Construct: sgRNA BRDN0001144977
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- GGGAAATTGCCTCACATGTG
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- PHKA1 (5255)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 77838
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000023.11 |
X |
72652587 |
- |
PHKA1 |
NNNAAATTGCCTCACATGTG |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000011.10 |
11 |
125644267 |
- |
CHEK1 |
NNNAAATTCCCTCACCTGTG |
NGG |
2 |
0.0 |
Tier I |
3 |
NC_000013.11 |
13 |
113044220 |
- |
MCF2L |
NNNAAAATGCCTCACATGTA |
NGG |
2 |
0.8203 |
Tier II |
4 |
NC_000007.14 |
7 |
80621555 |
+ |
CD36 |
NNNAAGTTGTCTCACATGTG |
NGG |
2 |
0.6723 |
Tier II |
5 |
NC_000022.11 |
22 |
21839989 |
- |
MAPK1 |
NNNAAATGGCATCACATGTG |
NGG |
2 |
0.55 |
Tier II |
6 |
NC_000002.12 |
2 |
233108463 |
+ |
INPP5D |
NNNAAATTGCATCACATATG |
NGG |
2 |
0.5192 |
Tier II |
7 |
NC_000001.11 |
1 |
96740509 |
+ |
PTBP2 |
NNNAAATTGCATCACATTTG |
NGG |
2 |
0.5 |
Tier II |
8 |
NC_000020.11 |
20 |
37758422 |
+ |
CTNNBL1 |
NNNAAACTGCCTTACATGTG |
NGG |
2 |
0.4812 |
Tier II |
9 |
NC_000015.10 |
15 |
98998368 |
- |
PGPEP1L |
NNNACAATGCCTCACATGTG |
NGG |
2 |
0.4375 |
Tier II |
10 |
NC_000023.11 |
X |
72361868 |
+ |
HDAC8 |
NNNAAATGCCCTCACATGTG |
NGG |
2 |
0.3949 |
Tier II |
11 |
NC_000013.11 |
13 |
92367755 |
- |
GPC5 |
NNNAAATTGCCTTACAAGTG |
NGG |
2 |
0.3733 |
Tier II |
12 |
NC_000010.11 |
10 |
76257868 |
+ |
LRMDA |
NNNAAATGGCCTCACATGTC |
NGG |
2 |
0.3143 |
Tier II |
13 |
NC_000021.9 |
21 |
44033432 |
+ |
TRAPPC10 |
NNNAAATTGCTTAACATGTG |
NGG |
2 |
0.1183 |
Tier II |
14 |
NC_000015.10 |
15 |
29831374 |
- |
TJP1 |
NNNCAATTGCCTCACATGGG |
NGG |
2 |
0.0882 |
Tier II |
15 |
NC_000011.10 |
11 |
56611517 |
- |
OR5M1 |
NNNAAATTGCCTCATATGTT |
NGG |
2 |
0.0467 |
Tier II |
16 |
NC_000005.10 |
5 |
13707338 |
- |
DNAH5 |
NNNAAATTGCCTCACATGTG |
NGC |
1 |
0.0222 |
Tier II |
17 |
NC_000013.11 |
13 |
94459357 |
+ |
DCT |
NNNAAATTGCCTCAAATGTG |
NGT |
2 |
0.0036 |
Tier II |
18 |
NC_000019.10 |
19 |
42000507 |
+ |
GRIK5 |
NNNAAATTGCCTCACAGGTG |
NGC |
2 |
0.0026 |
Tier II |
19 |
NC_000008.11 |
8 |
42961116 |
+ |
HOOK3 |
NNNAAATTCCCTCACTTGTG |
NGG |
2 |
0.0 |
Tier II |
20 |
NC_000019.10 |
19 |
23259442 |
- |
IPO5P1 |
NNNTAATTGCCTCTCATGTG |
NGG |
2 |
0.3394 |
Tier III |
21 |
NC_000007.14 |
7 |
35349729 |
- |
LOC401324 |
NNNAAATTGCCTCTCATCTG |
NGG |
2 |
0.254 |
Tier III |
22 |
NC_000009.12 |
9 |
70465860 |
+ |
KLF9-DT |
NNNAAATTGCATCACATGTG |
NGC |
2 |
0.0167 |
Tier III |
23 |
NC_000005.10 |
5 |
119938218 |
- |
LOC105379144 |
NNNAAATTGCCTCAATTGTG |
NGG |
2 |
0.0 |
Tier III |
24 |
NC_000002.12 |
2 |
21948188 |
- |
LOC124908056 |
NNNAAATTGCCTGACCTGTG |
NGG |
2 |
0.0 |
Tier III |
25 |
NC_000009.12 |
9 |
11381827 |
+ |
LOC105375974 |
NNNAAATTGCCTTACTTGTG |
NGG |
2 |
0.0 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000086.7 |
X |
102597445 |
- |
Phka1 |
NNNAAATTGCCTCACATGTG |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000087.7 |
Y |
726184 |
- |
Zfy1 |
NNNAAATTTCCTCACATTTG |
NGG |
2 |
0.3556 |
Tier I |
3 |
NC_000087.7 |
Y |
2107071 |
- |
Zfy2 |
NNNAAATTTCCTCACATTTG |
NGG |
2 |
0.3556 |
Tier I |
4 |
NC_000085.6 |
19 |
48789736 |
- |
Sorcs3 |
NNNAAAAAGCCTCACATGTG |
NGG |
2 |
0.7 |
Tier II |
5 |
NC_000072.6 |
6 |
145114169 |
- |
Lrmp |
NNNAAACTGACTCACATGTG |
NGG |
2 |
0.5958 |
Tier II |
6 |
NC_000071.6 |
5 |
129165309 |
+ |
Adgrd1 |
NNNGAAGTGCCTCACATGTG |
NGG |
2 |
0.3676 |
Tier II |
7 |
NC_000084.6 |
18 |
37329226 |
- |
Gm37013 |
NNNAAATTCCTTCACATGTG |
NGG |
2 |
0.1657 |
Tier II |
8 |
NC_000084.6 |
18 |
37329226 |
- |
Gm38666 |
NNNAAATTCCTTCACATGTG |
NGG |
2 |
0.1657 |
Tier II |
9 |
NC_000084.6 |
18 |
37329226 |
- |
Gm38667 |
NNNAAATTCCTTCACATGTG |
NGG |
2 |
0.1657 |
Tier II |
10 |
NC_000068.7 |
2 |
120717203 |
+ |
Cdan1 |
NNNCACTTGCCTCACATGTG |
NGG |
2 |
0.1604 |
Tier II |
11 |
NC_000068.7 |
2 |
120717203 |
+ |
Stard9 |
NNNCACTTGCCTCACATGTG |
NGG |
2 |
0.1604 |
Tier II |
12 |
NC_000077.6 |
11 |
104371202 |
- |
Kansl1 |
NNNAAATTGCCTCAAATTTG |
NGG |
2 |
0.1481 |
Tier II |
13 |
NC_000086.7 |
X |
134549787 |
+ |
Btk |
NNNAAAGTGCCTCAAATGTG |
NGG |
2 |
0.1307 |
Tier II |
14 |
NC_000068.7 |
2 |
115983495 |
- |
Meis2 |
NNNAAATTGCCTCACATGTG |
NGA |
1 |
0.0694 |
Tier II |
15 |
NC_000084.6 |
18 |
65882029 |
- |
Grp |
NNNAAATTGCCACAGATGTG |
NGG |
2 |
0.04 |
Tier II |
16 |
NC_000075.6 |
9 |
67905468 |
+ |
Vps13c |
NNNAAATTGCCTCACATGTT |
NTG |
2 |
0.0273 |
Tier II |
17 |
NC_000084.6 |
18 |
65882029 |
- |
Gm30094 |
NNNAAATTGCCACAGATGTG |
NGG |
2 |
0.04 |
Tier III |
Other clones with same target sequence:
(none)