Construct: sgRNA BRDN0001487084
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- GGCACGAGTAGAGAGCAAGA
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- PCK2 (5106)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 78082
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000014.9 |
14 |
24098250 |
+ |
PCK2 |
NNNACGAGTAGAGAGCAAGA |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000014.9 |
14 |
24098250 |
+ |
NRL |
NNNACGAGTAGAGAGCAAGA |
NGG |
0 |
1.0 |
Tier II |
3 |
NC_000013.11 |
13 |
71648414 |
+ |
DACH1 |
NNNACGAGAAGAGAGAAAGA |
NGG |
2 |
0.9286 |
Tier II |
4 |
NC_000001.11 |
1 |
107956243 |
+ |
VAV3 |
NNNACGAGTTGAGAGAAAGA |
NGG |
2 |
0.8824 |
Tier II |
5 |
NC_000001.11 |
1 |
203769910 |
+ |
LAX1 |
NNNACGAGTAGGGAACAAGA |
NGG |
2 |
0.6797 |
Tier II |
6 |
NC_000012.12 |
12 |
18387127 |
- |
PIK3C2G |
NNNATGAGTAGAGAGAAAGA |
NGG |
2 |
0.6364 |
Tier II |
7 |
NC_000001.11 |
1 |
215865568 |
+ |
USH2A |
NNNTGGAGTAGAGAGCAAGA |
NGG |
2 |
0.3818 |
Tier II |
8 |
NC_000012.12 |
12 |
125108324 |
- |
AACS |
NNNACGAGGACAGAGCAAGA |
NGG |
2 |
0.2653 |
Tier II |
9 |
NC_000005.10 |
5 |
11427208 |
+ |
CTNND2 |
NNNACGAGTTGAGAGCAAGA |
NAG |
2 |
0.2288 |
Tier II |
10 |
NC_000002.12 |
2 |
201442109 |
+ |
TRAK2 |
NNNACGAGCAGAGAGCAAGC |
NGG |
2 |
0.2098 |
Tier II |
11 |
NC_000014.9 |
14 |
33310452 |
+ |
NPAS3 |
NNNATGAGTAGAGAGCAAGA |
NAG |
2 |
0.165 |
Tier II |
12 |
NC_000020.11 |
20 |
34735031 |
+ |
NCOA6 |
NNNACAAGTAGAGATCAAGA |
NGG |
2 |
0.1429 |
Tier II |
13 |
NC_000003.12 |
3 |
170424506 |
- |
CLDN11 |
NNNACGAGAAGAGAGCTAGA |
NGG |
2 |
0.1238 |
Tier II |
14 |
NC_000016.10 |
16 |
24292626 |
- |
CACNG3 |
NNNAGGAGTAGAGAGGAAGA |
NGG |
2 |
0.0923 |
Tier II |
15 |
NC_000012.12 |
12 |
66746597 |
- |
GRIP1 |
NNNACGAGTAGAGAGCAACA |
NGA |
2 |
0.0311 |
Tier II |
16 |
NC_000011.10 |
11 |
30745489 |
- |
LOC101928338 |
NNNACCAGTAAAGAGCAAGA |
NGG |
2 |
0.6818 |
Tier III |
17 |
NC_000009.12 |
9 |
26798532 |
- |
LOC107987028 |
NNNAGGAGTAGAAAGCAAGA |
NGG |
2 |
0.5538 |
Tier III |
18 |
NC_000001.11 |
1 |
71193383 |
+ |
ZRANB2-DT |
NNNAAGAGTAGAGAGCCAGA |
NGG |
2 |
0.1008 |
Tier III |
19 |
NC_000001.11 |
1 |
56043645 |
- |
LOC105378737 |
NNNACGAGTAGAGAGGCAGA |
NGG |
2 |
0.0271 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000080.6 |
14 |
55543636 |
+ |
Pck2 |
NNNACGGGTAGAAAGCAAGA |
NGG |
2 |
0.6516 |
Tier I |
2 |
NC_000070.6 |
4 |
63471853 |
- |
Whrn |
NNNACAAGGAGAGAGCAAGA |
NGG |
2 |
0.619 |
Tier II |
3 |
NC_000067.6 |
1 |
133417233 |
+ |
Sox13 |
NNNAGGAGCAGAGAGCAAGA |
NGG |
2 |
0.5538 |
Tier II |
4 |
NC_000085.6 |
19 |
8826962 |
+ |
Hnrnpul2 |
NNNATGAGTAGAGAGCAAGG |
NGG |
2 |
0.4866 |
Tier II |
5 |
NC_000086.7 |
X |
16803487 |
+ |
Maob |
NNNATGAGGAGAGAGCAAGA |
NGG |
2 |
0.3939 |
Tier II |
6 |
NC_000076.6 |
10 |
40781002 |
+ |
Mettl24 |
NNNAGGAGGAGAGAGCAAGA |
NGG |
2 |
0.3714 |
Tier II |
7 |
NC_000067.6 |
1 |
55287128 |
- |
Boll |
NNNTAGAGTAGAGAGCAAGA |
NGG |
2 |
0.3636 |
Tier II |
8 |
NC_000071.6 |
5 |
108521474 |
- |
Cplx1 |
NNNAAGAGGAGAGAGCAAGA |
NGG |
2 |
0.3537 |
Tier II |
9 |
NC_000072.6 |
6 |
129565325 |
- |
Klre1 |
NNNAAGAGGAGAGAGCAAGA |
NGG |
2 |
0.3537 |
Tier II |
10 |
NC_000077.6 |
11 |
81208959 |
- |
Asic2 |
NNNACCTGTAGAGAGCAAGA |
NGG |
2 |
0.2983 |
Tier II |
11 |
NC_000082.6 |
16 |
74334183 |
- |
Robo2 |
NNNATGTGTAGAGAGCAAGA |
NGG |
2 |
0.2784 |
Tier II |
12 |
NC_000072.6 |
6 |
105726357 |
+ |
Cntn4 |
NNNAAGAGTAGAGAGCAACA |
NGG |
2 |
0.2562 |
Tier II |
13 |
NC_000075.6 |
9 |
7119770 |
- |
Dync2h1 |
NNNAAGAGTAGAGAGTAAGA |
NGG |
2 |
0.1758 |
Tier II |
14 |
NC_000070.6 |
4 |
96324501 |
- |
Cyp2j11 |
NNNAGGAGTAGAGAGCAAGA |
NAG |
2 |
0.1556 |
Tier II |
15 |
NC_000069.6 |
3 |
86431439 |
- |
Lrba |
NNNAAGAGTAGAGAGCAAGA |
NAG |
2 |
0.1481 |
Tier II |
16 |
NC_000075.6 |
9 |
44834146 |
+ |
Kmt2a |
NNNACGAGGAGAGAGCCAGA |
NGG |
2 |
0.1092 |
Tier II |
17 |
NC_000072.6 |
6 |
145073892 |
- |
Bcat1 |
NNNACCAGTAGAGAGGAAGA |
NGG |
2 |
0.1049 |
Tier II |
18 |
NC_000074.6 |
8 |
14131708 |
+ |
Dlgap2 |
NNNAGGAGTAGAGAGCAAGA |
NGT |
2 |
0.0097 |
Tier II |
19 |
NC_000075.6 |
9 |
96578184 |
- |
Rasa2 |
NNNAGGAGTAGAGAGCAAGA |
NGT |
2 |
0.0097 |
Tier II |
20 |
NC_000081.6 |
15 |
93689348 |
- |
Gm41387 |
NNNACAAGTATAGAGCAAGA |
NGG |
2 |
0.3846 |
Tier III |
21 |
NC_000079.6 |
13 |
56405911 |
- |
Gm46418 |
NNNACGAGGCGAGAGCAAGA |
NGG |
2 |
0.2063 |
Tier III |
Other clones with same target sequence:
(none)