Construct: sgRNA BRDN0001148530
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- ACTTTGCTAAGAGCAAGTGG
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- CAMK1G (57172)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000001.11 | 1 | 209611547 | + | CAMK1G | NNNTTGCTAAGAGCAAGTGG | NGG | 0 | 1.0 | Tier I |
2 | NC_000003.12 | 3 | 9759494 | - | CAMK1 | NNNTTGCCAAGAGCAAGTGG | NAG | 2 | 0.2593 | Tier I |
3 | NC_000012.12 | 12 | 121953923 | - | CFAP251 | NNNTTGCTAAGAGCAAGTGA | NGG | 1 | 0.9375 | Tier II |
4 | NC_000015.10 | 15 | 75626211 | - | SNUPN | NNNTTGTTAAGGGCAAGTGG | NGG | 2 | 0.5868 | Tier II |
5 | NC_000016.10 | 16 | 85436225 | - | GSE1 | NNNTTGCTAAGAGCAAGGGA | NGG | 2 | 0.3125 | Tier II |
6 | NC_000003.12 | 3 | 9759494 | - | OGG1 | NNNTTGCCAAGAGCAAGTGG | NAG | 2 | 0.2593 | Tier II |
7 | NC_000001.11 | 1 | 46303083 | - | LRRC41 | NNNTGGCTAAGAGCAAGGGG | NGG | 2 | 0.2133 | Tier II |
8 | NC_000001.11 | 1 | 205669090 | + | SLC45A3 | NNNTGGCTAAGAGCAAGGGG | NGG | 2 | 0.2133 | Tier II |
9 | NC_000009.12 | 9 | 68817601 | + | PIP5K1B | NNNTTGATAAGAGCAAGTGG | NAG | 2 | 0.1944 | Tier II |
10 | NC_000007.14 | 7 | 150035793 | + | ACTR3C | NNNTTCCTAAGAGCCAGTGG | NGG | 2 | 0.186 | Tier II |
11 | NC_000011.10 | 11 | 120852394 | + | GRIK4 | NNNTTGCTAAGCGCAAGTGT | NGG | 2 | 0.1842 | Tier II |
12 | NC_000001.11 | 1 | 12026347 | + | MIIP | NNNTTGCTGAGAGCAACTGG | NGG | 2 | 0.1569 | Tier II |
13 | NC_000001.11 | 1 | 46690903 | + | EFCAB14 | NNNTTGCAAAGAGCAGGTGG | NGG | 2 | 0.1538 | Tier II |
14 | NC_000008.11 | 8 | 74465623 | - | GDAP1 | NNNATGCTAAGAGCAATTGG | NGG | 2 | 0.119 | Tier II |
15 | NC_000015.10 | 15 | 89117685 | + | ABHD2 | NNNTTGCTAAGACCCAGTGG | NGG | 2 | 0.1148 | Tier II |
16 | NC_000022.11 | 22 | 48555126 | - | TAFA5 | NNNTTGCTAAGAGACAGTGG | NGG | 2 | 0.0955 | Tier II |
17 | NC_000003.12 | 3 | 129088463 | + | RAB43 | NNNTTGCTAAGAGCCAGGGG | NGG | 2 | 0.0909 | Tier II |
18 | NC_000003.12 | 3 | 129088463 | + | ISY1-RAB43 | NNNTTGCTAAGAGCCAGGGG | NGG | 2 | 0.0909 | Tier II |
19 | NC_000022.11 | 22 | 50558684 | + | SYCE3 | NNNTTGCTAAGAGTAAGTGG | NGA | 2 | 0.0509 | Tier II |
20 | NC_000003.12 | 3 | 151476825 | + | IGSF10 | NNNTTTCTAAGAGCAAGTGG | NGA | 2 | 0.0463 | Tier II |
21 | NC_000023.11 | X | 12099553 | - | FRMPD4 | NNNTTGCTAAGATCAAGTGG | NGA | 2 | 0.0208 | Tier II |
22 | NC_000002.12 | 2 | 27448730 | - | IFT172 | NNNTTGCTAAGAGCATGGGG | NGG | 2 | 0.0 | Tier II |
23 | NC_000008.11 | 8 | 72243131 | + | TRPA2P | NNNTTGGTAAGAGCAAGTAG | NGG | 2 | 0.3361 | Tier III |
24 | NC_000008.11 | 8 | 128163832 | - | LOC124902020 | NNNTTGCCAAGAGCAAGGGG | NGG | 2 | 0.3333 | Tier III |
25 | NC_000001.11 | 1 | 20374140 | - | LINC01141 | NNNTTGCTAAGAGCAGATGG | NGG | 2 | 0.1795 | Tier III |
26 | NC_000015.10 | 15 | 47897314 | + | LOC124900354 | NNNTTGCTAAGAGCAGATGG | NGG | 2 | 0.1795 | Tier III |
27 | NC_000001.11 | 1 | 46690903 | + | EFCAB14-AS1 | NNNTTGCAAAGAGCAGGTGG | NGG | 2 | 0.1538 | Tier III |
28 | NC_000016.10 | 16 | 46623765 | + | RAB43P1 | NNNTTGCTAAGAGCCAGGGG | NGG | 2 | 0.0909 | Tier III |
29 | NC_000011.10 | 11 | 109742435 | + | LINC02715 | NNNTAGCTAAGAGCATGTGG | NGG | 2 | 0.0 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000067.6 | 1 | 193348725 | - | Camk1g | NNNTTGCCAAGAGCAAGTGG | NGG | 1 | 1.0 | Tier I |
2 | NC_000072.6 | 6 | 113336180 | - | Camk1 | NNNTTGCCAAGAGCAAGTGG | NAG | 2 | 0.2593 | Tier I |
3 | NC_000067.6 | 1 | 53683992 | - | Dnah7a | NNNTTACGAAGAGCAAGTGG | NGG | 2 | 0.7333 | Tier II |
4 | NC_000076.6 | 10 | 123490338 | + | Tafa2 | NNNTTGCTAAAAGTAAGTGG | NGG | 2 | 0.7333 | Tier II |
5 | NC_000076.6 | 10 | 53042984 | + | Slc35f1 | NNNGTGCTAAGAACAAGTGG | NGG | 2 | 0.5769 | Tier II |
6 | NC_000085.6 | 19 | 24417082 | - | Pip5k1b | NNNTTGCTTAGAGCAAATGG | NGG | 2 | 0.56 | Tier II |
7 | NC_000067.6 | 1 | 91207614 | - | Ramp1 | NNNTTGCAAAGAGCAAGAGG | NGG | 2 | 0.5333 | Tier II |
8 | NC_000073.6 | 7 | 124175885 | + | Hs3st4 | NNNTTTCAAAGAGCAAGTGG | NGG | 2 | 0.5333 | Tier II |
9 | NC_000084.6 | 18 | 69519708 | + | Tcf4 | NNNTTGTTAAGAGAAAGTGG | NGG | 2 | 0.2844 | Tier II |
10 | NC_000068.7 | 2 | 150991165 | - | Ninl | NNNTTGCTCACAGCAAGTGG | NGG | 2 | 0.2449 | Tier II |
11 | NC_000080.6 | 14 | 27821518 | + | Erc2 | NNNTTTCTAAGAGCAAGGGG | NGG | 2 | 0.2222 | Tier II |
12 | NC_000067.6 | 1 | 39374064 | + | Tbc1d8 | NNNTTGCTAAGAGCCAGTAG | NGG | 2 | 0.1948 | Tier II |
13 | NC_000079.6 | 13 | 15700622 | + | Gli3 | NNNTTGCTGAGAGCAGGTGG | NGG | 2 | 0.1282 | Tier II |
14 | NC_000081.6 | 15 | 91357994 | + | Slc2a13 | NNNTTGCTCAGAGCAAGTGG | NGA | 2 | 0.0397 | Tier II |
15 | NC_000073.6 | 7 | 79450747 | - | Polg | NNNTTGCTAAGAGCAAGTGA | NTG | 2 | 0.0365 | Tier II |
16 | NC_000081.6 | 15 | 64055476 | + | Cyrib | NNNTTCCTAAGAGCAAGTGG | NTG | 2 | 0.0266 | Tier II |
17 | NC_000075.6 | 9 | 99215333 | + | Cep70 | NNNTTGCTAAGAGCAAGTGG | NCA | 2 | 0.0 | Tier II |
18 | NC_000067.6 | 1 | 93238318 | + | Sned1 | NNNTTGCTAAGAGCATGTGG | NGT | 2 | 0.0 | Tier II |
19 | NC_000081.6 | 15 | 12626024 | + | Pdzd2 | NNNTTGCTAAGGGGAAGTGG | NGG | 2 | 0.0 | Tier II |
20 | NC_000085.6 | 19 | 24417082 | - | Pip5k1bos | NNNTTGCTTAGAGCAAATGG | NGG | 2 | 0.56 | Tier III |
21 | NC_000075.6 | 9 | 68486434 | - | 4930502A04Rik | NNNTTGCTTGGAGCAAGTGG | NGG | 2 | 0.3333 | Tier III |
22 | NC_000085.6 | 19 | 26488362 | + | Gm34808 | NNNATGCTAAGAGAAAGTGG | NGG | 2 | 0.1667 | Tier III |