Construct: sgRNA BRDN0001149230
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- GCCTCCCCACTGAGGAACTG
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- RPS6KA2 (6196)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000006.12 | 6 | 166488900 | + | RPS6KA2 | NNNTCCCCACTGAGGAACTG | NGG | 0 | 1.0 | Tier I |
2 | NC_000022.11 | 22 | 31815092 | + | DEPDC5 | NNNTGCCCACTGAGGAAGTG | NGG | 2 | 0.08 | Tier I |
3 | NC_000016.10 | 16 | 77209422 | + | SYCE1L | NNNTCCCCACAGAGGCACTG | NGG | 2 | 0.0 | Tier I |
4 | NC_000010.11 | 10 | 44996363 | - | LOC124902530 | NNNTCACCACTGAGGAACTG | NGG | 1 | 0.9286 | Tier II |
5 | NC_000022.11 | 22 | 41250807 | - | RANGAP1 | NNNTCACCACTGAGAAACTG | NGG | 2 | 0.8739 | Tier II |
6 | NC_000022.11 | 22 | 37812699 | - | GCAT | NNNTTCCCACTGAGGAACTG | NGG | 1 | 0.6364 | Tier II |
7 | NC_000003.12 | 3 | 128283847 | + | EEFSEC | NNNTCCACACTGGGGAACTG | NGG | 2 | 0.4891 | Tier II |
8 | NC_000005.10 | 5 | 1109416 | + | SLC12A7 | NNNACCCCACTGAGAAACTG | NGG | 2 | 0.4482 | Tier II |
9 | NC_000016.10 | 16 | 83648995 | + | CDH13 | NNNTTCCCACTGGGGAACTG | NGG | 2 | 0.415 | Tier II |
10 | NC_000023.11 | X | 108407315 | + | COL4A6 | NNNTTCCAACTGAGGAACTG | NGG | 2 | 0.4136 | Tier II |
11 | NC_000016.10 | 16 | 2758705 | - | SRRM2 | NNNTCCCCACTGAGAAACTC | NGG | 2 | 0.4034 | Tier II |
12 | NC_000008.11 | 8 | 19603221 | - | CSGALNACT1 | NNNTCCCCATGGAGGAACTG | NGG | 2 | 0.3765 | Tier II |
13 | NC_000001.11 | 1 | 6125634 | - | CHD5 | NNNTCCCACCTGAGGAACTG | NGG | 2 | 0.3714 | Tier II |
14 | NC_000005.10 | 5 | 75140784 | + | ANKRD31 | NNNTCACCAGTGAGGAACTG | NGG | 2 | 0.3611 | Tier II |
15 | NC_000009.12 | 9 | 113564601 | - | RGS3 | NNNTCCCCAAGGAGGAACTG | NGG | 2 | 0.3467 | Tier II |
16 | NC_000008.11 | 8 | 14187125 | + | SGCZ | NNNTACCCTCTGAGGAACTG | NGG | 2 | 0.3429 | Tier II |
17 | NC_000014.9 | 14 | 81506983 | + | SEL1L | NNNTCCCCTCTCAGGAACTG | NGG | 2 | 0.3176 | Tier II |
18 | NC_000010.11 | 10 | 32713393 | - | CCDC7 | NNNTCCCCAGTGGGGAACTG | NGG | 2 | 0.2536 | Tier II |
19 | NC_000001.11 | 1 | 230172305 | + | GALNT2 | NNNGCCCCAGTGAGGAACTG | NGG | 2 | 0.2431 | Tier II |
20 | NC_000020.11 | 20 | 37353817 | - | SRC | NNNTGCCCAGTGAGGAACTG | NGG | 2 | 0.2333 | Tier II |
21 | NC_000003.12 | 3 | 38564943 | - | SCN5A | NNNTCCCCATTGAGGGACTG | NGG | 2 | 0.181 | Tier II |
22 | NC_000009.12 | 9 | 28589 | - | WASHC1 | NNNTACCCACTGTGGAACTG | NGG | 2 | 0.1714 | Tier II |
23 | NC_000017.11 | 17 | 32479984 | - | PSMD11 | NNNTCCCCACTGAGAAGCTG | NGG | 2 | 0.1661 | Tier II |
24 | NC_000007.14 | 7 | 139974894 | - | TBXAS1 | NNNTCCCCACTGATGAAATG | NGG | 2 | 0.1436 | Tier II |
25 | NC_000004.12 | 4 | 71320943 | + | SLC4A4 | NNNTCGCCACTGATGAACTG | NGG | 2 | 0.1333 | Tier II |
26 | NC_000006.12 | 6 | 52549324 | - | TRAM2 | NNNTCCCCACTGATGAACTC | NGG | 2 | 0.1143 | Tier II |
27 | NC_000007.14 | 7 | 2009974 | + | MAD1L1 | NNNTTCCCACTGAGGACCTG | NGG | 2 | 0.1123 | Tier II |
28 | NC_000016.10 | 16 | 11088119 | - | CLEC16A | NNNTCCGCACTGAGGGACTG | NGG | 2 | 0.0905 | Tier II |
29 | NC_000002.12 | 2 | 109515547 | + | RANBP2 | NNNTCCCCACTGAGGACCTC | NGG | 2 | 0.0756 | Tier II |
30 | NC_000010.11 | 10 | 46303836 | + | ANTXRL | NNNTCCCCACTGAGGGCCTG | NGG | 2 | 0.0339 | Tier II |
31 | NC_000001.11 | 1 | 63786047 | + | ROR1 | NNNTCCCCACTGAGGAAGGG | NGG | 2 | 0.0333 | Tier II |
32 | NC_000009.12 | 9 | 76412720 | - | GCNT1 | NNNACCCCACTGAGGAACTG | NGA | 2 | 0.0331 | Tier II |
33 | NC_000002.12 | 2 | 138694240 | + | NXPH2 | NNNTCCCAACTGAGGAACTG | NTG | 2 | 0.0253 | Tier II |
34 | NC_000001.11 | 1 | 183135682 | - | LAMC1 | NNNTCCCCAGTGAGGAACTG | NTG | 2 | 0.0152 | Tier II |
35 | NC_000020.11 | 20 | 47708654 | + | SULF2 | NNNTCCCCACTGGGGAACTG | NGT | 2 | 0.0105 | Tier II |
36 | NC_000002.12 | 2 | 36490865 | + | CRIM1 | NNNTCCCCACTGAGTAACTG | NGC | 2 | 0.0032 | Tier II |
37 | NC_000018.10 | 18 | 48202625 | - | ZBTB7C | NNNTCCCCACTGAGGATCTG | NGC | 2 | 0.003 | Tier II |
38 | NC_000017.11 | 17 | 1478219 | - | MYO1C | NNNTCCCCACTGAGCCACTG | NGG | 2 | 0.0 | Tier II |
39 | NC_000007.14 | 7 | 4720544 | - | FOXK1 | NNNTCCCCACTGAGGCACAG | NGG | 2 | 0.0 | Tier II |
40 | NC_000008.11 | 8 | 514691 | - | TDRP | NNNTCCCCACTGAGGCACTG | NGG | 1 | 0.0 | Tier II |
41 | NC_000019.10 | 19 | 47071091 | + | ZC3H4 | NNNTCCCCACTGAGGCACTG | NGC | 2 | 0.0 | Tier II |
42 | NC_000010.11 | 10 | 44996363 | - | ZNF22-AS1 | NNNTCACCACTGAGGAACTG | NGG | 1 | 0.9286 | Tier III |
43 | NC_000005.10 | 5 | 133117476 | - | LOC105379178 | NNNTGCCCATTGAGGAACTG | NGG | 2 | 0.5647 | Tier III |
44 | NC_000012.12 | 12 | 92275967 | + | LINC02391 | NNNACACCACTGAGGAACTG | NGG | 2 | 0.4422 | Tier III |
45 | NC_000005.10 | 5 | 17153711 | + | BASP1-AS1 | NNNTCCCCACTGGGGAACTC | NGG | 2 | 0.2795 | Tier III |
46 | NC_000003.12 | 3 | 126208894 | - | ALDH1L1-AS2 | NNNTCCCCTCTTAGGAACTG | NGG | 2 | 0.2308 | Tier III |
47 | NC_000023.11 | X | 8452048 | - | LOC107985675 | NNNTCCACACTGTGGAACTG | NGG | 2 | 0.225 | Tier III |
48 | NC_000001.11 | 1 | 28476 | - | WASH7P | NNNTACCCACTGTGGAACTG | NGG | 2 | 0.1714 | Tier III |
49 | NC_000001.11 | 1 | 198994 | - | WASH9P | NNNTACCCACTGTGGAACTG | NGG | 2 | 0.1714 | Tier III |
50 | NC_000002.12 | 2 | 113584979 | + | WASH2P | NNNTACCCACTGTGGAACTG | NGG | 2 | 0.1714 | Tier III |
51 | NC_000012.12 | 12 | 30532 | - | WASH8P | NNNTACCCACTGTGGAACTG | NGG | 2 | 0.1714 | Tier III |
52 | NC_000015.10 | 15 | 101962485 | + | WASH3P | NNNTACCCACTGTGGAACTG | NGG | 2 | 0.1714 | Tier III |
53 | NC_000019.10 | 19 | 70084 | - | WASH5P | NNNTACCCACTGTGGAACTG | NGG | 2 | 0.1714 | Tier III |
54 | NC_000013.11 | 13 | 100738696 | + | NALCN-AS1 | NNNTCACCACTGAGGAGCTG | NGG | 2 | 0.1639 | Tier III |
55 | NC_000017.11 | 17 | 83177922 | - | LOC101929650 | NNNTCCCCACAGAGGAGCTG | NGG | 2 | 0.1324 | Tier III |
56 | NC_000007.14 | 7 | 20972419 | + | LINC01162 | NNNTCCCCACTGAAGAGCTG | NGG | 2 | 0.1324 | Tier III |
57 | NC_000012.12 | 12 | 53817127 | - | LOC105378250 | NNNACCCCACTGAGGAGCTG | NGG | 2 | 0.084 | Tier III |
58 | NC_000012.12 | 12 | 74274689 | - | LINC02882 | NNNTCCCCACTGAGGAACTG | NTG | 1 | 0.039 | Tier III |
59 | NC_000010.11 | 10 | 46262492 | - | ANTXRLP1 | NNNTCCCCACTGAGGGCCTG | NGG | 2 | 0.0339 | Tier III |
60 | NC_000021.9 | 21 | 42018560 | + | ZNF295-AS1 | NNNTCCCCACTGTGGAACTG | NGA | 2 | 0.0208 | Tier III |
61 | NC_000001.11 | 1 | 221855028 | - | LOC124904517 | NNNTCCCCACTGAGGAACTT | NGT | 2 | 0.0113 | Tier III |
62 | NC_000006.12 | 6 | 76538198 | - | LINC02540 | NNNTCCCCACTGTGGAACTG | NGT | 2 | 0.0048 | Tier III |
63 | NC_000008.11 | 8 | 105918775 | + | ZFPM2-AS1 | NNNTCCCCACTGAGGAACTG | NCT | 2 | 0.0 | Tier III |
64 | NC_000014.9 | 14 | 44039130 | + | LINC02307 | NNNTCCCCACTGAGGAACTG | NCT | 2 | 0.0 | Tier III |
65 | NC_000016.10 | 16 | 56989236 | + | LOC124903696 | NNNTCCCCACTGAGGCACTG | NGA | 2 | 0.0 | Tier III |
66 | NC_000020.11 | 20 | 5492194 | + | LOC124904863 | NNNTCCCCACTGATGCACTG | NGG | 2 | 0.0 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000083.6 | 17 | 7262150 | - | Rps6ka2 | NNNTCCGCACTGAGGAACTG | NGG | 1 | 0.4706 | Tier I |
2 | NC_000068.7 | 2 | 91933851 | + | Dgkz | NNNTCCCCACTGGGGAACAG | NGG | 2 | 0.1863 | Tier I |
3 | NC_000071.6 | 5 | 32918025 | + | Depdc5 | NNNTGCCCACTGAGGAAGTG | NGG | 2 | 0.08 | Tier I |
4 | NC_000078.6 | 12 | 108870881 | - | Wars | NNNTCCCCACTGGGAAACTG | NGG | 2 | 0.6138 | Tier II |
5 | NC_000073.6 | 7 | 107403903 | - | Syt9 | NNNGCTCCACTGAGGAACTG | NGG | 2 | 0.5804 | Tier II |
6 | NC_000070.6 | 4 | 31970412 | + | Map3k7 | NNNTCTCCACTGAGGAAATG | NGG | 2 | 0.5 | Tier II |
7 | NC_000083.6 | 17 | 56107886 | + | Plin4 | NNNTCCCAACAGAGGAACTG | NGG | 2 | 0.4875 | Tier II |
8 | NC_000085.6 | 19 | 24697943 | + | Pgm5 | NNNTCCTCCCTGAGGAACTG | NGG | 2 | 0.4643 | Tier II |
9 | NC_000080.6 | 14 | 54647294 | - | Acin1 | NNNTGCCCACTGAGGAACTT | NGG | 2 | 0.42 | Tier II |
10 | NC_000077.6 | 11 | 80534857 | - | Myo1d | NNNTCCACACTCAGGAACTG | NGG | 2 | 0.3971 | Tier II |
11 | NC_000073.6 | 7 | 55928097 | + | Cyfip1 | NNNTCCCATCTGAGGAACTG | NGG | 2 | 0.39 | Tier II |
12 | NC_000073.6 | 7 | 144716974 | - | Ano1 | NNNTCTCCACTGAGGAACAG | NGG | 2 | 0.2653 | Tier II |
13 | NC_000076.6 | 10 | 79873046 | + | Plppr3 | NNNCCCCCAGTGAGGAACTG | NGG | 2 | 0.2516 | Tier II |
14 | NC_000075.6 | 9 | 26976652 | + | Acad8 | NNNTCCCCACTCAGGAACTC | NGG | 2 | 0.2269 | Tier II |
15 | NC_000082.6 | 16 | 90111776 | + | Tiam1 | NNNTCCCCACTGTAGAACTG | NGG | 2 | 0.225 | Tier II |
16 | NC_000071.6 | 5 | 112971388 | + | Grk3 | NNNTCCACACTGAGGAACAG | NGG | 2 | 0.2143 | Tier II |
17 | NC_000085.6 | 19 | 58954508 | + | Eno4 | NNNTCTCCACTGAGGACCTG | NGG | 2 | 0.1639 | Tier II |
18 | NC_000068.7 | 2 | 32037029 | - | Nup214 | NNNTCCCCACTGAGGAAATG | NAG | 2 | 0.1396 | Tier II |
19 | NC_000083.6 | 17 | 48415481 | - | Oard1 | NNNTCCCCACAGAGGAGCTG | NGG | 2 | 0.1324 | Tier II |
20 | NC_000073.6 | 7 | 19867430 | + | Ceacam16 | NNNCCCCCACTGAGGAGCTG | NGG | 2 | 0.1142 | Tier II |
21 | NC_000079.6 | 13 | 36944162 | + | F13a1 | NNNTCCACACTGAGGAAGTG | NGG | 2 | 0.1 | Tier II |
22 | NC_000073.6 | 7 | 37411204 | + | Zfp536 | NNNTCCCCAGTGAGGGACTG | NGG | 2 | 0.0748 | Tier II |
23 | NC_000073.6 | 7 | 43848204 | + | Klk5 | NNNTCCCCAGTGAGGGACTG | NGG | 2 | 0.0748 | Tier II |
24 | NC_000071.6 | 5 | 128822525 | - | Rimbp2 | NNNTCCCCAGTGAGGAGCTG | NGG | 2 | 0.0686 | Tier II |
25 | NC_000071.6 | 5 | 135469242 | + | Hip1 | NNNTCCCCAGTGAGGAGCTG | NGG | 2 | 0.0686 | Tier II |
26 | NC_000071.6 | 5 | 135469506 | + | Hip1 | NNNTCCCCAGTGAGGAGCTG | NGG | 2 | 0.0686 | Tier II |
27 | NC_000073.6 | 7 | 19789498 | - | Cblc | NNNTCCCCAGTGAGGAGCTG | NGG | 2 | 0.0686 | Tier II |
28 | NC_000083.6 | 17 | 90169904 | - | Nrxn1 | NNNTCCCCACTGGGGAACTG | NGA | 2 | 0.0453 | Tier II |
29 | NC_000083.6 | 17 | 63203938 | + | Fbxl17 | NNNGCCCCACTGAGGAACTG | NTG | 2 | 0.0244 | Tier II |
30 | NC_000084.6 | 18 | 75389426 | - | Smad7 | NNNTCCCCACTGAGAAACTG | NGT | 2 | 0.0152 | Tier II |
31 | NC_000074.6 | 8 | 13074230 | - | Proz | NNNTCCCCACTGAGGAGCTG | NTG | 2 | 0.0069 | Tier II |
32 | NC_000085.6 | 19 | 4590751 | - | Pcx | NNNTCCCCACTGTGGAACTG | NGC | 2 | 0.0067 | Tier II |
33 | NC_000083.6 | 17 | 56810983 | + | Rfx2 | NNNTCCCCACTGTGGAACTG | NGT | 2 | 0.0048 | Tier II |
34 | NC_000082.6 | 16 | 41942910 | - | Lsamp | NNNTCCCCACAGAGGTACTG | NGG | 2 | 0.0 | Tier II |
35 | NC_000073.6 | 7 | 142734241 | - | Gm39116 | NNNTCCCCACTGAGAAACTG | NGG | 1 | 0.9412 | Tier III |
36 | NC_000067.6 | 1 | 120434900 | + | Gm46154 | NNNACTCCACTGAGGAACTG | NGG | 2 | 0.4422 | Tier III |
37 | NC_000073.6 | 7 | 142846658 | - | Gm6471 | NNNTCCCCAGTGAGAAACTG | NGG | 2 | 0.366 | Tier III |
38 | NC_000073.6 | 7 | 142846658 | - | Gm39117 | NNNTCCCCAGTGAGAAACTG | NGG | 2 | 0.366 | Tier III |
39 | NC_000083.6 | 17 | 36760812 | - | Gm8878 | NNNTCCCCATTGAGGAACTG | NAG | 2 | 0.244 | Tier III |
40 | NC_000068.7 | 2 | 91933851 | + | Gm39876 | NNNTCCCCACTGGGGAACAG | NGG | 2 | 0.1863 | Tier III |
41 | NC_000078.6 | 12 | 90755177 | + | Gm26512 | NNNTCCCCACTGAGGATCTA | NGG | 2 | 0.125 | Tier III |
42 | NC_000068.7 | 2 | 113970428 | - | Gm39909 | NNNCCCCCACTGAGGACCTG | NGG | 2 | 0.1142 | Tier III |
43 | NC_000084.6 | 18 | 61472930 | + | Lncbate10 | NNNTCCCCAGTGAGCAACTG | NGG | 2 | 0.1061 | Tier III |
44 | NC_000079.6 | 13 | 34132383 | + | Gm36500 | NNNTCCCCCCTGAGGAGCTG | NGG | 2 | 0.1008 | Tier III |
45 | NC_000079.6 | 13 | 36944162 | + | Gm30489 | NNNTCCACACTGAGGAAGTG | NGG | 2 | 0.1 | Tier III |
46 | NC_000072.6 | 6 | 34212354 | - | Gm32533 | NNNTTCCCACTGAGGATCTG | NGG | 2 | 0.0848 | Tier III |
47 | NC_000073.6 | 7 | 19838614 | + | Gm34891 | NNNTCCCCAGTGAGGGACTG | NGG | 2 | 0.0748 | Tier III |
48 | NC_000070.6 | 4 | 131156560 | + | Gm42318 | NNNTCCCCACTGAGGATATG | NGG | 2 | 0.0718 | Tier III |
49 | NC_000081.6 | 15 | 36956141 | - | Gm34590 | NNNTCCCCAGTGAGGACCTG | NGG | 2 | 0.0686 | Tier III |
50 | NC_000071.6 | 5 | 128822525 | - | Gm34057 | NNNTCCCCAGTGAGGAGCTG | NGG | 2 | 0.0686 | Tier III |
51 | NC_000073.6 | 7 | 19789498 | - | LOC115486450 | NNNTCCCCAGTGAGGAGCTG | NGG | 2 | 0.0686 | Tier III |
52 | NC_000085.6 | 19 | 59537611 | - | 2700089I24Rik | NNNTCCCCAGTGAGGATCTG | NGG | 2 | 0.0519 | Tier III |
53 | NC_000078.6 | 12 | 79875221 | - | Gm46361 | NNNTCTCCACTGAGGAACTG | NGT | 2 | 0.015 | Tier III |
54 | NC_000078.6 | 12 | 114464017 | + | Igh | NNNTCCCAACTGAGGAACTG | NGC | 2 | 0.0144 | Tier III |
55 | NC_000079.6 | 13 | 107032901 | - | 3830408C21Rik | NNNTCCCCACTGAGGCACTG | NTG | 2 | 0.0 | Tier III |
56 | NC_000076.6 | 10 | 13077052 | + | Gm40602 | NNNTCCCCACTGATGCACTG | NGG | 2 | 0.0 | Tier III |