Construct: sgRNA BRDN0001487042
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- CGGCACTAGAAGTTTTTGAA
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- NO_SITE control
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000007.14 | 7 | 106868423 | - | PIK3CG | NNNCACTGGAAGTTTTTGAT | NGG | 2 | 0.44 | Tier I |
2 | NC_000006.12 | 6 | 53900918 | + | LRRC1 | NNNCAAAAGAAGTTTTTGAA | NGG | 2 | 0.8125 | Tier II |
3 | NC_000012.12 | 12 | 26604381 | - | ITPR2 | NNNCACTGGAAATTTTTGAA | NGG | 2 | 0.6844 | Tier II |
4 | NC_000003.12 | 3 | 63376365 | - | SYNPR | NNNCATTAGAGGTTTTTGAA | NGG | 2 | 0.6036 | Tier II |
5 | NC_000004.12 | 4 | 184769212 | + | ACSL1 | NNNAACTAGAAGTTTCTGAA | NGG | 2 | 0.5614 | Tier II |
6 | NC_000004.12 | 4 | 169462593 | + | NEK1 | NNNCACTAGAAGCTTTTTAA | NGG | 2 | 0.5263 | Tier II |
7 | NC_000011.10 | 11 | 106847712 | + | GUCY1A2 | NNNCCCTAGAAATTTTTGAA | NGG | 2 | 0.4667 | Tier II |
8 | NC_000003.12 | 3 | 169179633 | + | MECOM | NNNCACTAAAAGTTTTTAAA | NGG | 2 | 0.4451 | Tier II |
9 | NC_000013.11 | 13 | 30580194 | - | HMGB1 | NNNCACTAGAACTTTTTAAA | NGG | 2 | 0.3665 | Tier II |
10 | NC_000023.11 | X | 138697653 | + | FGF13 | NNNAACTAGAATTTTTTGAA | NGG | 2 | 0.3239 | Tier II |
11 | NC_000001.11 | 1 | 169531795 | - | F5 | NNNCACTAGAAGTTATAGAA | NGG | 2 | 0.3088 | Tier II |
12 | NC_000017.11 | 17 | 48790609 | + | TTLL6 | NNNTTCTAGAAGTTTTTGAA | NGG | 2 | 0.2909 | Tier II |
13 | NC_000007.14 | 7 | 21605561 | - | DNAH11 | NNNGACTAGGAGTTTTTGAA | NGG | 2 | 0.2778 | Tier II |
14 | NC_000013.11 | 13 | 40583313 | + | FOXO1 | NNNCACTAGAATTTTCTGAA | NGG | 2 | 0.2564 | Tier II |
15 | NC_000006.12 | 6 | 20812946 | + | CDKAL1 | NNNCACTAGCAGTTTTTGAG | NGG | 2 | 0.2549 | Tier II |
16 | NC_000006.12 | 6 | 106248346 | + | ATG5 | NNNCTCTAGAAGTTTCTGAA | NGG | 2 | 0.2424 | Tier II |
17 | NC_000003.12 | 3 | 186985485 | + | ST6GAL1 | NNNCTCTAAAAGTTTTTGAA | NGG | 2 | 0.2338 | Tier II |
18 | NC_000002.12 | 2 | 26280358 | - | HADHB | NNNCAATAGAAGTTTTTGAC | NGG | 2 | 0.211 | Tier II |
19 | NC_000012.12 | 12 | 42496422 | + | PRICKLE1 | NNNCCCTAGAATTTTTTGAA | NGG | 2 | 0.1923 | Tier II |
20 | NC_000013.11 | 13 | 35398784 | + | NBEA | NNNCCCTAGAATTTTTTGAA | NGG | 2 | 0.1923 | Tier II |
21 | NC_000005.10 | 5 | 115599909 | + | TICAM2 | NNNCACCAGAAGGTTTTGAA | NGG | 2 | 0.1793 | Tier II |
22 | NC_000005.10 | 5 | 115599909 | + | TMED7-TICAM2 | NNNCACCAGAAGGTTTTGAA | NGG | 2 | 0.1793 | Tier II |
23 | NC_000021.9 | 21 | 43513045 | - | HSF2BP | NNNCACTAGAATTTTTTGGA | NGG | 2 | 0.1442 | Tier II |
24 | NC_000016.10 | 16 | 70314813 | - | DDX19B | NNNCACTAGAAGTTTTTGTA | NAG | 2 | 0.1396 | Tier II |
25 | NC_000023.11 | X | 12643524 | + | FRMPD4 | NNNCATTAGAAGTTTTTGAA | NGA | 2 | 0.0645 | Tier II |
26 | NC_000004.12 | 4 | 102289146 | - | SLC39A8 | NNNCCCTAGAAGTTTTGGAA | NGG | 2 | 0.0588 | Tier II |
27 | NC_000010.11 | 10 | 102513785 | - | SUFU | NNNCACTAGAAGTTTTTGAA | NTA | 2 | 0.0 | Tier II |
28 | NC_000001.11 | 1 | 23103534 | - | LUZP1 | NNNCATTAGAAGTGTTTGAA | NGG | 2 | 0.0 | Tier II |
29 | NC_000008.11 | 8 | 10476195 | - | LINC03022 | NNNTAATAGAAGTTTTTGAA | NGG | 2 | 0.7429 | Tier III |
30 | NC_000008.11 | 8 | 10476195 | - | LOC124901887 | NNNTAATAGAAGTTTTTGAA | NGG | 2 | 0.7429 | Tier III |
31 | NC_000011.10 | 11 | 56620350 | - | OR5AM1P | NNNCACTATAAATTTTTGAA | NGG | 2 | 0.4978 | Tier III |
32 | NC_000003.12 | 3 | 117038744 | - | LOC124909415 | NNNCACTTGAAGTTTTTGAA | NGG | 1 | 0.4286 | Tier III |
33 | NC_000003.12 | 3 | 186985485 | + | LOC124906314 | NNNCTCTAAAAGTTTTTGAA | NGG | 2 | 0.2338 | Tier III |
34 | NC_000003.12 | 3 | 70075664 | - | SAMMSON | NNNCACTAGTAGGTTTTGAA | NGG | 2 | 0.2302 | Tier III |
35 | NC_000018.10 | 18 | 64896879 | + | LOC101927404 | NNNCACTAGGATTTTTTGAA | NGG | 2 | 0.2137 | Tier III |
36 | NC_000018.10 | 18 | 64896879 | + | LOC107985178 | NNNCACTAGGATTTTTTGAA | NGG | 2 | 0.2137 | Tier III |
37 | NC_000006.12 | 6 | 97372965 | - | LOC101927314 | NNNCCCTAGAATTTTTTGAA | NGG | 2 | 0.1923 | Tier III |
38 | NC_000022.11 | 22 | 34813339 | - | LINC02885 | NNNCACTAGAAGTTTCTGCA | NGG | 2 | 0.1379 | Tier III |
39 | NC_000002.12 | 2 | 37719882 | + | LOC105374465 | NNNCACTTGATGTTTTTGAA | NGG | 2 | 0.1319 | Tier III |
40 | NC_000014.9 | 14 | 44228831 | - | LINC02307 | NNNCACTAGAAGTTTTTGAA | NTT | 2 | 0.0 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000073.6 | 7 | 50187082 | + | Nell1 | NNNAACAAGAAGTTTTTGAA | NGG | 2 | 0.7368 | Tier II |
2 | NC_000076.6 | 10 | 90193893 | + | Anks1b | NNNAACTAGAAGCTTTTGAA | NGG | 2 | 0.6648 | Tier II |
3 | NC_000082.6 | 16 | 45816509 | - | Phldb2 | NNNAACTAGAAGTTTTTTAA | NGG | 2 | 0.5614 | Tier II |
4 | NC_000068.7 | 2 | 142387098 | + | Macrod2 | NNNCACTAGAAGTTTTAGAA | NGG | 1 | 0.5333 | Tier II |
5 | NC_000071.6 | 5 | 98622882 | + | Cfap299 | NNNCACTGGAAGTTTTCGAA | NGG | 2 | 0.5176 | Tier II |
6 | NC_000076.6 | 10 | 110401935 | - | Nav3 | NNNCACTGGAAGTTTTTAAA | NGG | 2 | 0.5077 | Tier II |
7 | NC_000072.6 | 6 | 66916168 | + | Gng12 | NNNCACTAGTACTTTTTGAA | NGG | 2 | 0.4671 | Tier II |
8 | NC_000072.6 | 6 | 146865993 | + | Smco2 | NNNCACTAGAAGATTTTTAA | NGG | 2 | 0.4615 | Tier II |
9 | NC_000075.6 | 9 | 80456569 | + | Impg1 | NNNCACTGGAACTTTTTGAA | NGG | 2 | 0.3882 | Tier II |
10 | NC_000073.6 | 7 | 82709716 | - | Efl1 | NNNCACTTGAAGTTTTTAAA | NGG | 2 | 0.2967 | Tier II |
11 | NC_000069.6 | 3 | 98384915 | - | Zfp697 | NNNCACTAGAAATTCTTGAA | NGG | 2 | 0.2545 | Tier II |
12 | NC_000077.6 | 11 | 86948631 | + | Ypel2 | NNNCACTAAATGTTTTTGAA | NGG | 2 | 0.1978 | Tier II |
13 | NC_000075.6 | 9 | 82950840 | + | Phip | NNNGACTAGAAGTCTTTGAA | NGG | 2 | 0.1429 | Tier II |
14 | NC_000067.6 | 1 | 134593826 | - | Kdm5b | NNNCACTAGAAGTTTTTGTA | NAG | 2 | 0.1396 | Tier II |
15 | NC_000071.6 | 5 | 35944709 | - | Afap1 | NNNCACTAGAAGTCTTTGAA | NGA | 2 | 0.0198 | Tier II |
16 | NC_000071.6 | 5 | 128174322 | + | Tmem132d | NNNGACTAGAAGTTTTTGAA | NTG | 2 | 0.0195 | Tier II |
17 | NC_000072.6 | 6 | 66916168 | + | 4930597O21Rik | NNNCACTAGTACTTTTTGAA | NGG | 2 | 0.4671 | Tier III |
18 | NC_000072.6 | 6 | 55556719 | - | Gm34441 | NNNCACTAGAAGTCTTTGGA | NGG | 2 | 0.1071 | Tier III |