Construct: sgRNA BRDN0001149287
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- CCTAATACTATTGAGTACAA
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- TAOK3 (51347)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000012.12 | 12 | 118243449 | - | TAOK3 | NNNAATACTATTGAGTACAA | NGG | 0 | 1.0 | Tier I |
2 | NC_000001.11 | 1 | 62525574 | + | DOCK7 | NNNAATACAATTGAGAACAA | NGG | 2 | 0.8442 | Tier II |
3 | NC_000005.10 | 5 | 132632203 | - | RAD50 | NNNAATATTATTAAGTACAA | NGG | 2 | 0.8077 | Tier II |
4 | NC_000003.12 | 3 | 105540826 | - | ALCAM | NNNAATACTATTGAGTACTG | NGG | 2 | 0.4118 | Tier II |
5 | NC_000005.10 | 5 | 38528123 | - | LIFR | NNNAAGAATATTGAGTACAA | NGG | 2 | 0.3714 | Tier II |
6 | NC_000015.10 | 15 | 53524243 | + | WDR72 | NNNGATACTGTTGAGTACAA | NGG | 2 | 0.3472 | Tier II |
7 | NC_000001.11 | 1 | 173543935 | + | SLC9C2 | NNNAATACTATTCAGTACAT | NGG | 2 | 0.2526 | Tier II |
8 | NC_000005.10 | 5 | 75875510 | + | SV2C | NNNAATACTATTCAGTACAT | NGG | 2 | 0.2526 | Tier II |
9 | NC_000003.12 | 3 | 196402012 | - | UBXN7 | NNNAATACAATTGAGTACAA | NAG | 2 | 0.2407 | Tier II |
10 | NC_000008.11 | 8 | 118369850 | + | SAMD12 | NNNAATACTATTGAGGACAT | NGG | 2 | 0.2077 | Tier II |
11 | NC_000005.10 | 5 | 120704542 | - | PRR16 | NNNAATACTCTTGAGTACAT | NGG | 2 | 0.2 | Tier II |
12 | NC_000010.11 | 10 | 54315613 | - | PCDH15 | NNNAATACTATTCAGGACAA | NGG | 2 | 0.1457 | Tier II |
13 | NC_000012.12 | 12 | 100934182 | - | ANO4 | NNNAATACTATTCAGGACAA | NGG | 2 | 0.1457 | Tier II |
14 | NC_000006.12 | 6 | 114292165 | - | HS3ST5 | NNNAATACTATTGTCTACAA | NGG | 2 | 0.1455 | Tier II |
15 | NC_000023.11 | X | 134385497 | - | PHF6 | NNNAACACTATTGAGTACAA | NGA | 2 | 0.0631 | Tier II |
16 | NC_000006.12 | 6 | 151335886 | - | AKAP12 | NNNAATAGTATTGAGTACAA | NGT | 2 | 0.0104 | Tier II |
17 | NC_000018.10 | 18 | 74259963 | - | CYB5A | NNNAATACTATTTAGTACAA | NGC | 2 | 0.0067 | Tier II |
18 | NC_000008.11 | 8 | 14400749 | - | SGCZ | NNNAATACTATTGATTACAA | NGT | 2 | 0.0023 | Tier II |
19 | NC_000004.12 | 4 | 89942344 | - | MMRN1 | NNNAATACTATTGAGTACAA | NTT | 2 | 0.0 | Tier II |
20 | NC_000015.10 | 15 | 45785912 | + | LOC105370802 | NNNAATATTATTGAATACAA | NGG | 2 | 0.8235 | Tier III |
21 | NC_000005.10 | 5 | 132632203 | - | TH2LCRR | NNNAATATTATTAAGTACAA | NGG | 2 | 0.8077 | Tier III |
22 | NC_000002.12 | 2 | 4138202 | + | LOC107985841 | NNNAATACTATAAAGTACAA | NGG | 2 | 0.7385 | Tier III |
23 | NC_000006.12 | 6 | 91725072 | - | LOC105377894 | NNNAATACTATTGAGAACAT | NGG | 2 | 0.5455 | Tier III |
24 | NC_000002.12 | 2 | 167910469 | + | B3GALT1-AS1 | NNNAATACTAAGGAGTACAA | NGG | 2 | 0.375 | Tier III |
25 | NC_000015.10 | 15 | 53524243 | + | LOC105370826 | NNNGATACTGTTGAGTACAA | NGG | 2 | 0.3472 | Tier III |
26 | NC_000012.12 | 12 | 16832835 | + | LOC105369677 | NNNAATAATATTGTGTACAA | NGG | 2 | 0.3467 | Tier III |
27 | NC_000002.12 | 2 | 40556630 | - | LOC101929667 | NNNAATACTATAGAGGACAA | NGG | 2 | 0.2769 | Tier III |
28 | NC_000008.11 | 8 | 118369850 | + | LOC105375724 | NNNAATACTATTGAGGACAT | NGG | 2 | 0.2077 | Tier III |
29 | NC_000016.10 | 16 | 72585860 | + | LINC01572 | NNNAATACTATTCAGGACAA | NGG | 2 | 0.1457 | Tier III |
30 | NC_000006.12 | 6 | 114292165 | - | HDAC2-AS2 | NNNAATACTATTGTCTACAA | NGG | 2 | 0.1455 | Tier III |
31 | NC_000006.12 | 6 | 8288482 | + | LOC105374911 | NNNAATACTAATGAGTGCAA | NGG | 2 | 0.1324 | Tier III |
32 | NC_000002.12 | 2 | 101309628 | + | LOC105373512 | NNNATTACTATTGAGTACAA | NAG | 2 | 0.0943 | Tier III |
33 | NC_000008.11 | 8 | 95620065 | + | CFAP418-AS1 | NNNAATACTATTGACTACAA | NAG | 2 | 0.0707 | Tier III |
34 | NC_000008.11 | 8 | 5851677 | + | LOC107986908 | NNNAAAACTATTGAGTACAA | NGT | 2 | 0.014 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000078.6 | 12 | 46717647 | + | Nova1 | NNNAATACTATCAAGTACAA | NGG | 2 | 0.8745 | Tier II |
2 | NC_000069.6 | 3 | 37444069 | - | Spata5 | NNNTACACTATTGAGTACAA | NGG | 2 | 0.5785 | Tier II |
3 | NC_000072.6 | 6 | 106331526 | + | Cntn4 | NNNAATACTGTTAAGTACAA | NGG | 2 | 0.5128 | Tier II |
4 | NC_000069.6 | 3 | 69114839 | - | Kpna4 | NNNTATAGTATTGAGTACAA | NGG | 2 | 0.4091 | Tier II |
5 | NC_000069.6 | 3 | 158472418 | + | Lrrc7 | NNNAATACTATTCAATACAA | NGG | 2 | 0.3963 | Tier II |
6 | NC_000083.6 | 17 | 74678112 | - | Birc6 | NNNAACACTCTTGAGTACAA | NGG | 2 | 0.303 | Tier II |
7 | NC_000085.6 | 19 | 11987255 | - | Osbp | NNNAATACTATGGAGTAAAA | NGG | 2 | 0.2692 | Tier II |
8 | NC_000079.6 | 13 | 90939506 | + | Atg10 | NNNTTTACTATTGAGTACAA | NGG | 2 | 0.2314 | Tier II |
9 | NC_000068.7 | 2 | 73877473 | - | Atf2 | NNNATTACTATTGAGTACTA | NGG | 2 | 0.1958 | Tier II |
10 | NC_000081.6 | 15 | 35081753 | + | Stk3 | NNNAATACTATTGAATGCAA | NGG | 2 | 0.1661 | Tier II |
11 | NC_000083.6 | 17 | 72544207 | + | Alk | NNNAATGCTATTGAGTTCAA | NGG | 2 | 0.0941 | Tier II |
12 | NC_000069.6 | 3 | 129817026 | + | Rrh | NNNATTACTATTGAGTACAC | NGG | 2 | 0.0826 | Tier II |
13 | NC_000078.6 | 12 | 57020747 | - | Slc25a21 | NNNAATACTATTGAGTACTA | NTG | 2 | 0.021 | Tier II |
14 | NC_000074.6 | 8 | 116798000 | - | 4930563M20Rik | NNNAAAACTATAGAGTACAA | NGG | 2 | 0.6933 | Tier III |
15 | NC_000081.6 | 15 | 42923291 | + | Gm46505 | NNNAATACTTTTGAGTATAA | NGG | 2 | 0.5672 | Tier III |
16 | NC_000080.6 | 14 | 122405758 | - | Gm5089 | NNNAAAACTATTGAGTGCAA | NGG | 2 | 0.1529 | Tier III |