Construct: sgRNA BRDN0001148598
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- AAACTTCTCAACATTGCAGA
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- PANK3 (79646)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000005.10 | 5 | 168568705 | - | PANK3 | NNNCTTCTCAACATTGCAGA | NGG | 0 | 1.0 | Tier I |
2 | NC_000010.11 | 10 | 28591894 | - | WAC | NNNCTTCTCAAAATTGCAAA | NGG | 2 | 0.5102 | Tier II |
3 | NC_000003.12 | 3 | 116415371 | + | LSAMP | NNNCTTCACAACATTGCTGA | NGG | 2 | 0.4 | Tier II |
4 | NC_000008.11 | 8 | 101940141 | - | NCALD | NNNCTTCTCAAGATTGCAAA | NGG | 2 | 0.3175 | Tier II |
5 | NC_000017.11 | 17 | 33200525 | + | ASIC2 | NNNCTTCTCTTCATTGCAGA | NGG | 2 | 0.2715 | Tier II |
6 | NC_000001.11 | 1 | 44440278 | + | RNF220 | NNNCTTTTCATCATTGCAGA | NGG | 2 | 0.25 | Tier II |
7 | NC_000001.11 | 1 | 97315043 | - | DPYD | NNNCTCCTCAACATTGCAGA | NAG | 2 | 0.2357 | Tier II |
8 | NC_000001.11 | 1 | 31701039 | + | COL16A1 | NNNCTTCTCATCAATGCAGA | NGG | 2 | 0.1905 | Tier II |
9 | NC_000011.10 | 11 | 75962333 | + | UVRAG | NNNCTTCTCAACTTAGCAGA | NGG | 2 | 0.1737 | Tier II |
10 | NC_000007.14 | 7 | 48377921 | - | ABCA13 | NNNCATCTCAACATTGCAGA | NAG | 2 | 0.1296 | Tier II |
11 | NC_000003.12 | 3 | 79339226 | + | ROBO1 | NNNCTTCTCAACATAGCAGA | NCG | 2 | 0.062 | Tier II |
12 | NC_000017.11 | 17 | 69504236 | - | MAP2K6 | NNNCTTCTCTACATTGCAGA | NGA | 2 | 0.0613 | Tier II |
13 | NC_000001.11 | 1 | 62617416 | - | DOCK7 | NNNCTTCTCAACATTGCAGC | NAG | 2 | 0.0589 | Tier II |
14 | NC_000016.10 | 16 | 84866886 | - | CRISPLD2 | NNNCTTCTTAACATTGGAGA | NGG | 2 | 0.0515 | Tier II |
15 | NC_000009.12 | 9 | 20290328 | - | SLC24A2 | NNNCTCCTCAACATGGCAGA | NGG | 2 | 0.0455 | Tier II |
16 | NC_000016.10 | 16 | 28571190 | - | SGF29 | NNNATTCTCAACATGGCAGA | NGG | 2 | 0.0421 | Tier II |
17 | NC_000005.10 | 5 | 38375783 | - | EGFLAM | NNNCTTCTCAACATTGCAGT | NGA | 2 | 0.0417 | Tier II |
18 | NC_000008.11 | 8 | 62689079 | - | NKAIN3 | NNNCTTCTCAACATTGAAGA | NGA | 2 | 0.0324 | Tier II |
19 | NC_000009.12 | 9 | 70124522 | - | MAMDC2 | NNNCATCTCAACATGGCAGA | NGG | 2 | 0.025 | Tier II |
20 | NC_000015.10 | 15 | 28286885 | - | HERC2 | NNNCTTCTCAACATTGCAGC | NTG | 2 | 0.0089 | Tier II |
21 | NC_000015.10 | 15 | 28624541 | + | LOC124903450 | NNNCTTCTCAACATTGCAGC | NTG | 2 | 0.0089 | Tier II |
22 | NC_000008.11 | 8 | 6817303 | + | XKR5 | NNNCTTCTCAACAGAGCAGA | NGG | 2 | 0.0 | Tier II |
23 | NC_000018.10 | 18 | 7772039 | - | PTPRM | NNNCTTCTCAACAGTGCAGA | NAG | 2 | 0.0 | Tier II |
24 | NC_000001.11 | 1 | 242241721 | - | PLD5 | NNNCTTCTCCACAGTGCAGA | NGG | 2 | 0.0 | Tier II |
25 | NC_000004.12 | 4 | 155367961 | - | MAP9 | NNNCTTCTGAACATTTCAGA | NGG | 2 | 0.0 | Tier II |
26 | NC_000017.11 | 17 | 66667916 | - | PRKCA | NNNCTTCTTAACATTTCAGA | NGG | 2 | 0.0 | Tier II |
27 | NC_000007.14 | 7 | 118549509 | - | LOC105375473 | NNNCTTCTTTACATTGCAGA | NGG | 2 | 0.7721 | Tier III |
28 | NC_000011.10 | 11 | 101135786 | - | PGR-AS1 | NNNCTAATCAACATTGCAGA | NGG | 2 | 0.65 | Tier III |
29 | NC_000011.10 | 11 | 50268483 | + | LOC646801 | NNNCTTCTCAATATTGCAAA | NGG | 2 | 0.3846 | Tier III |
30 | NC_000010.11 | 10 | 57829697 | - | LOC105378314 | NNNCTTCTCAAGGTTGCAGA | NGG | 2 | 0.2899 | Tier III |
31 | NC_000008.11 | 8 | 78829469 | + | MITA1 | NNNCTTCTCAACATTGCACT | NGG | 2 | 0.269 | Tier III |
32 | NC_000001.11 | 1 | 97315043 | - | DPYD-AS1 | NNNCTCCTCAACATTGCAGA | NAG | 2 | 0.2357 | Tier III |
33 | NC_000008.11 | 8 | 20717127 | + | LOC105379315 | NNNTTTCTCAACATTGCAGC | NGG | 2 | 0.1818 | Tier III |
34 | NC_000007.14 | 7 | 118505965 | - | LOC105375473 | NNNCTTCTCAACATGGCAGA | NGG | 1 | 0.05 | Tier III |
35 | NC_000004.12 | 4 | 31719512 | - | LOC105374566 | NNNCTTCACAACATGGCAGA | NGG | 2 | 0.04 | Tier III |
36 | NC_000018.10 | 18 | 5917355 | - | LOC121725015 | NNNCTTATCAACATGGCAGA | NGG | 2 | 0.0375 | Tier III |
37 | NC_000006.12 | 6 | 152685856 | - | LOC105378061 | NNNCATCTCAACATGGCAGA | NGG | 2 | 0.025 | Tier III |
38 | NC_000007.14 | 7 | 142506865 | - | TRB | NNNCTTCTCAACATTGCAGG | NGT | 2 | 0.0123 | Tier III |
39 | NC_000015.10 | 15 | 20471038 | - | HERC2P3 | NNNCTTCTCAACATTGCAGC | NTG | 2 | 0.0089 | Tier III |
40 | NC_000015.10 | 15 | 22529365 | + | HERC2P2 | NNNCTTCTCAACATTGCAGC | NTG | 2 | 0.0089 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000074.6 | 8 | 24920084 | - | Adam32 | NNNATTCTTAACATTGCAGA | NGG | 2 | 0.7368 | Tier I |
2 | NC_000069.6 | 3 | 93219996 | - | Flg2 | NNNCTTCTCAACCTTCCAGA | NGG | 2 | 0.0 | Tier I |
3 | NC_000067.6 | 1 | 66372558 | + | Map2 | NNNCTTCCCAACATTGCATA | NGG | 2 | 0.6667 | Tier II |
4 | NC_000077.6 | 11 | 57176405 | + | Gria1 | NNNCTTCCCACCATTGCAGA | NGG | 2 | 0.4 | Tier II |
5 | NC_000070.6 | 4 | 121162995 | + | Rlf | NNNATTCTCAACATTGAAGA | NGG | 2 | 0.393 | Tier II |
6 | NC_000083.6 | 17 | 75545974 | + | Fam98a | NNNCTTCTCAGTATTGCAGA | NGG | 2 | 0.35 | Tier II |
7 | NC_000086.7 | X | 9660349 | - | Dynlt3 | NNNCAGCTCAACATTGCAGA | NGG | 2 | 0.2857 | Tier II |
8 | NC_000086.7 | X | 120847597 | - | Pcdh11x | NNNCTTGTCAACATAGCAGA | NGG | 2 | 0.2724 | Tier II |
9 | NC_000075.6 | 9 | 71626733 | + | Cgnl1 | NNNCTTCTCAACATTGCACT | NGG | 2 | 0.269 | Tier II |
10 | NC_000068.7 | 2 | 35691113 | - | Dab2ip | NNNATTCTCAACACTGCAGA | NGG | 2 | 0.2406 | Tier II |
11 | NC_000071.6 | 5 | 103745604 | - | Aff1 | NNNCTTCCCAACATTGCAGC | NGG | 2 | 0.2273 | Tier II |
12 | NC_000071.6 | 5 | 118663926 | - | Med13l | NNNCTTCTCGCCATTGCAGA | NGG | 2 | 0.2222 | Tier II |
13 | NC_000082.6 | 16 | 11148224 | + | Zc3h7a | NNNCTTCTCAAAACTGCAGA | NGG | 2 | 0.2041 | Tier II |
14 | NC_000068.7 | 2 | 63098702 | - | Kcnh7 | NNNCTTCTCAACTATGCAGA | NGG | 2 | 0.1857 | Tier II |
15 | NC_000079.6 | 13 | 68782186 | - | Adcy2 | NNNCTTCTCAACATTGCAGA | NGA | 1 | 0.0694 | Tier II |
16 | NC_000079.6 | 13 | 74291694 | + | Ahrr | NNNCTTCTCAAAATTGGAGA | NGG | 2 | 0.042 | Tier II |
17 | NC_000084.6 | 18 | 69579915 | + | Tcf4 | NNNCTTCTCAACAATGGAGA | NGG | 2 | 0.0364 | Tier II |
18 | NC_000084.6 | 18 | 16680885 | - | Cdh2 | NNNCTTCTCAACACGGCAGA | NGG | 2 | 0.0143 | Tier II |
19 | NC_000078.6 | 12 | 85287620 | - | Acyp1 | NNNCTTCTCCACATTGCAGA | NGT | 2 | 0.0054 | Tier II |
20 | NC_000078.6 | 12 | 85287620 | - | Zc2hc1c | NNNCTTCTCCACATTGCAGA | NGT | 2 | 0.0054 | Tier II |
21 | NC_000082.6 | 16 | 97427153 | - | Bace2 | NNNCTTCACAACATTTCAGA | NGG | 2 | 0.0 | Tier II |
22 | NC_000074.6 | 8 | 67916229 | - | Psd3 | NNNCTTCTCAACATTTCAGA | NTG | 2 | 0.0 | Tier II |
23 | NC_000072.6 | 6 | 28799219 | + | Snd1 | NNNCTTCTCTACATTTCAGA | NGG | 2 | 0.0 | Tier II |
24 | NC_000071.6 | 5 | 3311397 | - | Gm36470 | NNNCTTCTCAACATAGCAGA | NAG | 2 | 0.1501 | Tier III |
25 | NC_000072.6 | 6 | 70079467 | + | Igk | NNNCTTCTCAACATTGAAGA | NGA | 2 | 0.0324 | Tier III |
26 | NC_000079.6 | 13 | 69004714 | - | Gm35161 | NNNCTTCTCAACATTTCAGA | NGA | 2 | 0.0 | Tier III |