Construct: sgRNA BRDN0001147535
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- AGATACTTCATCCCACCAGG
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- CAMK4 (814)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 77227
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000005.10 |
5 |
111478473 |
- |
CAMK4 |
NNNTACTTCATCCCACCAGG |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000016.10 |
16 |
55698835 |
+ |
SLC6A2 |
NNNTAATTCATCCTACCAGG |
NGG |
2 |
0.681 |
Tier II |
3 |
NC_000012.12 |
12 |
121668892 |
- |
MORN3 |
NNNTACTCCATCCCACAAGG |
NGG |
2 |
0.4667 |
Tier II |
4 |
NC_000020.11 |
20 |
58693534 |
+ |
NPEPL1 |
NNNGGCTTCATCCCACCAGG |
NGG |
2 |
0.45 |
Tier II |
5 |
NC_000011.10 |
11 |
132803517 |
- |
OPCML |
NNNTACCTCATTCCACCAGG |
NGG |
2 |
0.3702 |
Tier II |
6 |
NC_000018.10 |
18 |
33149091 |
- |
CCDC178 |
NNNTTCTTCATCCCAACAGG |
NGG |
2 |
0.3636 |
Tier II |
7 |
NC_000005.10 |
5 |
119364070 |
- |
TNFAIP8 |
NNNGACTTCATCCCACCTGG |
NGG |
2 |
0.3125 |
Tier II |
8 |
NC_000004.12 |
4 |
158586705 |
- |
RXFP1 |
NNNTACTTCCTCCCACCAGA |
NGG |
2 |
0.3125 |
Tier II |
9 |
NC_000008.11 |
8 |
104143468 |
- |
RIMS2 |
NNNTACTTCATCACACCAGT |
NGG |
2 |
0.2692 |
Tier II |
10 |
NC_000009.12 |
9 |
127545807 |
- |
NIBAN2 |
NNNGACTTCCTCCCACCAGG |
NGG |
2 |
0.2083 |
Tier II |
11 |
NC_000023.11 |
X |
47880106 |
+ |
ZNF81 |
NNNTAATTCATCCCTCCAGG |
NGG |
2 |
0.1857 |
Tier II |
12 |
NC_000004.12 |
4 |
90655293 |
- |
CCSER1 |
NNNTACTTCATCAAACCAGG |
NGG |
2 |
0.1346 |
Tier II |
13 |
NC_000017.11 |
17 |
79231309 |
- |
RBFOX3 |
NNNTCCTTCATCCCTCCAGG |
NGG |
2 |
0.1 |
Tier II |
14 |
NC_000008.11 |
8 |
41931724 |
- |
KAT6A |
NNNTACTTCATTCCAGCAGG |
NGG |
2 |
0.0828 |
Tier II |
15 |
NC_000008.11 |
8 |
31911030 |
+ |
NRG1 |
NNNTACTTCATTGCACCAGG |
NGG |
2 |
0.0734 |
Tier II |
16 |
NC_000017.11 |
17 |
70128433 |
- |
KCNJ16 |
NNNTACTTCATCCCACGAGG |
NGG |
1 |
0.0588 |
Tier II |
17 |
NC_000003.12 |
3 |
52470444 |
+ |
NISCH |
NNNTCCTTCATCCCACCAGG |
NTG |
2 |
0.0195 |
Tier II |
18 |
NC_000005.10 |
5 |
1945151 |
- |
LOC124901165 |
NNNTACTTCATCCCACCGGG |
NTG |
2 |
0.0156 |
Tier II |
19 |
NC_000001.11 |
1 |
53730937 |
+ |
GLIS1 |
NNNTACTTCATCCCACCAAG |
NGT |
2 |
0.0115 |
Tier II |
20 |
NC_000012.12 |
12 |
121668892 |
- |
LOC105370034 |
NNNTACTCCATCCCACAAGG |
NGG |
2 |
0.4667 |
Tier III |
21 |
NC_000020.11 |
20 |
58693534 |
+ |
STX16-NPEPL1 |
NNNGGCTTCATCCCACCAGG |
NGG |
2 |
0.45 |
Tier III |
22 |
NC_000017.11 |
17 |
70128433 |
- |
LOC124904052 |
NNNTACTTCATCCCACGAGG |
NGG |
1 |
0.0588 |
Tier III |
23 |
NC_000021.9 |
21 |
38336413 |
- |
LINC01423 |
NNNTACTGCATCCCACCAGG |
NGA |
2 |
0.0509 |
Tier III |
24 |
NC_000005.10 |
5 |
1945151 |
- |
LOC105374618 |
NNNTACTTCATCCCACCGGG |
NTG |
2 |
0.0156 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000084.6 |
18 |
33179590 |
- |
Camk4 |
NNNCACTTCATCCCACCAGG |
NGG |
1 |
0.6471 |
Tier I |
2 |
NC_000077.6 |
11 |
69050300 |
+ |
Aurkb |
NNNTCCCTCATCCCACCAGG |
NGG |
2 |
0.3438 |
Tier I |
3 |
NC_000072.6 |
6 |
40465906 |
- |
Wee2 |
NNNTCCTTCCTCCCACCAGG |
NGG |
2 |
0.1667 |
Tier I |
4 |
NC_000073.6 |
7 |
84035999 |
- |
Cemip |
NNNTAATTCATCCTACCAGG |
NGG |
2 |
0.681 |
Tier II |
5 |
NC_000081.6 |
15 |
58430411 |
- |
Fam91a1 |
NNNTATTTCATCCCACCTGG |
NGG |
2 |
0.4643 |
Tier II |
6 |
NC_000078.6 |
12 |
83692986 |
- |
Psen1 |
NNNCACTTCATCCCACCAAG |
NGG |
2 |
0.4622 |
Tier II |
7 |
NC_000072.6 |
6 |
65049298 |
+ |
Smarcad1 |
NNNTACTTCAGCTCACCAGG |
NGG |
2 |
0.28 |
Tier II |
8 |
NC_000078.6 |
12 |
91292848 |
- |
Cep128 |
NNNGACTTCAGCCCACCAGG |
NGG |
2 |
0.25 |
Tier II |
9 |
NC_000075.6 |
9 |
39142221 |
- |
Olfr27 |
NNNTACTTCATCCAACCAGG |
NAG |
2 |
0.0907 |
Tier II |
10 |
NC_000072.6 |
6 |
35316024 |
- |
Fam180a |
NNNTCCTTCATCCCACCAGG |
NGA |
2 |
0.0347 |
Tier II |
11 |
NC_000070.6 |
4 |
58524784 |
- |
Lpar1 |
NNNTACTTCCTCCCACCAGG |
NTG |
2 |
0.013 |
Tier II |
12 |
NC_000067.6 |
1 |
66379448 |
- |
Map2 |
NNNTACTTCATTCCACCAGG |
NGC |
2 |
0.012 |
Tier II |
13 |
NC_000073.6 |
7 |
71684874 |
+ |
Gm44689 |
NNNTAATTCATCCCACCATG |
NGG |
2 |
0.619 |
Tier III |
14 |
NC_000084.6 |
18 |
40795913 |
+ |
Gm41710 |
NNNTACTTGATCCCACCATG |
NGG |
2 |
0.4127 |
Tier III |
15 |
NC_000085.6 |
19 |
3733316 |
+ |
Gm36787 |
NNNTACTTCATTCTACCAGG |
NGG |
2 |
0.3949 |
Tier III |
16 |
NC_000078.6 |
12 |
93440809 |
- |
4930559C10Rik |
NNNTTCTTCATCCCCCCAGG |
NGG |
2 |
0.0992 |
Tier III |
17 |
NC_000072.6 |
6 |
35316024 |
- |
Gm38788 |
NNNTCCTTCATCCCACCAGG |
NGA |
2 |
0.0347 |
Tier III |
Other clones with same target sequence:
(none)