Construct: sgRNA BRDN0001145445
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- AGGGCTAATGCACAGAACAG
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- MYO3B (140469)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 75569
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000002.12 |
2 |
170401490 |
- |
MYO3B |
NNNGCTAATGCACAGAACAG |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000010.11 |
10 |
88965610 |
+ |
ACTA2 |
NNNGCCAATGCACAGAACAG |
NGG |
1 |
0.9091 |
Tier II |
3 |
NC_000010.11 |
10 |
88965610 |
+ |
FAS |
NNNGCCAATGCACAGAACAG |
NGG |
1 |
0.9091 |
Tier II |
4 |
NC_000013.11 |
13 |
113127889 |
+ |
F10 |
NNNGCCAAAGCACAGAACAG |
NGG |
2 |
0.8442 |
Tier II |
5 |
NC_000008.11 |
8 |
36932133 |
- |
KCNU1 |
NNNGCTAATGCACAGAACAT |
NGG |
1 |
0.7 |
Tier II |
6 |
NC_000002.12 |
2 |
127703353 |
- |
WDR33 |
NNNGCCAATGCACAGAAAAG |
NGG |
2 |
0.4895 |
Tier II |
7 |
NC_000002.12 |
2 |
127703353 |
- |
SFT2D3 |
NNNGCCAATGCACAGAAAAG |
NGG |
2 |
0.4895 |
Tier II |
8 |
NC_000004.12 |
4 |
153257533 |
- |
TRIM2 |
NNNGTTCATGCACAGAACAG |
NGG |
2 |
0.2784 |
Tier II |
9 |
NC_000015.10 |
15 |
89270237 |
- |
FANCI |
NNNTGTAATGCACAGAACAG |
NGG |
2 |
0.2182 |
Tier II |
10 |
NC_000011.10 |
11 |
68924747 |
- |
IGHMBP2 |
NNNTCTAATCCACAGAACAG |
NGG |
2 |
0.1455 |
Tier II |
11 |
NC_000013.11 |
13 |
77010873 |
+ |
FBXL3 |
NNNTCTAATGTACAGAACAG |
NGG |
2 |
0.1119 |
Tier II |
12 |
NC_000012.12 |
12 |
41434284 |
- |
PDZRN4 |
NNNGCGAATGCAGAGAACAG |
NGG |
2 |
0.0779 |
Tier II |
13 |
NC_000010.11 |
10 |
113091889 |
- |
TCF7L2 |
NNNGCTAATGCAGAGAAAAG |
NGG |
2 |
0.0734 |
Tier II |
14 |
NC_000019.10 |
19 |
18474772 |
+ |
ELL |
NNNGCTACTGCAGAGAACAG |
NGG |
2 |
0.0584 |
Tier II |
15 |
NC_000006.12 |
6 |
150230822 |
+ |
PPP1R14C |
NNNGGTAATGCACAGAACAG |
NGA |
2 |
0.0417 |
Tier II |
16 |
NC_000001.11 |
1 |
205012112 |
- |
NFASC |
NNNGCTAGTGCACAGCACAG |
NGG |
2 |
0.0 |
Tier II |
17 |
NC_000013.11 |
13 |
27853359 |
- |
PLUT |
NNNGCTGATGCACAGAACAG |
NCG |
2 |
0.0756 |
Tier III |
18 |
NC_000018.10 |
18 |
35464124 |
+ |
ZNF24TR |
NNNTCTAATGCACAGACCAG |
NGG |
2 |
0.0642 |
Tier III |
19 |
NC_000006.12 |
6 |
134442785 |
- |
LINC01010 |
NNNGCTAATGCAAAGAAGAG |
NGG |
2 |
0.0513 |
Tier III |
20 |
NC_000006.12 |
6 |
134442785 |
- |
CT69 |
NNNGCTAATGCAAAGAAGAG |
NGG |
2 |
0.0513 |
Tier III |
21 |
NC_000010.11 |
10 |
36055332 |
- |
LOC107984222 |
NNNGCTAATGCCCAGGACAG |
NGG |
2 |
0.0506 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000067.6 |
1 |
40629452 |
- |
Slc9a4 |
NNNGCTACTGCATAGAACAG |
NGG |
2 |
0.3 |
Tier I |
2 |
NC_000083.6 |
17 |
37009981 |
+ |
Zfp57 |
NNNGCTAAGGCACGGAACAG |
NGG |
2 |
0.2889 |
Tier I |
3 |
NC_000077.6 |
11 |
105412999 |
+ |
Marchf10 |
NNNGCCAGTGCACAGAACAG |
NGG |
2 |
0.6667 |
Tier II |
4 |
NC_000070.6 |
4 |
99729654 |
- |
Alg6 |
NNNGGTAATGCACAGAACAA |
NGG |
2 |
0.5625 |
Tier II |
5 |
NC_000067.6 |
1 |
186669972 |
+ |
Tgfb2 |
NNNGCTAAAGCACAGAAAAG |
NGG |
2 |
0.5 |
Tier II |
6 |
NC_000084.6 |
18 |
35599094 |
- |
Paip2 |
NNNGAAAATGCACAGAACAG |
NGG |
2 |
0.4952 |
Tier II |
7 |
NC_000077.6 |
11 |
70395616 |
+ |
Pelp1 |
NNNCCCAATGCACAGAACAG |
NGG |
2 |
0.4813 |
Tier II |
8 |
NC_000071.6 |
5 |
136830309 |
+ |
Col26a1 |
NNNGCTCATACACAGAACAG |
NGG |
2 |
0.4083 |
Tier II |
9 |
NC_000067.6 |
1 |
171154752 |
- |
Mpz |
NNNGCCAATGCACAGAACGG |
NGG |
2 |
0.3409 |
Tier II |
10 |
NC_000071.6 |
5 |
23945032 |
- |
Fam126a |
NNNGCTATTCCACAGAACAG |
NGG |
2 |
0.1714 |
Tier II |
11 |
NC_000077.6 |
11 |
57151476 |
+ |
Gria1 |
NNNGCTCATGCTCAGAACAG |
NGG |
2 |
0.1458 |
Tier II |
12 |
NC_000072.6 |
6 |
97436539 |
- |
Frmd4b |
NNNGCTAATGCCCAGAAAAG |
NGG |
2 |
0.1417 |
Tier II |
13 |
NC_000070.6 |
4 |
111277452 |
- |
Agbl4 |
NNNGCTACTGCACAGAACAG |
NAG |
2 |
0.1111 |
Tier II |
14 |
NC_000080.6 |
14 |
29423245 |
+ |
Cacna2d3 |
NNNGCTAATGCAAAGAACAG |
NAG |
2 |
0.0997 |
Tier II |
15 |
NC_000078.6 |
12 |
30245086 |
+ |
Sntg2 |
NNNGCTAATGCAAAGAAGAG |
NGG |
2 |
0.0513 |
Tier II |
16 |
NC_000084.6 |
18 |
38787330 |
- |
Arhgap26 |
NNNGCAAATGCACAGAACAG |
NGT |
2 |
0.014 |
Tier II |
17 |
NC_000078.6 |
12 |
117260294 |
+ |
Ptprn2 |
NNNGCTAGTGCACAGAACAG |
NGT |
2 |
0.0118 |
Tier II |
18 |
NC_000071.6 |
5 |
100862499 |
- |
Gpat3 |
NNNGCTAAGGCACAGCACAG |
NGG |
2 |
0.0 |
Tier II |
19 |
NC_000076.6 |
10 |
110203148 |
- |
Nav3 |
NNNGCTAATGCACAGAACAG |
NCC |
2 |
0.0 |
Tier II |
20 |
NC_000071.6 |
5 |
92689250 |
+ |
Shroom3 |
NNNGCTAATGTACAGCACAG |
NGG |
2 |
0.0 |
Tier II |
21 |
NC_000071.6 |
5 |
136830309 |
+ |
Gm30654 |
NNNGCTCATACACAGAACAG |
NGG |
2 |
0.4083 |
Tier III |
22 |
NC_000074.6 |
8 |
39685221 |
- |
Gm36741 |
NNNACTAATGCACAGAACAG |
NAG |
2 |
0.2333 |
Tier III |
23 |
NC_000072.6 |
6 |
53224741 |
- |
Gm4872 |
NNNGCTAATGCACATAACTG |
NGG |
2 |
0.0769 |
Tier III |
24 |
NC_000067.6 |
1 |
51514528 |
- |
Gm17767 |
NNNGCTAATGCTGAGAACAG |
NGG |
2 |
0.0455 |
Tier III |
25 |
NC_000078.6 |
12 |
117260294 |
+ |
Gm5441 |
NNNGCTAGTGCACAGAACAG |
NGT |
2 |
0.0118 |
Tier III |
26 |
NC_000076.6 |
10 |
110203148 |
- |
LOC115487471 |
NNNGCTAATGCACAGAACAG |
NCC |
2 |
0.0 |
Tier III |
Other clones with same target sequence:
(none)