Construct: sgRNA BRDN0001148876
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- TAAGAAGGGCTACAACCCAC
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- TSSK4 (283629)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 77044
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000014.9 |
14 |
24207243 |
- |
TSSK4 |
NNNGAAGGGCTACAACCCAC |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000001.11 |
1 |
119625920 |
- |
ZNF697 |
NNNGATGGGCTCCAACCCAC |
NGG |
2 |
0.188 |
Tier I |
3 |
NC_000016.10 |
16 |
14046382 |
- |
MRTFB |
NNNGATGGGCTACAACCCAC |
NGG |
1 |
0.7143 |
Tier II |
4 |
NC_000003.12 |
3 |
56796541 |
- |
ARHGEF3 |
NNNGAACGGCTGCAACCCAC |
NGG |
2 |
0.4965 |
Tier II |
5 |
NC_000005.10 |
5 |
153747779 |
- |
GRIA1 |
NNNGAAAGGCTACACCCCAC |
NGG |
2 |
0.2727 |
Tier II |
6 |
NC_000004.12 |
4 |
20734824 |
+ |
KCNIP4 |
NNNTAAGGGCTACAACCCTC |
NGG |
2 |
0.1958 |
Tier II |
7 |
NC_000004.12 |
4 |
20734824 |
+ |
PACRGL |
NNNTAAGGGCTACAACCCTC |
NGG |
2 |
0.1958 |
Tier II |
8 |
NC_000010.11 |
10 |
125994912 |
- |
FANK1 |
NNNGAAGGGCTTCGACCCAC |
NGG |
2 |
0.1556 |
Tier II |
9 |
NC_000022.11 |
22 |
19984149 |
- |
ARVCF |
NNNGAGGGGCTACATCCCAC |
NGG |
2 |
0.1429 |
Tier II |
10 |
NC_000011.10 |
11 |
204961 |
+ |
BET1L |
NNNGAAGGGCTGCAAGCCAC |
NGG |
2 |
0.1111 |
Tier II |
11 |
NC_000017.11 |
17 |
72871902 |
- |
SLC39A11 |
NNNGAAGGGCTACATCCCAC |
NAG |
2 |
0.0519 |
Tier II |
12 |
NC_000002.12 |
2 |
117819244 |
- |
DDX18 |
NNNGAAGGGCAACAACCCAC |
NTG |
2 |
0.0292 |
Tier II |
13 |
NC_000001.11 |
1 |
160841096 |
+ |
CD244 |
NNNGAAGGGCTACAAGGCAC |
NGG |
2 |
0.009 |
Tier II |
14 |
NC_000004.12 |
4 |
48256269 |
+ |
TEC |
NNNGAAGGGCTACAATCCAC |
NGC |
2 |
0.0068 |
Tier II |
15 |
NC_000012.12 |
12 |
114736925 |
- |
TBX3-AS1 |
NNNGAAAGGCTCCAACCCAC |
NGG |
2 |
0.2632 |
Tier III |
16 |
NC_000016.10 |
16 |
65481860 |
+ |
LINC00922 |
NNNGAAGGGGTACCACCCAC |
NGG |
2 |
0.0833 |
Tier III |
17 |
NC_000006.12 |
6 |
134705152 |
- |
LOC101928277 |
NNNGCAGGGCTAGAACCCAC |
NGG |
2 |
0.0682 |
Tier III |
18 |
NC_000014.9 |
14 |
47777269 |
- |
LINC00648 |
NNNGAAGGGCTGCAACCCAC |
NGA |
2 |
0.0502 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000069.6 |
3 |
80722228 |
- |
Gria2 |
NNNGAAAGGTTACAACCCAC |
NGG |
2 |
0.9412 |
Tier II |
2 |
NC_000072.6 |
6 |
118745598 |
- |
Cacna1c |
NNNAAAGGGCTACAACCCAC |
NGG |
1 |
0.9 |
Tier II |
3 |
NC_000073.6 |
7 |
81439205 |
- |
Cpeb1 |
NNNAAAGGGTTACAACCCAC |
NGG |
2 |
0.8471 |
Tier II |
4 |
NC_000067.6 |
1 |
62627207 |
+ |
Pard3b |
NNNGAAGGGTTGCAACCCAC |
NGG |
2 |
0.6797 |
Tier II |
5 |
NC_000071.6 |
5 |
35072785 |
- |
Dok7 |
NNNAAAGGGCTGCAACCCAC |
NGG |
2 |
0.65 |
Tier II |
6 |
NC_000071.6 |
5 |
92688197 |
+ |
Shroom3 |
NNNAAGGGGCTACAACCCAC |
NGG |
2 |
0.6429 |
Tier II |
7 |
NC_000080.6 |
14 |
55501938 |
- |
Carmil3 |
NNNGAAGGGTCACAACCCAC |
NGG |
2 |
0.6275 |
Tier II |
8 |
NC_000083.6 |
17 |
78680494 |
+ |
Strn |
NNNAAAGGGCCACAACCCAC |
NGG |
2 |
0.6 |
Tier II |
9 |
NC_000075.6 |
9 |
107155539 |
+ |
Dock3 |
NNNGAAGGGCTACTACCCAC |
NGG |
1 |
0.5333 |
Tier II |
10 |
NC_000083.6 |
17 |
46642861 |
+ |
Klc4 |
NNNCAAGGGTTACAACCCAC |
NGG |
2 |
0.4983 |
Tier II |
11 |
NC_000078.6 |
12 |
21334543 |
- |
Adam17 |
NNNGCAGGGTTACAACCCAC |
NGG |
2 |
0.4706 |
Tier II |
12 |
NC_000068.7 |
2 |
93982235 |
+ |
Alkbh3 |
NNNGAAGGGTTACAACTCAC |
NGG |
2 |
0.4392 |
Tier II |
13 |
NC_000075.6 |
9 |
103498222 |
+ |
Tmem108 |
NNNGAAGAGCTAAAACCCAC |
NGG |
2 |
0.3846 |
Tier II |
14 |
NC_000086.7 |
X |
18432287 |
+ |
Dipk2b |
NNNGAAGGGCAACAACACAC |
NGG |
2 |
0.35 |
Tier II |
15 |
NC_000071.6 |
5 |
128199042 |
- |
Tmem132d |
NNNGAAGGGATAAAACCCAC |
NGG |
2 |
0.3333 |
Tier II |
16 |
NC_000071.6 |
5 |
118082265 |
+ |
Fbxw8 |
NNNGAAGTGGTACAACCCAC |
NGG |
2 |
0.2431 |
Tier II |
17 |
NC_000076.6 |
10 |
64294111 |
+ |
Ctnna3 |
NNNGAAGGGCTTTAACCCAC |
NGG |
2 |
0.2333 |
Tier II |
18 |
NC_000076.6 |
10 |
94039271 |
- |
Fgd6 |
NNNGAAGGGTTACAACCGAC |
NGG |
2 |
0.1255 |
Tier II |
19 |
NC_000082.6 |
16 |
13404599 |
- |
Mrtfb |
NNNGAAGGGCTACATCCCTC |
NGG |
2 |
0.1077 |
Tier II |
20 |
NC_000067.6 |
1 |
36413782 |
- |
Fer1l5 |
NNNGTAGGGCTCCAACCCAC |
NGG |
2 |
0.0957 |
Tier II |
21 |
NC_000067.6 |
1 |
91053292 |
+ |
Lrrfip1 |
NNNGAAGGGGTACAACCCCC |
NGG |
2 |
0.0805 |
Tier II |
22 |
NC_000076.6 |
10 |
74291368 |
+ |
Pcdh15 |
NNNAAAGGGCTACAACCCAG |
NGG |
2 |
0.0529 |
Tier II |
23 |
NC_000085.6 |
19 |
23357669 |
+ |
Mamdc2 |
NNNGAAGGGCTACAACCCAC |
NCT |
2 |
0.0 |
Tier II |
24 |
NC_000076.6 |
10 |
100136608 |
+ |
Gm35533 |
NNNAAAGGGTTACAACCCAC |
NGG |
2 |
0.8471 |
Tier III |
25 |
NC_000076.6 |
10 |
56448634 |
- |
Gm36595 |
NNNAAGGGGCTACAACCCAC |
NGG |
2 |
0.6429 |
Tier III |
26 |
NC_000081.6 |
15 |
52448612 |
+ |
Gm41322 |
NNNAAGGGGCTACAACCCAC |
NGG |
2 |
0.6429 |
Tier III |
27 |
NC_000068.7 |
2 |
93982235 |
+ |
Alkbh3os1 |
NNNGAAGGGTTACAACTCAC |
NGG |
2 |
0.4392 |
Tier III |
28 |
NC_000075.6 |
9 |
103498222 |
+ |
Gm16252 |
NNNGAAGAGCTAAAACCCAC |
NGG |
2 |
0.3846 |
Tier III |
29 |
NC_000072.6 |
6 |
92292794 |
+ |
Gm30688 |
NNNGAAAGGCTTCAACCCAC |
NGG |
2 |
0.3333 |
Tier III |
30 |
NC_000070.6 |
4 |
39412178 |
- |
Gm17094 |
NNNGAAGTGCTACATCCCAC |
NGG |
2 |
0.125 |
Tier III |
31 |
NC_000082.6 |
16 |
13404599 |
- |
Gm15738 |
NNNGAAGGGCTACATCCCTC |
NGG |
2 |
0.1077 |
Tier III |
32 |
NC_000083.6 |
17 |
9456986 |
- |
Gm51424 |
NNNGAAGGGCTACAACCCAA |
NGT |
2 |
0.0081 |
Tier III |
Other clones with same target sequence:
(none)