Construct: sgRNA BRDN0001148207
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- TCCGAGTTGGAGAACAGGCG
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- AK4 (205)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000001.11 | 1 | 65190804 | + | AK4 | NNNGAGTTGGAGAACAGGCG | NGG | 0 | 1.0 | Tier I |
2 | NC_000022.11 | 22 | 26541118 | + | TPST2 | NNNGAGTTGGGGAACAGGCG | NGA | 2 | 0.0451 | Tier I |
3 | NC_000022.11 | 22 | 45325346 | + | FAM118A | NNNGAGTCGGAGAACAGGCA | NGG | 2 | 0.9375 | Tier II |
4 | NC_000022.11 | 22 | 23278446 | + | BCR | NNNGAGTTGGAGAACAGGCT | NGG | 1 | 0.7 | Tier II |
5 | NC_000008.11 | 8 | 106649011 | + | OXR1 | NNNGAGTTGAAGAACAGGCT | NGG | 2 | 0.6533 | Tier II |
6 | NC_000002.12 | 2 | 232134955 | + | DIS3L2 | NNNGACTTGGAGAACAGGCA | NGG | 2 | 0.6392 | Tier II |
7 | NC_000001.11 | 1 | 83995042 | - | TTLL7 | NNNAAGTTGGAGAACAGGCT | NGG | 2 | 0.63 | Tier II |
8 | NC_000018.10 | 18 | 9708668 | - | RAB31 | NNNGAGGCGGAGAACAGGCG | NGG | 2 | 0.5882 | Tier II |
9 | NC_000007.14 | 7 | 27145596 | + | HOXA3 | NNNAAGTTGGGGAACAGGCG | NGG | 2 | 0.585 | Tier II |
10 | NC_000007.14 | 7 | 27145596 | + | HOXA6 | NNNAAGTTGGGGAACAGGCG | NGG | 2 | 0.585 | Tier II |
11 | NC_000013.11 | 13 | 113990955 | + | RASA3 | NNNGGGCTGGAGAACAGGCG | NGG | 2 | 0.495 | Tier II |
12 | NC_000013.11 | 13 | 113991083 | + | RASA3 | NNNGGGCTGGAGAACAGGCG | NGG | 2 | 0.495 | Tier II |
13 | NC_000013.11 | 13 | 113991211 | + | RASA3 | NNNGGGCTGGAGAACAGGCG | NGG | 2 | 0.495 | Tier II |
14 | NC_000013.11 | 13 | 113991275 | + | RASA3 | NNNGGGCTGGAGAACAGGCG | NGG | 2 | 0.495 | Tier II |
15 | NC_000014.9 | 14 | 54431037 | - | CNIH1 | NNNGAGTTGGAGAACAGACT | NGG | 2 | 0.4846 | Tier II |
16 | NC_000017.11 | 17 | 75342482 | - | GRB2 | NNNGAATTGGAGAACAGCCG | NGG | 2 | 0.4762 | Tier II |
17 | NC_000018.10 | 18 | 46962213 | - | KATNAL2 | NNNGAGGTGGAGAACAGGCT | NGG | 2 | 0.4118 | Tier II |
18 | NC_000018.10 | 18 | 46968140 | - | KATNAL2 | NNNGAGGTGGAGAACAGGCT | NGG | 2 | 0.4118 | Tier II |
19 | NC_000018.10 | 18 | 47021732 | - | KATNAL2 | NNNGAGGTGGAGAACAGGCT | NGG | 2 | 0.4118 | Tier II |
20 | NC_000018.10 | 18 | 47027647 | - | KATNAL2 | NNNGAGGTGGAGAACAGGCT | NGG | 2 | 0.4118 | Tier II |
21 | NC_000001.11 | 1 | 19316593 | - | SLC66A1 | NNNGAGTTCGAGAACAGGCT | NGG | 2 | 0.3769 | Tier II |
22 | NC_000002.12 | 2 | 38904512 | + | ARHGEF33 | NNNGAGTTCGAGAACAGGCT | NGG | 2 | 0.3769 | Tier II |
23 | NC_000016.10 | 16 | 1389392 | + | UNKL | NNNGAGTTCGAGAACAGGCT | NGG | 2 | 0.3769 | Tier II |
24 | NC_000001.11 | 1 | 242190688 | + | PLD5 | NNNGAGTTGGAGATCAGGCT | NGG | 2 | 0.3733 | Tier II |
25 | NC_000008.11 | 8 | 76763429 | + | ZFHX4 | NNNGAGTTGGAGATCAGGCT | NGG | 2 | 0.3733 | Tier II |
26 | NC_000001.11 | 1 | 42535666 | + | CCDC30 | NNNGAGTTTGAGAACAGGCT | NGG | 2 | 0.3733 | Tier II |
27 | NC_000003.12 | 3 | 185651420 | - | IGF2BP2 | NNNGAGTTTGAGAACAGGCT | NGG | 2 | 0.3733 | Tier II |
28 | NC_000020.11 | 20 | 33602020 | - | CBFA2T2 | NNNGAGTTTGAGAACAGGCT | NGG | 2 | 0.3733 | Tier II |
29 | NC_000022.11 | 22 | 37862048 | - | EIF3L | NNNGAGTTTGAGAACAGGCT | NGG | 2 | 0.3733 | Tier II |
30 | NC_000022.11 | 22 | 24516172 | + | UPB1 | NNNGAGTTGGAGATCAGTCG | NGG | 2 | 0.3556 | Tier II |
31 | NC_000001.11 | 1 | 28084821 | - | EYA3 | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
32 | NC_000001.11 | 1 | 99723322 | + | FRRS1 | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
33 | NC_000001.11 | 1 | 151259793 | - | PSMD4 | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
34 | NC_000001.11 | 1 | 156822364 | + | NTRK1 | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
35 | NC_000002.12 | 2 | 69324017 | - | GFPT1 | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
36 | NC_000002.12 | 2 | 128149254 | - | UGGT1 | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
37 | NC_000003.12 | 3 | 31871677 | + | OSBPL10 | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
38 | NC_000003.12 | 3 | 98743232 | - | ST3GAL6 | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
39 | NC_000004.12 | 4 | 1594649 | + | FAM53A | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
40 | NC_000005.10 | 5 | 43309452 | - | HMGCS1 | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
41 | NC_000005.10 | 5 | 135751640 | + | SLC25A48 | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
42 | NC_000007.14 | 7 | 4919375 | + | MMD2 | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
43 | NC_000007.14 | 7 | 99269488 | - | MYH16 | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
44 | NC_000007.14 | 7 | 122876575 | - | CADPS2 | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
45 | NC_000007.14 | 7 | 152772325 | + | ACTR3B | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
46 | NC_000008.11 | 8 | 42962618 | - | HOOK3 | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
47 | NC_000008.11 | 8 | 102327112 | - | UBR5 | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
48 | NC_000009.12 | 9 | 37447963 | + | ZBTB5 | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
49 | NC_000009.12 | 9 | 111551614 | - | PTGR1 | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
50 | NC_000009.12 | 9 | 111551614 | - | ZNF483 | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
51 | NC_000010.11 | 10 | 14581707 | + | FAM107B | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
52 | NC_000010.11 | 10 | 24032459 | - | KIAA1217 | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
53 | NC_000010.11 | 10 | 102130859 | + | PPRC1 | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
54 | NC_000011.10 | 11 | 89920950 | - | TRIM49D1 | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
55 | NC_000013.11 | 13 | 30731581 | - | ALOX5AP | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
56 | NC_000014.9 | 14 | 73446845 | + | NUMB | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
57 | NC_000016.10 | 16 | 3838046 | - | CREBBP | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
58 | NC_000016.10 | 16 | 23349284 | + | SCNN1B | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
59 | NC_000016.10 | 16 | 46593537 | + | SHCBP1 | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
60 | NC_000016.10 | 16 | 56909265 | + | SLC12A3 | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
61 | NC_000017.11 | 17 | 29500119 | + | TAOK1 | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
62 | NC_000019.10 | 19 | 34467274 | + | UBA2 | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
63 | NC_000019.10 | 19 | 35014833 | + | GRAMD1A | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
64 | NC_000019.10 | 19 | 35304752 | - | MAG | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
65 | NC_000019.10 | 19 | 41004795 | + | CYP2B6 | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
66 | NC_000023.11 | X | 41592057 | + | CASK | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
67 | NC_000023.11 | X | 48525591 | - | EBP | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
68 | NC_000002.12 | 2 | 8729958 | + | KIDINS220 | NNNGAGTTGGAGAACAGACC | NGG | 2 | 0.2967 | Tier II |
69 | NC_000015.10 | 15 | 88613486 | + | AEN | NNNGAGCTGGAGAACAGGAG | NGG | 2 | 0.2946 | Tier II |
70 | NC_000005.10 | 5 | 154693037 | - | LARP1 | NNNGAGTTCGAGAACAGCCG | NGG | 2 | 0.2564 | Tier II |
71 | NC_000012.12 | 12 | 123779253 | - | DNAH10 | NNNGAGTTCGAGAACAGCCG | NGG | 2 | 0.2564 | Tier II |
72 | NC_000012.12 | 12 | 62554708 | - | MON2 | NNNGAGTTTGAGAACAGCCG | NGG | 2 | 0.254 | Tier II |
73 | NC_000019.10 | 19 | 17554286 | + | NIBAN3 | NNNGAGTTTGAGAACAGCCG | NGG | 2 | 0.254 | Tier II |
74 | NC_000005.10 | 5 | 128534851 | - | FBN2 | NNNGAGTTGGAGAGCAGCCG | NGG | 2 | 0.2222 | Tier II |
75 | NC_000001.11 | 1 | 31041289 | - | PUM1 | NNNGAGTTGGAGAACAGCTG | NGG | 2 | 0.2198 | Tier II |
76 | NC_000001.11 | 1 | 156764130 | - | HDGF | NNNGAGTTGGAGACCAGGCG | NGG | 1 | 0.2143 | Tier II |
77 | NC_000010.11 | 10 | 48529280 | + | ARHGAP22 | NNNGAGTTGGAGACCAGGCA | NGG | 2 | 0.2009 | Tier II |
78 | NC_000001.11 | 1 | 237209659 | + | RYR2 | NNNGAGTTGGAGACCAGGCT | NGG | 2 | 0.15 | Tier II |
79 | NC_000003.12 | 3 | 55997977 | - | ERC2 | NNNGAGTTGGAGACCAGGCT | NGG | 2 | 0.15 | Tier II |
80 | NC_000004.12 | 4 | 168818404 | + | PALLD | NNNGAGTTGGAGACCAGGCT | NGG | 2 | 0.15 | Tier II |
81 | NC_000005.10 | 5 | 54617774 | - | SNX18 | NNNGAGTTGGAGACCAGGCT | NGG | 2 | 0.15 | Tier II |
82 | NC_000005.10 | 5 | 95936589 | + | ELL2 | NNNGAGTTGGAGACCAGGCT | NGG | 2 | 0.15 | Tier II |
83 | NC_000006.12 | 6 | 32309162 | - | TSBP1 | NNNGAGTTGGAGACCAGGCT | NGG | 2 | 0.15 | Tier II |
84 | NC_000007.14 | 7 | 74513818 | + | GTF2IRD1 | NNNGAGTTGGAGACCAGGCT | NGG | 2 | 0.15 | Tier II |
85 | NC_000008.11 | 8 | 25223527 | - | DOCK5 | NNNGAGTTGGAGACCAGGCT | NGG | 2 | 0.15 | Tier II |
86 | NC_000011.10 | 11 | 47295224 | - | MADD | NNNGAGTTGGAGACCAGGCT | NGG | 2 | 0.15 | Tier II |
87 | NC_000014.9 | 14 | 63687794 | + | SGPP1 | NNNGAGTTGGAGACCAGGCT | NGG | 2 | 0.15 | Tier II |
88 | NC_000015.10 | 15 | 71473270 | - | THSD4 | NNNGAGTTGGAGACCAGGCT | NGG | 2 | 0.15 | Tier II |
89 | NC_000017.11 | 17 | 50672671 | + | ABCC3 | NNNGAGTTGGAGACCAGGCT | NGG | 2 | 0.15 | Tier II |
90 | NC_000020.11 | 20 | 34956861 | + | MYH7B | NNNGAGTTGGAGACCAGGCT | NGG | 2 | 0.15 | Tier II |
91 | NC_000021.9 | 21 | 36358562 | + | MORC3 | NNNGAGTTGGAGACCAGGCT | NGG | 2 | 0.15 | Tier II |
92 | NC_000023.11 | X | 43729690 | - | MAOA | NNNGAGTTGGAGACCAGGCT | NGG | 2 | 0.15 | Tier II |
93 | NC_000023.11 | X | 54618701 | + | GNL3L | NNNGAGTTGGAGACCAGGCT | NGG | 2 | 0.15 | Tier II |
94 | NC_000002.12 | 2 | 39665530 | + | TMEM178A | NNNGAGTTGGAGAAAAGTCG | NGG | 2 | 0.1481 | Tier II |
95 | NC_000003.12 | 3 | 7296861 | - | GRM7 | NNNGAGTTGGAGACCAGTCG | NGG | 2 | 0.1429 | Tier II |
96 | NC_000007.14 | 7 | 101527183 | - | COL26A1 | NNNGAGTTGGAGACCAGTCG | NGG | 2 | 0.1429 | Tier II |
97 | NC_000022.11 | 22 | 17396046 | + | CECR2 | NNNGAGTTGGAGACCAGTCG | NGG | 2 | 0.1429 | Tier II |
98 | NC_000017.11 | 17 | 67117763 | - | HELZ | NNNGAGTTCGAGACCAGGCG | NGG | 2 | 0.1154 | Tier II |
99 | NC_000021.9 | 21 | 39387072 | - | GET1 | NNNGAGTTCGAGACCAGGCG | NGG | 2 | 0.1154 | Tier II |
100 | NC_000021.9 | 21 | 39387072 | - | GET1-SH3BGR | NNNGAGTTCGAGACCAGGCG | NGG | 2 | 0.1154 | Tier II |
101 | NC_000010.11 | 10 | 126645374 | + | C10orf90 | NNNGAGTTTGAGACCAGGCG | NGG | 2 | 0.1143 | Tier II |
102 | NC_000007.14 | 7 | 5705441 | - | RNF216 | NNNGAGTTGGAGAACAGGAG | NAG | 2 | 0.1111 | Tier II |
103 | NC_000019.10 | 19 | 45691734 | - | SNRPD2 | NNNGAGTTTGAGAACGGGCG | NGG | 2 | 0.1026 | Tier II |
104 | NC_000004.12 | 4 | 134090571 | + | PABPC4L | NNNGAGTTGGAGACCAGCCG | NGG | 2 | 0.102 | Tier II |
105 | NC_000005.10 | 5 | 172966374 | - | RPL26L1 | NNNGAGTTGGAGACCAGCCG | NGG | 2 | 0.102 | Tier II |
106 | NC_000007.14 | 7 | 135608514 | + | NUP205 | NNNGAGTTGGAGACCAGCCG | NGG | 2 | 0.102 | Tier II |
107 | NC_000011.10 | 11 | 72042920 | + | NUMA1 | NNNGAGTTGGAGACCAGCCG | NGG | 2 | 0.102 | Tier II |
108 | NC_000013.11 | 13 | 41309401 | - | MTRF1 | NNNGAGTTGGAGACCAGCCG | NGG | 2 | 0.102 | Tier II |
109 | NC_000015.10 | 15 | 99236600 | - | TTC23 | NNNGAGTTGGAGACCAGCCG | NGG | 2 | 0.102 | Tier II |
110 | NC_000017.11 | 17 | 67732786 | - | NOL11 | NNNGAGTTGGAGACCAGCCG | NGG | 2 | 0.102 | Tier II |
111 | NC_000019.10 | 19 | 29819494 | - | CCNE1 | NNNGAGTTGGAGACCAGCCG | NGG | 2 | 0.102 | Tier II |
112 | NC_000022.11 | 22 | 39962230 | + | GRAP2 | NNNGAGTTGGAGACCAGCCG | NGG | 2 | 0.102 | Tier II |
113 | NC_000022.11 | 22 | 39962230 | + | TMA7B | NNNGAGTTGGAGACCAGCCG | NGG | 2 | 0.102 | Tier II |
114 | NC_000023.11 | X | 6202550 | - | NLGN4X | NNNGAGTTGGAGACCAGCCG | NGG | 2 | 0.102 | Tier II |
115 | NC_000023.11 | X | 101463970 | - | ARMCX4 | NNNGAGTTGGAGACCAGCCG | NGG | 2 | 0.102 | Tier II |
116 | NC_000004.12 | 4 | 139319095 | + | NAA15 | NNNGAGTTGGAGACCAGGCC | NGG | 2 | 0.0918 | Tier II |
117 | NC_000012.12 | 12 | 123466848 | - | SNRNP35 | NNNGAGTTGGAGACCAGGCC | NGG | 2 | 0.0918 | Tier II |
118 | NC_000015.10 | 15 | 78210826 | - | ACSBG1 | NNNGAGTTGGAGACCAGGCC | NGG | 2 | 0.0918 | Tier II |
119 | NC_000005.10 | 5 | 67010893 | + | MAST4 | NNNGACTTGGAGAACAGGGG | NGG | 2 | 0.0852 | Tier II |
120 | NC_000017.11 | 17 | 31345758 | + | NF1 | NNNGAGTTGGAGAATAGGCG | NGG | 1 | 0.0667 | Tier II |
121 | NC_000022.11 | 22 | 35836002 | - | RBFOX2 | NNNGAGTTGGAGGATAGGCG | NGG | 2 | 0.0435 | Tier II |
122 | NC_000020.11 | 20 | 35174353 | + | PROCR | NNNGAGATGGAGAACAGGCG | NTG | 2 | 0.0341 | Tier II |
123 | NC_000020.11 | 20 | 35174353 | + | MMP24-AS1-EDEM2 | NNNGAGATGGAGAACAGGCG | NTG | 2 | 0.0341 | Tier II |
124 | NC_000005.10 | 5 | 13774287 | + | DNAH5 | NNNGAGTTGGAGAAAAGGGG | NGG | 2 | 0.0278 | Tier II |
125 | NC_000003.12 | 3 | 105455896 | + | ALCAM | NNNGAGTTGGAGAACAGGCT | NGC | 2 | 0.0156 | Tier II |
126 | NC_000019.10 | 19 | 13298035 | - | CACNA1A | NNNGAGTTGGAGAACAGGCT | NGC | 2 | 0.0156 | Tier II |
127 | NC_000023.11 | X | 72358129 | - | HDAC8 | NNNGAGTTGGAGACCAGGCG | NGA | 2 | 0.0149 | Tier II |
128 | NC_000005.10 | 5 | 168390672 | - | WWC1 | NNNGAGTTAGAGAACAGGCG | NGT | 2 | 0.0104 | Tier II |
129 | NC_000015.10 | 15 | 74327697 | + | CCDC33 | NNNGAGTTGGAGAACAGGAG | NGT | 2 | 0.0069 | Tier II |
130 | NC_000009.12 | 9 | 96110315 | - | LOC158434 | NNNGAGTTGGAGAACAGGCT | NGG | 1 | 0.7 | Tier III |
131 | NC_000008.11 | 8 | 106649011 | + | OXR1-AS1 | NNNGAGTTGAAGAACAGGCT | NGG | 2 | 0.6533 | Tier III |
132 | NC_000018.10 | 18 | 9708668 | - | LOC105371981 | NNNGAGGCGGAGAACAGGCG | NGG | 2 | 0.5882 | Tier III |
133 | NC_000007.14 | 7 | 27145596 | + | HOXA-AS3 | NNNAAGTTGGGGAACAGGCG | NGG | 2 | 0.585 | Tier III |
134 | NC_000003.12 | 3 | 160751571 | + | PPM1L-DT | NNNGAGTTCGAGAACAGGCT | NGG | 2 | 0.3769 | Tier III |
135 | NC_000002.12 | 2 | 78919281 | + | LOC105374822 | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier III |
136 | NC_000002.12 | 2 | 156150416 | + | LINC01876 | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier III |
137 | NC_000008.11 | 8 | 33788190 | - | LOC105379364 | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier III |
138 | NC_000014.9 | 14 | 53883928 | + | LOC107984676 | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier III |
139 | NC_000012.12 | 12 | 123779253 | - | LOC105370044 | NNNGAGTTCGAGAACAGCCG | NGG | 2 | 0.2564 | Tier III |
140 | NC_000001.11 | 1 | 114844612 | - | NR1H5P | NNNGAGTTTGAGAACAGCCG | NGG | 2 | 0.254 | Tier III |
141 | NC_000007.14 | 7 | 118431786 | + | LOC105375471 | NNNGTGTTGGAGAACAGGCC | NGG | 2 | 0.1558 | Tier III |
142 | NC_000006.12 | 6 | 32309162 | - | TSBP1-AS1 | NNNGAGTTGGAGACCAGGCT | NGG | 2 | 0.15 | Tier III |
143 | NC_000016.10 | 16 | 58768782 | - | LOC107984867 | NNNGAGTTGGAGACCAGGCT | NGG | 2 | 0.15 | Tier III |
144 | NC_000006.12 | 6 | 146919957 | - | STXBP5-AS1 | NNNGAGTTGGAGAACAAGGG | NGG | 2 | 0.1167 | Tier III |
145 | NC_000007.14 | 7 | 38328568 | + | TRG | NNNGAGTTGGAGAACAGGAG | NAG | 2 | 0.1111 | Tier III |
146 | NC_000012.12 | 12 | 31616201 | - | AK4P3 | NNNGAGTTGGAGAATAGGCG | NGG | 1 | 0.0667 | Tier III |
147 | NC_000017.11 | 17 | 31345758 | + | AK4P1 | NNNGAGTTGGAGAATAGGCG | NGG | 1 | 0.0667 | Tier III |
148 | NC_000005.10 | 5 | 55552316 | - | AK4P2 | NNNGAGTTGGAGAATAGCCG | NGG | 2 | 0.0317 | Tier III |
149 | NC_000004.12 | 4 | 151027191 | + | AK4P6 | NNNGAGTTGGAGAATAGGTG | NGG | 2 | 0.0308 | Tier III |
150 | NC_000012.12 | 12 | 118131983 | - | LOC101928274 | NNNGAGTTGGAGAACAGGCT | NGC | 2 | 0.0156 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000071.6 | 5 | 112308149 | - | Tpst2 | NNNGAGTTGGGGAACAGGCG | NGC | 2 | 0.0144 | Tier I |
2 | NC_000073.6 | 7 | 101715694 | + | Clpb | NNNGAGTTGGAGAACAGTCA | NGG | 2 | 0.625 | Tier II |
3 | NC_000076.6 | 10 | 26299653 | + | L3mbtl3 | NNNGAGATGGAGAACAGGCT | NGG | 2 | 0.6125 | Tier II |
4 | NC_000076.6 | 10 | 92999433 | + | Cfap54 | NNNGGGTTGGAGAACAGGCT | NGG | 2 | 0.504 | Tier II |
5 | NC_000078.6 | 12 | 85630652 | + | Jdp2 | NNNGAGTTGGAGAACAGTCT | NGG | 2 | 0.4667 | Tier II |
6 | NC_000073.6 | 7 | 112136490 | - | Dkk3 | NNNGAGTTGGAGGACAGGCT | NGG | 2 | 0.4565 | Tier II |
7 | NC_000081.6 | 15 | 99998809 | - | Larp4 | NNNGAGTTGGAGAACAGCCA | NGG | 2 | 0.4464 | Tier II |
8 | NC_000073.6 | 7 | 72119579 | - | Mctp2 | NNNGAGTTTGAGAACAGGCT | NGG | 2 | 0.3733 | Tier II |
9 | NC_000086.7 | X | 85075324 | - | Dmd | NNNGAGTTTGAGAACAGGCT | NGG | 2 | 0.3733 | Tier II |
10 | NC_000077.6 | 11 | 74383790 | + | Rap1gap2 | NNNGAGCTGGAGATCAGGCG | NGG | 2 | 0.3667 | Tier II |
11 | NC_000077.6 | 11 | 29383454 | - | Ccdc88a | NNNGAGTTGGAGAACAGCCT | NGG | 2 | 0.3333 | Tier II |
12 | NC_000070.6 | 4 | 137893728 | - | Ece1 | NNNGAGTGGGAGAACAGGAG | NGG | 2 | 0.3143 | Tier II |
13 | NC_000072.6 | 6 | 28740830 | - | Snd1 | NNNGAGTTGGAGAACAGTCC | NGG | 2 | 0.2857 | Tier II |
14 | NC_000084.6 | 18 | 58206924 | - | Fbn2 | NNNGAGTTGGAGAGCAGCCG | NGG | 2 | 0.2222 | Tier II |
15 | NC_000070.6 | 4 | 21962864 | - | Faxc | NNNGAGTTGGAGAACAGGCT | NAG | 2 | 0.1815 | Tier II |
16 | NC_000079.6 | 13 | 104473238 | + | Adamts6 | NNNGAGTTGGAGAACAGGGA | NGG | 2 | 0.1172 | Tier II |
17 | NC_000086.7 | X | 161112866 | + | Scml2 | NNNGAGTTGGAGAACAGGAG | NAG | 2 | 0.1111 | Tier II |
18 | NC_000074.6 | 8 | 104838807 | - | Ces2b | NNNGAGTTGGAGAAAAGGAG | NGG | 2 | 0.0952 | Tier II |
19 | NC_000081.6 | 15 | 30731604 | + | Ctnnd2 | NNNGAGTGGGAGAACAGGGG | NGG | 2 | 0.0917 | Tier II |
20 | NC_000078.6 | 12 | 37544650 | - | Agmo | NNNGAGTTGGGGAACAGGGG | NGG | 2 | 0.0813 | Tier II |
21 | NC_000078.6 | 12 | 119211105 | - | Itgb8 | NNNGAGTTGGAGAACAGGGG | NTG | 2 | 0.0049 | Tier II |
22 | NC_000078.6 | 12 | 5602026 | - | Gm32398 | NNNGAGTTGGAAAACAAGCG | NGG | 2 | 0.8711 | Tier III |
23 | NC_000069.6 | 3 | 137983532 | - | Gm19708 | NNNGAGGTGGAGAGCAGGCG | NGG | 2 | 0.2745 | Tier III |
24 | NC_000071.6 | 5 | 136927943 | - | 4933404O12Rik | NNNGAGTTCCAGAACAGGCG | NGG | 2 | 0.2154 | Tier III |
25 | NC_000081.6 | 15 | 30731604 | + | Gm41283 | NNNGAGTGGGAGAACAGGGG | NGG | 2 | 0.0917 | Tier III |
26 | NC_000078.6 | 12 | 99031621 | - | Gm40554 | NNNGAGTTGGAGAACAGGGG | NAG | 2 | 0.0324 | Tier III |
27 | NC_000071.6 | 5 | 66664247 | + | Uchl1os | NNNGAGTTGGAGAAGAGGCG | NGC | 2 | 0.0011 | Tier III |