Construct: sgRNA BRDN0001148565
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- TCAAGACAGACCAACCTCAG
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- TAOK2 (9344)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 77249
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000016.10 |
16 |
29981924 |
+ |
TAOK2 |
NNNAGACAGACCAACCTCAG |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000005.10 |
5 |
122008244 |
- |
SRFBP1 |
NNNAGACAGGCCAACATCAG |
NGG |
2 |
0.5556 |
Tier II |
3 |
NC_000012.12 |
12 |
29172480 |
- |
FAR2 |
NNNAGACAAACAAACCTCAG |
NGG |
2 |
0.4592 |
Tier II |
4 |
NC_000023.11 |
X |
18922523 |
+ |
PHKA2 |
NNNAGAGGGACCAACCTCAG |
NGG |
2 |
0.3451 |
Tier II |
5 |
NC_000009.12 |
9 |
37188457 |
- |
ZCCHC7 |
NNNGGAGAGACCAACCTCAG |
NGG |
2 |
0.2941 |
Tier II |
6 |
NC_000012.12 |
12 |
6203510 |
+ |
CD9 |
NNNAGAGAGGCCAACCTCAG |
NGG |
2 |
0.2614 |
Tier II |
7 |
NC_000010.11 |
10 |
51237497 |
+ |
PRKG1 |
NNNAGATAGACCAACTTCAG |
NGG |
2 |
0.25 |
Tier II |
8 |
NC_000005.10 |
5 |
135585533 |
- |
SLC25A48 |
NNNACACAGAGCAACCTCAG |
NGG |
2 |
0.1964 |
Tier II |
9 |
NC_000011.10 |
11 |
113177812 |
- |
NCAM1 |
NNNAGACAGTCCCACCTCAG |
NGG |
2 |
0.1858 |
Tier II |
10 |
NC_000003.12 |
3 |
120709481 |
+ |
RABL3 |
NNNAGACAGAGCAACCCCAG |
NGG |
2 |
0.1765 |
Tier II |
11 |
NC_000018.10 |
18 |
23218779 |
+ |
CABLES1 |
NNNAGACAGACCAACCTTAG |
NAG |
2 |
0.1667 |
Tier II |
12 |
NC_000001.11 |
1 |
148587430 |
+ |
NBPF14 |
NNNAGACACACCTACCTCAG |
NGG |
2 |
0.1615 |
Tier II |
13 |
NC_000016.10 |
16 |
2028040 |
- |
NHERF2 |
NNNAGACAGACACACCTCAG |
NGG |
2 |
0.1504 |
Tier II |
14 |
NC_000014.9 |
14 |
72259055 |
+ |
RGS6 |
NNNAGAGAGACCACCCTCAG |
NGG |
2 |
0.1008 |
Tier II |
15 |
NC_000001.11 |
1 |
156168731 |
- |
SEMA4A |
NNNAGCCAGACCACCCTCAG |
NGG |
2 |
0.0974 |
Tier II |
16 |
NC_000002.12 |
2 |
136958960 |
+ |
THSD7B |
NNNAGACAGACGCACCTCAG |
NGG |
2 |
0.0936 |
Tier II |
17 |
NC_000019.10 |
19 |
6228843 |
+ |
MLLT1 |
NNNAGACAGCCCACCCTCAG |
NGG |
2 |
0.0714 |
Tier II |
18 |
NC_000016.10 |
16 |
3448911 |
- |
NAA60 |
NNNACACAGACCAATCTCAG |
NGG |
2 |
0.0524 |
Tier II |
19 |
NC_000007.14 |
7 |
1101203 |
- |
C7orf50 |
NNNAGACAGACCAACCGCAG |
NAG |
2 |
0.0305 |
Tier II |
20 |
NC_000012.12 |
12 |
5781108 |
+ |
ANO2 |
NNNAGACAGCCCAAGCTCAG |
NGG |
2 |
0.0167 |
Tier II |
21 |
NC_000013.11 |
13 |
110537576 |
+ |
RAB20 |
NNNAAACAGACCAACCTCAG |
NGT |
2 |
0.014 |
Tier II |
22 |
NC_000012.12 |
12 |
49912426 |
+ |
LINC02395 |
NNNAGACAGACCATCCCCAG |
NGG |
2 |
0.3765 |
Tier III |
23 |
NC_000011.10 |
11 |
30851143 |
- |
LOC107984419 |
NNNAGACAGACCAGCCTCAC |
NGG |
2 |
0.2 |
Tier III |
24 |
NC_000005.10 |
5 |
172760483 |
+ |
LOC101928093 |
NNNAGACAGATCACCCTCAG |
NGG |
2 |
0.0659 |
Tier III |
25 |
NC_000003.12 |
3 |
110457918 |
- |
LOC105374036 |
NNNAGACAGACCAAACTCAG |
NTG |
2 |
0.0087 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000073.6 |
7 |
126875870 |
- |
Taok2 |
NNNAGACAGACCAACCTCAG |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000069.6 |
3 |
157281370 |
- |
Negr1 |
NNNACACAGACCAACCTCAG |
NGG |
1 |
0.7857 |
Tier II |
3 |
NC_000067.6 |
1 |
58045988 |
- |
Aox1 |
NNNAGACAGAACAACCCCAG |
NGG |
2 |
0.5294 |
Tier II |
4 |
NC_000070.6 |
4 |
125650306 |
- |
Grik3 |
NNNAGACAGACCAGCCTCAG |
NGG |
1 |
0.4667 |
Tier II |
5 |
NC_000067.6 |
1 |
39970064 |
- |
Map4k4 |
NNNAGACAGACAGACCTCAG |
NGG |
2 |
0.4658 |
Tier II |
6 |
NC_000072.6 |
6 |
51561836 |
- |
Snx10 |
NNNAGACAGACAGACCTCAG |
NGG |
2 |
0.4658 |
Tier II |
7 |
NC_000079.6 |
13 |
57768042 |
+ |
Spock1 |
NNNGGGCAGACCAACCTCAG |
NGG |
2 |
0.4464 |
Tier II |
8 |
NC_000072.6 |
6 |
127617647 |
+ |
Cracr2a |
NNNAGAGAGACCAACCTCAA |
NGG |
2 |
0.4412 |
Tier II |
9 |
NC_000074.6 |
8 |
84701453 |
+ |
Lyl1 |
NNNAGCTAGACCAACCTCAG |
NGG |
2 |
0.3693 |
Tier II |
10 |
NC_000067.6 |
1 |
167263266 |
+ |
Uck2 |
NNNAGACAGACTGACCTCAG |
NGG |
2 |
0.3512 |
Tier II |
11 |
NC_000085.6 |
19 |
53771316 |
- |
Rbm20 |
NNNTGACAGACCAACCACAG |
NGG |
2 |
0.3394 |
Tier II |
12 |
NC_000077.6 |
11 |
118775877 |
+ |
Rbfox3 |
NNNAGACAGACTAACCTCTG |
NGG |
2 |
0.2899 |
Tier II |
13 |
NC_000068.7 |
2 |
26428077 |
- |
Sec16a |
NNNAGAGAGACCAACCTCTG |
NGG |
2 |
0.2534 |
Tier II |
14 |
NC_000075.6 |
9 |
90210473 |
+ |
Tbc1d2b |
NNNAGACAGACCAGCCACAG |
NGG |
2 |
0.2489 |
Tier II |
15 |
NC_000072.6 |
6 |
72515080 |
+ |
Sh2d6 |
NNNAGACAGAACTACCTCAG |
NGG |
2 |
0.225 |
Tier II |
16 |
NC_000075.6 |
9 |
86307981 |
+ |
Ube2cbp |
NNNACACAGACCAACCTCAG |
NAG |
2 |
0.2037 |
Tier II |
17 |
NC_000077.6 |
11 |
6401894 |
+ |
Zmiz2 |
NNNAGACAGACCTACCACAG |
NGG |
2 |
0.16 |
Tier II |
18 |
NC_000084.6 |
18 |
7262802 |
- |
Armc4 |
NNNAGACAGGCCAACCTCAG |
NAG |
2 |
0.144 |
Tier II |
19 |
NC_000068.7 |
2 |
57337187 |
- |
Gpd2 |
NNNAGACAGACCAACCTAAG |
NAG |
2 |
0.1396 |
Tier II |
20 |
NC_000075.6 |
9 |
27086232 |
- |
Ncapd3 |
NNNAGAGAGAGCAACCTCAG |
NGG |
2 |
0.1176 |
Tier II |
21 |
NC_000085.6 |
19 |
5770890 |
+ |
Scyl1 |
NNNAGACAGAGCAACCTGAG |
NGG |
2 |
0.0333 |
Tier II |
22 |
NC_000072.6 |
6 |
97963918 |
- |
Mitf |
NNNAGACAGACCAAGCTCAC |
NGG |
2 |
0.0214 |
Tier II |
23 |
NC_000070.6 |
4 |
151476595 |
- |
Camta1 |
NNNAGACAGACCAGCCTCAG |
NTG |
2 |
0.0182 |
Tier II |
24 |
NC_000071.6 |
5 |
36951286 |
- |
Ppp2r2c |
NNNAGACAGACCAAGTTCAG |
NGG |
2 |
0.0154 |
Tier II |
25 |
NC_000076.6 |
10 |
63455435 |
- |
Ctnna3 |
NNNAGACAGACCAAGCTCAG |
NAG |
2 |
0.013 |
Tier II |
26 |
NC_000084.6 |
18 |
31997516 |
+ |
Myo7b |
NNNACACAGACCAACCTCAG |
NGT |
2 |
0.0127 |
Tier II |
27 |
NC_000078.6 |
12 |
74114120 |
+ |
Syt16 |
NNNAGACATACCAACCTCAG |
NGT |
2 |
0.0086 |
Tier II |
28 |
NC_000076.6 |
10 |
43607834 |
- |
F930017D23Rik |
NNNAGACAGACAGACCTCAG |
NGG |
2 |
0.4658 |
Tier III |
29 |
NC_000084.6 |
18 |
67795736 |
+ |
4930549G23Rik |
NNNAGCCAGAACAACCTCAG |
NGG |
2 |
0.3409 |
Tier III |
30 |
NC_000085.6 |
19 |
53771316 |
- |
Gm30890 |
NNNTGACAGACCAACCACAG |
NGG |
2 |
0.3394 |
Tier III |
31 |
NC_000067.6 |
1 |
43718232 |
- |
Gm30634 |
NNNAGCCAGACAAACCTCAG |
NGG |
2 |
0.3247 |
Tier III |
32 |
NC_000067.6 |
1 |
164464370 |
+ |
Gm32391 |
NNNAGACTGACCAACCCCAG |
NGG |
2 |
0.3025 |
Tier III |
33 |
NC_000076.6 |
10 |
42740117 |
- |
Gm15199 |
NNNAGACAGACCAACCCCAG |
NAG |
2 |
0.183 |
Tier III |
34 |
NC_000082.6 |
16 |
31488551 |
+ |
Gm34032 |
NNNAGACAGACCTACCTAAG |
NGG |
2 |
0.1615 |
Tier III |
35 |
NC_000084.6 |
18 |
38089102 |
+ |
Gm30093 |
NNNAGACAGACCGACCTCAG |
NGA |
2 |
0.0453 |
Tier III |
36 |
NC_000072.6 |
6 |
49634064 |
- |
Gm31226 |
NNNAGACAGACCAACCCCAG |
NGC |
2 |
0.0157 |
Tier III |
Other clones with same target sequence:
(none)