Construct: sgRNA BRDN0001147254
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- GAAGAAAAGGCATCTCCAGA
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- COL4A3BP (10087)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000005.10 | 5 | 75400250 | + | CERT1 | NNNGAAAAGGCATCTCCAGA | NGG | 0 | 1.0 | Tier I |
2 | NC_000012.12 | 12 | 15551662 | + | PTPRO | NNNGAAAAAGCATCTGCAGA | NGG | 2 | 0.0989 | Tier I |
3 | NC_000001.11 | 1 | 154750464 | - | KCNN3 | NNNGAGAAGGCATCTCCAGA | NGG | 1 | 0.7143 | Tier II |
4 | NC_000003.12 | 3 | 140686078 | - | TRIM42 | NNNAAAAAGGCATCTCCAGG | NGG | 2 | 0.6882 | Tier II |
5 | NC_000023.11 | X | 80027054 | + | TBX22 | NNNGAGAAGGCAACTCCAGA | NGG | 2 | 0.4945 | Tier II |
6 | NC_000010.11 | 10 | 104063731 | + | COL17A1 | NNNGAAAAGTCATCTCAAGA | NGG | 2 | 0.3792 | Tier II |
7 | NC_000006.12 | 6 | 147282442 | - | STXBP5 | NNNGAAAAGGAATCTCCACA | NGG | 2 | 0.3362 | Tier II |
8 | NC_000006.12 | 6 | 42624788 | + | UBR2 | NNNGAAAAGGCATCTCAAAA | NGG | 2 | 0.3333 | Tier II |
9 | NC_000015.10 | 15 | 54044130 | - | UNC13C | NNNGAAAAGGCAACTCCACA | NGG | 2 | 0.3103 | Tier II |
10 | NC_000011.10 | 11 | 62350204 | - | ASRGL1 | NNNGAAAAGCCATTTCCAGA | NGG | 2 | 0.2933 | Tier II |
11 | NC_000003.12 | 3 | 38055554 | + | DLEC1 | NNNGTAAAGGCATTTCCAGA | NGG | 2 | 0.2667 | Tier II |
12 | NC_000009.12 | 9 | 121088102 | - | CNTRL | NNNGAAAAGGGATCTCCAGA | NGG | 1 | 0.25 | Tier II |
13 | NC_000007.14 | 7 | 112111248 | + | DOCK4 | NNNGAAAAGCCATCTCCAGT | NGG | 2 | 0.24 | Tier II |
14 | NC_000017.11 | 17 | 79239934 | - | RBFOX3 | NNNGAAAAGGCCTCTCCAGG | NGG | 2 | 0.2012 | Tier II |
15 | NC_000020.11 | 20 | 45843146 | + | ACOT8 | NNNGAAAAGGCATCCCCAAA | NGG | 2 | 0.1948 | Tier II |
16 | NC_000020.11 | 20 | 45843146 | + | SNX21 | NNNGAAAAGGCATCCCCAAA | NGG | 2 | 0.1948 | Tier II |
17 | NC_000007.14 | 7 | 70093519 | + | AUTS2 | NNNGAAAAGCCATCTCTAGA | NGG | 2 | 0.1867 | Tier II |
18 | NC_000023.11 | X | 124931215 | - | TENM1 | NNNGAAAATGCATCTTCAGA | NGG | 2 | 0.1641 | Tier II |
19 | NC_000011.10 | 11 | 35165310 | + | CD44 | NNNGAAAAGGCAGCACCAGA | NGG | 2 | 0.151 | Tier II |
20 | NC_000010.11 | 10 | 97984887 | + | CRTAC1 | NNNGAAAAGGCAGCTCAAGA | NGG | 2 | 0.1217 | Tier II |
21 | NC_000017.11 | 17 | 67682546 | + | PITPNC1 | NNNGAAATGGCCTCTCCAGA | NGG | 2 | 0.1128 | Tier II |
22 | NC_000008.11 | 8 | 22743577 | - | PEBP4 | NNNGAAAAGGCAGCTCCGGA | NGG | 2 | 0.1043 | Tier II |
23 | NC_000014.9 | 14 | 21526553 | - | SALL2 | NNNGCAAAGGCATCTGCAGA | NGG | 2 | 0.0769 | Tier II |
24 | NC_000002.12 | 2 | 161177745 | + | TANK | NNNGAAAAGGCATCTACAGA | NTG | 2 | 0.039 | Tier II |
25 | NC_000002.12 | 2 | 31076445 | - | GALNT14 | NNNGAAAAGGGATCTCCAGA | NGA | 2 | 0.0174 | Tier II |
26 | NC_000013.11 | 13 | 40574233 | - | FOXO1 | NNNGAAAAGGCATCTCCAAA | NGT | 2 | 0.0115 | Tier II |
27 | NC_000011.10 | 11 | 71208969 | + | SHANK2 | NNNGAAAAGGCATCTGCAGA | NGT | 2 | 0.0025 | Tier II |
28 | NC_000002.12 | 2 | 74008151 | - | TET3 | NNNGAAAAGTCATGTCCAGA | NGG | 2 | 0.0 | Tier II |
29 | NC_000020.11 | 20 | 33204863 | + | BPIFA4P | NNNAAGAAGGCATCTCCAGA | NGG | 2 | 0.6429 | Tier III |
30 | NC_000021.9 | 21 | 22081717 | + | LINC01687 | NNNGAAAAGGCATCTCAAAA | NGG | 2 | 0.3333 | Tier III |
31 | NC_000020.11 | 20 | 52535140 | + | LOC105372666 | NNNGAAAAGCCAACTCCAGA | NGG | 2 | 0.2769 | Tier III |
32 | NC_000018.10 | 18 | 47936370 | - | LOC124904297 | NNNGAAAAAGCTTCTCCAGA | NGG | 2 | 0.2143 | Tier III |
33 | NC_000009.12 | 9 | 2561052 | + | VLDLR-AS1 | NNNGAAAAGCCTTCTCCAGA | NGG | 2 | 0.1333 | Tier III |
34 | NC_000008.11 | 8 | 29737145 | - | LINC00589 | NNNGAAAAGGCATCACCAGC | NGG | 2 | 0.1316 | Tier III |
35 | NC_000017.11 | 17 | 67682546 | + | LOC101928045 | NNNGAAATGGCCTCTCCAGA | NGG | 2 | 0.1128 | Tier III |
36 | NC_000008.11 | 8 | 22743577 | - | LOC124901908 | NNNGAAAAGGCAGCTCCGGA | NGG | 2 | 0.1043 | Tier III |
37 | NC_000012.12 | 12 | 15551662 | + | LOC105369672 | NNNGAAAAAGCATCTGCAGA | NGG | 2 | 0.0989 | Tier III |
38 | NC_000009.12 | 9 | 117831343 | + | LOC105376244 | NNNGAAAAGGCCTCTCCCGA | NGG | 2 | 0.0501 | Tier III |
39 | NC_000004.12 | 4 | 123536633 | - | LOC105377405 | NNNTAAAAGGCATCTCCAGA | NGA | 2 | 0.0253 | Tier III |
40 | NC_000004.12 | 4 | 66974817 | + | LOC105377262 | NNNGAACAGGCATCTCCAGA | NTG | 2 | 0.017 | Tier III |
41 | NC_000013.11 | 13 | 69296336 | - | LINC00383 | NNNTAAAAGGCATCTCCAGA | NTG | 2 | 0.0142 | Tier III |
42 | NC_000001.11 | 1 | 146374537 | - | SEC22B4P | NNNGAAAAGGCATCTCAAGA | NGC | 2 | 0.0104 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000068.7 | 2 | 119381902 | - | Ino80 | NNNGAAAAGGTATCTCCAGA | NGG | 1 | 0.3077 | Tier I |
2 | NC_000079.6 | 13 | 96616505 | - | Cert1 | NNNGAAAAGGTGTCTCCAGA | NGG | 2 | 0.2222 | Tier I |
3 | NC_000076.6 | 10 | 78459239 | + | Pdxk | NNNGGAGAGGCATCTCCAGA | NGG | 2 | 0.5082 | Tier II |
4 | NC_000078.6 | 12 | 52742519 | + | Akap6 | NNNGAAAAAGCATTTCCAGA | NGG | 2 | 0.4714 | Tier II |
5 | NC_000068.7 | 2 | 17558540 | + | Nebl | NNNGCTAAGGCATCTCCAGA | NGG | 2 | 0.3571 | Tier II |
6 | NC_000084.6 | 18 | 66263732 | + | Ccbe1 | NNNGAAAAGGCATCTCCTGT | NGG | 2 | 0.3 | Tier II |
7 | NC_000067.6 | 1 | 6776103 | + | St18 | NNNGAAACAGCATCTCCAGA | NGG | 2 | 0.2755 | Tier II |
8 | NC_000074.6 | 8 | 117378604 | - | Cmip | NNNGTAAAGGCATTTCCAGA | NGG | 2 | 0.2667 | Tier II |
9 | NC_000076.6 | 10 | 26816400 | + | Arhgap18 | NNNGAAACCGCATCTCCAGA | NGG | 2 | 0.2308 | Tier II |
10 | NC_000078.6 | 12 | 116663872 | + | Ptprn2 | NNNGAAAAGGCATCTCCAAA | NAG | 2 | 0.1852 | Tier II |
11 | NC_000070.6 | 4 | 42227183 | - | Ccl21b | NNNGAAAAAGCAGCTCCAGA | NGG | 2 | 0.1677 | Tier II |
12 | NC_000070.6 | 4 | 147486376 | - | Zfp982 | NNNGAAAAAGCAGCTCCAGA | NGG | 2 | 0.1677 | Tier II |
13 | NC_000076.6 | 10 | 36614558 | - | Hs3st5 | NNNGAAAAAGCAGCTCCAGA | NGG | 2 | 0.1677 | Tier II |
14 | NC_000079.6 | 13 | 62552922 | - | Zfp934 | NNNGAAAAAGCAGCTCCAGA | NGG | 2 | 0.1677 | Tier II |
15 | NC_000080.6 | 14 | 87086092 | + | Diaph3 | NNNGAAAAAGCAGCTCCAGA | NGG | 2 | 0.1677 | Tier II |
16 | NC_000081.6 | 15 | 4560021 | + | Plcxd3 | NNNGAAAAAGCAGCTCCAGA | NGG | 2 | 0.1677 | Tier II |
17 | NC_000081.6 | 15 | 22700523 | - | Cdh18 | NNNGAAAAAGCAGCTCCAGA | NGG | 2 | 0.1677 | Tier II |
18 | NC_000083.6 | 17 | 6576751 | - | Gm29721 | NNNGAAAAAGCAGCTCCAGA | NGG | 2 | 0.1677 | Tier II |
19 | NC_000083.6 | 17 | 70649388 | + | Dlgap1 | NNNGAAAAGACATCTGCAGA | NGG | 2 | 0.1436 | Tier II |
20 | NC_000078.6 | 12 | 99422883 | - | Foxn3 | NNNGAACAGGCATCCCCAGA | NGG | 2 | 0.1193 | Tier II |
21 | NC_000071.6 | 5 | 19922866 | - | Magi2 | NNNGAAAAGGCATCTCCTGC | NGG | 2 | 0.1136 | Tier II |
22 | NC_000071.6 | 5 | 113902886 | + | Coro1c | NNNGAATAGGCATCTCCAGA | NAG | 2 | 0.1134 | Tier II |
23 | NC_000070.6 | 4 | 118232891 | + | Ptprf | NNNGACAAGGCATCTCCAGC | NGG | 2 | 0.1033 | Tier II |
24 | NC_000083.6 | 17 | 12622207 | + | Slc22a2 | NNNGAAAAGGCATCTCCACC | NGG | 2 | 0.1019 | Tier II |
25 | NC_000085.6 | 19 | 28840087 | - | Slc1a1 | NNNGAAAAGGCAGATCCAGA | NGG | 2 | 0.0913 | Tier II |
26 | NC_000081.6 | 15 | 37338867 | - | Grhl2 | NNNGAAAAGGCTTCTCCAGA | NAG | 2 | 0.0864 | Tier II |
27 | NC_000084.6 | 18 | 30310820 | + | Pik3c3 | NNNGAAAAGGTAGCTCCAGA | NGG | 2 | 0.0803 | Tier II |
28 | NC_000068.7 | 2 | 6880565 | - | Celf2 | NNNGAAATGGCATCTGCAGA | NGG | 2 | 0.0659 | Tier II |
29 | NC_000073.6 | 7 | 25071597 | + | Grik5 | NNNGTAAAGGCATCTCCAGA | NGA | 2 | 0.0253 | Tier II |
30 | NC_000073.6 | 7 | 83966535 | + | Cemip | NNNGAAAAGGCTTCGCCAGA | NGG | 2 | 0.0167 | Tier II |
31 | NC_000081.6 | 15 | 39908078 | + | Lrp12 | NNNGAAAAGGGATCGCCAGA | NGG | 2 | 0.0125 | Tier II |
32 | NC_000068.7 | 2 | 174611615 | - | Zfp831 | NNNGAAAGGGCATCTCCAGA | NGT | 2 | 0.0118 | Tier II |
33 | NC_000081.6 | 15 | 82093834 | - | Mei1 | NNNGAAAAGGCATCTTCAGA | NGT | 2 | 0.005 | Tier II |
34 | NC_000085.6 | 19 | 7525729 | + | Atl3 | NNNGAAAAGGCAAGTCCAGA | NGG | 2 | 0.0 | Tier II |
35 | NC_000067.6 | 1 | 45971969 | + | Gm9496 | NNNGGAAAGGCATCTCCAGA | NGG | 1 | 0.72 | Tier III |
36 | NC_000075.6 | 9 | 72408763 | + | BC065403 | NNNGAAATGGCATCTCCAGA | NGG | 1 | 0.4286 | Tier III |
37 | NC_000075.6 | 9 | 72408763 | + | Gm27230 | NNNGAAATGGCATCTCCAGA | NGG | 1 | 0.4286 | Tier III |
38 | NC_000071.6 | 5 | 134769622 | - | Gm30003 | NNNCAAAAGGCAACTCCAGA | NGG | 2 | 0.3665 | Tier III |
39 | NC_000067.6 | 1 | 103050211 | - | Gm18728 | NNNGAAAAAGCAGCTCCAGA | NGG | 2 | 0.1677 | Tier III |
40 | NC_000068.7 | 2 | 126529195 | - | Gm26697 | NNNGAAAAAGCAGCTCCAGA | NGG | 2 | 0.1677 | Tier III |
41 | NC_000079.6 | 13 | 62552922 | - | Gm38639 | NNNGAAAAAGCAGCTCCAGA | NGG | 2 | 0.1677 | Tier III |
42 | NC_000084.6 | 18 | 17070016 | - | 1700001G01Rik | NNNGAAAAAGCAGCTCCAGA | NGG | 2 | 0.1677 | Tier III |
43 | NC_000085.6 | 19 | 28840087 | - | Gm52404 | NNNGAAAAGGCAGATCCAGA | NGG | 2 | 0.0913 | Tier III |
44 | NC_000076.6 | 10 | 50481157 | + | Gm6991 | NNNGAAAAGGCATCTCCAAA | NTG | 2 | 0.0278 | Tier III |