Construct: sgRNA BRDN0001146019
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- TGTCCCACAAAATGTGGTAG
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- SGK3 (23678)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 75540
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000008.11 |
8 |
66841088 |
- |
SGK3 |
NNNCCCACAAAATGTGGTAG |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000008.11 |
8 |
66841088 |
- |
C8orf44-SGK3 |
NNNCCCACAAAATGTGGTAG |
NGG |
0 |
1.0 |
Tier I |
3 |
NC_000011.10 |
11 |
27442261 |
- |
LGR4 |
NNNCCCACAAAATGTGGTAT |
NGG |
1 |
0.7 |
Tier II |
4 |
NC_000013.11 |
13 |
69887912 |
- |
KLHL1 |
NNNCCCAAAAAATGTGGAAG |
NGG |
2 |
0.4333 |
Tier II |
5 |
NC_000015.10 |
15 |
27916946 |
+ |
OCA2 |
NNNCCCTCAAAATGTGGAAG |
NGG |
2 |
0.2917 |
Tier II |
6 |
NC_000018.10 |
18 |
80032927 |
- |
TXNL4A |
NNNCAGACAAAATGTGGTAG |
NGG |
2 |
0.2857 |
Tier II |
7 |
NC_000002.12 |
2 |
86776463 |
- |
RMND5A |
NNNCCCACAAAATGTGGTGT |
NGG |
2 |
0.2625 |
Tier II |
8 |
NC_000001.11 |
1 |
26167139 |
- |
C1orf232 |
NNNCACACAAAATGTGGCAG |
NGG |
2 |
0.2449 |
Tier II |
9 |
NC_000001.11 |
1 |
232510018 |
- |
SIPA1L2 |
NNNCCCACAAAATGAGGGAG |
NGG |
2 |
0.193 |
Tier II |
10 |
NC_000016.10 |
16 |
20552984 |
- |
ACSM2B |
NNNCCCAAAAAATTTGGTAG |
NGG |
2 |
0.1733 |
Tier II |
11 |
NC_000010.11 |
10 |
52316032 |
- |
DKK1 |
NNNCCCACCAACTGTGGTAG |
NGG |
2 |
0.1504 |
Tier II |
12 |
NC_000023.11 |
X |
53650173 |
+ |
HUWE1 |
NNNCCCACTAAATGTGTTAG |
NGG |
2 |
0.15 |
Tier II |
13 |
NC_000016.10 |
16 |
28593850 |
- |
SULT1A2 |
NNNCCCACAAAATTTGGTGG |
NGG |
2 |
0.1 |
Tier II |
14 |
NC_000016.10 |
16 |
28607359 |
- |
SULT1A1 |
NNNCCCACAAAATTTGGTGG |
NGG |
2 |
0.1 |
Tier II |
15 |
NC_000012.12 |
12 |
23662543 |
- |
SOX5 |
NNNCCCACAAAATGTGGTTG |
NTG |
2 |
0.021 |
Tier II |
16 |
NC_000020.11 |
20 |
3625427 |
- |
ATRN |
NNNCCCAAAAAATGTGGTAG |
NGT |
2 |
0.0105 |
Tier II |
17 |
NC_000020.11 |
20 |
34744565 |
- |
NCOA6 |
NNNCCCACAAAATTTGGTAG |
NTG |
2 |
0.0104 |
Tier II |
18 |
NC_000004.12 |
4 |
161688484 |
- |
FSTL5 |
NNNCCCACAAAATGTGGTAG |
NAA |
2 |
0.0 |
Tier II |
19 |
NC_000009.12 |
9 |
40514578 |
+ |
LOC102724580 |
NNNCCAACTAAATGTGGTAG |
NGG |
2 |
0.5571 |
Tier III |
20 |
NC_000009.12 |
9 |
64654552 |
+ |
LOC101929583 |
NNNCCAACTAAATGTGGTAG |
NGG |
2 |
0.5571 |
Tier III |
21 |
NC_000009.12 |
9 |
65159747 |
+ |
LOC105379443 |
NNNCCAACTAAATGTGGTAG |
NGG |
2 |
0.5571 |
Tier III |
22 |
NC_000009.12 |
9 |
65861797 |
- |
LOC101928195 |
NNNCCAACTAAATGTGGTAG |
NGG |
2 |
0.5571 |
Tier III |
23 |
NC_000020.11 |
20 |
24322452 |
+ |
LOC105372577 |
NNNCACACAAAATGTGATAG |
NGG |
2 |
0.5333 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000084.6 |
18 |
37728104 |
- |
Pcdhga8 |
NNNCCCACAAAATGTGATGG |
NGG |
2 |
0.35 |
Tier I |
2 |
NC_000069.6 |
3 |
104076404 |
+ |
Magi3 |
NNNCCTACAAAATGTGGTAG |
NGG |
1 |
0.9286 |
Tier II |
3 |
NC_000077.6 |
11 |
30999978 |
- |
Asb3 |
NNNTCCAAAAAATGTGGTAG |
NGG |
2 |
0.52 |
Tier II |
4 |
NC_000071.6 |
5 |
48584105 |
- |
Kcnip4 |
NNNGCCATAAAATGTGGTAG |
NGG |
2 |
0.4375 |
Tier II |
5 |
NC_000082.6 |
16 |
38929337 |
+ |
Igsf11 |
NNNCCCACAAAACGTGGTTG |
NGG |
2 |
0.4251 |
Tier II |
6 |
NC_000067.6 |
1 |
60005045 |
+ |
Ica1l |
NNNCACACAAAATGTGGTAT |
NGG |
2 |
0.4 |
Tier II |
7 |
NC_000068.7 |
2 |
160893465 |
+ |
Lpin3 |
NNNCCCAAAAAATGAGGTAG |
NGG |
2 |
0.3763 |
Tier II |
8 |
NC_000084.6 |
18 |
37728104 |
- |
Pcdhgb1 |
NNNCCCACAAAATGTGATGG |
NGG |
2 |
0.35 |
Tier II |
9 |
NC_000084.6 |
18 |
37728104 |
- |
Pcdhgb2 |
NNNCCCACAAAATGTGATGG |
NGG |
2 |
0.35 |
Tier II |
10 |
NC_000084.6 |
18 |
37728104 |
- |
Pcdhgb4 |
NNNCCCACAAAATGTGATGG |
NGG |
2 |
0.35 |
Tier II |
11 |
NC_000084.6 |
18 |
37728104 |
- |
Pcdhga1 |
NNNCCCACAAAATGTGATGG |
NGG |
2 |
0.35 |
Tier II |
12 |
NC_000084.6 |
18 |
37728104 |
- |
Pcdhga2 |
NNNCCCACAAAATGTGATGG |
NGG |
2 |
0.35 |
Tier II |
13 |
NC_000084.6 |
18 |
37728104 |
- |
Pcdhga3 |
NNNCCCACAAAATGTGATGG |
NGG |
2 |
0.35 |
Tier II |
14 |
NC_000084.6 |
18 |
37728104 |
- |
Pcdhga4 |
NNNCCCACAAAATGTGATGG |
NGG |
2 |
0.35 |
Tier II |
15 |
NC_000084.6 |
18 |
37728104 |
- |
Pcdhga5 |
NNNCCCACAAAATGTGATGG |
NGG |
2 |
0.35 |
Tier II |
16 |
NC_000084.6 |
18 |
37728104 |
- |
Pcdhga6 |
NNNCCCACAAAATGTGATGG |
NGG |
2 |
0.35 |
Tier II |
17 |
NC_000084.6 |
18 |
37728104 |
- |
Pcdhga7 |
NNNCCCACAAAATGTGATGG |
NGG |
2 |
0.35 |
Tier II |
18 |
NC_000084.6 |
18 |
37728104 |
- |
Gm37013 |
NNNCCCACAAAATGTGATGG |
NGG |
2 |
0.35 |
Tier II |
19 |
NC_000084.6 |
18 |
37728104 |
- |
Gm38666 |
NNNCCCACAAAATGTGATGG |
NGG |
2 |
0.35 |
Tier II |
20 |
NC_000084.6 |
18 |
37728104 |
- |
Gm38667 |
NNNCCCACAAAATGTGATGG |
NGG |
2 |
0.35 |
Tier II |
21 |
NC_000075.6 |
9 |
32446767 |
- |
Fli1 |
NNNCCCATAAAATGTGGGAG |
NGG |
2 |
0.2917 |
Tier II |
22 |
NC_000083.6 |
17 |
68582791 |
+ |
L3mbtl4 |
NNNCCTACAAAATGTGGTAG |
NAG |
2 |
0.2407 |
Tier II |
23 |
NC_000069.6 |
3 |
123364738 |
- |
Sec24d |
NNNCCCACCAAATGTGGTAG |
NAG |
2 |
0.1481 |
Tier II |
24 |
NC_000070.6 |
4 |
133729009 |
+ |
Arid1a |
NNNCCCACACCATGTGGTAG |
NGG |
2 |
0.1333 |
Tier II |
25 |
NC_000082.6 |
16 |
38929337 |
+ |
Gm34258 |
NNNCCCACAAAACGTGGTTG |
NGG |
2 |
0.4251 |
Tier III |
26 |
NC_000080.6 |
14 |
54087329 |
- |
Tcra |
NNNCCCACAACATGTGGTAG |
NTG |
2 |
0.0156 |
Tier III |
27 |
NC_000080.6 |
14 |
54087329 |
- |
Tcrd |
NNNCCCACAACATGTGGTAG |
NTG |
2 |
0.0156 |
Tier III |
28 |
NC_000080.6 |
14 |
54087329 |
- |
Gm30275 |
NNNCCCACAACATGTGGTAG |
NTG |
2 |
0.0156 |
Tier III |
Other clones with same target sequence:
(none)