Construct: sgRNA BRDN0001148688
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- CCAGAATCTGATGTATACAG
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- CAMK2G (818)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000010.11 | 10 | 73849328 | + | CAMK2G | NNNGAATCTGATGTATACAG | NGG | 0 | 1.0 | Tier I |
2 | NC_000002.12 | 2 | 72759138 | - | EXOC6B | NNNGAAACTGAAGTATACAG | NGG | 2 | 0.7 | Tier II |
3 | NC_000022.11 | 22 | 33742203 | - | LARGE1 | NNNGAAACTGAAGTATACAG | NGG | 2 | 0.7 | Tier II |
4 | NC_000017.11 | 17 | 37224606 | - | ACACA | NNNGAATCAGATGTATACAT | NGG | 2 | 0.65 | Tier II |
5 | NC_000018.10 | 18 | 10902522 | - | PIEZO2 | NNNGAATCTGATGTAAACAT | NGG | 2 | 0.6364 | Tier II |
6 | NC_000016.10 | 16 | 24732540 | + | TNRC6A | NNNGAATTTGATGTATAAAG | NGG | 2 | 0.4712 | Tier II |
7 | NC_000003.12 | 3 | 171173796 | - | TNIK | NNNGAGTCTGGTGTATACAG | NGG | 2 | 0.4643 | Tier II |
8 | NC_000016.10 | 16 | 27524502 | + | GTF3C1 | NNNGAAACTGAGGTATACAG | NGG | 2 | 0.4375 | Tier II |
9 | NC_000008.11 | 8 | 115456268 | - | TRPS1 | NNNGAATAGGATGTATACAG | NGG | 2 | 0.4024 | Tier II |
10 | NC_000017.11 | 17 | 42411866 | - | CAVIN1 | NNNGAATGGGATGTATACAG | NGG | 2 | 0.398 | Tier II |
11 | NC_000008.11 | 8 | 50001609 | - | SNTG1 | NNNCAGTCTGATGTATACAG | NGG | 2 | 0.3782 | Tier II |
12 | NC_000012.12 | 12 | 29746326 | + | TMTC1 | NNNGAATATGATGTATAAAG | NGG | 2 | 0.35 | Tier II |
13 | NC_000012.12 | 12 | 24999016 | - | IRAG2 | NNNGCATATGATGTATACAG | NGG | 2 | 0.325 | Tier II |
14 | NC_000011.10 | 11 | 85820663 | + | SYTL2 | NNNGCATCTGAGGTATACAG | NGG | 2 | 0.25 | Tier II |
15 | NC_000003.12 | 3 | 114735435 | - | ZBTB20 | NNNGCATCTGCTGTATACAG | NGG | 2 | 0.2 | Tier II |
16 | NC_000012.12 | 12 | 121427060 | - | KDM2B | NNNGAATCTGATGTTTACAA | NGG | 2 | 0.1875 | Tier II |
17 | NC_000014.9 | 14 | 99801309 | - | EML1 | NNNGAATCTAATGTTTACAG | NGG | 2 | 0.1867 | Tier II |
18 | NC_000020.11 | 20 | 34301494 | - | AHCY | NNNGAAACTGATGTTTACAG | NGG | 2 | 0.175 | Tier II |
19 | NC_000010.11 | 10 | 105147076 | - | SORCS3 | NNNGCATCTGTTGTATACAG | NGG | 2 | 0.1538 | Tier II |
20 | NC_000004.12 | 4 | 113677811 | + | CAMK2D | NNNTAATCTCATGTATACAG | NGG | 2 | 0.1455 | Tier II |
21 | NC_000006.12 | 6 | 157117076 | + | ARID1B | NNNGAATCTGATGTTCACAG | NGG | 2 | 0.1333 | Tier II |
22 | NC_000008.11 | 8 | 476006 | + | FBXO25 | NNNGAATATGATGTTTACAG | NGG | 2 | 0.13 | Tier II |
23 | NC_000001.11 | 1 | 232404911 | + | SIPA1L2 | NNNGAATCTGAGGTATACAG | NAG | 2 | 0.1296 | Tier II |
24 | NC_000006.12 | 6 | 79037839 | - | PHIP | NNNGTATCTGATGTATACAG | NAG | 2 | 0.0943 | Tier II |
25 | NC_000005.10 | 5 | 65388333 | + | ADAMTS6 | NNNGCATCTGATGTATGCAG | NGG | 2 | 0.0882 | Tier II |
26 | NC_000014.9 | 14 | 70646327 | + | TTC9 | NNNGAATCTGATCTTTACAG | NGG | 2 | 0.0842 | Tier II |
27 | NC_000004.12 | 4 | 26961551 | + | STIM2 | NNNGAATCTGGTGTATACAG | NGC | 2 | 0.0144 | Tier II |
28 | NC_000009.12 | 9 | 10589700 | + | PTPRD | NNNGAAACTGATGGATACAG | NGG | 2 | 0.0 | Tier II |
29 | NC_000022.11 | 22 | 33742203 | - | LARGE-AS1 | NNNGAAACTGAAGTATACAG | NGG | 2 | 0.7 | Tier III |
30 | NC_000007.14 | 7 | 25952984 | - | LOC105375199 | NNNGAATCTGATGTACACAA | NGG | 2 | 0.625 | Tier III |
31 | NC_000003.12 | 3 | 65182130 | - | LINC02040 | NNNGAAGCTGATGTATACAG | NGG | 1 | 0.5882 | Tier III |
32 | NC_000011.10 | 11 | 93956727 | - | LOC101060084 | NNNGAAACTGAGGTATACAG | NGG | 2 | 0.4375 | Tier III |
33 | NC_000014.9 | 14 | 97773791 | - | LOC105370651 | NNNCAATGTGATGTATACAG | NGG | 2 | 0.3403 | Tier III |
34 | NC_000007.14 | 7 | 13689213 | - | LOC107986770 | NNNGAATATGATGTATACAG | NAG | 2 | 0.1685 | Tier III |
35 | NC_000013.11 | 13 | 106337243 | + | LOC107984626 | NNNGAAGCTGATGTATACAG | NAG | 2 | 0.1525 | Tier III |
36 | NC_000006.12 | 6 | 79037839 | - | LOC124901346 | NNNGTATCTGATGTATACAG | NAG | 2 | 0.0943 | Tier III |
37 | NC_000010.11 | 10 | 7031170 | + | LOC105376387 | NNNGAATCTGATGGATGCAG | NGG | 2 | 0.0 | Tier III |
38 | NC_000012.12 | 12 | 93055889 | + | LOC643339 | NNNGAATCTGATGTATACAG | NAA | 2 | 0.0 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000080.6 | 14 | 20766220 | + | Camk2g | NNNGGATCTGATGTATACAG | NGG | 1 | 0.72 | Tier I |
2 | NC_000068.7 | 2 | 146502056 | + | Ralgapa2 | NNNGAAACTGATGAATACAG | NGG | 2 | 0.5417 | Tier II |
3 | NC_000071.6 | 5 | 136022772 | + | Dtx2 | NNNGAATCTCATGTATACAG | NGG | 1 | 0.4 | Tier II |
4 | NC_000070.6 | 4 | 140209438 | + | Igsf21 | NNNGCATCTGCTGTATACAG | NGG | 2 | 0.2 | Tier II |
5 | NC_000082.6 | 16 | 59455565 | + | Gabrr3 | NNNGAATCTGATGTATACTG | NAG | 2 | 0.1396 | Tier II |
6 | NC_000067.6 | 1 | 181802630 | - | Dnah14 | NNNGAATGTGATGTTTACAG | NGG | 2 | 0.1286 | Tier II |
7 | NC_000086.7 | X | 72599171 | + | Gabra3 | NNNGAAACTGATGTATAGAG | NGG | 2 | 0.1167 | Tier II |
8 | NC_000084.6 | 18 | 43326086 | - | Dpysl3 | NNNGAATCTCATGTCTACAG | NGG | 2 | 0.1091 | Tier II |
9 | NC_000076.6 | 10 | 117737586 | - | Slc35e3 | NNNGAATCTGAGGTATAGAG | NGG | 2 | 0.0667 | Tier II |
10 | NC_000072.6 | 6 | 53491390 | - | Creb5 | NNNGAATCTGAAGTATACAG | NGA | 2 | 0.0556 | Tier II |
11 | NC_000084.6 | 18 | 61566573 | - | Csnk1a1 | NNNGAATCTGATGTTTACAG | NAG | 2 | 0.0519 | Tier II |
12 | NC_000082.6 | 16 | 18452454 | - | Txnrd2 | NNNGCATCTGATGTATACAG | NGA | 2 | 0.0347 | Tier II |
13 | NC_000074.6 | 8 | 106626043 | - | Cdh1 | NNNGAAGCTGATGGATACAG | NGG | 2 | 0.0 | Tier II |
14 | NC_000081.6 | 15 | 24299064 | - | Gm36147 | NNNGAACCTGATGTATACAG | NGG | 1 | 0.6875 | Tier III |
15 | NC_000083.6 | 17 | 22792837 | + | Gm16386 | NNNGTATCTGATGAATACAG | NGG | 2 | 0.2251 | Tier III |