Construct: sgRNA BRDN0001148372
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- GAGATGATAACTTAATTTGT
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- ONE_INTERGENIC_SITE control
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000023.11 | X | 130230699 | - | ZNF280C | NNNATGATAACTAAATTTTT | NGG | 2 | 0.4615 | Tier I |
2 | NC_000019.10 | 19 | 36515779 | - | ZNF260 | NNNATGATAACCTAATTTAT | NGG | 2 | 0.6767 | Tier II |
3 | NC_000007.14 | 7 | 94590335 | - | SGCE | NNNATGGTAACCTAATTTGT | NGG | 2 | 0.6687 | Tier II |
4 | NC_000007.14 | 7 | 94590335 | - | CASD1 | NNNATGGTAACCTAATTTGT | NGG | 2 | 0.6687 | Tier II |
5 | NC_000008.11 | 8 | 28501424 | - | FZD3 | NNNATGATAACTTAGATTGT | NGG | 2 | 0.5909 | Tier II |
6 | NC_000007.14 | 7 | 13927760 | - | ETV1 | NNNATGAAAACTTAATCTGT | NGG | 2 | 0.5647 | Tier II |
7 | NC_000011.10 | 11 | 22819868 | + | SVIP | NNNATGAATACTTAATTTGT | NGG | 2 | 0.48 | Tier II |
8 | NC_000008.11 | 8 | 60699394 | - | CHD7 | NNNATGATCACATAATTTGT | NGG | 2 | 0.4571 | Tier II |
9 | NC_000007.14 | 7 | 44684572 | + | OGDH | NNNATATTAACTTAATTTGT | NGG | 2 | 0.4375 | Tier II |
10 | NC_000001.11 | 1 | 216720191 | + | ESRRG | NNNATGATTACTTAATTTTT | NGG | 2 | 0.4 | Tier II |
11 | NC_000004.12 | 4 | 39619048 | - | SMIM14 | NNNATCATCACTTAATTTGT | NGG | 2 | 0.3896 | Tier II |
12 | NC_000009.12 | 9 | 69338932 | + | ENTREP1 | NNNAAGATAAATTAATTTGT | NGG | 2 | 0.375 | Tier II |
13 | NC_000002.12 | 2 | 175094672 | - | ATF2 | NNNATGATAACTTTATTTTT | NGG | 2 | 0.3556 | Tier II |
14 | NC_000006.12 | 6 | 135356821 | - | AHI1 | NNNTTGATAACTTAATATGT | NGG | 2 | 0.3394 | Tier II |
15 | NC_000001.11 | 1 | 178407954 | - | RASAL2 | NNNATGATAACTAAAGTTGT | NGG | 2 | 0.2396 | Tier II |
16 | NC_000023.11 | X | 86421592 | - | DACH2 | NNNATAATAACTTCATTTGT | NGG | 2 | 0.2143 | Tier II |
17 | NC_000005.10 | 5 | 26901417 | - | CDH9 | NNNATGATGATTTAATTTGT | NGG | 2 | 0.2051 | Tier II |
18 | NC_000020.11 | 20 | 46264198 | - | CDH22 | NNNATGATAACTTACTTTAT | NGG | 2 | 0.1948 | Tier II |
19 | NC_000010.11 | 10 | 33327289 | + | NRP1 | NNNATGATAACTTATTTTGA | NGG | 2 | 0.1125 | Tier II |
20 | NC_000002.12 | 2 | 148135014 | + | MBD5 | NNNATGATAACTTACTTGGT | NGG | 2 | 0.0909 | Tier II |
21 | NC_000023.11 | X | 102765684 | - | ARMCX5-GPRASP2 | NNNATGAAAACTTAATTTGT | NGA | 2 | 0.0556 | Tier II |
22 | NC_000003.12 | 3 | 7624601 | - | GRM7 | NNNATGATAACTAAATTTGT | NGA | 2 | 0.0481 | Tier II |
23 | NC_000004.12 | 4 | 31115171 | - | PCDH7 | NNNATGACAACTTAATTTGT | NTG | 2 | 0.039 | Tier II |
24 | NC_000008.11 | 8 | 80052924 | + | TPD52 | NNNATGAAAACTTAATTTGT | NTG | 2 | 0.0312 | Tier II |
25 | NC_000008.11 | 8 | 80052924 | + | TPD52-MRPS28 | NNNATGAAAACTTAATTTGT | NTG | 2 | 0.0312 | Tier II |
26 | NC_000003.12 | 3 | 56558580 | + | CCDC66 | NNNATGATAACTTAATTTAT | NGT | 2 | 0.0115 | Tier II |
27 | NC_000003.12 | 3 | 94010637 | - | ARL13B | NNNATGATAACTTAATTAGT | NGT | 2 | 0.0108 | Tier II |
28 | NC_000013.11 | 13 | 110426465 | - | COL4A2 | NNNATGTTAACTTAATTTGT | NGT | 2 | 0.0071 | Tier II |
29 | NC_000004.12 | 4 | 122354540 | + | BLTP1 | NNNATGATAACTTATTTTGT | NGT | 2 | 0.0032 | Tier II |
30 | NC_000002.12 | 2 | 206243888 | + | CMKLR2-AS | NNNATAATAACTTAATTAGT | NGG | 2 | 0.6667 | Tier III |
31 | NC_000023.11 | X | 27234561 | + | LOC105373150 | NNNTTGATAAATTAATTTGT | NGG | 2 | 0.4773 | Tier III |
32 | NC_000014.9 | 14 | 22197036 | - | TRA | NNNTTGAGAACTTAATTTGT | NGG | 2 | 0.4667 | Tier III |
33 | NC_000010.11 | 10 | 69990334 | - | LINC02636 | NNNTTTATAACTTAATTTGT | NGG | 2 | 0.4242 | Tier III |
34 | NC_000004.12 | 4 | 98674035 | - | LOC112267901 | NNNATGATAACTTACATTGT | NGG | 2 | 0.2479 | Tier III |
35 | NC_000023.11 | X | 129182911 | + | LOC124905213 | NNNATGATAACTTAATTTTT | NAG | 2 | 0.1728 | Tier III |
36 | NC_000001.11 | 1 | 106059491 | - | LOC105378885 | NNNATGATAAGTTAATTTTT | NGG | 2 | 0.1667 | Tier III |
37 | NC_000005.10 | 5 | 117571647 | + | LINC00992 | NNNATGATAACTTACTTTGT | NAG | 2 | 0.0707 | Tier III |
38 | NC_000003.12 | 3 | 164490907 | + | LOC105374191 | NNNATGATAACTTAAATTGT | NGA | 2 | 0.0631 | Tier III |
39 | NC_000007.14 | 7 | 136211826 | + | LOC105375523 | NNNATGATAAATTAATTTGT | NGA | 2 | 0.0521 | Tier III |
40 | NC_000009.12 | 9 | 119442075 | + | LOC105376250 | NNNATGATAACTAAATTTGT | NGA | 2 | 0.0481 | Tier III |
41 | NC_000010.11 | 10 | 123957820 | + | LOC107984128 | NNNATGAAAACTTAATTTGT | NTG | 2 | 0.0312 | Tier III |
42 | NC_000007.14 | 7 | 80312126 | - | LOC107986744 | NNNATTATAACTTAATTTGT | NTG | 2 | 0.026 | Tier III |
43 | NC_000005.10 | 5 | 90225824 | - | LINC01339 | NNNATGATAACTAAATTTGT | NGT | 2 | 0.0112 | Tier III |
44 | NC_000003.12 | 3 | 191430586 | + | PYDC2-AS1 | NNNATGATAACTTAATTTTT | NGT | 2 | 0.0108 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000072.6 | 6 | 146235487 | - | Itpr2 | NNNATTAGAACTTAATTTGT | NGG | 2 | 0.4889 | Tier II |
2 | NC_000077.6 | 11 | 6356624 | - | Ogdh | NNNATGATAACTTAGTTTAT | NGG | 2 | 0.4643 | Tier II |
3 | NC_000073.6 | 7 | 144386227 | - | Shank2 | NNNATGATCACTTAATTTTT | NGG | 2 | 0.381 | Tier II |
4 | NC_000080.6 | 14 | 56366286 | + | Atp12a | NNNATGATAACTTTACTTGT | NGG | 2 | 0.3556 | Tier II |
5 | NC_000081.6 | 15 | 12729283 | - | Pdzd2 | NNNATGACAACTTACTTTGT | NGG | 2 | 0.2727 | Tier II |
6 | NC_000075.6 | 9 | 95090095 | - | Slc9a9 | NNNATGGTAATTTAATTTGT | NGG | 2 | 0.2172 | Tier II |
7 | NC_000079.6 | 13 | 109783314 | - | Pde4d | NNNATGATAACTTACTCTGT | NGG | 2 | 0.1925 | Tier II |
8 | NC_000067.6 | 1 | 46597408 | + | Dnah7c | NNNATGATAACCTATTTTGT | NGG | 2 | 0.1895 | Tier II |
9 | NC_000085.6 | 19 | 17036670 | + | Prune2 | NNNATGATAACTTGATTTGT | NAG | 2 | 0.121 | Tier II |
10 | NC_000077.6 | 11 | 22130027 | - | Ehbp1 | NNNATGATAAATTAATGTGT | NGG | 2 | 0.0882 | Tier II |
11 | NC_000080.6 | 14 | 23749780 | - | Kcnma1 | NNNATGATAACTTATTTTGT | NAG | 2 | 0.0519 | Tier II |
12 | NC_000067.6 | 1 | 119643639 | - | Epb41l5 | NNNATAATAACTTAATTTGT | NTG | 2 | 0.039 | Tier II |
13 | NC_000076.6 | 10 | 52861472 | + | Slc35f1 | NNNATGATAACATAATTTGT | NTG | 2 | 0.0312 | Tier II |
14 | NC_000082.6 | 16 | 33648539 | - | Slc12a8 | NNNATGATAAATTAATTTGT | NTG | 2 | 0.0292 | Tier II |
15 | NC_000074.6 | 8 | 15939929 | + | Csmd1 | NNNATGATAACTTGATTTGT | NGT | 2 | 0.0075 | Tier II |
16 | NC_000072.6 | 6 | 146235487 | - | Gm35596 | NNNATTAGAACTTAATTTGT | NGG | 2 | 0.4889 | Tier III |
17 | NC_000073.6 | 7 | 144386227 | - | Gm14372 | NNNATGATCACTTAATTTTT | NGG | 2 | 0.381 | Tier III |
18 | NC_000067.6 | 1 | 137953422 | - | Gm4258 | NNNATGATAAATTAATTTCT | NGG | 2 | 0.3362 | Tier III |
19 | NC_000075.6 | 9 | 77375934 | - | 5730403I07Rik | NNNATGTTAACTTCATTTGT | NGG | 2 | 0.0938 | Tier III |