Construct: sgRNA BRDN0001162456
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- GACCATGGAGCTACATGACA
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- STKLD1 (169436)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000009.12 | 9 | 133400470 | + | STKLD1 | NNNCATGGAGCTACATGACA | NGG | 0 | 1.0 | Tier I |
2 | NC_000006.12 | 6 | 159109435 | + | LOC124901449 | NNNCATGGTGCTACATGAAA | NGG | 2 | 0.2571 | Tier I |
3 | NC_000020.11 | 20 | 32215262 | - | POFUT1 | NNNCATGGAGCTACAGGAAA | NGG | 2 | 0.1484 | Tier I |
4 | NC_000023.11 | X | 34944378 | + | FAM47B | NNNCATGGAGCTAGACGACA | NGG | 2 | 0.0 | Tier I |
5 | NC_000023.11 | X | 34130295 | - | FAM47A | NNNCATGGAGCTAGATGAAA | NGG | 2 | 0.0 | Tier I |
6 | NC_000006.12 | 6 | 4788970 | - | CDYL | NNNCATGTAGCTACAAGACA | NGG | 2 | 0.5682 | Tier II |
7 | NC_000016.10 | 16 | 14104347 | + | MRTFB | NNNCAGGGAGCAACATGACA | NGG | 2 | 0.4571 | Tier II |
8 | NC_000008.11 | 8 | 142846117 | + | GML | NNNCGTGTAGCTACATGACA | NGG | 2 | 0.45 | Tier II |
9 | NC_000017.11 | 17 | 79520113 | - | RBFOX3 | NNNCATGGAGCTGCATGACT | NGG | 2 | 0.3913 | Tier II |
10 | NC_000006.12 | 6 | 159109435 | + | LOC112267968 | NNNCATGGTGCTACATGAAA | NGG | 2 | 0.2571 | Tier II |
11 | NC_000006.12 | 6 | 159109480 | + | LOC112267968 | NNNCATGGTGCTACATGAAA | NGG | 2 | 0.2571 | Tier II |
12 | NC_000006.12 | 6 | 159109480 | + | LOC124901449 | NNNCATGGTGCTACATGAAA | NGG | 2 | 0.2571 | Tier II |
13 | NC_000022.11 | 22 | 20797744 | + | PI4KA | NNNCATGCAGCTACATGGCA | NGG | 2 | 0.2462 | Tier II |
14 | NC_000018.10 | 18 | 53394159 | + | DCC | NNNCATGGAGCCACATGACC | NGG | 2 | 0.2153 | Tier II |
15 | NC_000017.11 | 17 | 14104043 | - | COX10 | NNNCATGGAGGAACATGACA | NGG | 2 | 0.2 | Tier II |
16 | NC_000015.10 | 15 | 28002333 | + | OCA2 | NNNCATGGAGCTACAGGGCA | NGG | 2 | 0.1385 | Tier II |
17 | NC_000011.10 | 11 | 10768570 | - | CTR9 | NNNCATGCAGCTCCATGACA | NGG | 2 | 0.1296 | Tier II |
18 | NC_000022.11 | 22 | 37380890 | - | ELFN2 | NNNCAGGGAGCTCCATGACA | NGG | 2 | 0.1203 | Tier II |
19 | NC_000020.11 | 20 | 19969620 | - | RIN2 | NNNCATGGAGCTCCATGTCA | NGG | 2 | 0.1053 | Tier II |
20 | NC_000003.12 | 3 | 10434703 | - | ATP2B2 | NNNCCTGGAGCTACTTGACA | NGG | 2 | 0.1 | Tier II |
21 | NC_000010.11 | 10 | 866485 | + | LARP4B | NNNCATGGAGCTACATGAGG | NGG | 2 | 0.0956 | Tier II |
22 | NC_000016.10 | 16 | 24266321 | - | CACNG3 | NNNCATGGAGCTAAATGACA | NAG | 2 | 0.0907 | Tier II |
23 | NC_000017.11 | 17 | 74990663 | + | CDR2L | NNNCATGGAGCGACATGAGA | NGG | 2 | 0.0625 | Tier II |
24 | NC_000007.14 | 7 | 148048291 | - | CNTNAP2 | NNNCATGCAGCTACATGACA | NTG | 2 | 0.024 | Tier II |
25 | NC_000019.10 | 19 | 57544213 | + | ZNF550 | NNNCATGGAGCTAAATGACA | NGT | 2 | 0.0056 | Tier II |
26 | NC_000010.11 | 10 | 4399790 | + | LINC00703 | NNNAAAGGAGCTACATGACA | NGG | 2 | 0.7298 | Tier III |
27 | NC_000010.11 | 10 | 4399790 | + | LOC105376372 | NNNAAAGGAGCTACATGACA | NGG | 2 | 0.7298 | Tier III |
28 | NC_000008.11 | 8 | 8462722 | + | LOC107986913 | NNNCATGAAGCTGCATGACA | NGG | 2 | 0.6522 | Tier III |
29 | NC_000017.11 | 17 | 68122199 | - | LINC00674 | NNNCATGAAGCTGCATGACA | NGG | 2 | 0.6522 | Tier III |
30 | NC_000004.12 | 4 | 96399755 | - | LINC02267 | NNNCATGGTGCTACAAGACA | NGG | 2 | 0.5455 | Tier III |
31 | NC_000005.10 | 5 | 54388221 | + | LINC01033 | NNNTATTGAGCTACATGACA | NGG | 2 | 0.4571 | Tier III |
32 | NC_000022.11 | 22 | 37380890 | - | LOC124905114 | NNNCAGGGAGCTCCATGACA | NGG | 2 | 0.1203 | Tier III |
33 | NC_000003.12 | 3 | 178369264 | - | LOC105374235 | NNNCATGGAGGTACATGACA | NAG | 2 | 0.0648 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000069.6 | 3 | 136866888 | - | Ppp3ca | NNNCATGAAGCTACATGACA | NGG | 1 | 1.0 | Tier II |
2 | NC_000073.6 | 7 | 79692796 | + | Ticrr | NNNCACAGAGCTACATGACA | NGG | 2 | 0.9091 | Tier II |
3 | NC_000071.6 | 5 | 93167320 | - | Septin11 | NNNCATGGCACTACATGACA | NGG | 2 | 0.5333 | Tier II |
4 | NC_000085.6 | 19 | 39535170 | - | Cyp2c39 | NNNCATGGAGCTACATGATA | NGG | 1 | 0.4615 | Tier II |
5 | NC_000083.6 | 17 | 28875864 | - | Pnpla1 | NNNCCTGGAGCTATATGACA | NGG | 2 | 0.3667 | Tier II |
6 | NC_000074.6 | 8 | 87788396 | + | Zfp423 | NNNCATGGAGCTACAAGGCA | NGG | 2 | 0.3636 | Tier II |
7 | NC_000076.6 | 10 | 28523001 | - | Ptprk | NNNCATGGAGCTACATGATG | NGG | 2 | 0.3529 | Tier II |
8 | NC_000084.6 | 18 | 64653898 | + | Atp8b1 | NNNCATGGAGCTACAGAACA | NGG | 2 | 0.3231 | Tier II |
9 | NC_000068.7 | 2 | 20233890 | + | Etl4 | NNNCATGGAGGTACATGACA | NGG | 1 | 0.25 | Tier II |
10 | NC_000076.6 | 10 | 9325932 | - | Samd5 | NNNCATGGGGCTAAATGACA | NGG | 2 | 0.2333 | Tier II |
11 | NC_000081.6 | 15 | 91418659 | - | Slc2a13 | NNNCATGGAGCTACTTGACA | NGG | 1 | 0.2 | Tier II |
12 | NC_000074.6 | 8 | 109814421 | - | Ap1g1 | NNNCATGGAGCTACATGCCA | NGG | 1 | 0.1905 | Tier II |
13 | NC_000070.6 | 4 | 103705166 | + | Dab1 | NNNCATGGAGCTACATGGAA | NGG | 2 | 0.1714 | Tier II |
14 | NC_000072.6 | 6 | 141336664 | - | Pde3a | NNNCATTGAGCTTCATGACA | NGG | 2 | 0.1714 | Tier II |
15 | NC_000083.6 | 17 | 73205334 | + | Lclat1 | NNNCATGGAGCTACGTGACA | NAG | 2 | 0.1685 | Tier II |
16 | NC_000071.6 | 5 | 112831032 | - | Myo18b | NNNCTTGGACCTACATGACA | NGG | 2 | 0.1455 | Tier II |
17 | NC_000068.7 | 2 | 125388869 | + | Fbn1 | NNNCATGGAGCTACTTGTCA | NGG | 2 | 0.1 | Tier II |
18 | NC_000086.7 | X | 73003754 | - | Zfp185 | NNNCATGGAGGTACATGGCA | NGG | 2 | 0.1 | Tier II |
19 | NC_000068.7 | 2 | 114653129 | - | Dph6 | NNNGATGGAGCTACATGAGA | NGG | 2 | 0.0625 | Tier II |
20 | NC_000083.6 | 17 | 24756291 | + | Hs3st6 | NNNCATGGAGCTACTTGACA | NAG | 2 | 0.0519 | Tier II |
21 | NC_000067.6 | 1 | 115721184 | + | Cntnap5a | NNNCATGGAGCTACATGCCA | NAG | 2 | 0.0494 | Tier II |
22 | NC_000076.6 | 10 | 85411171 | + | Btbd11 | NNNCATGGAGCTACATGATA | NGA | 2 | 0.0321 | Tier II |
23 | NC_000083.6 | 17 | 6550579 | + | Gm29721 | NNNCATGGAGCTACATGGCA | NGA | 2 | 0.0278 | Tier II |
24 | NC_000083.6 | 17 | 6700610 | - | Sytl3 | NNNCATGGAGCTACATGGCA | NGA | 2 | 0.0278 | Tier II |
25 | NC_000084.6 | 18 | 44386834 | - | Dcp2 | NNNCAAGGAGCTACATGACA | NGT | 2 | 0.014 | Tier II |
26 | NC_000079.6 | 13 | 70240202 | + | 4930520P13Rik | NNNCATGGAGCCACAAGACA | NGG | 2 | 0.8612 | Tier III |
27 | NC_000075.6 | 9 | 115656373 | - | Gm39448 | NNNCAAGGAGCCACATGACA | NGG | 2 | 0.8211 | Tier III |
28 | NC_000069.6 | 3 | 135475883 | - | Gm30992 | NNNCATGGAGCTGCATGATA | NGG | 2 | 0.301 | Tier III |
29 | NC_000074.6 | 8 | 127636298 | - | Gm32478 | NNNAATGGAGCTACTTGACA | NGG | 2 | 0.1684 | Tier III |
30 | NC_000083.6 | 17 | 6383699 | + | Gm29719 | NNNCATGGAGCTACATGGCA | NGA | 2 | 0.0278 | Tier III |