Construct: sgRNA BRDN0001148975
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- AAAGTTTGATTATGTGAGGG
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- SIK2 (23235)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000011.10 | 11 | 111616338 | - | SIK2 | NNNGTTTGATTATGTGAGGG | NGG | 0 | 1.0 | Tier I |
2 | NC_000012.12 | 12 | 100880698 | + | ANO4 | NNNATTTGATTATGTGAGGA | NGG | 2 | 0.8438 | Tier II |
3 | NC_000004.12 | 4 | 70980560 | + | MOB1B | NNNGTTTGATTAAGTAAGGG | NGG | 2 | 0.6923 | Tier II |
4 | NC_000009.12 | 9 | 20207003 | - | SLC24A2 | NNNGTTTAATCATGTGAGGG | NGG | 2 | 0.6667 | Tier II |
5 | NC_000004.12 | 4 | 47910094 | - | NFXL1 | NNNGTTTGTTTATGTGAGAG | NGG | 2 | 0.4286 | Tier II |
6 | NC_000011.10 | 11 | 57234989 | - | APLNR | NNNGTTTCATTATGTGAGTG | NGG | 2 | 0.4103 | Tier II |
7 | NC_000017.11 | 17 | 18128973 | - | MYO15A | NNNGTTTGATTATCTGAGGA | NGG | 2 | 0.4018 | Tier II |
8 | NC_000015.10 | 15 | 65541549 | + | HACD3 | NNNCTTTGATTATGTGATGG | NGG | 2 | 0.3529 | Tier II |
9 | NC_000007.14 | 7 | 159060535 | - | VIPR2 | NNNGTTAGATGATGTGAGGG | NGG | 2 | 0.35 | Tier II |
10 | NC_000004.12 | 4 | 185759435 | + | SORBS2 | NNNGTTTGTGTATGTGAGGG | NGG | 2 | 0.3 | Tier II |
11 | NC_000010.11 | 10 | 86269980 | - | GRID1 | NNNGTTTAATTCTGTGAGGG | NGG | 2 | 0.2632 | Tier II |
12 | NC_000018.10 | 18 | 76873624 | + | ZNF236 | NNNGTGTGATGATGTGAGGG | NGG | 2 | 0.2286 | Tier II |
13 | NC_000023.11 | X | 110212056 | - | AMMECR1 | NNNGTTTGATAATGTGAGGG | NTG | 2 | 0.0292 | Tier II |
14 | NC_000009.12 | 9 | 96816947 | + | ZNF782 | NNNGTTTTATTATGTGAGGG | NTG | 2 | 0.0244 | Tier II |
15 | NC_000003.12 | 3 | 134248438 | - | RYK | NNNGTTTGATTATGTCATGG | NGG | 2 | 0.0 | Tier II |
16 | NC_000012.12 | 12 | 119265053 | - | LOC124903032 | NNNGTTAGATTATGTGAGTG | NGG | 2 | 0.5833 | Tier III |
17 | NC_000005.10 | 5 | 102694150 | - | LOC105379104 | NNNGTGTGAATATGTGAGGG | NGG | 2 | 0.4898 | Tier III |
18 | NC_000006.12 | 6 | 44772989 | - | LOC101929770 | NNNCTTTGATTATGTGATGG | NGG | 2 | 0.3529 | Tier III |
19 | NC_000013.11 | 13 | 41140791 | + | KBTBD6-DT | NNNGTTTGATTATCTGAGTG | NGG | 2 | 0.2857 | Tier III |
20 | NC_000023.11 | X | 128581379 | + | LOC107985698 | NNNGTTGGATTTTGTGAGGG | NGG | 2 | 0.1961 | Tier III |
21 | NC_000004.12 | 4 | 58526906 | + | LINC02494 | NNNGTATGATTATGTGAGGG | NGT | 2 | 0.014 | Tier III |
22 | NC_000007.14 | 7 | 19831964 | - | LOC105379720 | NNNGTTTGATTATGGGTGGG | NGG | 2 | 0.0067 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000081.6 | 15 | 5160730 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGC | 2 | 0.0089 | Tier I |
2 | NC_000083.6 | 17 | 24403264 | - | Abca3 | NNNGTTTGTTTATGTGAGGG | NGG | 1 | 0.6 | Tier II |
3 | NC_000068.7 | 2 | 14885472 | + | Cacnb2 | NNNGTTTGAGTATGTAAGGG | NGG | 2 | 0.5 | Tier II |
4 | NC_000086.7 | X | 56786953 | + | Fhl1 | NNNGTTTGATCATATGAGGG | NGG | 2 | 0.5 | Tier II |
5 | NC_000071.6 | 5 | 92363585 | - | Art3 | NNNGTGTGGTTATGTGAGGG | NGG | 2 | 0.381 | Tier II |
6 | NC_000073.6 | 7 | 80657603 | - | Crtc3 | NNNTTTTAATTATGTGAGGG | NGG | 2 | 0.3636 | Tier II |
7 | NC_000079.6 | 13 | 96593108 | + | Cert1 | NNNTTTTAATTATGTGAGGG | NGG | 2 | 0.3636 | Tier II |
8 | NC_000070.6 | 4 | 101261535 | - | Jak1 | NNNGTGTGTTTATGTGAGGG | NGG | 2 | 0.3429 | Tier II |
9 | NC_000069.6 | 3 | 138544607 | + | Eif4e | NNNGTTTGTGTATGTGAGGG | NGG | 2 | 0.3 | Tier II |
10 | NC_000072.6 | 6 | 61428576 | + | Ccser1 | NNNGAGTGATTATGTGAGGG | NGG | 2 | 0.2857 | Tier II |
11 | NC_000074.6 | 8 | 108712508 | + | Zfhx3 | NNNGTTTCATTATGTGAGCG | NGG | 2 | 0.2759 | Tier II |
12 | NC_000073.6 | 7 | 106630553 | - | Gm1966 | NNNGTTTTATTATTTGAGGG | NGG | 2 | 0.1667 | Tier II |
13 | NC_000072.6 | 6 | 87210457 | + | Antxr1 | NNNGTTTGATCATGTGTGGG | NGG | 2 | 0.0889 | Tier II |
14 | NC_000081.6 | 15 | 5160960 | - | Prkaa1 | NNNGTTTGATCATGTGAGGG | NGA | 2 | 0.0463 | Tier II |
15 | NC_000081.6 | 15 | 5160776 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
16 | NC_000081.6 | 15 | 5160868 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
17 | NC_000081.6 | 15 | 5160914 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
18 | NC_000081.6 | 15 | 5161006 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
19 | NC_000081.6 | 15 | 5161051 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
20 | NC_000081.6 | 15 | 5161097 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
21 | NC_000081.6 | 15 | 5161143 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
22 | NC_000081.6 | 15 | 5161189 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
23 | NC_000081.6 | 15 | 5161235 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
24 | NC_000081.6 | 15 | 5161281 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
25 | NC_000081.6 | 15 | 5161327 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
26 | NC_000081.6 | 15 | 5161373 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
27 | NC_000081.6 | 15 | 5161419 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
28 | NC_000081.6 | 15 | 5161465 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
29 | NC_000081.6 | 15 | 5161511 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
30 | NC_000081.6 | 15 | 5161556 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
31 | NC_000081.6 | 15 | 5161615 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
32 | NC_000081.6 | 15 | 5161753 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
33 | NC_000081.6 | 15 | 5161799 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
34 | NC_000081.6 | 15 | 5161845 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
35 | NC_000081.6 | 15 | 5161891 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
36 | NC_000081.6 | 15 | 5161936 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
37 | NC_000081.6 | 15 | 5161995 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
38 | NC_000081.6 | 15 | 5162039 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
39 | NC_000081.6 | 15 | 5162098 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
40 | NC_000081.6 | 15 | 5162144 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
41 | NC_000081.6 | 15 | 5162203 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
42 | NC_000081.6 | 15 | 5162248 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
43 | NC_000081.6 | 15 | 5162293 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
44 | NC_000081.6 | 15 | 5162338 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
45 | NC_000081.6 | 15 | 5162428 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
46 | NC_000081.6 | 15 | 5162473 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
47 | NC_000081.6 | 15 | 5162518 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
48 | NC_000081.6 | 15 | 5162564 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
49 | NC_000081.6 | 15 | 5162623 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
50 | NC_000081.6 | 15 | 5162668 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
51 | NC_000081.6 | 15 | 5162727 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
52 | NC_000081.6 | 15 | 5162786 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
53 | NC_000081.6 | 15 | 5162878 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
54 | NC_000081.6 | 15 | 5162937 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
55 | NC_000081.6 | 15 | 5162984 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
56 | NC_000081.6 | 15 | 5163030 | - | Prkaa1 | NNNGTTTGATGATGTGAGGG | NGA | 2 | 0.0278 | Tier II |
57 | NC_000086.7 | X | 41567162 | + | Gria3 | NNNGTTTTATTATGTGAGGG | NTG | 2 | 0.0244 | Tier II |
58 | NC_000079.6 | 13 | 93681018 | - | Dmgdh | NNNGTTTGTTTATGTGAGGG | NGT | 2 | 0.0097 | Tier II |
59 | NC_000073.6 | 7 | 63149585 | - | Chrna7 | NNNGTTTGATTATGGGGGGG | NGG | 2 | 0.0088 | Tier II |
60 | NC_000075.6 | 9 | 76251810 | + | Hcrtr2 | NNNGTTTGATTATGTGTGGG | NGC | 2 | 0.003 | Tier II |
61 | NC_000073.6 | 7 | 80657603 | - | Gm51450 | NNNTTTTAATTATGTGAGGG | NGG | 2 | 0.3636 | Tier III |
62 | NC_000084.6 | 18 | 38029339 | + | Gm30093 | NNNGTTTGCTTATGTGGGGG | NGG | 2 | 0.1008 | Tier III |
63 | NC_000071.6 | 5 | 131393177 | + | Gm29681 | NNNGTTTGATTATGTGTGAG | NGG | 2 | 0.0952 | Tier III |
64 | NC_000080.6 | 14 | 41891783 | - | LOC115488376 | NNNGTTTGATTATGGGAGGG | NGG | 1 | 0.05 | Tier III |