGGTGGCCCACAAAATG | NGG | 2 | 0.2948 | Tier II |
6 | NC_000068.7 | 2 | 41903406 | - | Lrp1b | NNNTGATGTCCCACAAAAGG | NGG | 2 | 0.25 | Tier II |
7 | NC_000078.6 | 12 | 108375535 | + | Eml1 | NNNTGGTCTCCCACAAAATG | NAG | 2 | 0.1595 | Tier II |
8 | NC_000077.6 | 11 | 77479793 | + | Ankrd13b | NNNTGGAGTCCCACAACATG | NGG | 2 | 0.1544 | Tier II |
9 | NC_000073.6 | 7 | 14114926 | + | Sult2a3 | NNNTGGTGTCCAACAGAATG | NGG | 2 | 0.1374 | Tier II |
10 | NC_000076.6 | 10 | 70453500 | + | Fam13c | NNNTGGTGTCACACAACATG | NGG | 2 | 0.1324 | Tier II |
11 | NC_000067.6 | 1 | 44662377 | + | Gulp1 | NNNTGGGGTCCCACAACATG | NGG | 2 | 0.1038 | Tier II |
12 | NC_000070.6 | 4 | 46798219 | + | Gabbr2 | NNNTGGTGTCCCACAAGTTG | NGG | 2 | 0.0882 | Tier II |
13 | NC_000082.6 | 16 | 24666641 | + | Lpp | NNNTAGTGTCCCACAAAATG | NTG | 2 | 0.0338 | Tier II |
14 | NC_000079.6 | 13 | 57610554 | + | Spock1 | NNNAGGTGTCCCACAAAATG | NTG | 2 | 0.0186 | Tier II |
15 | NC_000078.6 | 12 | 5121102 | + | Klhl29 | NNNTGGTGACCCACAAAATG | NGT | 2 | 0.015 | Tier II |
16 | NC_000067.6 | 1 | 182329488 | - | Fbxo28 | NNNTGGTGACCCACATAATG | NGG | 2 | 0.0 | Tier II |
17 | NC_000085.6 | 19 | 35875446 | - | A830019P07Rik | NNNTGGTGTCTTACAAAATG | NGG | 2 | 0.1657 | Tier III |
18 | NC_000080.6 | 14 | 70796909 | + | Gm34442 | NNNTTGTGTCCCACAAAATG | NAG | 2 | 0.0778 | Tier III |
19 | NC_000081.6 | 15 | 102271136 | + | Gm9918 | NNNTTGTGTCCCACAAAAGG | NGG | 2 | 0.075 | Tier III |
20 | NC_000072.6 | 6 | 42934215 | + | Olrf445-ps1 | NNNTGGTGTGCCACAACATG | NGG | 2 | 0.0686 | Tier III |