Construct: sgRNA BRDN0001148626
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- CGGTTGAGCACAGCATATCG
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- PPIP5K1 (9677)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000015.10 | 15 | 43582601 | + | PPIP5K1 | NNNTTGAGCACAGCATATCG | NGG | 0 | 1.0 | Tier I |
2 | NC_000006.12 | 6 | 126072348 | + | TRMT11 | NNNTTGAGCACAGCATATTG | NGG | 1 | 0.4615 | Tier II |
3 | NC_000003.12 | 3 | 169280677 | - | MECOM | NNNTTGAGCACAGCATATTA | NGG | 2 | 0.4327 | Tier II |
4 | NC_000008.11 | 8 | 88253463 | - | MMP16 | NNNTTCATCACAGCATATCG | NGG | 2 | 0.4261 | Tier II |
5 | NC_000002.12 | 2 | 137348417 | - | THSD7B | NNNTTGAACACTGCATATCG | NGG | 2 | 0.3333 | Tier II |
6 | NC_000012.12 | 12 | 95889999 | - | CCDC38 | NNNTTGAGCCCAGCAAATCG | NGG | 2 | 0.303 | Tier II |
7 | NC_000002.12 | 2 | 61932082 | - | COMMD1 | NNNTTGAGGACAGCAGATCG | NGG | 2 | 0.2143 | Tier II |
8 | NC_000011.10 | 11 | 77670057 | + | RSF1 | NNNTTGAGCACAGCAGATTG | NGG | 2 | 0.1598 | Tier II |
9 | NC_000007.14 | 7 | 69666833 | + | AUTS2 | NNNTTGAGCCCAGCATATTG | NGG | 2 | 0.1538 | Tier II |
10 | NC_000012.12 | 12 | 27634257 | - | PPFIBP1 | NNNTTGAGCACAGCATTTCA | NGG | 2 | 0.125 | Tier II |
11 | NC_000012.12 | 12 | 94986172 | + | NDUFA12 | NNNTTGAGCACAGCATATTG | NAG | 2 | 0.1197 | Tier II |
12 | NC_000005.10 | 5 | 13904842 | + | DNAH5 | NNNTTGAGCCCAGCAGATCG | NGG | 2 | 0.1154 | Tier II |
13 | NC_000021.9 | 21 | 6446516 | + | LOC102724560 | NNNTTGAGCACAGCAGGTCG | NGG | 2 | 0.0611 | Tier II |
14 | NC_000021.9 | 21 | 43054838 | + | CBS | NNNTTGAGCACAGCAGGTCG | NGG | 2 | 0.0611 | Tier II |
15 | NC_000003.12 | 3 | 138827610 | + | PIK3CB | NNNTTGAGCACAGCAGTTCG | NGG | 2 | 0.0462 | Tier II |
16 | NC_000010.11 | 10 | 73391543 | + | ANXA7 | NNNTTGAGCCCAGCATTTCG | NGG | 2 | 0.0444 | Tier II |
17 | NC_000023.11 | X | 6963737 | - | PUDP | NNNTTGAGCACAGCATTTGG | NGG | 2 | 0.0167 | Tier II |
18 | NC_000002.12 | 2 | 151258632 | + | RBM43 | NNNTTGAGCACAGGAGATCG | NGG | 2 | 0.0 | Tier II |
19 | NC_000015.10 | 15 | 78574904 | + | CHRNA5 | NNNTTGAGCACAGGAGATCG | NGG | 2 | 0.0 | Tier II |
20 | NC_000019.10 | 19 | 5023851 | - | KDM4B | NNNTTGAGCACAGGAGATCG | NGG | 2 | 0.0 | Tier II |
21 | NC_000017.11 | 17 | 17926102 | + | TOM1L2 | NNNTTGAGCACAGGATGTCG | NGG | 2 | 0.0 | Tier II |
22 | NC_000003.12 | 3 | 146198488 | - | PLSCR4 | NNNTTGAGCCCAGGATATCG | NGG | 2 | 0.0 | Tier II |
23 | NC_000005.10 | 5 | 150360824 | - | TCOF1 | NNNTTGAGCCCAGGATATCG | NGG | 2 | 0.0 | Tier II |
24 | NC_000006.12 | 6 | 25293473 | - | CARMIL1 | NNNTTGAGCCCAGGATATCG | NGG | 2 | 0.0 | Tier II |
25 | NC_000006.12 | 6 | 97261899 | - | MMS22L | NNNTTGAGCCCAGGATATCG | NGG | 2 | 0.0 | Tier II |
26 | NC_000013.11 | 13 | 48050315 | + | NUDT15 | NNNTTGAGCCCAGGATATCG | NGG | 2 | 0.0 | Tier II |
27 | NC_000017.11 | 17 | 19576438 | - | SLC47A1 | NNNTTGAGCCCAGGATATCG | NGG | 2 | 0.0 | Tier II |
28 | NC_000018.10 | 18 | 24126118 | + | TTC39C | NNNTTGAGCCCAGGATATCG | NGG | 2 | 0.0 | Tier II |
29 | NC_000015.10 | 15 | 43682436 | + | PPIP5K1P1 | NNNTTGAGCACAGCATATCG | NGG | 0 | 1.0 | Tier III |
30 | NC_000015.10 | 15 | 43682436 | + | PPIP5K1P1-CATSPER2 | NNNTTGAGCACAGCATATCG | NGG | 0 | 1.0 | Tier III |
31 | NC_000003.12 | 3 | 169280677 | - | LOC105374206 | NNNTTGAGCACAGCATATTA | NGG | 2 | 0.4327 | Tier III |
32 | NC_000002.12 | 2 | 199625227 | + | LINC01877 | NNNTTGAGCACAGCATAGCA | NGG | 2 | 0.3125 | Tier III |
33 | NC_000002.12 | 2 | 58987732 | + | LINC01122 | NNNTTGAGCATAGCATATAG | NGG | 2 | 0.1319 | Tier III |
34 | NC_000012.12 | 12 | 27122531 | - | LOC124902904 | NNNTTGAGCACAGCATTTCA | NGG | 2 | 0.125 | Tier III |
35 | NC_000008.11 | 8 | 80221670 | + | LOC105375920 | NNNTTGAGCCCAGCAGATCG | NGG | 2 | 0.1154 | Tier III |
36 | NC_000021.9 | 21 | 6446516 | + | LOC102724701 | NNNTTGAGCACAGCAGGTCG | NGG | 2 | 0.0611 | Tier III |
37 | NC_000008.11 | 8 | 101056905 | - | SLEAR | NNNTTGAGCACAGGAAATCG | NGG | 2 | 0.0 | Tier III |
38 | NC_000003.12 | 3 | 159964928 | - | IL12A-AS1 | NNNTTGAGCCCAGGATATCG | NGG | 2 | 0.0 | Tier III |
39 | NC_000013.11 | 13 | 104855311 | - | LOC105370342 | NNNTTGAGCCCAGGATATCG | NGG | 2 | 0.0 | Tier III |
40 | NC_000013.11 | 13 | 104855311 | - | LOC107984608 | NNNTTGAGCCCAGGATATCG | NGG | 2 | 0.0 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000068.7 | 2 | 120066048 | - | Sptbn5 | NNNTCGAGCTCAGCATATCG | NGG | 2 | 0.8824 | Tier I |
2 | NC_000068.7 | 2 | 121349211 | + | Ppip5k1 | NNNTTGAGGACAGCATATCT | NGG | 2 | 0.4333 | Tier I |
3 | NC_000069.6 | 3 | 158274803 | - | Lrrc7 | NNNATGAGCACAGCATATCA | NGG | 2 | 0.4464 | Tier II |
4 | NC_000079.6 | 13 | 91040354 | + | Atg10 | NNNTAGATCACAGCATATCG | NGG | 2 | 0.3125 | Tier II |
5 | NC_000073.6 | 7 | 121014698 | - | Mfsd13b | NNNTTGAGCACAGCATAACC | NGG | 2 | 0.2857 | Tier II |
6 | NC_000079.6 | 13 | 24515308 | - | Ripor2 | NNNTTGAGCACAGCAGATAG | NGG | 2 | 0.1484 | Tier II |
7 | NC_000077.6 | 11 | 29548035 | - | Clhc1 | NNNTTGAGCACATCATTTCG | NGG | 2 | 0.04 | Tier II |
8 | NC_000077.6 | 11 | 29548035 | - | Rps27a | NNNTTGAGCACATCATTTCG | NGG | 2 | 0.04 | Tier II |
9 | NC_000068.7 | 2 | 120066048 | - | Gm52559 | NNNTCGAGCTCAGCATATCG | NGG | 2 | 0.8824 | Tier III |