Construct: sgRNA BRDN0001145269
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- CTTAAGGCGAGAAAAATTAG
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- NO_SITE control
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000017.11 | 17 | 68887048 | - | ABCA8 | NNNAAGGGGAGAAAAAATAG | NGG | 2 | 0.3429 | Tier I |
2 | NC_000001.11 | 1 | 42290185 | + | FOXJ3 | NNNAAGAAGAGAAAAATTAG | NGG | 2 | 0.65 | Tier II |
3 | NC_000001.11 | 1 | 715900 | + | OR4F16 | NNNAAGGTAAGAAAAATTAG | NGG | 2 | 0.5625 | Tier II |
4 | NC_000007.14 | 7 | 11663604 | + | THSD7A | NNNAAGGAGAGGAAAATTAG | NGG | 2 | 0.4694 | Tier II |
5 | NC_000006.12 | 6 | 116178920 | - | COL10A1 | NNNAAGGAAAGAAAAATTAG | NGG | 2 | 0.4179 | Tier II |
6 | NC_000006.12 | 6 | 116178920 | - | NT5DC1 | NNNAAGGAAAGAAAAATTAG | NGG | 2 | 0.4179 | Tier II |
7 | NC_000010.11 | 10 | 45628278 | + | ZFAND4 | NNNGAGGCAAGAAAAATTAG | NGG | 2 | 0.4018 | Tier II |
8 | NC_000015.10 | 15 | 42981102 | - | UBR1 | NNNAAGGAGGGAAAAATTAG | NGG | 2 | 0.3611 | Tier II |
9 | NC_000007.14 | 7 | 24734865 | + | GSDME | NNNAAGGAGAGAAAAAATAG | NGG | 2 | 0.3467 | Tier II |
10 | NC_000005.10 | 5 | 95468789 | + | SKIC3 | NNNAAGGCGATAAAAATTAT | NGG | 2 | 0.2692 | Tier II |
11 | NC_000005.10 | 5 | 142597163 | + | FGF1 | NNNTTGGCGAGAAAAATTAG | NGG | 2 | 0.2314 | Tier II |
12 | NC_000006.12 | 6 | 13980272 | + | RNF182 | NNNCAGGGGAGAAAAATTAG | NGG | 2 | 0.2269 | Tier II |
13 | NC_000010.11 | 10 | 45455257 | + | MARCHF8 | NNNAAGGGGAGAAACATTAG | NGG | 2 | 0.1753 | Tier II |
14 | NC_000003.12 | 3 | 101460271 | + | SENP7 | NNNAAGGAGAGCAAAATTAG | NGG | 2 | 0.1711 | Tier II |
15 | NC_000005.10 | 5 | 53043846 | + | ITGA2 | NNNAAGGAGAGAAAAATTAG | NAG | 2 | 0.1685 | Tier II |
16 | NC_000013.11 | 13 | 35474883 | - | MAB21L1 | NNNAAGGGGAGAAAAAGTAG | NGG | 2 | 0.0756 | Tier II |
17 | NC_000013.11 | 13 | 35474883 | - | NBEA | NNNAAGGGGAGAAAAAGTAG | NGG | 2 | 0.0756 | Tier II |
18 | NC_000003.12 | 3 | 62329488 | + | CEP15 | NNNAAGGAGAGAAAAATTAG | NGA | 2 | 0.0451 | Tier II |
19 | NC_000007.14 | 7 | 55379325 | + | LANCL2 | NNNAAGGGGAGAAAAATTAG | NGA | 2 | 0.0446 | Tier II |
20 | NC_000003.12 | 3 | 158290201 | + | RSRC1 | NNNAAGGCGAGAAAAATTTG | NGA | 2 | 0.0374 | Tier II |
21 | NC_000006.12 | 6 | 22055956 | - | CASC15 | NNNAAGAAGAGAAAAATTAG | NGG | 2 | 0.65 | Tier III |
22 | NC_000002.12 | 2 | 113566091 | - | PGM5P4 | NNNAAGGTAAGAAAAATTAG | NGG | 2 | 0.5625 | Tier III |
23 | NC_000002.12 | 2 | 242126659 | - | LINC01881 | NNNAAGGTAAGAAAAATTAG | NGG | 2 | 0.5625 | Tier III |
24 | NC_000020.11 | 20 | 64299194 | - | SEPTIN14P20 | NNNAAGGTAAGAAAAATTAG | NGG | 2 | 0.5625 | Tier III |
25 | NC_000024.10 | Y | 24287369 | - | LINC00266-2P | NNNAAGGTAAGAAAAATTAG | NGG | 2 | 0.5625 | Tier III |
26 | NC_000024.10 | Y | 25382779 | + | SEPTIN14P23 | NNNAAGGTAAGAAAAATTAG | NGG | 2 | 0.5625 | Tier III |
27 | NC_000017.11 | 17 | 49258654 | - | FLJ40194 | NNNAAGGAGAGAAAAATAAG | NGG | 2 | 0.4333 | Tier III |
28 | NC_000001.11 | 1 | 124922 | + | LOC124900384 | NNNAAGGAAAGAAAAATTAG | NGG | 2 | 0.4179 | Tier III |
29 | NC_000006.12 | 6 | 114441284 | - | LOC107986638 | NNNAAGGAAAGAAAAATTAG | NGG | 2 | 0.4179 | Tier III |
30 | NC_000008.11 | 8 | 127333616 | + | CASC8 | NNNAAGGGGAGAAAAATGAG | NGG | 2 | 0.2143 | Tier III |
31 | NC_000008.11 | 8 | 127333616 | + | CASC21 | NNNAAGGGGAGAAAAATGAG | NGG | 2 | 0.2143 | Tier III |
32 | NC_000016.10 | 16 | 65311070 | - | LINC00922 | NNNAAGGAGAGAACAATTAG | NGG | 2 | 0.1393 | Tier III |
33 | NC_000016.10 | 16 | 65311070 | - | LOC124903780 | NNNAAGGAGAGAACAATTAG | NGG | 2 | 0.1393 | Tier III |
34 | NC_000012.12 | 12 | 127505670 | - | LOC105370067 | NNNAAGGAGAGAAAAGTTAG | NGG | 2 | 0.125 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000077.6 | 11 | 110053047 | - | Abca8a | NNNAAGGGGAGAAAAAATAG | NGG | 2 | 0.3429 | Tier I |
2 | NC_000068.7 | 2 | 92949540 | + | Syt13 | NNNAAGAGGAGAAAAATTAG | NGG | 2 | 0.6429 | Tier II |
3 | NC_000069.6 | 3 | 145389838 | + | Col24a1 | NNNAAGGAGAGAAAAATTAA | NGG | 2 | 0.6094 | Tier II |
4 | NC_000082.6 | 16 | 45026912 | + | Cd200r3 | NNNAAGGTGAGAAAAATAAG | NGG | 2 | 0.5833 | Tier II |
5 | NC_000084.6 | 18 | 37799890 | + | Pcdhgb1 | NNNTAGGTGAGAAAAATTAG | NGG | 2 | 0.5568 | Tier II |
6 | NC_000084.6 | 18 | 37799890 | + | Pcdhgb2 | NNNTAGGTGAGAAAAATTAG | NGG | 2 | 0.5568 | Tier II |
7 | NC_000084.6 | 18 | 37799890 | + | Pcdhgb4 | NNNTAGGTGAGAAAAATTAG | NGG | 2 | 0.5568 | Tier II |
8 | NC_000084.6 | 18 | 37799890 | + | Pcdhgb5 | NNNTAGGTGAGAAAAATTAG | NGG | 2 | 0.5568 | Tier II |
9 | NC_000084.6 | 18 | 37799890 | + | Pcdhgb6 | NNNTAGGTGAGAAAAATTAG | NGG | 2 | 0.5568 | Tier II |
10 | NC_000084.6 | 18 | 37799890 | + | Pcdhgb7 | NNNTAGGTGAGAAAAATTAG | NGG | 2 | 0.5568 | Tier II |
11 | NC_000084.6 | 18 | 37799890 | + | Pcdhga1 | NNNTAGGTGAGAAAAATTAG | NGG | 2 | 0.5568 | Tier II |
12 | NC_000084.6 | 18 | 37799890 | + | Pcdhga2 | NNNTAGGTGAGAAAAATTAG | NGG | 2 | 0.5568 | Tier II |
13 | NC_000084.6 | 18 | 37799890 | + | Pcdhga3 | NNNTAGGTGAGAAAAATTAG | NGG | 2 | 0.5568 | Tier II |
14 | NC_000084.6 | 18 | 37799890 | + | Pcdhga4 | NNNTAGGTGAGAAAAATTAG | NGG | 2 | 0.5568 | Tier II |
15 | NC_000084.6 | 18 | 37799890 | + | Pcdhga5 | NNNTAGGTGAGAAAAATTAG | NGG | 2 | 0.5568 | Tier II |
16 | NC_000084.6 | 18 | 37799890 | + | Pcdhga6 | NNNTAGGTGAGAAAAATTAG | NGG | 2 | 0.5568 | Tier II |
17 | NC_000084.6 | 18 | 37799890 | + | Pcdhga7 | NNNTAGGTGAGAAAAATTAG | NGG | 2 | 0.5568 | Tier II |
18 | NC_000084.6 | 18 | 37799890 | + | Pcdhga8 | NNNTAGGTGAGAAAAATTAG | NGG | 2 | 0.5568 | Tier II |
19 | NC_000084.6 | 18 | 37799890 | + | Pcdhga9 | NNNTAGGTGAGAAAAATTAG | NGG | 2 | 0.5568 | Tier II |
20 | NC_000084.6 | 18 | 37799890 | + | Pcdhga10 | NNNTAGGTGAGAAAAATTAG | NGG | 2 | 0.5568 | Tier II |
21 | NC_000084.6 | 18 | 37799890 | + | Pcdhga11 | NNNTAGGTGAGAAAAATTAG | NGG | 2 | 0.5568 | Tier II |
22 | NC_000084.6 | 18 | 37799890 | + | Pcdhga12 | NNNTAGGTGAGAAAAATTAG | NGG | 2 | 0.5568 | Tier II |
23 | NC_000084.6 | 18 | 37799890 | + | Gm37013 | NNNTAGGTGAGAAAAATTAG | NGG | 2 | 0.5568 | Tier II |
24 | NC_000084.6 | 18 | 37799890 | + | Gm38666 | NNNTAGGTGAGAAAAATTAG | NGG | 2 | 0.5568 | Tier II |
25 | NC_000084.6 | 18 | 37799890 | + | Gm38667 | NNNTAGGTGAGAAAAATTAG | NGG | 2 | 0.5568 | Tier II |
26 | NC_000083.6 | 17 | 86021326 | - | Srbd1 | NNNAAGGATAGAAAAATTAG | NGG | 2 | 0.3467 | Tier II |
27 | NC_000081.6 | 15 | 96401127 | - | Arid2 | NNNAATGCGAGAAAAATCAG | NGG | 2 | 0.2857 | Tier II |
28 | NC_000078.6 | 12 | 100438911 | + | Ttc7b | NNNAAGGCTATAAAAATTAG | NGG | 2 | 0.2051 | Tier II |
29 | NC_000072.6 | 6 | 35179661 | + | Nup205 | NNNAAGGCTAGAAAAATGAG | NGG | 2 | 0.1778 | Tier II |
30 | NC_000071.6 | 5 | 73646018 | - | Sgcb | NNNAAGGGGAGAAAAATTAG | NAG | 2 | 0.1667 | Tier II |
31 | NC_000068.7 | 2 | 161629827 | + | Ptprt | NNNAAGGCTAGAAAAATTAG | NGA | 2 | 0.037 | Tier II |
32 | NC_000075.6 | 9 | 77975763 | - | Elovl5 | NNNAAGGGGAGAAAAATTAG | NTG | 2 | 0.025 | Tier II |
33 | NC_000075.6 | 9 | 66009373 | - | Csnk1g1 | NNNAAGGAGAGAAAAATTAG | NGC | 2 | 0.0144 | Tier II |
34 | NC_000070.6 | 4 | 76265095 | - | Ptprd | NNNAAGGCTAGAAAACTTAG | NGG | 2 | 0.0 | Tier II |
35 | NC_000069.6 | 3 | 145389838 | + | Gm35133 | NNNAAGGAGAGAAAAATTAA | NGG | 2 | 0.6094 | Tier III |
36 | NC_000084.6 | 18 | 37799890 | + | Pcdhgb8 | NNNTAGGTGAGAAAAATTAG | NGG | 2 | 0.5568 | Tier III |
37 | NC_000077.6 | 11 | 44015374 | - | Gm12153 | NNNAAGACTAGAAAAATTAG | NGG | 2 | 0.5333 | Tier III |
38 | NC_000071.6 | 5 | 87961492 | + | 1700066N21Rik | NNNGAGGAGAGAAAAATTAG | NGG | 2 | 0.4063 | Tier III |
39 | NC_000071.6 | 5 | 87961492 | + | BC051076 | NNNGAGGAGAGAAAAATTAG | NGG | 2 | 0.4063 | Tier III |