Construct: sgRNA BRDN0001149198
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- GTATTACTGATATTGGTGGG
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- ONE_INTERGENIC_SITE control
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000011.10 | 11 | 10285835 | - | SBF2 | NNNTTACTGTTATTGGTGGA | NGG | 2 | 0.8272 | Tier II |
2 | NC_000002.12 | 2 | 101755471 | + | MAP4K4 | NNNTTACTGAAATTGGTGGG | NGG | 1 | 0.75 | Tier II |
3 | NC_000002.12 | 2 | 196339173 | + | HECW2 | NNNTTTCTGATATTGGTGGG | NGG | 1 | 0.7143 | Tier II |
4 | NC_000019.10 | 19 | 56607950 | + | ZNF71 | NNNTTACTGACATTGGTGGG | NGG | 1 | 0.6667 | Tier II |
5 | NC_000001.11 | 1 | 183599910 | - | NCF2 | NNNTTACTGATATTGGTAGA | NGG | 2 | 0.649 | Tier II |
6 | NC_000010.11 | 10 | 11201337 | + | CELF2 | NNNTTATGGATATTGGTGGG | NGG | 2 | 0.5958 | Tier II |
7 | NC_000011.10 | 11 | 124673073 | - | SIAE | NNNTTACAGATATTGGTGGT | NGG | 2 | 0.56 | Tier II |
8 | NC_000007.14 | 7 | 32033912 | - | PDE1C | NNNTTACTGATAATGGTTGG | NGG | 2 | 0.4615 | Tier II |
9 | NC_000023.11 | X | 143033551 | + | SPANXN4 | NNNTTACAGGTATTGGTGGG | NGG | 2 | 0.4444 | Tier II |
10 | NC_000018.10 | 18 | 36458101 | - | FHOD3 | NNNTTTCTGATATAGGTGGG | NGG | 2 | 0.4422 | Tier II |
11 | NC_000001.11 | 1 | 175706085 | - | TNR | NNNTTATTGATTTTGGTGGG | NGG | 2 | 0.2708 | Tier II |
12 | NC_000002.12 | 2 | 239971544 | + | NDUFA10 | NNNTTACTGATATTAGTGGG | NAG | 2 | 0.244 | Tier II |
13 | NC_000002.12 | 2 | 32235101 | + | NLRC4 | NNNTTCCTGATATTGGAGGG | NGG | 2 | 0.2424 | Tier II |
14 | NC_000012.12 | 12 | 920829 | - | RAD52 | NNNTTTCTGCTATTGGTGGG | NGG | 2 | 0.2381 | Tier II |
15 | NC_000002.12 | 2 | 86504329 | + | CHMP3 | NNNATACTGATAGTGGTGGG | NGG | 2 | 0.1242 | Tier II |
16 | NC_000002.12 | 2 | 86504329 | + | RNF103-CHMP3 | NNNATACTGATAGTGGTGGG | NGG | 2 | 0.1242 | Tier II |
17 | NC_000009.12 | 9 | 8576375 | + | PTPRD | NNNTTACTGATATTTGTGGG | NAG | 2 | 0.037 | Tier II |
18 | NC_000006.12 | 6 | 16534669 | - | ATXN1 | NNNTTACTGATCTTGGTGGG | NTG | 2 | 0.0103 | Tier II |
19 | NC_000004.12 | 4 | 39467866 | - | LIAS | NNNTAACTGATATTGCTGGG | NGG | 2 | 0.0 | Tier II |
20 | NC_000001.11 | 1 | 165631423 | - | MGST3 | NNNTTACTGATAAGGGTGGG | NGG | 2 | 0.0 | Tier II |
21 | NC_000011.10 | 11 | 99745326 | - | CNTN5 | NNNTTACTGATATTTCTGGG | NGG | 2 | 0.0 | Tier II |
22 | NC_000019.10 | 19 | 56607950 | + | ZNF71-SMIM17 | NNNTTACTGACATTGGTGGG | NGG | 1 | 0.6667 | Tier III |
23 | NC_000010.11 | 10 | 11201337 | + | LOC124902375 | NNNTTATGGATATTGGTGGG | NGG | 2 | 0.5958 | Tier III |
24 | NC_000006.12 | 6 | 167462737 | - | LOC105378127 | NNNTTACTCATATTGGTGGG | NGG | 1 | 0.5385 | Tier III |
25 | NC_000010.11 | 10 | 70997369 | + | LOC105378350 | NNNCTTCTGATATTGGTGGG | NGG | 2 | 0.4622 | Tier III |
26 | NC_000002.12 | 2 | 8289031 | - | LINC00299 | NNNTTACTGATATTGATGGG | NAG | 2 | 0.2593 | Tier III |
27 | NC_000014.9 | 14 | 86113140 | - | LINC02328 | NNNTTACTGAAATTGGTGGG | NGA | 2 | 0.0521 | Tier III |
28 | NC_000001.11 | 1 | 113924661 | - | HIPK1-AS1 | NNNTTACTGATATTGGTGAG | NGC | 2 | 0.0159 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000085.6 | 19 | 40754777 | + | Cc2d2b | NNNTTAATGAAATTGGTGGG | NGG | 2 | 0.5625 | Tier II |
2 | NC_000067.6 | 1 | 133176097 | + | Plekha6 | NNNTTACTGAAATAGGTGGG | NGG | 2 | 0.4643 | Tier II |
3 | NC_000068.7 | 2 | 163292681 | - | Tox2 | NNNTTCCTGATATTGGAGGG | NGG | 2 | 0.2424 | Tier II |
4 | NC_000071.6 | 5 | 74253035 | + | Scfd2 | NNNATACTGCTATTGGTGGG | NGG | 2 | 0.1587 | Tier II |
5 | NC_000070.6 | 4 | 98998866 | - | Dock7 | NNNTTTCTGATATTGGGGGG | NGG | 2 | 0.084 | Tier II |
6 | NC_000084.6 | 18 | 56392263 | - | Gramd3 | NNNTTACTGATATTTGTGGG | NAG | 2 | 0.037 | Tier II |
7 | NC_000078.6 | 12 | 5443061 | + | Gm32214 | NNNTTGCTAATATTGGTGGG | NGG | 2 | 0.4592 | Tier III |