Construct: sgRNA BRDN0001147231
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- GGAAGCTCAGAAAGCCACGC
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- SH3BP5 (9467)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 76846
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000003.12 |
3 |
15269853 |
- |
SH3BP5 |
NNNAGCTCAGAAAGCCACGC |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000009.12 |
9 |
122553717 |
- |
OR1N2 |
NNNGGCACAGAAAGCCACGC |
NGG |
2 |
0.5469 |
Tier I |
3 |
NC_000016.10 |
16 |
74630782 |
- |
RFWD3 |
NNNAGCTCAGAAAGCCAGGT |
NGG |
2 |
0.04 |
Tier I |
4 |
NC_000009.12 |
9 |
122553717 |
- |
OR1J2 |
NNNGGCACAGAAAGCCACGC |
NGG |
2 |
0.5469 |
Tier II |
5 |
NC_000009.12 |
9 |
122553717 |
- |
OR1L8 |
NNNGGCACAGAAAGCCACGC |
NGG |
2 |
0.5469 |
Tier II |
6 |
NC_000007.14 |
7 |
150959797 |
+ |
KCNH2 |
NNNAGAGCAGAAAGCCACGC |
NGG |
2 |
0.5462 |
Tier II |
7 |
NC_000022.11 |
22 |
43172627 |
+ |
TTLL12 |
NNNAGCACACAAAGCCACGC |
NGG |
2 |
0.35 |
Tier II |
8 |
NC_000020.11 |
20 |
9094848 |
- |
PLCB4 |
NNNAGCTAAGAAAGCCACGA |
NGG |
2 |
0.325 |
Tier II |
9 |
NC_000017.11 |
17 |
8096305 |
+ |
ALOXE3 |
NNNAGCTCAGAAACCCAAGC |
NGG |
2 |
0.2308 |
Tier II |
10 |
NC_000001.11 |
1 |
43999266 |
+ |
SLC6A9 |
NNNAGCCCAGAAAGCCAGGC |
NGG |
2 |
0.0917 |
Tier II |
11 |
NC_000009.12 |
9 |
98118581 |
- |
TRIM14 |
NNNAGCTCAGAAAGCCACAC |
NGA |
2 |
0.0496 |
Tier II |
12 |
NC_000016.10 |
16 |
50618777 |
- |
NKD1 |
NNNAGCTCAGAAAGCCACAC |
NGA |
2 |
0.0496 |
Tier II |
13 |
NC_000016.10 |
16 |
72208010 |
+ |
PMFBP1 |
NNNAGCTCAGATAGCCAGGC |
NGG |
2 |
0.0444 |
Tier II |
14 |
NC_000023.11 |
X |
108339179 |
+ |
COL4A6 |
NNNAGCTCAGAAAGCCAGGC |
NAG |
2 |
0.0346 |
Tier II |
15 |
NC_000008.11 |
8 |
41719301 |
+ |
ANK1 |
NNNAGCTCAGAAAGCCACGC |
NGC |
1 |
0.0222 |
Tier II |
16 |
NC_000011.10 |
11 |
125426948 |
+ |
PKNOX2 |
NNNAGCTCAGAAAGGCACGC |
NAG |
2 |
0.013 |
Tier II |
17 |
NC_000001.11 |
1 |
14927740 |
+ |
KAZN |
NNNAGCTCAGAAAGCCACGT |
NGC |
2 |
0.0067 |
Tier II |
18 |
NC_000012.12 |
12 |
96492308 |
- |
CFAP54 |
NNNAGCTCAGAAAGGCAGGC |
NGG |
2 |
0.0067 |
Tier II |
19 |
NC_000012.12 |
12 |
130504594 |
+ |
RIMBP2 |
NNNAGCTCAGAAAGGCACGC |
NGT |
2 |
0.0008 |
Tier II |
20 |
NC_000022.11 |
22 |
18031831 |
- |
LINC01634 |
NNNAGCCCAGGAAGCCACGC |
NGG |
2 |
0.4469 |
Tier III |
21 |
NC_000009.12 |
9 |
11397640 |
+ |
LOC105375974 |
NNNAGCTCCGAAAGCCACTC |
NGG |
2 |
0.381 |
Tier III |
22 |
NC_000014.9 |
14 |
46334185 |
+ |
LINC00871 |
NNNAGCTCAGAAAGCCTCCC |
NGG |
2 |
0.0598 |
Tier III |
23 |
NC_000016.10 |
16 |
72208010 |
+ |
LOC105371341 |
NNNAGCTCAGATAGCCAGGC |
NGG |
2 |
0.0444 |
Tier III |
24 |
NC_000013.11 |
13 |
105606853 |
+ |
LOC105370345 |
NNNAGCTCAGAAAGCCCCGC |
NGT |
2 |
0.0028 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000068.7 |
2 |
36907453 |
- |
Olfr354 |
NNNAGCACAGAAAGCCACAC |
NGG |
2 |
0.625 |
Tier I |
2 |
NC_000077.6 |
11 |
3367484 |
+ |
Limk2 |
NNNACCTCAGAAAGCCACAC |
NGG |
2 |
0.5612 |
Tier II |
3 |
NC_000071.6 |
5 |
147315522 |
+ |
Urad |
NNNAGATCAGAAAGCCAAGC |
NGG |
2 |
0.5 |
Tier II |
4 |
NC_000085.6 |
19 |
46621774 |
- |
Wbp1l |
NNNAGCCCAGAGAGCCACGC |
NGG |
2 |
0.4965 |
Tier II |
5 |
NC_000079.6 |
13 |
49144683 |
+ |
Wnk2 |
NNNTGCTCAGAGAGCCACGC |
NGG |
2 |
0.4596 |
Tier II |
6 |
NC_000082.6 |
16 |
58459159 |
- |
Dcbld2 |
NNNAGCCCAGAAAGCCATGC |
NGG |
2 |
0.442 |
Tier II |
7 |
NC_000076.6 |
10 |
81049092 |
+ |
Sgta |
NNNAGGACAGAAAGCCACGC |
NGG |
2 |
0.4375 |
Tier II |
8 |
NC_000073.6 |
7 |
27198052 |
+ |
BC024978 |
NNNAGCTCAGGAAGCCAAGC |
NGG |
2 |
0.35 |
Tier II |
9 |
NC_000077.6 |
11 |
96074811 |
+ |
Atp5g1 |
NNNCGCTCAGAAAGCCACGA |
NGG |
2 |
0.1765 |
Tier II |
10 |
NC_000083.6 |
17 |
11330842 |
- |
Prkn |
NNNAGCTCAGGAATCCACGC |
NGG |
2 |
0.1733 |
Tier II |
11 |
NC_000071.6 |
5 |
63920244 |
+ |
Rell1 |
NNNAGCTCAGAAACACACGC |
NGG |
2 |
0.0952 |
Tier II |
12 |
NC_000077.6 |
11 |
115979885 |
+ |
Itgb4 |
NNNAGCTCAGGAAGCCACGC |
NCG |
2 |
0.0696 |
Tier II |
13 |
NC_000068.7 |
2 |
157340082 |
+ |
Ghrh |
NNNAGCTCAGAAAGCCAAGC |
NGA |
2 |
0.0374 |
Tier II |
14 |
NC_000072.6 |
6 |
32499267 |
- |
Plxna4 |
NNNAGCTCAGACAGCCAGGC |
NGG |
2 |
0.0351 |
Tier II |
15 |
NC_000075.6 |
9 |
121037342 |
+ |
Ulk4 |
NNNAGCTCAGAAAGCCAGGC |
NCG |
2 |
0.0143 |
Tier II |
16 |
NC_000085.6 |
19 |
48392675 |
- |
Sorcs3 |
NNNAGCTCAGAAAGGCAGGC |
NGG |
2 |
0.0067 |
Tier II |
17 |
NC_000073.6 |
7 |
124027124 |
+ |
Hs3st4 |
NNNAGCTCAGAAAGGCACGC |
NGC |
2 |
0.0011 |
Tier II |
Other clones with same target sequence:
(none)