pB03 program activity among B cells

Activation of pB03
pB03 gene program activation in B cells.
Gene program activation of pB03 by different cell subtypes
pB03 gene program activation among cells of different subtypes (B cells).

pB03 top program genes

Top genes of pB03 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pB03 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pB03
pB03 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0045321 leukocyte activation 0.00281456406647431 1332 83 20 0.240963855421687 0.015015015015015
GO:BP GO:0042113 B cell activation 0.00281456406647431 330 47 8 0.170212765957447 0.0242424242424242
GO:BP GO:1903131 mononuclear cell differentiation 0.00451267632003062 430 41 8 0.195121951219512 0.0186046511627907
GO:BP GO:0001775 cell activation 0.00736679003359452 1495 83 20 0.240963855421687 0.0133779264214047
GO:BP GO:0002252 immune effector process 0.0079785464910031 1309 88 19 0.215909090909091 0.014514896867838
GO:BP GO:0051649 establishment of localization in cell 0.00914379795994642 2813 129 39 0.302325581395349 0.0138642019196587
GO:BP GO:0046649 lymphocyte activation 0.00970132482403453 771 47 10 0.212765957446809 0.012970168612192
GO:BP GO:0002521 leukocyte differentiation 0.0100980034963353 550 41 8 0.195121951219512 0.0145454545454545
GO:BP GO:0006955 immune response 0.0106034186205996 2311 56 19 0.339285714285714 0.00822154911293812
GO:BP GO:0051641 cellular localization 0.0106034186205996 3541 134 46 0.343283582089552 0.0129906805987009
GO:BP GO:0030183 B cell differentiation 0.0106034186205996 140 25 4 0.16 0.0285714285714286
GO:BP GO:0016032 viral process 0.0128357885338101 942 110 17 0.154545454545455 0.0180467091295117
GO:BP GO:0050854 regulation of antigen receptor-mediated signaling pathway 0.0169923104256527 68 22 3 0.136363636363636 0.0441176470588235
GO:BP GO:0050708 regulation of protein secretion 0.0189748953775291 295 29 5 0.172413793103448 0.0169491525423729
GO:BP GO:0046907 intracellular transport 0.0197326774117851 1767 123 26 0.211382113821138 0.0147142048670062
GO:BP GO:0044403 biological process involved in symbiotic interaction 0.0197326774117851 1001 110 17 0.154545454545455 0.016983016983017
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 0.0197326774117851 2255 98 26 0.26530612244898 0.011529933481153
GO:BP GO:0002791 regulation of peptide secretion 0.0201626360947351 325 29 5 0.172413793103448 0.0153846153846154
GO:BP GO:0002376 immune system process 0.0201626360947351 3278 56 22 0.392857142857143 0.00671140939597315
GO:BP GO:0016192 vesicle-mediated transport 0.0201626360947351 2180 125 30 0.24 0.0137614678899083
GO:BP GO:0018027 peptidyl-lysine dimethylation 0.0217004356692313 23 89 3 0.0337078651685393 0.130434782608696
GO:BP GO:0030098 lymphocyte differentiation 0.0217004356692313 376 41 6 0.146341463414634 0.0159574468085106
GO:BP GO:0006810 transport 0.023356022797051 5224 131 57 0.435114503816794 0.0109111791730475
GO:BP GO:0050796 regulation of insulin secretion 0.023356022797051 189 29 4 0.137931034482759 0.0211640211640212
GO:BP GO:0051223 regulation of protein transport 0.0241160601177422 586 111 12 0.108108108108108 0.0204778156996587
GO:BP GO:0051234 establishment of localization 0.0245459924022906 5372 131 58 0.442748091603053 0.0107967237527923
GO:BP GO:0051248 negative regulation of protein metabolic process 0.0265114070256904 1151 134 20 0.149253731343284 0.0173761946133797
GO:BP GO:0045732 positive regulation of protein catabolic process 0.0265114070256904 237 11 3 0.272727272727273 0.0126582278481013
GO:BP GO:0035592 establishment of protein localization to extracellular region 0.0265114070256904 385 29 5 0.172413793103448 0.012987012987013
GO:BP GO:0009306 protein secretion 0.0265114070256904 384 29 5 0.172413793103448 0.0130208333333333
GO:BP GO:0090087 regulation of peptide transport 0.0265448459978729 618 29 6 0.206896551724138 0.00970873786407767
GO:BP GO:0071692 protein localization to extracellular region 0.0265448459978729 392 29 5 0.172413793103448 0.0127551020408163
GO:BP GO:0045576 mast cell activation 0.0265448459978729 62 41 3 0.0731707317073171 0.0483870967741935
GO:BP GO:0070201 regulation of establishment of protein localization 0.0265448459978729 611 29 6 0.206896551724138 0.00981996726677578
GO:BP GO:0030073 insulin secretion 0.0265522526998235 218 29 4 0.137931034482759 0.018348623853211
GO:BP GO:0051172 negative regulation of nitrogen compound metabolic process 0.0265866488518016 2518 110 29 0.263636363636364 0.011517077045274
GO:BP GO:0090276 regulation of peptide hormone secretion 0.0267193348929164 221 29 4 0.137931034482759 0.0180995475113122
GO:BP GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.0268829693729061 217 53 5 0.0943396226415094 0.0230414746543779
GO:BP GO:0009636 response to toxic substance 0.0277550905585895 243 134 8 0.0597014925373134 0.0329218106995885
GO:BP GO:0015031 protein transport 0.0281721025923741 1929 123 26 0.211382113821138 0.0134784862623121
GO:BP GO:0002275 myeloid cell activation involved in immune response 0.0285229756931544 547 79 9 0.113924050632911 0.0164533820840951
GO:BP GO:2000116 regulation of cysteine-type endopeptidase activity 0.0285229756931544 240 53 5 0.0943396226415094 0.0208333333333333
GO:BP GO:0002274 myeloid leukocyte activation 0.0285229756931544 667 79 10 0.126582278481013 0.0149925037481259
GO:BP GO:0050853 B cell receptor signaling pathway 0.0285229756931544 135 134 6 0.0447761194029851 0.0444444444444444
GO:BP GO:0002444 myeloid leukocyte mediated immunity 0.0285229756931544 551 79 9 0.113924050632911 0.0163339382940109
GO:BP GO:0002790 peptide secretion 0.0285229756931544 421 29 5 0.172413793103448 0.0118764845605701
GO:BP GO:0070861 regulation of protein exit from endoplasmic reticulum 0.0285229756931544 27 111 3 0.027027027027027 0.111111111111111
GO:BP GO:0050851 antigen receptor-mediated signaling pathway 0.0285229756931544 323 22 4 0.181818181818182 0.0123839009287926
GO:BP GO:0043299 leukocyte degranulation 0.0285229756931544 535 79 9 0.113924050632911 0.0168224299065421
GO:BP GO:0050864 regulation of B cell activation 0.0285229756931544 194 134 7 0.0522388059701493 0.0360824742268041
GO:BP GO:0002443 leukocyte mediated immunity 0.0285229756931544 877 83 12 0.144578313253012 0.0136830102622577
GO:BP GO:0015833 peptide transport 0.0285229756931544 1971 123 26 0.211382113821138 0.0131912734652461
GO:BP GO:0071705 nitrogen compound transport 0.0299374044724931 2322 123 29 0.235772357723577 0.012489233419466
GO:BP GO:0019079 viral genome replication 0.0299374044724931 131 98 5 0.0510204081632653 0.0381679389312977
GO:BP GO:0030072 peptide hormone secretion 0.0299374044724931 260 29 4 0.137931034482759 0.0153846153846154
GO:BP GO:0043067 regulation of programmed cell death 0.0314842016933409 1582 25 8 0.32 0.00505689001264223
GO:BP GO:1905710 positive regulation of membrane permeability 0.0314842016933409 72 108 4 0.037037037037037 0.0555555555555556
GO:BP GO:0048518 positive regulation of biological process 0.0314842016933409 6363 29 19 0.655172413793103 0.00298601288700299
GO:BP GO:0002263 cell activation involved in immune response 0.0314842016933409 721 134 14 0.104477611940299 0.0194174757281553
GO:BP GO:0046883 regulation of hormone secretion 0.0314842016933409 275 29 4 0.137931034482759 0.0145454545454545
GO:BP GO:0002366 leukocyte activation involved in immune response 0.0314842016933409 717 134 14 0.104477611940299 0.0195258019525802
GO:BP GO:0042886 amide transport 0.0314842016933409 2007 123 26 0.211382113821138 0.012954658694569
GO:BP GO:0030097 hemopoiesis 0.0322376492359418 928 41 8 0.195121951219512 0.00862068965517241
GO:BP GO:0019058 viral life cycle 0.0338263199968156 353 106 8 0.0754716981132075 0.0226628895184136
GO:BP GO:0045582 positive regulation of T cell differentiation 0.0338263199968156 91 41 3 0.0731707317073171 0.032967032967033
GO:BP GO:0032269 negative regulation of cellular protein metabolic process 0.0338263199968156 1082 134 18 0.134328358208955 0.0166358595194085
GO:BP GO:0002683 negative regulation of immune system process 0.0338263199968156 420 51 6 0.117647058823529 0.0142857142857143
GO:BP GO:0050855 regulation of B cell receptor signaling pathway 0.0338263199968156 28 134 3 0.0223880597014925 0.107142857142857
GO:BP GO:0045184 establishment of protein localization 0.0338263199968156 2035 123 26 0.211382113821138 0.0127764127764128
GO:BP GO:0031503 protein-containing complex localization 0.0338263199968156 289 29 4 0.137931034482759 0.013840830449827
GO:BP GO:0048534 hematopoietic or lymphoid organ development 0.0344503153743054 966 41 8 0.195121951219512 0.0082815734989648
GO:BP GO:0050714 positive regulation of protein secretion 0.0349293217511324 136 29 3 0.103448275862069 0.0220588235294118
GO:BP GO:0031324 negative regulation of cellular metabolic process 0.0354157693930772 2719 110 29 0.263636363636364 0.0106656859139389
GO:BP GO:0002757 immune response-activating signal transduction 0.0354157693930772 477 47 6 0.127659574468085 0.0125786163522013
GO:BP GO:0043304 regulation of mast cell degranulation 0.0354157693930772 30 134 3 0.0223880597014925 0.1
GO:BP GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process 0.0354157693930772 36 110 3 0.0272727272727273 0.0833333333333333
GO:BP GO:0002429 immune response-activating cell surface receptor signaling pathway 0.0354157693930772 477 47 6 0.127659574468085 0.0125786163522013
GO:BP GO:0002684 positive regulation of immune system process 0.0365780544930873 1065 47 9 0.191489361702128 0.00845070422535211
GO:BP GO:0045861 negative regulation of proteolysis 0.0367791942128025 359 110 8 0.0727272727272727 0.0222841225626741
GO:BP GO:0060341 regulation of cellular localization 0.0367791942128025 851 134 15 0.111940298507463 0.0176263219741481
GO:BP GO:0061647 histone H3-K9 modification 0.0367791942128025 47 89 3 0.0337078651685393 0.0638297872340425
GO:BP GO:0007159 leukocyte cell-cell adhesion 0.0367791942128025 375 41 5 0.121951219512195 0.0133333333333333
GO:BP GO:0042176 regulation of protein catabolic process 0.0367791942128025 401 11 3 0.272727272727273 0.00748129675810474
GO:BP GO:0033006 regulation of mast cell activation involved in immune response 0.0367791942128025 31 134 3 0.0223880597014925 0.0967741935483871
GO:BP GO:0046879 hormone secretion 0.0367791942128025 317 29 4 0.137931034482759 0.0126182965299685
GO:BP GO:0010941 regulation of cell death 0.0368602449980478 1720 25 8 0.32 0.00465116279069767
GO:BP GO:0051249 regulation of lymphocyte activation 0.0368900394048529 518 134 11 0.082089552238806 0.0212355212355212
GO:BP GO:0045621 positive regulation of lymphocyte differentiation 0.0375216962284509 104 41 3 0.0731707317073171 0.0288461538461538
GO:BP GO:0002520 immune system development 0.0377176094272965 1020 41 8 0.195121951219512 0.00784313725490196
GO:BP GO:0009914 hormone transport 0.0377176094272965 327 29 4 0.137931034482759 0.0122324159021407
GO:BP GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.0377176094272965 81 53 3 0.0566037735849057 0.037037037037037
GO:BP GO:0008380 RNA splicing 0.0377176094272965 456 109 9 0.0825688073394495 0.0197368421052632
GO:BP GO:0051222 positive regulation of protein transport 0.0377176094272965 329 29 4 0.137931034482759 0.0121580547112462
GO:BP GO:0002697 regulation of immune effector process 0.0377345518228201 461 51 6 0.117647058823529 0.0130151843817787
GO:BP GO:0032386 regulation of intracellular transport 0.0385261406972399 367 111 8 0.0720720720720721 0.0217983651226158
GO:BP GO:0001819 positive regulation of cytokine production 0.0385261406972399 452 53 6 0.113207547169811 0.0132743362831858
GO:BP GO:0002768 immune response-regulating cell surface receptor signaling pathway 0.0385261406972399 512 47 6 0.127659574468085 0.01171875
GO:BP GO:1903530 regulation of secretion by cell 0.0385261406972399 588 41 6 0.146341463414634 0.0102040816326531
GO:BP GO:0002764 immune response-regulating signaling pathway 0.0389382479905329 515 47 6 0.127659574468085 0.0116504854368932
GO:BP GO:0002793 positive regulation of peptide secretion 0.0389382479905329 159 29 3 0.103448275862069 0.0188679245283019
GO:BP GO:0045055 regulated exocytosis 0.0389382479905329 785 134 14 0.104477611940299 0.0178343949044586
GO:BP GO:1904951 positive regulation of establishment of protein localization 0.0395522485410768 345 29 4 0.137931034482759 0.0115942028985507
GO:BP GO:0051240 positive regulation of multicellular organismal process 0.039732868129512 1455 44 10 0.227272727272727 0.00687285223367698
GO:BP GO:0001817 regulation of cytokine production 0.0405887515850323 806 53 8 0.150943396226415 0.00992555831265509
GO:BP GO:0052548 regulation of endopeptidase activity 0.0405887515850323 437 56 6 0.107142857142857 0.0137299771167048
GO:BP GO:2000117 negative regulation of cysteine-type endopeptidase activity 0.040670587176151 89 53 3 0.0566037735849057 0.0337078651685393
GO:BP GO:0032418 lysosome localization 0.0410236205695097 76 134 4 0.0298507462686567 0.0526315789473684
GO:BP GO:0009896 positive regulation of catabolic process 0.0410236205695097 464 11 3 0.272727272727273 0.00646551724137931
GO:BP GO:0061462 protein localization to lysosome 0.0412799762481926 46 106 3 0.0283018867924528 0.0652173913043478
GO:BP GO:0000380 alternative mRNA splicing, via spliceosome 0.0415605677948379 89 55 3 0.0545454545454545 0.0337078651685393
GO:BP GO:0071331 cellular response to hexose stimulus 0.0415605677948379 139 74 4 0.0540540540540541 0.0287769784172662
GO:BP GO:0090559 regulation of membrane permeability 0.0415605677948379 95 108 4 0.037037037037037 0.0421052631578947
GO:BP GO:0048522 positive regulation of cellular process 0.0416214721817231 5757 88 41 0.465909090909091 0.00712176480805975
GO:BP GO:0071326 cellular response to monosaccharide stimulus 0.0416583574566216 140 74 4 0.0540540540540541 0.0285714285714286
GO:BP GO:0044070 regulation of anion transport 0.0416583574566216 896 29 6 0.206896551724138 0.00669642857142857
GO:BP GO:0022618 ribonucleoprotein complex assembly 0.0430153543659378 197 26 3 0.115384615384615 0.0152284263959391
GO:BP GO:0006887 exocytosis 0.0434473822933985 904 134 15 0.111940298507463 0.0165929203539823
GO:BP GO:0052547 regulation of peptidase activity 0.0437832004585038 467 56 6 0.107142857142857 0.012847965738758
GO:BP GO:0001816 cytokine production 0.0437832004585038 844 53 8 0.150943396226415 0.00947867298578199
GO:BP GO:0032880 regulation of protein localization 0.0437832004585038 922 29 6 0.206896551724138 0.00650759219088937
GO:BP GO:0071322 cellular response to carbohydrate stimulus 0.0437832004585038 148 74 4 0.0540540540540541 0.027027027027027
GO:BP GO:0022407 regulation of cell-cell adhesion 0.0437832004585038 445 41 5 0.121951219512195 0.0112359550561798
GO:BP GO:0051046 regulation of secretion 0.0437832004585038 647 41 6 0.146341463414634 0.00927357032457496
GO:BP GO:0022607 cellular component assembly 0.0437832004585038 3010 91 26 0.285714285714286 0.00863787375415282
GO:BP GO:0032527 protein exit from endoplasmic reticulum 0.0437832004585038 48 111 3 0.027027027027027 0.0625
GO:BP GO:0050778 positive regulation of immune response 0.0437832004585038 753 47 7 0.148936170212766 0.00929614873837981
GO:BP GO:0071826 ribonucleoprotein complex subunit organization 0.0437832004585038 204 26 3 0.115384615384615 0.0147058823529412
GO:BP GO:0009267 cellular response to starvation 0.0437832004585038 160 33 3 0.0909090909090909 0.01875
GO:BP GO:1903362 regulation of cellular protein catabolic process 0.0437832004585038 257 135 7 0.0518518518518519 0.0272373540856031
GO:BP GO:0002253 activation of immune response 0.0448101200802925 568 47 6 0.127659574468085 0.0105633802816901
GO:BP GO:0022613 ribonucleoprotein complex biogenesis 0.0461916769327018 446 26 4 0.153846153846154 0.00896860986547085
GO:BP GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process 0.0461916769327018 50 110 3 0.0272727272727273 0.06
GO:BP GO:1901799 negative regulation of proteasomal protein catabolic process 0.0461916769327018 50 110 3 0.0272727272727273 0.06
GO:BP GO:0009893 positive regulation of metabolic process 0.0463422274986194 3783 23 11 0.478260869565217 0.00290774517578641
GO:BP GO:0033003 regulation of mast cell activation 0.0469712565344164 42 134 3 0.0223880597014925 0.0714285714285714
GO:BP GO:0051336 regulation of hydrolase activity 0.0469712565344164 1321 60 11 0.183333333333333 0.00832702498107494
GO:BP GO:0071345 cellular response to cytokine stimulus 0.0470468956741633 1132 25 6 0.24 0.00530035335689046
GO:BP GO:0010466 negative regulation of peptidase activity 0.0477145146480263 267 101 6 0.0594059405940594 0.0224719101123595
GO:BP GO:1903532 positive regulation of secretion by cell 0.0477185096767216 285 41 4 0.0975609756097561 0.0140350877192982
GO:BP GO:0002431 Fc receptor mediated stimulatory signaling pathway 0.0479095723672017 141 134 5 0.0373134328358209 0.0354609929078014
GO:BP GO:0042981 regulation of apoptotic process 0.0479552595774958 1549 25 7 0.28 0.00451904454486766
GO:BP GO:0016482 cytosolic transport 0.0484064589625995 168 113 5 0.0442477876106195 0.0297619047619048
GO:BP GO:0032922 circadian regulation of gene expression 0.0488262706441052 67 87 3 0.0344827586206897 0.0447761194029851
GO:BP GO:0009615 response to virus 0.0491239214121462 364 53 5 0.0943396226415094 0.0137362637362637
GO:BP GO:0043484 regulation of RNA splicing 0.0497244269247474 160 37 3 0.0810810810810811 0.01875
GO:BP GO:0006360 transcription by RNA polymerase I 0.0499101368393881 68 87 3 0.0344827586206897 0.0441176470588235
GO:CC GO:0005829 cytosol 0.000261681350026827 5303 104 53 0.509615384615385 0.00999434282481614
GO:CC GO:0070062 extracellular exosome 0.00250302185699326 2176 115 30 0.260869565217391 0.0137867647058824
GO:CC GO:1903561 extracellular vesicle 0.00268866455890612 2261 115 30 0.260869565217391 0.0132684652808492
GO:CC GO:0043230 extracellular organelle 0.00268866455890612 2263 115 30 0.260869565217391 0.0132567388422448
GO:CC GO:0031083 BLOC-1 complex 0.00651129328317024 17 103 3 0.029126213592233 0.176470588235294
GO:CC GO:0001772 immunological synapse 0.00651129328317024 43 106 4 0.0377358490566038 0.0930232558139535
GO:CC GO:0031982 vesicle 0.00920727056860825 4055 134 47 0.350746268656716 0.0115906288532676
GO:CC GO:0031082 BLOC complex 0.00920727056860825 22 103 3 0.029126213592233 0.136363636363636
GO:CC GO:0005730 nucleolus 0.0213263952833116 955 82 12 0.146341463414634 0.012565445026178
GO:CC GO:0005740 mitochondrial envelope 0.0322526017882692 797 135 14 0.103703703703704 0.0175658720200753
GO:CC GO:0016604 nuclear body 0.0322526017882692 816 92 11 0.119565217391304 0.0134803921568627
GO:CC GO:0005739 mitochondrion 0.0322526017882692 1673 135 23 0.17037037037037 0.013747758517633
GO:CC GO:0101002 ficolin-1-rich granule 0.0322662695593553 184 56 4 0.0714285714285714 0.0217391304347826
GO:CC GO:0030055 cell-substrate junction 0.0346197644559762 427 108 8 0.0740740740740741 0.0187353629976581
GO:CC GO:0005925 focal adhesion 0.0346197644559762 420 108 8 0.0740740740740741 0.019047619047619
GO:CC GO:0005758 mitochondrial intermembrane space 0.0346197644559762 87 134 4 0.0298507462686567 0.0459770114942529
GO:CC GO:0031981 nuclear lumen 0.0346197644559762 4444 56 23 0.410714285714286 0.00517551755175518
GO:CC GO:0032991 protein-containing complex 0.0346197644559762 5548 29 16 0.551724137931034 0.00288392213410238
GO:CC GO:0043231 intracellular membrane-bounded organelle 0.0346197644559762 11296 11 11 1 0.000973796033994334
GO:CC GO:0043227 membrane-bounded organelle 0.037168241588705 12858 135 106 0.785185185185185 0.00824389485145435
GO:CC GO:0005615 extracellular space 0.037168241588705 3594 115 34 0.295652173913043 0.00946021146355036
GO:CC GO:0005737 cytoplasm 0.0385041530240944 11911 131 97 0.740458015267176 0.00814373268407355
GO:CC GO:1904115 axon cytoplasm 0.0394940636580484 62 103 3 0.029126213592233 0.0483870967741935
GO:CC GO:0042571 immunoglobulin complex, circulating 0.0394940636580484 77 83 3 0.036144578313253 0.038961038961039
GO:CC GO:0015630 microtubule cytoskeleton 0.0394940636580484 1307 103 15 0.145631067961165 0.0114766641162969
GO:CC GO:0031970 organelle envelope lumen 0.0411834713895325 97 134 4 0.0298507462686567 0.0412371134020619
GO:CC GO:0098552 side of membrane 0.043838057278033 619 83 8 0.0963855421686747 0.012924071082391
GO:CC GO:1904813 ficolin-1-rich granule lumen 0.0438615107609592 124 56 3 0.0535714285714286 0.0241935483870968
GO:CC GO:0045121 membrane raft 0.043982388132686 335 95 6 0.0631578947368421 0.017910447761194
GO:CC GO:0032838 plasma membrane bounded cell projection cytoplasm 0.043982388132686 226 33 3 0.0909090909090909 0.0132743362831858
GO:CC GO:0070161 anchoring junction 0.043982388132686 836 134 13 0.0970149253731343 0.0155502392344498
GO:CC GO:0009898 cytoplasmic side of plasma membrane 0.043982388132686 168 134 5 0.0373134328358209 0.0297619047619048
GO:CC GO:0005654 nucleoplasm 0.043982388132686 4102 94 31 0.329787234042553 0.007557289127255
GO:CC GO:0031966 mitochondrial membrane 0.043982388132686 746 135 12 0.0888888888888889 0.0160857908847185
GO:CC GO:0098857 membrane microdomain 0.043982388132686 335 95 6 0.0631578947368421 0.017910447761194
GO:CC GO:0031967 organelle envelope 0.043982388132686 1237 135 17 0.125925925925926 0.0137429264349232
GO:CC GO:0031975 envelope 0.043982388132686 1237 135 17 0.125925925925926 0.0137429264349232
GO:CC GO:0019898 extrinsic component of membrane 0.045274393890491 313 136 7 0.0514705882352941 0.0223642172523962
GO:CC GO:0048471 perinuclear region of cytoplasm 0.0453872976769509 735 11 3 0.272727272727273 0.00408163265306122
GO:MF GO:0008022 protein C-terminus binding 0.0106996822338463 202 108 8 0.0740740740740741 0.0396039603960396
GO:MF GO:0005515 protein binding 0.016523990426696 14767 136 124 0.911764705882353 0.00839710164556105
GO:MF GO:0090079 translation regulator activity, nucleic acid binding 0.0174226073776311 123 98 5 0.0510204081632653 0.040650406504065
GO:MF GO:0003723 RNA binding 0.0174226073776311 1943 98 22 0.224489795918367 0.011322696860525
GO:MF GO:0008135 translation factor activity, RNA binding 0.0174226073776311 99 26 3 0.115384615384615 0.0303030303030303
GO:MF GO:0030234 enzyme regulator activity 0.0271868122689974 1248 60 11 0.183333333333333 0.00881410256410256
GO:MF GO:0004857 enzyme inhibitor activity 0.0271868122689974 385 56 6 0.107142857142857 0.0155844155844156
GO:MF GO:0045182 translation regulator activity 0.0271868122689974 155 26 3 0.115384615384615 0.0193548387096774
GO:MF GO:0051117 ATPase binding 0.0271868122689974 86 116 4 0.0344827586206897 0.0465116279069767
GO:MF GO:0031625 ubiquitin protein ligase binding 0.0271868122689974 296 134 8 0.0597014925373134 0.027027027027027
GO:MF GO:0003676 nucleic acid binding 0.0271868122689974 4276 28 14 0.5 0.00327408793264733
GO:MF GO:0044389 ubiquitin-like protein ligase binding 0.0271868122689974 314 134 8 0.0597014925373134 0.0254777070063694
GO:MF GO:0042802 identical protein binding 0.0311839421903962 2067 19 7 0.368421052631579 0.00338655055636188
GO:MF GO:0003697 single-stranded DNA binding 0.0410444256251874 119 51 3 0.0588235294117647 0.0252100840336134
GO:MF GO:0034987 immunoglobulin receptor binding 0.044489872410731 79 83 3 0.036144578313253 0.0379746835443038
GO:MF GO:0019899 enzyme binding 0.044978353853154 2074 73 16 0.219178082191781 0.0077145612343298

pB03 transcription factor target enrichment of top program genes

TF enrichment of pB03
TFs corrosponding to activation of pB03. (Left) pearson correlation of TF expression and gene expression program activatity in B cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.