pEpiTd22 program activity among Epithelial cells

Activation of pEpiTd22
pEpiTd22 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpiTd22 by different cell subtypes
pEpiTd22 gene program activation among cells of different subtypes (Epithelial cells).

pEpiTd22 top program genes

Top genes of pEpiTd22 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpiTd22 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpiTd22
pEpiTd22 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
CORUM CORUM:7298 ACTB-ANP32A-C1QBP-PSMA1-PTMA-PSMA1 complex 0.000125575137627364 6 19 3 0.157894736842105 0.5
GO:BP GO:0051641 cellular localization 0.000203269284143164 3541 18 14 0.777777777777778 0.00395368539960463
GO:BP GO:0048870 cell motility 0.000203269284143164 1828 10 8 0.8 0.00437636761487965
GO:BP GO:0051674 localization of cell 0.000203269284143164 1828 10 8 0.8 0.00437636761487965
GO:BP GO:0040011 locomotion 0.000228576986284915 2028 10 8 0.8 0.00394477317554241
GO:BP GO:0030036 actin cytoskeleton organization 0.000228576986284915 709 10 6 0.6 0.00846262341325811
GO:BP GO:0030029 actin filament-based process 0.000249599045632789 808 10 6 0.6 0.00742574257425743
GO:BP GO:0070527 platelet aggregation 0.000249599045632789 64 7 3 0.428571428571429 0.046875
GO:BP GO:0051649 establishment of localization in cell 0.000249599045632789 2813 18 12 0.666666666666667 0.00426590828297192
GO:BP GO:0007015 actin filament organization 0.000306858766054313 445 10 5 0.5 0.0112359550561798
GO:BP GO:0006928 movement of cell or subcellular component 0.000344276164274237 2311 10 8 0.8 0.00346170488965816
GO:BP GO:0034109 homotypic cell-cell adhesion 0.000474427870892091 87 7 3 0.428571428571429 0.0344827586206897
GO:BP GO:0008154 actin polymerization or depolymerization 0.000515874410990874 223 10 4 0.4 0.0179372197309417
GO:BP GO:0032879 regulation of localization 0.000515874410990874 2872 22 13 0.590909090909091 0.00452646239554318
GO:BP GO:0030837 negative regulation of actin filament polymerization 0.00057398030300983 68 10 3 0.3 0.0441176470588235
GO:BP GO:0032507 maintenance of protein location in cell 0.00057398030300983 67 10 3 0.3 0.0447761194029851
GO:BP GO:0007010 cytoskeleton organization 0.00081441285842241 1423 12 7 0.583333333333333 0.00491918482080112
GO:BP GO:0032272 negative regulation of protein polymerization 0.00081441285842241 82 10 3 0.3 0.0365853658536585
GO:BP GO:0110053 regulation of actin filament organization 0.00081441285842241 284 10 4 0.4 0.0140845070422535
GO:BP GO:0030334 regulation of cell migration 0.000853204750868785 999 22 8 0.363636363636364 0.00800800800800801
GO:BP GO:0065008 regulation of biological quality 0.000853204750868785 4131 10 9 0.9 0.00217864923747277
GO:BP GO:0060548 negative regulation of cell death 0.000887120510207969 1038 16 7 0.4375 0.00674373795761079
GO:BP GO:0045185 maintenance of protein location 0.00103057502654149 98 10 3 0.3 0.0306122448979592
GO:BP GO:0140352 export from cell 0.00108210338191876 1418 22 9 0.409090909090909 0.00634696755994358
GO:BP GO:2000145 regulation of cell motility 0.00108210338191876 1061 22 8 0.363636363636364 0.00754005655042413
GO:BP GO:0097435 supramolecular fiber organization 0.00111087964692081 734 10 5 0.5 0.00681198910081744
GO:BP GO:0030168 platelet activation 0.00111087964692081 160 7 3 0.428571428571429 0.01875
GO:BP GO:0040012 regulation of locomotion 0.00128358491877483 1104 22 8 0.363636363636364 0.0072463768115942
GO:BP GO:0016192 vesicle-mediated transport 0.00132882724873448 2180 13 8 0.615384615384615 0.0036697247706422
GO:BP GO:0032956 regulation of actin cytoskeleton organization 0.00132882724873448 366 10 4 0.4 0.0109289617486339
GO:BP GO:0070887 cellular response to chemical stimulus 0.00137333946461138 3393 12 9 0.75 0.0026525198938992
GO:BP GO:0051270 regulation of cellular component movement 0.00137333946461138 1141 22 8 0.363636363636364 0.007011393514461
GO:BP GO:0051179 localization 0.00137333946461138 6901 22 18 0.818181818181818 0.00260831763512534
GO:BP GO:0051234 establishment of localization 0.00140263710936737 5372 22 16 0.727272727272727 0.00297840655249442
GO:BP GO:1902903 regulation of supramolecular fiber organization 0.00140334152413079 387 10 4 0.4 0.0103359173126615
GO:BP GO:0071345 cellular response to cytokine stimulus 0.00140334152413079 1132 12 6 0.5 0.00530035335689046
GO:BP GO:0099173 postsynapse organization 0.00151210329833344 169 8 3 0.375 0.0177514792899408
GO:BP GO:0030335 positive regulation of cell migration 0.00152501426440766 567 22 6 0.272727272727273 0.0105820105820106
GO:BP GO:0032970 regulation of actin filament-based process 0.00153841738675591 406 10 4 0.4 0.00985221674876847
GO:BP GO:0001738 morphogenesis of a polarized epithelium 0.00153841738675591 152 9 3 0.333333333333333 0.0197368421052632
GO:BP GO:2000147 positive regulation of cell motility 0.00160380860169128 591 22 6 0.272727272727273 0.0101522842639594
GO:BP GO:0045859 regulation of protein kinase activity 0.00160380860169128 809 6 4 0.666666666666667 0.00494437577255871
GO:BP GO:0016477 cell migration 0.00160380860169128 1649 13 7 0.538461538461538 0.00424499696785931
GO:BP GO:0031333 negative regulation of protein-containing complex assembly 0.00163424306104052 147 10 3 0.3 0.0204081632653061
GO:BP GO:0034097 response to cytokine 0.00163424306104052 1226 12 6 0.5 0.00489396411092985
GO:BP GO:0010634 positive regulation of epithelial cell migration 0.00163424306104052 181 22 4 0.181818181818182 0.0220994475138122
GO:BP GO:0051272 positive regulation of cellular component movement 0.00165450448480411 604 22 6 0.272727272727273 0.00993377483443709
GO:BP GO:0040017 positive regulation of locomotion 0.0016570975391821 606 22 6 0.272727272727273 0.0099009900990099
GO:BP GO:0032535 regulation of cellular component size 0.00167443719877764 388 21 5 0.238095238095238 0.0128865979381443
GO:BP GO:0006887 exocytosis 0.00167443719877764 904 22 7 0.318181818181818 0.00774336283185841
GO:BP GO:0071310 cellular response to organic substance 0.00197626858396335 2776 12 8 0.666666666666667 0.00288184438040346
GO:BP GO:0043549 regulation of kinase activity 0.00198757817634555 921 6 4 0.666666666666667 0.00434310532030402
GO:BP GO:0043066 negative regulation of apoptotic process 0.00198757817634555 921 16 6 0.375 0.00651465798045603
GO:BP GO:1902904 negative regulation of supramolecular fiber organization 0.00198757817634555 170 10 3 0.3 0.0176470588235294
GO:BP GO:0008104 protein localization 0.00198757817634555 2770 18 10 0.555555555555556 0.0036101083032491
GO:BP GO:0051494 negative regulation of cytoskeleton organization 0.00198757817634555 166 10 3 0.3 0.0180722891566265
GO:BP GO:0034599 cellular response to oxidative stress 0.00210689085011492 316 6 3 0.5 0.00949367088607595
GO:BP GO:0043069 negative regulation of programmed cell death 0.00210689085011492 943 16 6 0.375 0.0063626723223754
GO:BP GO:0030833 regulation of actin filament polymerization 0.00215074832655776 177 10 3 0.3 0.0169491525423729
GO:BP GO:0019221 cytokine-mediated signaling pathway 0.0021801967033742 810 12 5 0.416666666666667 0.00617283950617284
GO:BP GO:0044070 regulation of anion transport 0.00232421348055458 896 3 3 1 0.00334821428571429
GO:BP GO:0032940 secretion by cell 0.00236430600094914 1364 22 8 0.363636363636364 0.00586510263929619
GO:BP GO:0080134 regulation of response to stress 0.00236875916619946 1443 21 8 0.380952380952381 0.00554400554400554
GO:BP GO:0080135 regulation of cellular response to stress 0.00241210679190535 725 21 6 0.285714285714286 0.00827586206896552
GO:BP GO:0032880 regulation of protein localization 0.00241210679190535 922 3 3 1 0.00325379609544469
GO:BP GO:0051493 regulation of cytoskeleton organization 0.00241502956847596 531 10 4 0.4 0.00753295668549906
GO:BP GO:0008064 regulation of actin polymerization or depolymerization 0.00242380151359527 193 10 3 0.3 0.0155440414507772
GO:BP GO:0030832 regulation of actin filament length 0.00243286568403523 194 10 3 0.3 0.0154639175257732
GO:BP GO:0030041 actin filament polymerization 0.00247932743921448 196 10 3 0.3 0.0153061224489796
GO:BP GO:0045055 regulated exocytosis 0.00248611994691977 785 13 5 0.384615384615385 0.00636942675159236
GO:BP GO:0051338 regulation of transferase activity 0.00248611994691977 1035 6 4 0.666666666666667 0.00386473429951691
GO:BP GO:0006810 transport 0.00252721225838069 5224 22 15 0.681818181818182 0.00287136294027565
GO:BP GO:0062197 cellular response to chemical stress 0.00257092051171376 365 6 3 0.5 0.00821917808219178
GO:BP GO:0002252 immune effector process 0.00257092051171376 1309 13 6 0.461538461538462 0.00458365164247517
GO:BP GO:0019220 regulation of phosphate metabolic process 0.00275822048463824 1645 11 6 0.545454545454545 0.00364741641337386
GO:BP GO:0051174 regulation of phosphorus metabolic process 0.00275822048463824 1645 11 6 0.545454545454545 0.00364741641337386
GO:BP GO:1902414 protein localization to cell junction 0.00286254601131841 113 18 3 0.166666666666667 0.0265486725663717
GO:BP GO:0033209 tumor necrosis factor-mediated signaling pathway 0.00294440625266884 177 12 3 0.25 0.0169491525423729
GO:BP GO:0051651 maintenance of location in cell 0.00312560345709469 223 10 3 0.3 0.0134529147982063
GO:BP GO:0050808 synapse organization 0.00312560345709469 428 24 5 0.208333333333333 0.0116822429906542
GO:BP GO:0050790 regulation of catalytic activity 0.00312560345709469 2545 11 7 0.636363636363636 0.00275049115913556
GO:BP GO:0033273 response to vitamin 0.00322137766634326 98 22 3 0.136363636363636 0.0306122448979592
GO:BP GO:0050817 coagulation 0.00334275502893094 354 7 3 0.428571428571429 0.00847457627118644
GO:BP GO:0007166 cell surface receptor signaling pathway 0.00334275502893094 3210 12 8 0.666666666666667 0.00249221183800623
GO:BP GO:0051128 regulation of cellular component organization 0.00334275502893094 2412 22 10 0.454545454545455 0.00414593698175788
GO:BP GO:0032271 regulation of protein polymerization 0.00334275502893094 236 10 3 0.3 0.0127118644067797
GO:BP GO:0046903 secretion 0.00334275502893094 1501 22 8 0.363636363636364 0.00532978014656895
GO:BP GO:0007599 hemostasis 0.00334275502893094 351 7 3 0.428571428571429 0.00854700854700855
GO:BP GO:0007596 blood coagulation 0.00334275502893094 347 7 3 0.428571428571429 0.00864553314121038
GO:BP GO:0090066 regulation of anatomical structure size 0.00349809649467164 518 21 5 0.238095238095238 0.00965250965250965
GO:BP GO:0098609 cell-cell adhesion 0.00355102697673347 894 13 5 0.384615384615385 0.00559284116331096
GO:BP GO:0048871 multicellular organismal homeostasis 0.00376422371961207 530 21 5 0.238095238095238 0.00943396226415094
GO:BP GO:0001932 regulation of protein phosphorylation 0.00376422371961207 1240 6 4 0.666666666666667 0.0032258064516129
GO:BP GO:0043312 neutrophil degranulation 0.00376422371961207 482 13 4 0.307692307692308 0.00829875518672199
GO:BP GO:0010941 regulation of cell death 0.00376422371961207 1720 20 8 0.4 0.00465116279069767
GO:BP GO:0002283 neutrophil activation involved in immune response 0.00381371443308002 485 13 4 0.307692307692308 0.00824742268041237
GO:BP GO:0008219 cell death 0.00388309637546847 2292 16 8 0.5 0.00349040139616056
GO:BP GO:0006979 response to oxidative stress 0.00388309637546847 466 6 3 0.5 0.00643776824034335
GO:BP GO:0001775 cell activation 0.00388309637546847 1495 13 6 0.461538461538462 0.0040133779264214
GO:BP GO:0042119 neutrophil activation 0.00388309637546847 498 13 4 0.307692307692308 0.00803212851405622
GO:BP GO:0002446 neutrophil mediated immunity 0.00388309637546847 497 13 4 0.307692307692308 0.00804828973843058
GO:BP GO:0033036 macromolecule localization 0.00388309637546847 3218 21 11 0.523809523809524 0.00341827221876942
GO:BP GO:0036230 granulocyte activation 0.00401710345275255 504 13 4 0.307692307692308 0.00793650793650794
GO:BP GO:0034613 cellular protein localization 0.00410496466829869 2014 18 8 0.444444444444444 0.00397219463753724
GO:BP GO:0048518 positive regulation of biological process 0.00410496466829869 6363 22 16 0.727272727272727 0.00251453716800251
GO:BP GO:0070727 cellular macromolecule localization 0.00419286501672676 2024 18 8 0.444444444444444 0.00395256916996047
GO:BP GO:0010033 response to organic substance 0.00419766635891889 3412 12 8 0.666666666666667 0.00234466588511137
GO:BP GO:0048523 negative regulation of cellular process 0.00430332002814837 5139 13 10 0.769230769230769 0.00194590387234871
GO:BP GO:0097190 apoptotic signaling pathway 0.00433184990707936 600 20 5 0.25 0.00833333333333333
GO:BP GO:0071900 regulation of protein serine/threonine kinase activity 0.00433184990707936 503 6 3 0.5 0.00596421471172962
GO:BP GO:0043299 leukocyte degranulation 0.00462335782276684 535 13 4 0.307692307692308 0.00747663551401869
GO:BP GO:0043269 regulation of ion transport 0.00463202336738537 1379 3 3 1 0.00217548948513416
GO:BP GO:0010632 regulation of epithelial cell migration 0.00471893780912598 306 22 4 0.181818181818182 0.0130718954248366
GO:BP GO:0002275 myeloid cell activation involved in immune response 0.00482931627173537 547 13 4 0.307692307692308 0.00731261425959781
GO:BP GO:0002444 myeloid leukocyte mediated immunity 0.00489960825897369 551 13 4 0.307692307692308 0.00725952813067151
GO:BP GO:0042325 regulation of phosphorylation 0.0049247548682972 1431 3 3 1 0.00209643605870021
GO:BP GO:0006996 organelle organization 0.00502213751622334 4104 18 11 0.611111111111111 0.00268031189083821
GO:BP GO:0051258 protein polymerization 0.00513345805138376 305 10 3 0.3 0.00983606557377049
GO:BP GO:0006611 protein export from nucleus 0.00522444743282521 185 16 3 0.1875 0.0162162162162162
GO:BP GO:0060326 cell chemotaxis 0.00531493805715598 310 10 3 0.3 0.00967741935483871
GO:BP GO:0051049 regulation of transport 0.00577930693292004 1809 21 8 0.380952380952381 0.00442233278054174
GO:BP GO:0042221 response to chemical 0.00577930693292004 4781 12 9 0.75 0.00188245137000627
GO:BP GO:0051235 maintenance of location 0.00637622041696971 337 10 3 0.3 0.00890207715133531
GO:BP GO:0051168 nuclear export 0.00645121075977951 204 16 3 0.1875 0.0147058823529412
GO:BP GO:0050878 regulation of body fluid levels 0.00661906943977755 514 7 3 0.428571428571429 0.00583657587548638
GO:BP GO:0031399 regulation of protein modification process 0.00694220523033778 1671 3 3 1 0.00179533213644524
GO:BP GO:0006915 apoptotic process 0.00694220523033778 1990 20 8 0.4 0.00402010050251256
GO:BP GO:0006468 protein phosphorylation 0.00694220523033778 1668 3 3 1 0.00179856115107914
GO:BP GO:0010639 negative regulation of organelle organization 0.00739166858381831 361 10 3 0.3 0.00831024930747922
GO:BP GO:0042060 wound healing 0.00766043691060677 549 7 3 0.428571428571429 0.00546448087431694
GO:BP GO:0010631 epithelial cell migration 0.00793998216256227 370 22 4 0.181818181818182 0.0108108108108108
GO:BP GO:0065009 regulation of molecular function 0.00793998216256227 3221 11 7 0.636363636363636 0.00217323812480596
GO:BP GO:0071356 cellular response to tumor necrosis factor 0.00793998216256227 306 12 3 0.25 0.00980392156862745
GO:BP GO:0042981 regulation of apoptotic process 0.00793998216256227 1549 20 7 0.35 0.00451904454486766
GO:BP GO:0043270 positive regulation of ion transport 0.00805675859509488 694 21 5 0.238095238095238 0.00720461095100865
GO:BP GO:1905475 regulation of protein localization to membrane 0.00805675859509488 201 18 3 0.166666666666667 0.0149253731343284
GO:BP GO:0002274 myeloid leukocyte activation 0.00805675859509488 667 13 4 0.307692307692308 0.00599700149925037
GO:BP GO:0090132 epithelium migration 0.00805675859509488 373 22 4 0.181818181818182 0.0107238605898123
GO:BP GO:0090130 tissue migration 0.00821574106053296 379 22 4 0.181818181818182 0.0105540897097625
GO:BP GO:0043067 regulation of programmed cell death 0.00853807913011917 1582 20 7 0.35 0.00442477876106195
GO:BP GO:0048519 negative regulation of biological process 0.00858374524310183 5757 13 10 0.769230769230769 0.00173701580684384
GO:BP GO:0042592 homeostatic process 0.00860567684386085 1981 21 8 0.380952380952381 0.00403836446239273
GO:BP GO:0099003 vesicle-mediated transport in synapse 0.00860567684386085 210 18 3 0.166666666666667 0.0142857142857143
GO:BP GO:0009611 response to wounding 0.00860567684386085 674 22 5 0.227272727272727 0.00741839762611276
GO:BP GO:0034612 response to tumor necrosis factor 0.00880510525499919 331 12 3 0.25 0.00906344410876133
GO:BP GO:0012501 programmed cell death 0.00934678156620654 2143 20 8 0.4 0.00373308446103593
GO:BP GO:0007584 response to nutrient 0.00939436540641962 182 22 3 0.136363636363636 0.0164835164835165
GO:BP GO:0002263 cell activation involved in immune response 0.00939436540641962 721 13 4 0.307692307692308 0.00554785020804438
GO:BP GO:0002366 leukocyte activation involved in immune response 0.00939436540641962 717 13 4 0.307692307692308 0.00557880055788006
GO:BP GO:0044087 regulation of cellular component biogenesis 0.00987338036877472 990 10 4 0.4 0.00404040404040404
GO:BP GO:0051239 regulation of multicellular organismal process 0.0102559226510804 2861 23 10 0.434782608695652 0.0034952813701503
GO:BP GO:0016310 phosphorylation 0.0108601469851798 2138 3 3 1 0.00140318054256314
GO:BP GO:0043254 regulation of protein-containing complex assembly 0.011162155969857 460 10 3 0.3 0.00652173913043478
GO:BP GO:0032989 cellular component morphogenesis 0.0113414295983341 791 21 5 0.238095238095238 0.00632111251580278
GO:BP GO:0022898 regulation of transmembrane transporter activity 0.0113414295983341 281 16 3 0.1875 0.0106761565836299
GO:BP GO:0097191 extrinsic apoptotic signaling pathway 0.0114024691864639 223 20 3 0.15 0.0134529147982063
GO:BP GO:0009653 anatomical structure morphogenesis 0.0115964892187804 2797 24 10 0.416666666666667 0.00357525920629246
GO:BP GO:0048522 positive regulation of cellular process 0.0127359393604764 5757 22 14 0.636363636363636 0.00243182212958138
GO:BP GO:0032409 regulation of transporter activity 0.0127359393604764 297 16 3 0.1875 0.0101010101010101
GO:BP GO:0071705 nitrogen compound transport 0.0127670060191312 2322 3 3 1 0.00129198966408269
GO:BP GO:0034284 response to monosaccharide 0.0129074918733709 215 22 3 0.136363636363636 0.013953488372093
GO:BP GO:0002009 morphogenesis of an epithelium 0.0129074918733709 560 9 3 0.333333333333333 0.00535714285714286
GO:BP GO:0048584 positive regulation of response to stimulus 0.0129298807572594 2344 3 3 1 0.00127986348122867
GO:BP GO:0034330 cell junction organization 0.0131422729648162 722 24 5 0.208333333333333 0.00692520775623269
GO:BP GO:0051223 regulation of protein transport 0.0132817500756442 586 18 4 0.222222222222222 0.0068259385665529
GO:BP GO:0007165 signal transduction 0.0137036185357377 6309 13 10 0.769230769230769 0.00158503724837534
GO:BP GO:0031667 response to nutrient levels 0.0139686354149936 482 22 4 0.181818181818182 0.00829875518672199
GO:BP GO:0051716 cellular response to stimulus 0.0143257936073507 7781 13 11 0.846153846153846 0.00141370003855546
GO:BP GO:0072659 protein localization to plasma membrane 0.0143257936073507 283 18 3 0.166666666666667 0.0106007067137809
GO:BP GO:0050794 regulation of cellular process 0.0143257936073507 11473 13 13 1 0.00113309509282664
GO:BP GO:0070201 regulation of establishment of protein localization 0.0144920900965717 611 18 4 0.222222222222222 0.00654664484451719
GO:BP GO:0001667 ameboidal-type cell migration 0.014520709448193 494 22 4 0.181818181818182 0.00809716599190283
GO:BP GO:0002443 leukocyte mediated immunity 0.0145481485533151 877 13 4 0.307692307692308 0.00456100342075257
GO:BP GO:0007155 cell adhesion 0.0145481485533151 1492 13 5 0.384615384615385 0.00335120643431635
GO:BP GO:0032268 regulation of cellular protein metabolic process 0.0145481485533151 2541 3 3 1 0.00118063754427391
GO:BP GO:0090087 regulation of peptide transport 0.0145828129267061 618 18 4 0.222222222222222 0.00647249190938511
GO:BP GO:0022610 biological adhesion 0.0145828129267061 1499 13 5 0.384615384615385 0.00333555703802535
GO:BP GO:1902532 negative regulation of intracellular signal transduction 0.0146066869554405 549 10 3 0.3 0.00546448087431694
GO:BP GO:0033043 regulation of organelle organization 0.0149987510989667 1203 10 4 0.4 0.00332502078137988
GO:BP GO:0009743 response to carbohydrate 0.0153179786389507 243 22 3 0.136363636363636 0.0123456790123457
GO:BP GO:0009991 response to extracellular stimulus 0.0154373033559436 512 22 4 0.181818181818182 0.0078125
GO:BP GO:0044092 negative regulation of molecular function 0.0154373033559436 1219 10 4 0.4 0.00328137817883511
GO:BP GO:0006820 anion transport 0.0154601463539836 2889 21 9 0.428571428571429 0.00311526479750779
GO:BP GO:0006955 immune response 0.0160929070529929 2311 13 6 0.461538461538462 0.00259627866724362
GO:BP GO:0051246 regulation of protein metabolic process 0.0161067677579797 2704 3 3 1 0.0011094674556213
GO:BP GO:0006913 nucleocytoplasmic transport 0.0164711466842988 354 16 3 0.1875 0.00847457627118644
GO:BP GO:0051050 positive regulation of transport 0.0165025992312826 923 21 5 0.238095238095238 0.00541711809317443
GO:BP GO:0051169 nuclear transport 0.0165578484804852 357 16 3 0.1875 0.00840336134453781
GO:BP GO:0048729 tissue morphogenesis 0.0165615932899242 667 9 3 0.333333333333333 0.00449775112443778
GO:BP GO:0071702 organic substance transport 0.0166137950728141 2766 3 3 1 0.00108459869848156
GO:BP GO:0001894 tissue homeostasis 0.0166264421051512 270 21 3 0.142857142857143 0.0111111111111111
GO:BP GO:0072657 protein localization to membrane 0.0168478663776384 665 18 4 0.222222222222222 0.00601503759398496
GO:BP GO:0006796 phosphate-containing compound metabolic process 0.018008197596611 3087 17 8 0.470588235294118 0.00259151279559443
GO:BP GO:0006793 phosphorus metabolic process 0.0187138880422174 3114 17 8 0.470588235294118 0.00256904303147078
GO:BP GO:1990778 protein localization to cell periphery 0.0188343464688922 338 18 3 0.166666666666667 0.00887573964497041
GO:BP GO:0006811 ion transport 0.0190525072433645 3661 21 10 0.476190476190476 0.00273149412728763
GO:BP GO:0023052 signaling 0.0193991237579945 6810 13 10 0.769230769230769 0.00146842878120411
GO:BP GO:0048667 cell morphogenesis involved in neuron differentiation 0.0193991237579945 602 21 4 0.19047619047619 0.00664451827242525
GO:BP GO:0061024 membrane organization 0.0193991237579945 973 7 3 0.428571428571429 0.00308324768756423
GO:BP GO:0006935 chemotaxis 0.0193991237579945 653 10 3 0.3 0.00459418070444104
GO:BP GO:0042330 taxis 0.0195844990162751 656 10 3 0.3 0.00457317073170732
GO:BP GO:0007154 cell communication 0.0196539513267562 6829 13 10 0.769230769230769 0.00146434324205594
GO:BP GO:0090150 establishment of protein localization to membrane 0.0196539513267562 351 18 3 0.166666666666667 0.00854700854700855
GO:BP GO:0050789 regulation of biological process 0.0203346933592667 12091 24 22 0.916666666666667 0.00181953519146473
GO:BP GO:0043085 positive regulation of catalytic activity 0.0216125723807457 1418 10 4 0.4 0.00282087447108604
GO:BP GO:0009893 positive regulation of metabolic process 0.0223344453900274 3783 21 10 0.476190476190476 0.00264340470526038
GO:BP GO:0120035 regulation of plasma membrane bounded cell projection organization 0.0224145465938567 638 21 4 0.19047619047619 0.00626959247648903
GO:BP GO:1901700 response to oxygen-containing compound 0.0232015213698014 1739 24 7 0.291666666666667 0.00402530189764232
GO:BP GO:0031344 regulation of cell projection organization 0.0242198353668693 656 21 4 0.19047619047619 0.00609756097560976
GO:BP GO:0048812 neuron projection morphogenesis 0.0247369881243222 664 21 4 0.19047619047619 0.00602409638554217
GO:BP GO:0009605 response to external stimulus 0.0254818685759664 2944 12 6 0.5 0.00203804347826087
GO:BP GO:0120039 plasma membrane bounded cell projection morphogenesis 0.0255797420740657 678 21 4 0.19047619047619 0.00589970501474926
GO:BP GO:0051129 negative regulation of cellular component organization 0.0256858734399969 759 10 3 0.3 0.00395256916996047
GO:BP GO:0010604 positive regulation of macromolecule metabolic process 0.0257536540319308 3483 3 3 1 0.000861326442721792
GO:BP GO:0000902 cell morphogenesis 0.0257536540319308 1037 22 5 0.227272727272727 0.00482160077145612
GO:BP GO:0048858 cell projection morphogenesis 0.0257752744981577 682 21 4 0.19047619047619 0.00586510263929619
GO:BP GO:0120036 plasma membrane bounded cell projection organization 0.0258331281839516 1569 21 6 0.285714285714286 0.00382409177820268
GO:BP GO:0022603 regulation of anatomical structure morphogenesis 0.0258331281839516 1042 22 5 0.227272727272727 0.00479846449136276
GO:BP GO:0010467 gene expression 0.0272258256821466 6179 7 6 0.857142857142857 0.000971030911150672
GO:BP GO:0032990 cell part morphogenesis 0.0272258256821466 699 21 4 0.19047619047619 0.00572246065808298
GO:BP GO:0016043 cellular component organization 0.0273934871946531 6566 24 15 0.625 0.0022844958879074
GO:BP GO:0016032 viral process 0.0275941805983552 942 16 4 0.25 0.00424628450106157
GO:BP GO:0030030 cell projection organization 0.028257215697968 1609 21 6 0.285714285714286 0.00372902423865755
GO:BP GO:0048545 response to steroid hormone 0.0284398725201706 349 22 3 0.136363636363636 0.00859598853868195
GO:BP GO:0048468 cell development 0.0292318299701279 2100 8 4 0.5 0.0019047619047619
GO:BP GO:0015031 protein transport 0.0295152402020719 1929 18 6 0.333333333333333 0.0031104199066874
GO:BP GO:0060429 epithelium development 0.0297376820524776 1325 12 4 0.333333333333333 0.0030188679245283
GO:BP GO:0006950 response to stress 0.0298025899554302 4170 7 5 0.714285714285714 0.00119904076738609
GO:BP GO:0015833 peptide transport 0.0318320326248582 1971 18 6 0.333333333333333 0.0030441400304414
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 0.032026947984285 2255 16 6 0.375 0.00266075388026608
GO:BP GO:0000904 cell morphogenesis involved in differentiation 0.0323217682058373 749 21 4 0.19047619047619 0.00534045393858478
GO:BP GO:0044403 biological process involved in symbiotic interaction 0.0323217682058373 1001 16 4 0.25 0.003996003996004
GO:BP GO:0048583 regulation of response to stimulus 0.0324369242948452 4278 7 5 0.714285714285714 0.00116877045348294
GO:BP GO:0042886 amide transport 0.0336198816519403 2007 18 6 0.333333333333333 0.00298953662182362
GO:BP GO:0071840 cellular component organization or biogenesis 0.0340440011972536 6760 24 15 0.625 0.0022189349112426
GO:BP GO:0035556 intracellular signal transduction 0.0340440011972536 2772 10 5 0.5 0.0018037518037518
GO:BP GO:0048585 negative regulation of response to stimulus 0.0344634548626274 1733 10 4 0.4 0.00230813618003462
GO:BP GO:0065007 biological regulation 0.034578317277495 12809 13 13 1 0.0010149113904286
GO:BP GO:0036211 protein modification process 0.0346892242950667 4041 3 3 1 0.000742390497401633
GO:BP GO:0006464 cellular protein modification process 0.0346892242950667 4041 3 3 1 0.000742390497401633
GO:BP GO:0045936 negative regulation of phosphate metabolic process 0.0348385075645945 543 16 3 0.1875 0.00552486187845304
GO:BP GO:0045184 establishment of protein localization 0.0348385075645945 2035 18 6 0.333333333333333 0.00294840294840295
GO:BP GO:0010563 negative regulation of phosphorus metabolic process 0.0348758710092443 544 16 3 0.1875 0.00551470588235294
GO:BP GO:0044093 positive regulation of molecular function 0.0358694483563224 1771 10 4 0.4 0.00225861095426313
GO:BP GO:0045321 leukocyte activation 0.036299845841734 1332 13 4 0.307692307692308 0.003003003003003
GO:BP GO:0043412 macromolecule modification 0.0380259617933365 4257 3 3 1 0.000704721634954193
GO:BP GO:0031400 negative regulation of protein modification process 0.0384970524812366 578 16 3 0.1875 0.00519031141868512
GO:BP GO:1902531 regulation of intracellular signal transduction 0.0389232938484263 1842 10 4 0.4 0.00217155266015201
GO:BP GO:0034762 regulation of transmembrane transport 0.0394591425132023 588 16 3 0.1875 0.00510204081632653
GO:BP GO:0010975 regulation of neuron projection development 0.0409083842417592 451 21 3 0.142857142857143 0.00665188470066519
GO:BP GO:0022607 cellular component assembly 0.0419487616208925 3010 10 5 0.5 0.00166112956810631
GO:BP GO:0001503 ossification 0.0419487616208925 417 23 3 0.130434782608696 0.00719424460431655
GO:BP GO:0030198 extracellular matrix organization 0.0421836984490084 401 24 3 0.125 0.00748129675810474
GO:BP GO:0043062 extracellular structure organization 0.0422395013694279 402 24 3 0.125 0.00746268656716418
GO:BP GO:0009628 response to abiotic stimulus 0.0424075582324071 1261 22 5 0.227272727272727 0.00396510705789056
GO:BP GO:0045229 external encapsulating structure organization 0.0424075582324071 404 24 3 0.125 0.00742574257425743
GO:BP GO:0050896 response to stimulus 0.0425779746172984 9407 13 11 0.846153846153846 0.00116934197937706
GO:BP GO:0009888 tissue development 0.0433337121717664 2107 24 7 0.291666666666667 0.00332225913621262
GO:BP GO:0060255 regulation of macromolecule metabolic process 0.043706122544079 6603 17 11 0.647058823529412 0.00166590943510526
GO:BP GO:0043933 protein-containing complex subunit organization 0.0440070899801872 1963 10 4 0.4 0.00203769740193581
GO:BP GO:0007409 axonogenesis 0.0442596876825387 478 21 3 0.142857142857143 0.00627615062761506
GO:BP GO:0048731 system development 0.0455209149269631 5052 24 12 0.5 0.00237529691211401
GO:BP GO:0002376 immune system process 0.0471864096409788 3278 13 6 0.461538461538462 0.00183038438071995
GO:BP GO:0120031 plasma membrane bounded cell projection assembly 0.0491035817589516 593 18 3 0.166666666666667 0.00505902192242833
GO:BP GO:0034622 cellular protein-containing complex assembly 0.0491035817589516 1107 10 3 0.3 0.002710027100271
GO:BP GO:0009719 response to endogenous stimulus 0.0493145669006171 1683 24 6 0.25 0.0035650623885918
GO:CC GO:0043230 extracellular organelle 1.18543041251072e-08 2263 23 16 0.695652173913043 0.0070702607158639
GO:CC GO:0070062 extracellular exosome 1.18543041251072e-08 2176 23 16 0.695652173913043 0.00735294117647059
GO:CC GO:1903561 extracellular vesicle 1.18543041251072e-08 2261 23 16 0.695652173913043 0.0070765148164529
GO:CC GO:0005615 extracellular space 2.04348903454793e-07 3594 24 18 0.75 0.00500834724540901
GO:CC GO:0031982 vesicle 3.80714495885148e-07 4055 23 18 0.782608695652174 0.00443896424167694
GO:CC GO:0005576 extracellular region 6.95699006472212e-07 4567 24 19 0.791666666666667 0.00416028027151303
GO:CC GO:0070161 anchoring junction 3.80051046528139e-06 836 16 8 0.5 0.00956937799043062
GO:CC GO:0030055 cell-substrate junction 1.50780197542793e-05 427 9 5 0.555555555555556 0.0117096018735363
GO:CC GO:0005925 focal adhesion 1.50780197542793e-05 420 9 5 0.555555555555556 0.0119047619047619
GO:CC GO:0005856 cytoskeleton 2.13734726142591e-05 2332 18 11 0.611111111111111 0.00471698113207547
GO:CC GO:0005829 cytosol 2.13734726142591e-05 5303 16 14 0.875 0.00264001508580049
GO:CC GO:0034774 secretory granule lumen 2.13734726142591e-05 320 22 6 0.272727272727273 0.01875
GO:CC GO:0060205 cytoplasmic vesicle lumen 2.13734726142591e-05 324 22 6 0.272727272727273 0.0185185185185185
GO:CC GO:0031983 vesicle lumen 2.13734726142591e-05 326 22 6 0.272727272727273 0.0184049079754601
GO:CC GO:0015629 actin cytoskeleton 0.000250919134716901 513 14 5 0.357142857142857 0.00974658869395711
GO:CC GO:0072562 blood microparticle 0.000328418890655466 140 9 3 0.333333333333333 0.0214285714285714
GO:CC GO:0005737 cytoplasm 0.000350604689477986 11911 22 22 1 0.0018470321551507
GO:CC GO:1904813 ficolin-1-rich granule lumen 0.000404016975575285 124 11 3 0.272727272727273 0.0241935483870968
GO:CC GO:0030054 cell junction 0.000427613414218771 2105 18 9 0.5 0.00427553444180523
GO:CC GO:0005634 nucleus 0.000472003302436652 7592 17 15 0.882352941176471 0.00197576396206533
GO:CC GO:0098685 Schaffer collateral - CA1 synapse 0.000472003302436652 80 18 3 0.166666666666667 0.0375
GO:CC GO:0005938 cell cortex 0.000492179927005319 311 14 4 0.285714285714286 0.0128617363344051
GO:CC GO:0043229 intracellular organelle 0.000776859435967474 12491 22 22 1 0.00176126811304139
GO:CC GO:0101002 ficolin-1-rich granule 0.00102575408382419 184 11 3 0.272727272727273 0.016304347826087
GO:CC GO:0031252 cell leading edge 0.00104264457562229 422 13 4 0.307692307692308 0.00947867298578199
GO:CC GO:0030141 secretory granule 0.00117112222297388 851 13 5 0.384615384615385 0.00587544065804935
GO:CC GO:0005912 adherens junction 0.00132016676897553 173 13 3 0.230769230769231 0.0173410404624277
GO:CC GO:0001726 ruffle 0.00141410700663449 179 13 3 0.230769230769231 0.0167597765363128
GO:CC GO:0005911 cell-cell junction 0.00167707893042635 494 13 4 0.307692307692308 0.00809716599190283
GO:CC GO:0099503 secretory vesicle 0.00227482715634758 1020 13 5 0.384615384615385 0.00490196078431373
GO:CC GO:0031974 membrane-enclosed lumen 0.00288251353423575 5565 13 10 0.769230769230769 0.00179694519317161
GO:CC GO:0043233 organelle lumen 0.00288251353423575 5565 13 10 0.769230769230769 0.00179694519317161
GO:CC GO:0098978 glutamatergic synapse 0.00325400317336148 349 22 4 0.181818181818182 0.0114613180515759
GO:CC GO:0043226 organelle 0.00348048785799729 14008 24 24 1 0.00171330668189606
GO:CC GO:0031410 cytoplasmic vesicle 0.00429872751083172 2424 22 9 0.409090909090909 0.00371287128712871
GO:CC GO:0097708 intracellular vesicle 0.00429872751083172 2428 22 9 0.409090909090909 0.00370675453047776
GO:CC GO:0043227 membrane-bounded organelle 0.00471329913438782 12858 24 23 0.958333333333333 0.00178876963757972
GO:CC GO:0043231 intracellular membrane-bounded organelle 0.00540462048629144 11296 22 20 0.909090909090909 0.00177053824362606
GO:CC GO:0150034 distal axon 0.00771425710238274 308 16 3 0.1875 0.00974025974025974
GO:CC GO:0042995 cell projection 0.00869492786140641 2330 21 8 0.380952380952381 0.00343347639484979
GO:CC GO:0120025 plasma membrane bounded cell projection 0.0096586470229447 2229 18 7 0.388888888888889 0.00314042171377299
GO:CC GO:0043232 intracellular non-membrane-bounded organelle 0.0096586470229447 5338 20 12 0.6 0.00224803297115024
GO:CC GO:0030424 axon 0.0096586470229447 660 18 4 0.222222222222222 0.00606060606060606
GO:CC GO:0043228 non-membrane-bounded organelle 0.0096586470229447 5346 20 12 0.6 0.00224466891133558
GO:CC GO:0005622 intracellular anatomical structure 0.0129134540002242 14790 22 22 1 0.00148749154834348
GO:CC GO:0030139 endocytic vesicle 0.0137751856670721 306 22 3 0.136363636363636 0.00980392156862745
GO:CC GO:0099513 polymeric cytoskeletal fiber 0.0137751856670721 764 18 4 0.222222222222222 0.00523560209424084
GO:CC GO:0099081 supramolecular polymer 0.0186337017108042 1001 24 5 0.208333333333333 0.004995004995005
GO:CC GO:0071944 cell periphery 0.0198727780558666 6169 24 14 0.583333333333333 0.00226941157399903
GO:CC GO:0099512 supramolecular fiber 0.0279826221056771 993 18 4 0.222222222222222 0.0040281973816717
GO:CC GO:0062023 collagen-containing extracellular matrix 0.0328930108316017 421 24 3 0.125 0.00712589073634204
GO:CC GO:0045202 synapse 0.0356259081076601 1349 22 5 0.227272727272727 0.00370644922164566
GO:CC GO:0032991 protein-containing complex 0.0358744624350383 5548 18 10 0.555555555555556 0.00180245133381399
GO:CC GO:0099080 supramolecular complex 0.0452657589991389 1323 24 5 0.208333333333333 0.00377928949357521
GO:MF GO:0003785 actin monomer binding 6.78936034036633e-05 30 10 3 0.3 0.1
GO:MF GO:0050839 cell adhesion molecule binding 0.000852246205724394 546 21 6 0.285714285714286 0.010989010989011
GO:MF GO:0003779 actin binding 0.00159812330568932 448 10 4 0.4 0.00892857142857143
GO:MF GO:0044877 protein-containing complex binding 0.00159812330568932 1287 22 8 0.363636363636364 0.00621600621600622
GO:MF GO:0008092 cytoskeletal protein binding 0.00161556923293514 996 10 5 0.5 0.00502008032128514
GO:MF GO:0003723 RNA binding 0.00161556923293514 1943 16 8 0.5 0.00411734431291817
GO:MF GO:0045296 cadherin binding 0.00260620843046321 333 16 4 0.25 0.012012012012012
GO:MF GO:0005198 structural molecule activity 0.00280525747890566 698 24 6 0.25 0.00859598853868195
GO:MF GO:0005201 extracellular matrix structural constituent 0.00803646033919509 171 24 3 0.125 0.0175438596491228
GO:MF GO:0003676 nucleic acid binding 0.0086283365239837 4276 17 10 0.588235294117647 0.00233863423760524
GO:MF GO:0005515 protein binding 0.0145178155322225 14767 24 24 1 0.00162524547978601
GO:MF GO:1901363 heterocyclic compound binding 0.0145913142911628 6228 18 12 0.666666666666667 0.00192678227360308
GO:MF GO:0097159 organic cyclic compound binding 0.0145913142911628 6309 18 12 0.666666666666667 0.0019020446980504
GO:MF GO:0019899 enzyme binding 0.0145913142911628 2074 11 5 0.454545454545455 0.00241080038572806
GO:MF GO:0019901 protein kinase binding 0.0187676885014804 673 11 3 0.272727272727273 0.00445765230312036
GO:MF GO:0019900 kinase binding 0.022525264236612 752 11 3 0.272727272727273 0.00398936170212766
GO:MF GO:0043168 anion binding 0.022525264236612 2418 11 5 0.454545454545455 0.00206782464846981
GO:MF GO:0005509 calcium ion binding 0.0275997205446787 721 23 4 0.173913043478261 0.00554785020804438
GO:MF GO:0017076 purine nucleotide binding 0.0428813996733749 1933 11 4 0.363636363636364 0.00206932229694775
HP HP:0007227 Macrogyria 0.0421350307071539 23 24 3 0.125 0.130434782608696
KEGG KEGG:04810 Regulation of actin cytoskeleton 6.51823118848944e-05 216 14 6 0.428571428571429 0.0277777777777778
KEGG KEGG:05418 Fluid shear stress and atherosclerosis 0.000102569068426417 138 7 4 0.571428571428571 0.0289855072463768
KEGG KEGG:05132 Salmonella infection 0.00107036171138499 249 14 5 0.357142857142857 0.0200803212851406
KEGG KEGG:05225 Hepatocellular carcinoma 0.00415792345351357 166 7 3 0.428571428571429 0.0180722891566265
KEGG KEGG:04510 Focal adhesion 0.00415792345351357 200 24 5 0.208333333333333 0.025
KEGG KEGG:04670 Leukocyte transendothelial migration 0.00790387582478318 114 14 3 0.214285714285714 0.0263157894736842
KEGG KEGG:05131 Shigellosis 0.00790387582478318 246 14 4 0.285714285714286 0.016260162601626
KEGG KEGG:04611 Platelet activation 0.00840465024282197 124 14 3 0.214285714285714 0.0241935483870968
KEGG KEGG:04015 Rap1 signaling pathway 0.00871883271989011 210 9 3 0.333333333333333 0.0142857142857143
KEGG KEGG:04530 Tight junction 0.011355857439377 169 14 3 0.214285714285714 0.0177514792899408
KEGG KEGG:04390 Hippo signaling pathway 0.0130367247254758 157 16 3 0.1875 0.0191082802547771
KEGG KEGG:05164 Influenza A 0.0187255774030066 169 18 3 0.166666666666667 0.0177514792899408
KEGG KEGG:05014 Amyotrophic lateral sclerosis 0.0190230671743201 363 9 3 0.333333333333333 0.00826446280991736
MIRNA MIRNA:hsa-miR-7150 hsa-miR-7150 0.00310048258898026 136 13 4 0.307692307692308 0.0294117647058824
MIRNA MIRNA:hsa-miR-221-3p hsa-miR-221-3p 0.00627139489187724 366 17 5 0.294117647058824 0.0136612021857923
MIRNA MIRNA:hsa-miR-100-5p hsa-miR-100-5p 0.00627139489187724 250 24 5 0.208333333333333 0.02
MIRNA MIRNA:hsa-miR-320a hsa-miR-320a 0.00627139489187724 584 18 6 0.333333333333333 0.0102739726027397
MIRNA MIRNA:hsa-miR-876-3p hsa-miR-876-3p 0.00627139489187724 68 16 3 0.1875 0.0441176470588235
MIRNA MIRNA:hsa-miR-222-3p hsa-miR-222-3p 0.00627139489187724 393 9 4 0.444444444444444 0.0101781170483461
MIRNA MIRNA:hsa-miR-5087 hsa-miR-5087 0.0087695860285501 83 16 3 0.1875 0.036144578313253
MIRNA MIRNA:hsa-miR-1307-3p hsa-miR-1307-3p 0.010473324605166 239 7 3 0.428571428571429 0.0125523012552301
MIRNA MIRNA:hsa-miR-329-5p hsa-miR-329-5p 0.0106010611759965 103 16 3 0.1875 0.029126213592233
MIRNA MIRNA:hsa-miR-197-3p hsa-miR-197-3p 0.0106010611759965 407 11 4 0.363636363636364 0.00982800982800983
MIRNA MIRNA:hsa-miR-877-5p hsa-miR-877-5p 0.0108862433506237 233 19 4 0.210526315789474 0.0171673819742489
MIRNA MIRNA:hsa-miR-324-5p hsa-miR-324-5p 0.0140042873318364 297 8 3 0.375 0.0101010101010101
MIRNA MIRNA:hsa-miR-4736 hsa-miR-4736 0.0140042873318364 171 13 3 0.230769230769231 0.0175438596491228
MIRNA MIRNA:hsa-miR-1914-3p hsa-miR-1914-3p 0.0140042873318364 141 16 3 0.1875 0.0212765957446809
MIRNA MIRNA:hsa-miR-5194 hsa-miR-5194 0.0140042873318364 135 16 3 0.1875 0.0222222222222222
MIRNA MIRNA:hsa-miR-6738-5p hsa-miR-6738-5p 0.0140042873318364 134 16 3 0.1875 0.0223880597014925
MIRNA MIRNA:hsa-miR-423-5p hsa-miR-423-5p 0.0140042873318364 342 7 3 0.428571428571429 0.0087719298245614
MIRNA MIRNA:hsa-miR-320b hsa-miR-320b 0.0148004999214126 145 17 3 0.176470588235294 0.0206896551724138
MIRNA MIRNA:hsa-miR-1226-3p hsa-miR-1226-3p 0.0148004999214126 226 11 3 0.272727272727273 0.0132743362831858
MIRNA MIRNA:hsa-miR-491-5p hsa-miR-491-5p 0.0156679328694479 171 15 3 0.2 0.0175438596491228
MIRNA MIRNA:hsa-miR-1-3p hsa-miR-1-3p 0.0165288225316709 915 13 5 0.384615384615385 0.00546448087431694
MIRNA MIRNA:hsa-miR-744-5p hsa-miR-744-5p 0.0171579974232913 435 7 3 0.428571428571429 0.00689655172413793
MIRNA MIRNA:hsa-miR-92a-3p hsa-miR-92a-3p 0.0175574745993695 1404 24 8 0.333333333333333 0.0056980056980057
MIRNA MIRNA:hsa-miR-6783-5p hsa-miR-6783-5p 0.0175574745993695 185 16 3 0.1875 0.0162162162162162
MIRNA MIRNA:hsa-miR-423-3p hsa-miR-423-3p 0.0180156657921379 229 15 3 0.2 0.0131004366812227
MIRNA MIRNA:hsa-miR-4763-3p hsa-miR-4763-3p 0.0190647558766594 282 13 3 0.230769230769231 0.0106382978723404
MIRNA MIRNA:hsa-miR-1207-5p hsa-miR-1207-5p 0.0195828259848839 287 13 3 0.230769230769231 0.0104529616724739
MIRNA MIRNA:hsa-miR-296-3p hsa-miR-296-3p 0.0212811847025471 255 15 3 0.2 0.0117647058823529
MIRNA MIRNA:hsa-miR-3662 hsa-miR-3662 0.0231668924228667 252 16 3 0.1875 0.0119047619047619
MIRNA MIRNA:hsa-miR-484 hsa-miR-484 0.0243013675668383 890 17 5 0.294117647058824 0.00561797752808989
MIRNA MIRNA:hsa-miR-3613-3p hsa-miR-3613-3p 0.0297323476102149 503 10 3 0.3 0.00596421471172962
MIRNA MIRNA:hsa-miR-765 hsa-miR-765 0.0340004190725055 347 16 3 0.1875 0.00864553314121038
MIRNA MIRNA:hsa-miR-193b-3p hsa-miR-193b-3p 0.037726598600267 847 14 4 0.285714285714286 0.00472255017709563
MIRNA MIRNA:hsa-miR-6825-5p hsa-miR-6825-5p 0.0395600881468474 380 16 3 0.1875 0.00789473684210526
MIRNA MIRNA:hsa-let-7b-5p hsa-let-7b-5p 0.0395902384799608 1212 16 5 0.3125 0.00412541254125413
MIRNA MIRNA:hsa-miR-149-5p hsa-miR-149-5p 0.0400959018940033 394 16 3 0.1875 0.00761421319796954
REAC REAC:R-HSA-114608 Platelet degranulation 0.000216051743088088 125 10 4 0.4 0.032
REAC REAC:R-HSA-195258 RHO GTPase Effectors 0.000216051743088088 283 16 6 0.375 0.0212014134275618
REAC REAC:R-HSA-3928662 EPHB-mediated forward signaling 0.000216051743088088 40 8 3 0.375 0.075
REAC REAC:R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.000216051743088088 130 10 4 0.4 0.0307692307692308
REAC REAC:R-HSA-2682334 EPH-Ephrin signaling 0.000216051743088088 90 14 4 0.285714285714286 0.0444444444444444
REAC REAC:R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 0.000220064178352058 72 18 4 0.222222222222222 0.0555555555555556
REAC REAC:R-HSA-168249 Innate Immune System 0.000299841114811033 1073 13 8 0.615384615384615 0.00745573159366263
REAC REAC:R-HSA-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 0.000480813197316904 413 16 6 0.375 0.0145278450363196
REAC REAC:R-HSA-194315 Signaling by Rho GTPases 0.000480813197316904 413 16 6 0.375 0.0145278450363196
REAC REAC:R-HSA-76002 Platelet activation, signaling and aggregation 0.00115697794515583 258 10 4 0.4 0.0155038759689922
REAC REAC:R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.00115697794515583 116 8 3 0.375 0.0258620689655172
REAC REAC:R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.00187275648605091 140 8 3 0.375 0.0214285714285714
REAC REAC:R-HSA-109582 Hemostasis 0.00187275648605091 657 10 5 0.5 0.0076103500761035
REAC REAC:R-HSA-5663220 RHO GTPases Activate Formins 0.00187275648605091 136 9 3 0.333333333333333 0.0220588235294118
REAC REAC:R-HSA-5663205 Infectious disease 0.00254297576906115 815 3 3 1 0.00368098159509202
REAC REAC:R-HSA-422475 Axon guidance 0.00267926448888771 549 14 5 0.357142857142857 0.00910746812386157
REAC REAC:R-HSA-9675108 Nervous system development 0.00321592611931719 574 14 5 0.357142857142857 0.00871080139372822
REAC REAC:R-HSA-9658195 Leishmania infection 0.0035743750827976 303 7 3 0.428571428571429 0.0099009900990099
REAC REAC:R-HSA-168256 Immune System 0.00560012921692016 2139 8 6 0.75 0.00280504908835905
REAC REAC:R-HSA-1266738 Developmental Biology 0.00639438495664073 1069 14 6 0.428571428571429 0.00561272217025257
REAC REAC:R-HSA-6798695 Neutrophil degranulation 0.00793091100791664 474 13 4 0.307692307692308 0.00843881856540084
REAC REAC:R-HSA-1280215 Cytokine Signaling in Immune system 0.00814799318355532 842 8 4 0.5 0.00475059382422803
REAC REAC:R-HSA-1643685 Disease 0.00943170677416905 1509 3 3 1 0.00198807157057654
REAC REAC:R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.0120242166483361 485 24 5 0.208333333333333 0.0103092783505155
REAC REAC:R-HSA-5653656 Vesicle-mediated transport 0.0125606383162034 717 24 6 0.25 0.00836820083682008
REAC REAC:R-HSA-2262752 Cellular responses to stress 0.019457160400765 546 16 4 0.25 0.00732600732600733
REAC REAC:R-HSA-8953897 Cellular responses to external stimuli 0.0205509822779778 560 16 4 0.25 0.00714285714285714
REAC REAC:R-HSA-199991 Membrane Trafficking 0.0362662607950097 625 18 4 0.222222222222222 0.0064
REAC REAC:R-HSA-1474244 Extracellular matrix organization 0.0490420194112458 298 24 3 0.125 0.0100671140939597
TF TF:M08208_1 Factor: E2F-3:FOXI1; motif: NGACACCGCGCCCAC; match class: 1 0.000395887072126705 7127 16 16 1 0.00224498386417848
TF TF:M11988_1 Factor: NFATc3; motif: NTTTCCRYGGAAAN; match class: 1 0.0048087702370396 6648 24 19 0.791666666666667 0.00285800240673887
TF TF:M00933_1 Factor: Sp1; motif: CCCCGCCCCN; match class: 1 0.0048087702370396 5166 9 9 1 0.00174216027874564
TF TF:M10072 Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR 0.0048087702370396 10494 19 19 1 0.001810558414332
TF TF:M11415_1 Factor: GABP-alpha; motif: NRCCGGAAGTN; match class: 1 0.0048087702370396 546 18 6 0.333333333333333 0.010989010989011
TF TF:M09973_1 Factor: CPBP; motif: GNNRGGGHGGGGNNGGGRN; match class: 1 0.00615273543278416 6607 16 14 0.875 0.00211896473437264
TF TF:M01655 Factor: p53; motif: GGACATGYYCGGACATGYYC 0.00615273543278416 3419 22 13 0.590909090909091 0.00380228136882129
TF TF:M12351_1 Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1 0.00615273543278416 8180 13 13 1 0.00158924205378973
TF TF:M09973 Factor: CPBP; motif: GNNRGGGHGGGGNNGGGRN 0.00778667995525832 10853 18 18 1 0.00165852759605639
TF TF:M11988 Factor: NFATc3; motif: NTTTCCRYGGAAAN 0.00778667995525832 7175 24 19 0.791666666666667 0.00264808362369338
TF TF:M01104_1 Factor: MOVO-B; motif: GNGGGGG; match class: 1 0.00778667995525832 5626 18 14 0.777777777777778 0.00248844649840028
TF TF:M04146_1 Factor: TFAP2A; motif: YGCCCNNRGGCN; match class: 1 0.00778667995525832 3800 16 11 0.6875 0.00289473684210526
TF TF:M00803_1 Factor: E2F; motif: GGCGSG; match class: 1 0.00804842100205684 10230 16 16 1 0.00156402737047898
TF TF:M10026 Factor: PATZ; motif: GGGGNGGGGGMKGGRRNGGNRN 0.00804842100205684 8389 16 15 0.9375 0.00178805578734057
TF TF:M00938_1 Factor: E2F-1; motif: TTGGCGCGRAANNGNM; match class: 1 0.00804842100205684 2573 7 6 0.857142857142857 0.00233190827827439
TF TF:M04953_1 Factor: Sp1; motif: GGNDGGRGGCGGGG; match class: 1 0.00804842100205684 4065 18 12 0.666666666666667 0.0029520295202952
TF TF:M00008 Factor: Sp1; motif: GGGGCGGGGT 0.0101260851739808 10055 15 15 1 0.00149179512680259
TF TF:M03811_1 Factor: AP-2gamma; motif: GCCYNCRGSN; match class: 1 0.0116486017375714 3812 6 6 1 0.00157397691500525
TF TF:M04953 Factor: Sp1; motif: GGNDGGRGGCGGGG 0.0116486017375714 8688 12 12 1 0.00138121546961326
TF TF:M00933 Factor: Sp1; motif: CCCCGCCCCN 0.0116486017375714 9715 18 17 0.944444444444444 0.00174987133299022
TF TF:M07380_1 Factor: E2F-4; motif: NTTTCSCGCC; match class: 1 0.0116486017375714 7965 20 17 0.85 0.00213433772755807
TF TF:M03989 Factor: FLI1; motif: ACCGGAAATCCGGT 0.0171345995045142 10442 19 18 0.947368421052632 0.00172380769967439
TF TF:M03983_1 Factor: ETV5; motif: NCCGGAWGYN; match class: 1 0.0171345995045142 537 18 5 0.277777777777778 0.00931098696461825
TF TF:M08874 Factor: E2F1; motif: NNNNNGCGSSAAAN 0.0171345995045142 7201 15 13 0.866666666666667 0.00180530481877517
TF TF:M12351 Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC 0.0186579586889232 12302 19 19 1 0.00154446431474557
TF TF:M11422_1 Factor: Erm; motif: NRCMGGAAGTN; match class: 1 0.0186579586889232 934 18 6 0.333333333333333 0.00642398286937901
TF TF:M00976_1 Factor: AhR,; motif: NRCGTGNGN; match class: 1 0.0186579586889232 1011 11 5 0.454545454545455 0.00494559841740851
TF TF:M10435 Factor: Sp2; motif: GGGGCGGGG 0.0186579586889232 7696 18 15 0.833333333333333 0.00194906444906445
TF TF:M07063_1 Factor: Sp1; motif: GGGGCGGGGC; match class: 1 0.0186579586889232 3495 9 7 0.777777777777778 0.00200286123032904
TF TF:M10435_1 Factor: Sp2; motif: GGGGCGGGG; match class: 1 0.0186579586889232 3495 9 7 0.777777777777778 0.00200286123032904
TF TF:M10432 Factor: MAZ; motif: GGGMGGGGS 0.0186579586889232 9259 19 17 0.894736842105263 0.00183605140943946
TF TF:M11983 Factor: NFATc2; motif: NTTTCCGCGGAAAN 0.0186579586889232 8048 24 19 0.791666666666667 0.00236083499005964
TF TF:M07063 Factor: Sp1; motif: GGGGCGGGGC 0.0186579586889232 7696 18 15 0.833333333333333 0.00194906444906445
TF TF:M01303_1 Factor: SP1; motif: GGGGYGGGGNS; match class: 1 0.0186579586889232 3507 9 7 0.777777777777778 0.00199600798403194
TF TF:M01104 Factor: MOVO-B; motif: GNGGGGG 0.0186579586889232 10261 18 17 0.944444444444444 0.00165675860052626
TF TF:M12160_1 Factor: KLF15; motif: RCCMCRCCCMCN; match class: 1 0.0187316289938596 8031 16 14 0.875 0.00174324492591209
TF TF:M00932 Factor: Sp1; motif: NNGGGGCGGGGNN 0.0201308163034106 10419 18 17 0.944444444444444 0.00163163451386889
TF TF:M02074_1 Factor: GABPalpha; motif: RCCGGAWRYN; match class: 1 0.0203243926071638 1005 18 6 0.333333333333333 0.00597014925373134
TF TF:M03834 Factor: N-Myc; motif: GSSCACGYGS 0.0203243926071638 1414 9 5 0.555555555555556 0.00353606789250354
TF TF:M11448 Factor: Elf-1; motif: NANGCGGAAGTN 0.0203243926071638 7600 20 16 0.8 0.00210526315789474
TF TF:M00652_1 Factor: NRF-1; motif: CGCATGCGCR; match class: 1 0.0218405696448192 317 8 3 0.375 0.00946372239747634
TF TF:M00034_1 Factor: p53; motif: GGACATGCCCGGGCATGTCY; match class: 1 0.022093929204083 2646 6 5 0.833333333333333 0.0018896447467876
TF TF:M08993_1 Factor: ZNF777; motif: GTCCGYCCCGTCSAACAAT; match class: 1 0.022093929204083 4112 18 11 0.611111111111111 0.00267509727626459
TF TF:M07226 Factor: SP1; motif: NCCCCKCCCCC 0.022093929204083 8292 16 14 0.875 0.00168837433671008
TF TF:M01253_1 Factor: CNOT3; motif: GGCCGCGSSS; match class: 1 0.022093929204083 1026 7 4 0.571428571428571 0.00389863547758285
TF TF:M07380 Factor: E2F-4; motif: NTTTCSCGCC 0.0222038554166919 13022 20 20 1 0.00153586238673015
TF TF:M07277_1 Factor: BTEB2; motif: RGGGNGKGGN; match class: 1 0.0222038554166919 4149 13 9 0.692307692307692 0.00216919739696312
TF TF:M03976 Factor: ERG; motif: ACCGGAWATCCGGT 0.0237343649250988 12803 19 19 1 0.00148402718112942
TF TF:M08874_1 Factor: E2F1; motif: NNNNNGCGSSAAAN; match class: 1 0.0251481496150236 2135 14 7 0.5 0.00327868852459016
TF TF:M07226_1 Factor: SP1; motif: NCCCCKCCCCC; match class: 1 0.0251481496150236 3915 9 7 0.777777777777778 0.00178799489144317
TF TF:M02089_1 Factor: E2F-3; motif: GGCGGGN; match class: 1 0.0253145274631026 9362 18 16 0.888888888888889 0.00170903653065584
TF TF:M00428 Factor: E2F-1; motif: NKTSSCGC 0.0254760704654632 8947 17 15 0.882352941176471 0.00167653962221974
TF TF:M00800 Factor: AP-2; motif: GSCCSCRGGCNRNRNN 0.0266587980838893 9119 14 13 0.928571428571429 0.00142559491172278
TF TF:M07395_1 Factor: Sp1; motif: NGGGGCGGGGN; match class: 1 0.0266587980838893 6334 7 7 1 0.00110514682664983
TF TF:M08917_1 Factor: GABP-ALPHA; motif: RCCGGAARTNN; match class: 1 0.0266587980838893 389 18 4 0.222222222222222 0.0102827763496144
TF TF:M04869 Factor: Egr-1; motif: GCGCATGCG 0.0266587980838893 11232 19 18 0.947368421052632 0.0016025641025641
TF TF:M07208_1 Factor: EGR1; motif: NCNCCGCCCCCGCN; match class: 1 0.0266587980838893 2194 18 8 0.444444444444444 0.00364630811303555
TF TF:M01253 Factor: CNOT3; motif: GGCCGCGSSS 0.0266587980838893 3926 7 6 0.857142857142857 0.00152827305145186
TF TF:M09895_1 Factor: E2F-6; motif: NGGGCGGGARRNN; match class: 1 0.0278075352337021 2711 9 6 0.666666666666667 0.00221320545924013
TF TF:M11221 Factor: CREB1; motif: RTGACGYGTCAN 0.0279452447112984 9677 11 11 1 0.00113671592435672
TF TF:M10432_1 Factor: MAZ; motif: GGGMGGGGS; match class: 1 0.028359983198447 4365 18 11 0.611111111111111 0.00252004581901489
TF TF:M00649_1 Factor: MAZ; motif: GGGGAGGG; match class: 1 0.0290520975039979 4166 9 7 0.777777777777778 0.00168026884301488
TF TF:M12217 Factor: GLIS2; motif: ACCCCCCRCGWNGC 0.0290520975039979 567 6 3 0.5 0.00529100529100529
TF TF:M07232 Factor: TP53; motif: RCATGYCCAGACATG 0.0290520975039979 2606 16 8 0.5 0.00306983883346124
TF TF:M01857 Factor: AP-2alpha; motif: NGCCYSNNGSN 0.0290520975039979 9178 17 15 0.882352941176471 0.00163434299411637
TF TF:M07615_1 Factor: Sp3; motif: GGGGCGGGGSNN; match class: 1 0.0292232985935608 2885 4 4 1 0.00138648180242634
TF TF:M11438_1 Factor: SAP-1; motif: NTCGTAAATGCN; match class: 1 0.0293782080177912 1191 18 6 0.333333333333333 0.00503778337531486
TF TF:M11414_1 Factor: GABP-alpha; motif: NACCGGAAGTN; match class: 1 0.0293782080177912 442 17 4 0.235294117647059 0.00904977375565611
TF TF:M11434_1 Factor: Elk-1; motif: NRSCGGAAGNN; match class: 1 0.0293782080177912 2935 18 9 0.5 0.0030664395229983
TF TF:M08205_1 Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1 0.0295807830967543 10438 20 18 0.9 0.00172446828894424
TF TF:M03988_1 Factor: FLI1; motif: ACCGGAARTN; match class: 1 0.0295807830967543 2950 18 9 0.5 0.00305084745762712
TF TF:M03990_1 Factor: GABPA; motif: ACCGGAAGTN; match class: 1 0.0295807830967543 1206 18 6 0.333333333333333 0.00497512437810945
TF TF:M09826_1 Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC; match class: 1 0.0304219272949758 7508 16 13 0.8125 0.00173148641449121
TF TF:M12313 Factor: ZNF460; motif: NNACNCCCCCCNN 0.0313716934514154 5825 17 12 0.705882352941177 0.00206008583690987
TF TF:M08662_1 Factor: AP-2gamma:HES-7; motif: NNCACGYGNNNNNNSCCNNNGGS; match class: 1 0.0314060865780894 220 15 3 0.2 0.0136363636363636
TF TF:M04515 Factor: E2F-1; motif: WWTGGCGCCAAA 0.0322722717735869 13334 19 19 1 0.00142492875356232
TF TF:M02059_1 Factor: ELK-1; motif: ACCGGAAGTN; match class: 1 0.032344612431728 3759 18 10 0.555555555555556 0.00266028198989093
TF TF:M08441_1 Factor: AP-2gamma:Elk-1; motif: NGCCKNRGGSGRCGGAAGTG; match class: 1 0.032344612431728 12761 17 17 1 0.00133218399811927
TF TF:M01588_1 Factor: GKLF; motif: GCCMCRCCCNNN; match class: 1 0.032344612431728 3962 12 8 0.666666666666667 0.00201918223119637
TF TF:M08913_1 Factor: FLI-1; motif: NAYTTCCGGT; match class: 1 0.0340294779450746 3055 18 9 0.5 0.00294599018003273
TF TF:M00769 Factor: AML; motif: NNGKNTGTGGTTWNC 0.0340294779450746 1501 21 7 0.333333333333333 0.00466355762824783
TF TF:M01118_1 Factor: WT1; motif: SMCNCCNSC; match class: 1 0.0340586087776871 2766 16 8 0.5 0.00289226319595083
TF TF:M00678_1 Factor: Tel-2; motif: YTACTTCCTG; match class: 1 0.0340586087776871 874 17 5 0.294117647058824 0.005720823798627
TF TF:M11530_1 Factor: E2F-2; motif: NWTTTGGCGCCAWWNN; match class: 1 0.0347623491350071 13449 19 19 1 0.00141274444196595
TF TF:M11420_1 Factor: ER81; motif: NACCGGAAGTN; match class: 1 0.0352239457222777 494 17 4 0.235294117647059 0.00809716599190283
TF TF:M11397_1 Factor: Erg; motif: NACCGGATATCCGGTN; match class: 1 0.0352239457222777 11731 19 18 0.947368421052632 0.00153439604466797
TF TF:M08208 Factor: E2F-3:FOXI1; motif: NGACACCGCGCCCAC 0.0352239457222777 12560 16 16 1 0.00127388535031847
TF TF:M02056_1 Factor: ELF4; motif: NCCGGAARTN; match class: 1 0.0352239457222777 1291 18 6 0.333333333333333 0.00464756003098373
TF TF:M01214 Factor: ESE-1; motif: NSMGGAARTN 0.0357839228726784 7559 18 14 0.777777777777778 0.00185209683820611
TF TF:M12121 Factor: ZNF449; motif: MMGCCCAACC 0.0357839228726784 856 5 3 0.6 0.00350467289719626
TF TF:M11496 Factor: ONECUT3; motif: NNATCGATYN 0.0357839228726784 284 13 3 0.230769230769231 0.0105633802816901
TF TF:M02055 Factor: ESE-1; motif: NSMGGAARTN 0.0357839228726784 7559 18 14 0.777777777777778 0.00185209683820611
TF TF:M11983_1 Factor: NFATc2; motif: NTTTCCGCGGAAAN; match class: 1 0.0360673352806328 7294 24 17 0.708333333333333 0.00233068275294763
TF TF:M00034 Factor: p53; motif: GGACATGCCCGGGCATGTCY 0.0365271397506097 4510 7 6 0.857142857142857 0.00133037694013304
TF TF:M09972_1 Factor: BTEB2; motif: WGGGTGKGGCNGGN; match class: 1 0.0365509346044024 3919 10 7 0.7 0.00178616994131156
TF TF:M07354 Factor: Egr-1; motif: GCGGGGGCGG 0.0365509346044024 7801 16 13 0.8125 0.00166645301884374
TF TF:M00982 Factor: KROX; motif: CCCGCCCCCRCCCC 0.0368204228356524 7815 16 13 0.8125 0.00166346769033909
TF TF:M11404_1 Factor: Fli-1; motif: NACCGGAARTN; match class: 1 0.0371472746659571 3171 18 9 0.5 0.00283822138126774
TF TF:M07039_1 Factor: ETF; motif: CCCCGCCCCYN; match class: 1 0.0371472746659571 13611 19 19 1 0.00139592976269194
TF TF:M04152_1 Factor: TFAP2C; motif: NGCCCNNRGGCA; match class: 1 0.0371472746659571 5580 8 7 0.875 0.00125448028673835
TF TF:M00695 Factor: ETF; motif: GVGGMGG 0.03750496076335 10430 11 11 1 0.00105465004793864
TF TF:M12160 Factor: KLF15; motif: RCCMCRCCCMCN 0.03750496076335 12729 16 16 1 0.00125697226804934
TF TF:M09834 Factor: ZNF148; motif: NNNNNNCCNNCCCCTCCCCCACCCN 0.03750496076335 6953 12 10 0.833333333333333 0.00143822810297713
TF TF:M12345 Factor: Zbtb37; motif: NYACCGCRNTCACCGCR 0.0380049676407466 5505 10 8 0.8 0.00145322434150772
TF TF:M00470_1 Factor: AP-2gamma; motif: GCCYNNGGS; match class: 1 0.0380049676407466 5600 16 11 0.6875 0.00196428571428571
TF TF:M09894_1 Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 0.0380810703839166 13929 20 20 1 0.00143585325579726
TF TF:M09971 Factor: GKLF; motif: WGGGYGKGGC 0.0383283101128582 5546 10 8 0.8 0.00144248106743599
TF TF:M12313_1 Factor: ZNF460; motif: NNACNCCCCCCNN; match class: 1 0.0383283101128582 2203 16 7 0.4375 0.00317748524738992
TF TF:M02065 Factor: ER81; motif: RCCGGAARYN 0.0383283101128582 12550 21 20 0.952380952380952 0.00159362549800797
TF TF:M00938 Factor: E2F-1; motif: TTGGCGCGRAANNGNM 0.0383283101128582 7334 7 7 1 0.000954458685574039
TF TF:M08875 Factor: E2F; motif: NNTTTCGCGCN 0.0390547509128841 6203 19 13 0.684210526315789 0.00209576011607287
TF TF:M11482_1 Factor: AP-2gamma; motif: NSCCYNNRGSN; match class: 1 0.0398746064496288 2050 9 5 0.555555555555556 0.0024390243902439
TF TF:M11397 Factor: Erg; motif: NACCGGATATCCGGTN 0.0398746064496288 12005 19 18 0.947368421052632 0.0014993752603082
TF TF:M01660_1 Factor: GABP-alpha; motif: CTTCCK; match class: 1 0.0398746064496288 5133 22 13 0.590909090909091 0.0025326319890902
TF TF:M04918 Factor: Egr-1; motif: ACCGCCC 0.0399485359219831 5608 10 8 0.8 0.0014265335235378
TF TF:M00237 Factor: AhR:Arnt; motif: GRGKATYGCGTGMCWNSCC 0.0401804989582445 6327 6 6 1 0.000948316737790422
TF TF:M00196 Factor: Sp1; motif: NGGGGGCGGGGYN 0.0401804989582445 10233 18 16 0.888888888888889 0.00156356884589075
TF TF:M09606 Factor: nerf; motif: NRRNSCGGAAGNRNNNN 0.0401804989582445 6249 19 13 0.684210526315789 0.00208033285325652
TF TF:M03567_1 Factor: Sp2; motif: NYSGCCCCGCCCCCY; match class: 1 0.0403588396612313 3614 4 4 1 0.00110680686220255
TF TF:M07397 Factor: ZBP89; motif: CCCCKCCCCCNN 0.0409776235829069 7143 12 10 0.833333333333333 0.00139997200055999
TF TF:M00931 Factor: Sp1; motif: GGGGCGGGGC 0.0414234387103497 10281 18 16 0.888888888888889 0.00155626884544305
TF TF:M08281 Factor: Fli-1:C/EBPbeta; motif: RNCGGAWRTTGCGCAAY 0.0414234387103497 7571 10 9 0.9 0.00118874653282261
TF TF:M09636_1 Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1 0.0414689546343606 14096 20 20 1 0.00141884222474461
TF TF:M11419_1 Factor: ER81; motif: NNCCGGAWGYN; match class: 1 0.0414689546343606 1427 18 6 0.333333333333333 0.00420462508759636
TF TF:M11882_1 Factor: pax-6; motif: NYACGCNYSANYGMNCN; match class: 1 0.0414689546343606 11423 17 16 0.941176470588235 0.00140068283288103
TF TF:M07615 Factor: Sp3; motif: GGGGCGGGGSNN 0.0414689546343606 6807 18 13 0.722222222222222 0.00190979873659468
TF TF:M01118 Factor: WT1; motif: SMCNCCNSC 0.0414689546343606 6808 18 13 0.722222222222222 0.00190951821386604
TF TF:M01303 Factor: SP1; motif: GGGGYGGGGNS 0.042984712296451 7898 18 14 0.777777777777778 0.00177260065839453
TF TF:M00772 Factor: IRF; motif: RRAANTGAAASYGNV 0.042984712296451 1029 5 3 0.6 0.00291545189504373
TF TF:M00986_1 Factor: Churchill; motif: CGGGNN; match class: 1 0.042984712296451 10357 18 16 0.888888888888889 0.00154484889446751
TF TF:M04515_1 Factor: E2F-1; motif: WWTGGCGCCAAA; match class: 1 0.0433461053176705 12173 19 18 0.947368421052632 0.00147868232974616
TF TF:M11450 Factor: Elf-1; motif: NANSCGGAAGTR 0.0437336507482795 5601 21 13 0.619047619047619 0.00232101410462417
TF TF:M01660 Factor: GABP-alpha; motif: CTTCCK 0.0437336507482795 11116 20 18 0.9 0.00161928751349406
TF TF:M08345_1 Factor: HOXB2:PEA3; motif: ACCGGAAATGRN; match class: 1 0.0437336507482795 2198 3 3 1 0.00136487716105551
TF TF:M10098_1 Factor: DP-1; motif: NRNNGGCGGGAANN; match class: 1 0.0437336507482795 2168 9 5 0.555555555555556 0.00230627306273063
TF TF:M00931_1 Factor: Sp1; motif: GGGGCGGGGC; match class: 1 0.0437336507482795 5905 18 12 0.666666666666667 0.00203217612193057
TF TF:M08487 Factor: GCMa:Erg; motif: ATGCGGGCGGAARKG 0.0437336507482795 13942 19 19 1 0.0013627886960264
TF TF:M09738 Factor: ZNF511; motif: GGRRGRGGCWGNG 0.0440542788044755 10865 11 11 1 0.00101242521859181
TF TF:M03558 Factor: P73; motif: GNNNRRRCNTGCMNNTSASN 0.0442376761744232 4679 14 9 0.642857142857143 0.00192348792477025
TF TF:M10144_1 Factor: ZNF341; motif: GRGGRRNRGNRGNRGGAASAGC; match class: 1 0.0442376761744232 972 18 5 0.277777777777778 0.0051440329218107
TF TF:M12187 Factor: KLF17; motif: NMCCACNCWCCCNTN 0.0447480073947918 2886 17 8 0.470588235294118 0.00277200277200277
TF TF:M07409 Factor: BTEB2; motif: GCCCCRCCCH 0.0451621580939206 5198 13 9 0.692307692307692 0.00173143516737207
TF TF:M00189_1 Factor: AP-2; motif: MKCCCSCNGGCG; match class: 1 0.0451857406609358 6093 8 7 0.875 0.0011488593467914
TF TF:M08345 Factor: HOXB2:PEA3; motif: ACCGGAAATGRN 0.0451857406609358 8027 18 14 0.777777777777778 0.00174411361654416
TF TF:M00915 Factor: AP-2; motif: SNNNCCNCAGGCN 0.0451857406609358 9612 9 9 1 0.000936329588014981
TF TF:M09871 Factor: bach2; motif: TGCTGAGTCAN 0.0451857406609358 395 12 3 0.25 0.00759493670886076
TF TF:M12186_1 Factor: BTEB4; motif: NCCACGCCCM; match class: 1 0.0451857406609358 3958 19 10 0.526315789473684 0.00252652854977261
TF TF:M00803 Factor: E2F; motif: GGCGSG 0.0451857406609358 13190 16 16 1 0.00121304018195603
TF TF:M07261 Factor: LKLF; motif: GGGGTGGKSN 0.0451857406609358 9774 13 12 0.923076923076923 0.00122774708410068
TF TF:M03978_1 Factor: ETS1; motif: GCCGGAWGTACTTCCGGN; match class: 1 0.0451857406609358 6486 19 13 0.684210526315789 0.00200431699044095
TF TF:M11603_1 Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 0.0451857406609358 13184 16 16 1 0.00121359223300971
TF TF:M01045_1 Factor: AP-2alphaA; motif: ANNGCCTNAGGSNNT; match class: 1 0.0453422230572063 2116 6 4 0.666666666666667 0.00189035916824197
TF TF:M09893 Factor: E2F-3; motif: NNGGCGGGAAA 0.0453422230572063 6065 20 13 0.65 0.0021434460016488
TF TF:M09611_1 Factor: ER81; motif: NNNGRCMGGAAGYRNNNNNNNS; match class: 1 0.0453422230572063 319 15 3 0.2 0.00940438871473354
TF TF:M11541_1 Factor: Foxn2; motif: NNGCGTCNNNNNGACGCNN; match class: 1 0.0455120396221996 5493 5 5 1 0.000910249408337885
TF TF:M02064 Factor: c-ets-2; motif: ACCGGAWRTN 0.0466352085915936 10939 19 17 0.894736842105263 0.00155407258433129
TF TF:M11432_1 Factor: Elk-1; motif: NACMGGAAGTN; match class: 1 0.0467639985846114 1525 18 6 0.333333333333333 0.0039344262295082
TF TF:M10098 Factor: DP-1; motif: NRNNGGCGGGAANN 0.0467639985846114 7015 20 14 0.7 0.00199572344975053
TF TF:M07261_1 Factor: LKLF; motif: GGGGTGGKSN; match class: 1 0.0467639985846114 4062 16 9 0.5625 0.00221565731166913
TF TF:M11402_1 Factor: Fli-1; motif: NACCGGAARTN; match class: 1 0.0467639985846114 601 18 4 0.222222222222222 0.00665557404326123
TF TF:M05439_1 Factor: RREB-1; motif: GGGWCSA; match class: 1 0.0467639985846114 3200 7 5 0.714285714285714 0.0015625
TF TF:M08457_1 Factor: ER71:SREBP-2; motif: NTSACGTGACGGAARY; match class: 1 0.0467639985846114 5591 5 5 1 0.000894294401717045
TF TF:M02036 Factor: WT1; motif: CGCCCCCNCN 0.0467639985846114 9767 9 9 1 0.000921470256987816
TF TF:M07290_1 Factor: GLI; motif: NGACCMCCCAN; match class: 1 0.0467639985846114 1902 15 6 0.4 0.00315457413249211
TF TF:M09734 Factor: ZNF692; motif: SYNGGSCCCASCCNC 0.0467639985846114 11678 12 12 1 0.00102757321459154
TF TF:M11531 Factor: E2F-2; motif: GCGCGCGCGYW 0.0467639985846114 13270 16 16 1 0.00120572720422005
TF TF:M07395 Factor: Sp1; motif: NGGGGCGGGGN 0.047788247671354 10640 18 16 0.888888888888889 0.00150375939849624
TF TF:M09658 Factor: Sp2; motif: GGSNNGGGGGCGGGGCCNGNGS 0.0484087089887772 5262 7 6 0.857142857142857 0.00114025085518814
TF TF:M02053_1 Factor: ELF1; motif: NCCGGAARTN; match class: 1 0.0484159703959176 1559 18 6 0.333333333333333 0.00384862091084028
TF TF:M08283 Factor: Fli-1:ETV7; motif: NSMGGAMGGATNTCCGNN 0.0488484592888354 2910 14 7 0.5 0.00240549828178694
TF TF:M09935_1 Factor: GABP-alpha; motif: NNNRCCGGAAGTGN; match class: 1 0.0488484592888354 1047 18 5 0.277777777777778 0.00477554918815664
TF TF:M02068_1 Factor: etv3; motif: ACCGGAAGYN; match class: 1 0.0488484592888354 613 18 4 0.222222222222222 0.0065252854812398
TF TF:M00738 Factor: E2F-4:DP-1; motif: TTTSGCGC 0.0493479617343285 9812 19 16 0.842105263157895 0.00163065633917652
TF TF:M04152 Factor: TFAP2C; motif: NGCCCNNRGGCA 0.0493479617343285 7738 17 13 0.764705882352941 0.00168002067717757
TF TF:M07041_1 Factor: HDAC1; motif: KGCARGGTC; match class: 1 0.0493479617343285 6354 8 7 0.875 0.00110166824047844
TF TF:M11529_1 Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1 0.0493479617343285 14473 20 20 1 0.00138188350722034
TF TF:M01072 Factor: HIC1; motif: NSNNNNTGCCCSSNN 0.0493479617343285 4166 6 5 0.833333333333333 0.00120019203072492
TF TF:M11541 Factor: Foxn2; motif: NNGCGTCNNNNNGACGCNN 0.0498138240549809 5751 5 5 1 0.000869414014953921
WP WP:WP3888 VEGFA-VEGFR2 Signaling Pathway 1.30464534484042e-05 437 18 9 0.5 0.0205949656750572
WP WP:WP51 Regulation of Actin Cytoskeleton 2.10714879805962e-05 149 10 5 0.5 0.0335570469798658
WP WP:WP2272 Pathogenic Escherichia coli infection 0.00167002059013015 55 12 3 0.25 0.0545454545454545
WP WP:WP306 Focal Adhesion 0.00579556107435011 201 24 5 0.208333333333333 0.0248756218905473
WP WP:WP289 Myometrial Relaxation and Contraction Pathways 0.0221664515923846 155 16 3 0.1875 0.0193548387096774

pEpiTd22 transcription factor target enrichment of top program genes

TF enrichment of pEpiTd22
Possible regulators of activation of pEpiTd22 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.