Construct: sgRNA BRDN0001147422
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- ACATCCCTGAAGAGTAACTG
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- MAP2K5 (5607)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000015.10 | 15 | 67543450 | - | MAP2K5 | NNNTCCCTGAAGAGTAACTG | NGG | 0 | 1.0 | Tier I |
2 | NC_000012.12 | 12 | 30711080 | - | CAPRIN2 | NNNTCACTGAAGAGTAACTT | NGG | 2 | 0.65 | Tier II |
3 | NC_000022.11 | 22 | 31282338 | + | PIK3IP1 | NNNTCCCTGAAGAGAAACTG | NGG | 1 | 0.5789 | Tier II |
4 | NC_000005.10 | 5 | 96489301 | + | CAST | NNNTGCCTGAAGAGTAACTT | NGG | 2 | 0.42 | Tier II |
5 | NC_000023.11 | X | 13902462 | - | GPM6B | NNNTCCCTGAAGAATAAATG | NGG | 2 | 0.4038 | Tier II |
6 | NC_000017.11 | 17 | 1737279 | + | WDR81 | NNNTCCCTGGAGAGAAACTG | NGG | 2 | 0.3216 | Tier II |
7 | NC_000003.12 | 3 | 71485483 | + | FOXP1 | NNNTCCCTGAATAATAACTG | NGG | 2 | 0.2885 | Tier II |
8 | NC_000017.11 | 17 | 63910604 | - | CSHL1 | NNNTCCCAGAAGAGTAACAG | NGG | 2 | 0.2286 | Tier II |
9 | NC_000007.14 | 7 | 141184342 | - | TMEM178B | NNNTCCCTAAAGAGTAACAG | NGG | 2 | 0.1837 | Tier II |
10 | NC_000001.11 | 1 | 204451650 | - | PIK3C2B | NNNTCCCTGATGAGAAACTG | NGG | 2 | 0.1781 | Tier II |
11 | NC_000022.11 | 22 | 41504415 | - | ACO2 | NNNTCCCTGAGGATTAACTG | NGG | 2 | 0.1733 | Tier II |
12 | NC_000005.10 | 5 | 137477678 | - | SPOCK1 | NNNTCCCTGGAGAGTAAGTG | NGG | 2 | 0.0741 | Tier II |
13 | NC_000012.12 | 12 | 26651612 | - | ITPR2 | NNNTCTCTGAAGAGTAACTG | NGA | 2 | 0.0645 | Tier II |
14 | NC_000003.12 | 3 | 52345376 | - | DNAH1 | NNNTCCCTGAAGAGTGACTG | NCG | 2 | 0.0206 | Tier II |
15 | NC_000002.12 | 2 | 197203129 | - | ANKRD44 | NNNTCCCTGAAGAGGGACTG | NGG | 2 | 0.0096 | Tier II |
16 | NC_000007.14 | 7 | 141214560 | - | TMEM178B | NNNTCCCTGAAGAGTATCTG | NGC | 2 | 0.003 | Tier II |
17 | NC_000005.10 | 5 | 141506114 | + | PCDHGC3 | NNNTCCCTGAAGAGTCACTA | NGG | 2 | 0.0 | Tier II |
18 | NC_000005.10 | 5 | 141506114 | + | PCDHGB4 | NNNTCCCTGAAGAGTCACTA | NGG | 2 | 0.0 | Tier II |
19 | NC_000005.10 | 5 | 141506114 | + | PCDHGA8 | NNNTCCCTGAAGAGTCACTA | NGG | 2 | 0.0 | Tier II |
20 | NC_000005.10 | 5 | 141506114 | + | PCDHGA12 | NNNTCCCTGAAGAGTCACTA | NGG | 2 | 0.0 | Tier II |
21 | NC_000005.10 | 5 | 141506114 | + | PCDHGC5 | NNNTCCCTGAAGAGTCACTA | NGG | 2 | 0.0 | Tier II |
22 | NC_000005.10 | 5 | 141506114 | + | PCDHGC4 | NNNTCCCTGAAGAGTCACTA | NGG | 2 | 0.0 | Tier II |
23 | NC_000005.10 | 5 | 141506114 | + | PCDHGB7 | NNNTCCCTGAAGAGTCACTA | NGG | 2 | 0.0 | Tier II |
24 | NC_000005.10 | 5 | 141506114 | + | PCDHGB6 | NNNTCCCTGAAGAGTCACTA | NGG | 2 | 0.0 | Tier II |
25 | NC_000005.10 | 5 | 141506114 | + | PCDHGB5 | NNNTCCCTGAAGAGTCACTA | NGG | 2 | 0.0 | Tier II |
26 | NC_000005.10 | 5 | 141506114 | + | PCDHGB3 | NNNTCCCTGAAGAGTCACTA | NGG | 2 | 0.0 | Tier II |
27 | NC_000005.10 | 5 | 141506114 | + | PCDHGB2 | NNNTCCCTGAAGAGTCACTA | NGG | 2 | 0.0 | Tier II |
28 | NC_000005.10 | 5 | 141506114 | + | PCDHGB1 | NNNTCCCTGAAGAGTCACTA | NGG | 2 | 0.0 | Tier II |
29 | NC_000005.10 | 5 | 141506114 | + | PCDHGA11 | NNNTCCCTGAAGAGTCACTA | NGG | 2 | 0.0 | Tier II |
30 | NC_000005.10 | 5 | 141506114 | + | PCDHGA10 | NNNTCCCTGAAGAGTCACTA | NGG | 2 | 0.0 | Tier II |
31 | NC_000005.10 | 5 | 141506114 | + | PCDHGA9 | NNNTCCCTGAAGAGTCACTA | NGG | 2 | 0.0 | Tier II |
32 | NC_000005.10 | 5 | 141506114 | + | PCDHGA7 | NNNTCCCTGAAGAGTCACTA | NGG | 2 | 0.0 | Tier II |
33 | NC_000005.10 | 5 | 141506114 | + | PCDHGA6 | NNNTCCCTGAAGAGTCACTA | NGG | 2 | 0.0 | Tier II |
34 | NC_000005.10 | 5 | 141506114 | + | PCDHGA5 | NNNTCCCTGAAGAGTCACTA | NGG | 2 | 0.0 | Tier II |
35 | NC_000005.10 | 5 | 141506114 | + | PCDHGA4 | NNNTCCCTGAAGAGTCACTA | NGG | 2 | 0.0 | Tier II |
36 | NC_000005.10 | 5 | 141506114 | + | PCDHGA3 | NNNTCCCTGAAGAGTCACTA | NGG | 2 | 0.0 | Tier II |
37 | NC_000005.10 | 5 | 141506114 | + | PCDHGA2 | NNNTCCCTGAAGAGTCACTA | NGG | 2 | 0.0 | Tier II |
38 | NC_000005.10 | 5 | 141506114 | + | PCDHGA1 | NNNTCCCTGAAGAGTCACTA | NGG | 2 | 0.0 | Tier II |
39 | NC_000004.12 | 4 | 108089496 | - | LEF1 | NNNTCCCTGAAGAGTCACTG | NTG | 2 | 0.0 | Tier II |
40 | NC_000006.12 | 6 | 33802868 | + | MLN | NNNTCCCTGAAGAGTCTCTG | NGG | 2 | 0.0 | Tier II |
41 | NC_000015.10 | 15 | 59650397 | - | GTF2A2 | NNNTCCCTGAAGAGTTACTG | NGA | 2 | 0.0 | Tier II |
42 | NC_000002.12 | 2 | 33080691 | + | LTBP1 | NNNTCCCTGAATAGTTACTG | NGG | 2 | 0.0 | Tier II |
43 | NC_000023.11 | X | 104794503 | - | IL1RAPL2 | NNNTCCCTGAGGAGTCACTG | NGG | 2 | 0.0 | Tier II |
44 | NC_000014.9 | 14 | 69333385 | - | GALNT16 | NNNTCCCTGCAGAGTCACTG | NGG | 2 | 0.0 | Tier II |
45 | NC_000015.10 | 15 | 85582165 | + | AKAP13 | NNNTCCCTTAAGAGTCACTG | NGG | 2 | 0.0 | Tier II |
46 | NC_000003.12 | 3 | 5973733 | - | LOC102723596 | NNNTCTCTGAAGAATAACTG | NGG | 2 | 0.6964 | Tier III |
47 | NC_000006.12 | 6 | 90723301 | - | LOC107986623 | NNNTACTTGAAGAGTAACTG | NGG | 2 | 0.4643 | Tier III |
48 | NC_000007.14 | 7 | 131870211 | + | LOC107986849 | NNNCCCCTGAGGAGTAACTG | NGG | 2 | 0.4206 | Tier III |
49 | NC_000005.10 | 5 | 96489301 | + | LOC101929710 | NNNTGCCTGAAGAGTAACTT | NGG | 2 | 0.42 | Tier III |
50 | NC_000005.10 | 5 | 96489301 | + | LOC102724070 | NNNTGCCTGAAGAGTAACTT | NGG | 2 | 0.42 | Tier III |
51 | NC_000003.12 | 3 | 150597561 | + | LOC124900547 | NNNCCCCTGAAGAGAAACTG | NGG | 2 | 0.3746 | Tier III |
52 | NC_000008.11 | 8 | 37521938 | - | LINC01605 | NNNACCCTGAAGGGTAACTG | NGG | 2 | 0.3106 | Tier III |
53 | NC_000014.9 | 14 | 106442388 | + | IGH | NNNTCCCTGAAGGGCAACTG | NGG | 2 | 0.1779 | Tier III |
54 | NC_000014.9 | 14 | 106442388 | + | LOC124903400 | NNNTCCCTGAAGGGCAACTG | NGG | 2 | 0.1779 | Tier III |
55 | NC_000017.11 | 17 | 70830855 | + | LOC105371884 | NNNTTCCTGAAGAGTAGCTG | NGG | 2 | 0.1123 | Tier III |
56 | NC_000002.12 | 2 | 129460788 | - | LOC105373613 | NNNTCCCTGCAGAGTGACTG | NGG | 2 | 0.0641 | Tier III |
57 | NC_000004.12 | 4 | 186019524 | + | LOC124900830 | NNNTCCCTGAAGAGTAAATG | NGC | 2 | 0.012 | Tier III |
58 | NC_000004.12 | 4 | 180512122 | - | LOC105377565 | NNNTCCCTGAAGACTAACTG | NGT | 2 | 0.0069 | Tier III |
59 | NC_000004.12 | 4 | 180512122 | - | LOC105377567 | NNNTCCCTGAAGACTAACTG | NGT | 2 | 0.0069 | Tier III |
60 | NC_000005.10 | 5 | 141506114 | + | PCDHG@ | NNNTCCCTGAAGAGTCACTA | NGG | 2 | 0.0 | Tier III |
61 | NC_000006.12 | 6 | 33802868 | + | LOC105375024 | NNNTCCCTGAAGAGTCTCTG | NGG | 2 | 0.0 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000075.6 | 9 | 63377144 | + | Map2k5 | NNNTCCCTGAAGAGTAACTG | NGG | 0 | 1.0 | Tier I |
2 | NC_000067.6 | 1 | 52596038 | - | Nemp2 | NNNTCACTGTAGAGTAACTG | NGG | 2 | 0.8193 | Tier II |
3 | NC_000067.6 | 1 | 11460134 | - | A830018L16Rik | NNNTCCTTGAAGAGTAACTA | NGG | 2 | 0.7617 | Tier II |
4 | NC_000078.6 | 12 | 106026624 | + | Vrk1 | NNNTCCCAGAAGAATAACTG | NGG | 2 | 0.6 | Tier II |
5 | NC_000080.6 | 14 | 120277973 | - | Mbnl2 | NNNTCCCTGAAGAGAAACTG | NGG | 1 | 0.5789 | Tier II |
6 | NC_000076.6 | 10 | 76458499 | - | 2610028H24Rik | NNNGCCCTGTAGAGTAACTG | NGG | 2 | 0.5515 | Tier II |
7 | NC_000076.6 | 10 | 76458499 | - | Ybey | NNNGCCCTGTAGAGTAACTG | NGG | 2 | 0.5515 | Tier II |
8 | NC_000074.6 | 8 | 76905023 | + | Nr3c2 | NNNTCCCTGTAGAGAAACTG | NGG | 2 | 0.5108 | Tier II |
9 | NC_000073.6 | 7 | 99232291 | - | Mogat2 | NNNTCACTGAAGAGTAAATG | NGG | 2 | 0.5 | Tier II |
10 | NC_000077.6 | 11 | 118567233 | + | Rbfox3 | NNNCCCCTGAAGAATAACTG | NGG | 2 | 0.4853 | Tier II |
11 | NC_000072.6 | 6 | 15266753 | - | Foxp2 | NNNACCCTGTAGAGTAACTG | NGG | 2 | 0.4202 | Tier II |
12 | NC_000068.7 | 2 | 10191292 | + | Itih5 | NNNTTCCTGAAGAGAAACTG | NGG | 2 | 0.3684 | Tier II |
13 | NC_000083.6 | 17 | 5431222 | + | Tmem242 | NNNTCTCTGCAGAGTAACTG | NGG | 2 | 0.3095 | Tier II |
14 | NC_000079.6 | 13 | 73757247 | - | Slc12a7 | NNNTCCTTGCAGAGTAACTG | NGG | 2 | 0.2708 | Tier II |
15 | NC_000077.6 | 11 | 43120177 | + | Atp10b | NNNTCTCTGAAGAGTAACTG | NAG | 2 | 0.2407 | Tier II |
16 | NC_000071.6 | 5 | 122744195 | - | Camkk2 | NNNTCCCTGAAGAATAACAG | NGG | 2 | 0.2143 | Tier II |
17 | NC_000082.6 | 16 | 34454627 | - | Kalrn | NNNTCCATGAAGAGTAACTG | NAG | 2 | 0.1944 | Tier II |
18 | NC_000085.6 | 19 | 55302955 | - | Zdhhc6 | NNNTCCCTGATGAGAAACTG | NGG | 2 | 0.1781 | Tier II |
19 | NC_000068.7 | 2 | 24705644 | + | Cacna1b | NNNTCCCTGAACTGTAACTG | NGG | 2 | 0.1588 | Tier II |
20 | NC_000073.6 | 7 | 96548637 | + | Tenm4 | NNNTCCTTGAAGAGTGACTG | NGG | 2 | 0.1563 | Tier II |
21 | NC_000071.6 | 5 | 122001302 | + | Cux2 | NNNTCCCTGAAGAGTAAAGG | NGG | 2 | 0.1346 | Tier II |
22 | NC_000068.7 | 2 | 105244955 | - | Them7 | NNNTCCCTGAGGAGTGACTG | NGG | 2 | 0.125 | Tier II |
23 | NC_000069.6 | 3 | 129608623 | - | Elovl6 | NNNTCTCTGAAGAGTATCTG | NGG | 2 | 0.1238 | Tier II |
24 | NC_000067.6 | 1 | 153083791 | - | Nmnat2 | NNNTCCCAGAAGAGTAAGTG | NGG | 2 | 0.1067 | Tier II |
25 | NC_000083.6 | 17 | 24529655 | + | Rab26 | NNNTCCCTGAAGAGCAACAG | NGG | 2 | 0.0779 | Tier II |
26 | NC_000073.6 | 7 | 55141077 | - | Luzp2 | NNNTCCCTGAAGAGAATCTG | NGG | 2 | 0.0772 | Tier II |
27 | NC_000072.6 | 6 | 94133120 | - | Magi1 | NNNTCCCTGCAGAGTACCTG | NGG | 2 | 0.0588 | Tier II |
28 | NC_000086.7 | X | 51672729 | - | Hs6st2 | NNNTCCCTGAAGACTATCTG | NGG | 2 | 0.0571 | Tier II |
29 | NC_000068.7 | 2 | 162645890 | + | Ptprt | NNNTCCCTGAAGAGTAAATG | NGA | 2 | 0.0374 | Tier II |
30 | NC_000077.6 | 11 | 47817922 | + | Sgcd | NNNCCCCTGAAGAGGAACTG | NGG | 2 | 0.0324 | Tier II |
31 | NC_000071.6 | 5 | 131065479 | + | Galnt17 | NNNTCCCTGAAGAGGAAATG | NGG | 2 | 0.0269 | Tier II |
32 | NC_000078.6 | 12 | 77324330 | + | Fut8 | NNNTCCCTGAACAGGAACTG | NGG | 2 | 0.0265 | Tier II |
33 | NC_000068.7 | 2 | 84812537 | + | Smtnl1 | NNNTCCCTCAAGAGTAACTG | NTG | 2 | 0.021 | Tier II |
34 | NC_000071.6 | 5 | 90350893 | + | Ankrd17 | NNNTCCATGAAGAGTAACTG | NGT | 2 | 0.0121 | Tier II |
35 | NC_000083.6 | 17 | 43290911 | - | Adgrf1 | NNNTCCCTGAAGATTTACTG | NGG | 2 | 0.0 | Tier II |
36 | NC_000071.6 | 5 | 119824129 | + | Tbx5 | NNNTCCCTGAGGAGTCACTG | NGG | 2 | 0.0 | Tier II |
37 | NC_000080.6 | 14 | 120277973 | - | Gm52122 | NNNTCCCTGAAGAGAAACTG | NGG | 1 | 0.5789 | Tier III |
38 | NC_000075.6 | 9 | 47352025 | + | Gm31816 | NNNTCCCTGAATAGTAACTT | NGG | 2 | 0.2692 | Tier III |
39 | NC_000068.7 | 2 | 144911488 | - | Gm39952 | NNNTCCCTGAAGTGAAACTG | NGG | 2 | 0.1737 | Tier III |
40 | NC_000072.6 | 6 | 94133120 | - | 4930511A08Rik | NNNTCCCTGCAGAGTACCTG | NGG | 2 | 0.0588 | Tier III |
41 | NC_000079.6 | 13 | 15830808 | - | B230303A05Rik | NNNTCCCTGATGAGTAACTG | NGA | 2 | 0.0214 | Tier III |
42 | NC_000071.6 | 5 | 119824129 | + | Gm5563 | NNNTCCCTGAGGAGTCACTG | NGG | 2 | 0.0 | Tier III |