pEpi25 program activity among Epithelial cells

Activation of pEpi25
pEpi25 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpi25 by different cell subtypes
pEpi25 gene program activation among cells of different subtypes (Epithelial cells).

pEpi25 top program genes

Top genes of pEpi25 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpi25 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpi25
pEpi25 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
CORUM CORUM:306 Ribosome, cytoplasmic 2.66795743237014e-26 80 19 17 0.894736842105263 0.2125
CORUM CORUM:338 40S ribosomal subunit, cytoplasmic 2.5501140942361e-16 31 19 10 0.526315789473684 0.32258064516129
CORUM CORUM:305 40S ribosomal subunit, cytoplasmic 3.53187047100638e-16 33 19 10 0.526315789473684 0.303030303030303
CORUM CORUM:3055 Nop56p-associated pre-rRNA complex 2.42925343577618e-14 104 19 12 0.631578947368421 0.115384615384615
CORUM CORUM:308 60S ribosomal subunit, cytoplasmic 1.13318631774143e-09 47 16 7 0.4375 0.148936170212766
GO:BP GO:0006614 SRP-dependent cotranslational protein targeting to membrane 5.80546472074737e-35 96 19 17 0.894736842105263 0.177083333333333
GO:BP GO:0006613 cotranslational protein targeting to membrane 8.93147683755631e-35 102 19 17 0.894736842105263 0.166666666666667
GO:BP GO:0045047 protein targeting to ER 3.92080495000281e-34 113 19 17 0.894736842105263 0.150442477876106
GO:BP GO:0072599 establishment of protein localization to endoplasmic reticulum 5.55735085698404e-34 117 19 17 0.894736842105263 0.145299145299145
GO:BP GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 1.10677069321948e-33 123 19 17 0.894736842105263 0.138211382113821
GO:BP GO:0070972 protein localization to endoplasmic reticulum 2.0509796514184e-32 146 19 17 0.894736842105263 0.116438356164384
GO:BP GO:0019083 viral transcription 8.2025794126877e-31 181 19 17 0.894736842105263 0.0939226519337017
GO:BP GO:0019080 viral gene expression 3.85878965886179e-30 199 19 17 0.894736842105263 0.085427135678392
GO:BP GO:0006413 translational initiation 4.09415429454828e-30 201 19 17 0.894736842105263 0.0845771144278607
GO:BP GO:0006612 protein targeting to membrane 4.78873401662628e-30 204 19 17 0.894736842105263 0.0833333333333333
GO:BP GO:0000956 nuclear-transcribed mRNA catabolic process 1.01386110044481e-29 214 19 17 0.894736842105263 0.0794392523364486
GO:BP GO:0090150 establishment of protein localization to membrane 5.3393269593229e-26 351 19 17 0.894736842105263 0.0484330484330484
GO:BP GO:0006402 mRNA catabolic process 2.3416431298222e-25 384 19 17 0.894736842105263 0.0442708333333333
GO:BP GO:0006401 RNA catabolic process 1.20779672613239e-24 424 19 17 0.894736842105263 0.0400943396226415
GO:BP GO:0006605 protein targeting 2.22325942360845e-24 441 19 17 0.894736842105263 0.0385487528344671
GO:BP GO:0034655 nucleobase-containing compound catabolic process 1.58123988572821e-22 567 19 17 0.894736842105263 0.0299823633156966
GO:BP GO:0072594 establishment of protein localization to organelle 2.47214104241528e-22 584 19 17 0.894736842105263 0.0291095890410959
GO:BP GO:0046700 heterocycle catabolic process 3.93198568627411e-22 602 19 17 0.894736842105263 0.0282392026578073
GO:BP GO:0044270 cellular nitrogen compound catabolic process 4.41628407222895e-22 608 19 17 0.894736842105263 0.0279605263157895
GO:BP GO:0019439 aromatic compound catabolic process 6.37377137338639e-22 623 19 17 0.894736842105263 0.0272873194221509
GO:BP GO:1901361 organic cyclic compound catabolic process 1.29010591082564e-21 651 19 17 0.894736842105263 0.0261136712749616
GO:BP GO:0072657 protein localization to membrane 1.77336994354393e-21 665 19 17 0.894736842105263 0.0255639097744361
GO:BP GO:0006412 translation 1.82451618024648e-20 764 19 17 0.894736842105263 0.0222513089005236
GO:BP GO:0043043 peptide biosynthetic process 3.09807422727984e-20 790 19 17 0.894736842105263 0.0215189873417722
GO:BP GO:0016071 mRNA metabolic process 1.66994992505165e-19 874 19 17 0.894736842105263 0.0194508009153318
GO:BP GO:0043604 amide biosynthetic process 4.80339239452337e-19 932 19 17 0.894736842105263 0.0182403433476395
GO:BP GO:0016032 viral process 5.54826547472288e-19 942 19 17 0.894736842105263 0.0180467091295117
GO:BP GO:0006518 peptide metabolic process 6.75770575306517e-19 955 19 17 0.894736842105263 0.0178010471204188
GO:BP GO:0044403 biological process involved in symbiotic interaction 1.45398947300352e-18 1001 19 17 0.894736842105263 0.016983016983017
GO:BP GO:0033365 protein localization to organelle 1.84114845476698e-18 1017 19 17 0.894736842105263 0.0167158308751229
GO:BP GO:0006886 intracellular protein transport 2.43261884540269e-17 1186 19 17 0.894736842105263 0.0143338954468803
GO:BP GO:0044265 cellular macromolecule catabolic process 4.43502356066818e-17 1231 19 17 0.894736842105263 0.0138099106417547
GO:BP GO:0043603 cellular amide metabolic process 4.93368644706542e-17 1241 19 17 0.894736842105263 0.0136986301369863
GO:BP GO:0010629 negative regulation of gene expression 7.52692090848866e-16 1460 19 17 0.894736842105263 0.0116438356164384
GO:BP GO:0009057 macromolecule catabolic process 8.02052248500644e-16 1468 19 17 0.894736842105263 0.0115803814713896
GO:BP GO:0046907 intracellular transport 1.78944940360062e-14 1767 19 17 0.894736842105263 0.00962082625919638
GO:BP GO:1901566 organonitrogen compound biosynthetic process 3.88099605437907e-14 1853 19 17 0.894736842105263 0.00917431192660551
GO:BP GO:0015031 protein transport 7.44001375435054e-14 1929 19 17 0.894736842105263 0.00881285640228098
GO:BP GO:0015833 peptide transport 1.04197505081277e-13 1971 19 17 0.894736842105263 0.00862506341958397
GO:BP GO:0042886 amide transport 1.37789803939145e-13 2007 19 17 0.894736842105263 0.00847035376183358
GO:BP GO:0034613 cellular protein localization 1.42543593285514e-13 2014 19 17 0.894736842105263 0.00844091360476663
GO:BP GO:0070727 cellular macromolecule localization 1.51248044982475e-13 2024 19 17 0.894736842105263 0.00839920948616601
GO:BP GO:0045184 establishment of protein localization 1.61841079030125e-13 2035 19 17 0.894736842105263 0.00835380835380835
GO:BP GO:0051649 establishment of localization in cell 7.244490416485e-13 2813 19 18 0.947368421052632 0.00639886242445787
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 8.68710920288414e-13 2255 19 17 0.894736842105263 0.00753880266075388
GO:BP GO:1901575 organic substance catabolic process 9.29047923699242e-13 2267 19 17 0.894736842105263 0.00749889722099691
GO:BP GO:0071705 nitrogen compound transport 1.3597915997994e-12 2322 19 17 0.894736842105263 0.00732127476313523
GO:BP GO:0044248 cellular catabolic process 1.59359417508731e-12 2347 19 17 0.894736842105263 0.00724328930549638
GO:BP GO:0009056 catabolic process 2.13879440828954e-11 2744 19 17 0.894736842105263 0.00619533527696793
GO:BP GO:0071702 organic substance transport 2.3953090343563e-11 2766 19 17 0.894736842105263 0.00614605929139552
GO:BP GO:0008104 protein localization 2.40574655820027e-11 2770 19 17 0.894736842105263 0.00613718411552347
GO:BP GO:0051641 cellular localization 3.73002556535626e-11 3541 19 18 0.947368421052632 0.00508330979949167
GO:BP GO:0006820 anion transport 4.67369952121492e-11 2889 19 17 0.894736842105263 0.00588438906195916
GO:BP GO:0006811 ion transport 6.50293287995254e-11 3661 19 18 0.947368421052632 0.00491668942911773
GO:BP GO:0033036 macromolecule localization 2.71780908008244e-10 3218 19 17 0.894736842105263 0.0052827843380982
GO:BP GO:0010605 negative regulation of macromolecule metabolic process 3.00506395257184e-10 3241 19 17 0.894736842105263 0.00524529466214131
GO:BP GO:0009892 negative regulation of metabolic process 9.5839229491033e-10 3479 19 17 0.894736842105263 0.00488646162690428
GO:BP GO:0042254 ribosome biogenesis 3.02350667983531e-09 307 18 8 0.444444444444444 0.0260586319218241
GO:BP GO:0016070 RNA metabolic process 5.22124084537595e-09 4710 19 18 0.947368421052632 0.00382165605095541
GO:BP GO:0044271 cellular nitrogen compound biosynthetic process 1.56894058226864e-08 5017 19 18 0.947368421052632 0.00358780147498505
GO:BP GO:0034645 cellular macromolecule biosynthetic process 1.73887352830077e-08 5051 19 18 0.947368421052632 0.0035636507622253
GO:BP GO:0009059 macromolecule biosynthetic process 2.12970871499365e-08 5114 19 18 0.947368421052632 0.00351974970668752
GO:BP GO:0010468 regulation of gene expression 2.77573977838745e-08 5196 19 18 0.947368421052632 0.00346420323325635
GO:BP GO:0090304 nucleic acid metabolic process 2.97815775863087e-08 5226 19 18 0.947368421052632 0.0034443168771527
GO:BP GO:0006810 transport 2.97815775863087e-08 5224 19 18 0.947368421052632 0.00344563552833078
GO:BP GO:0051234 establishment of localization 4.76952661612355e-08 5372 19 18 0.947368421052632 0.00335070737155622
GO:BP GO:0022613 ribonucleoprotein complex biogenesis 4.98693296647088e-08 446 18 8 0.444444444444444 0.0179372197309417
GO:BP GO:0042274 ribosomal small subunit biogenesis 8.96141101076816e-08 74 18 5 0.277777777777778 0.0675675675675676
GO:BP GO:0006139 nucleobase-containing compound metabolic process 1.49325518286673e-07 5746 19 18 0.947368421052632 0.0031326139923425
GO:BP GO:0046483 heterocycle metabolic process 2.37185395863647e-07 5904 19 18 0.947368421052632 0.00304878048780488
GO:BP GO:0006725 cellular aromatic compound metabolic process 2.72812573919826e-07 5956 19 18 0.947368421052632 0.00302216252518469
GO:BP GO:0044249 cellular biosynthetic process 4.77770937323285e-07 6154 19 18 0.947368421052632 0.00292492687682808
GO:BP GO:0010467 gene expression 5.05973503117462e-07 6179 19 18 0.947368421052632 0.00291309273345201
GO:BP GO:1901360 organic cyclic compound metabolic process 5.31253730921254e-07 6201 19 18 0.947368421052632 0.00290275761973875
GO:BP GO:0006364 rRNA processing 5.464133136246e-07 224 18 6 0.333333333333333 0.0267857142857143
GO:BP GO:0044267 cellular protein metabolic process 5.82865562652282e-07 5229 19 17 0.894736842105263 0.00325109963664181
GO:BP GO:1901576 organic substance biosynthetic process 5.82865562652282e-07 6248 19 18 0.947368421052632 0.0028809218950064
GO:BP GO:0016072 rRNA metabolic process 6.80880420139506e-07 234 18 6 0.333333333333333 0.0256410256410256
GO:BP GO:0009058 biosynthetic process 7.3407483684229e-07 6340 19 18 0.947368421052632 0.0028391167192429
GO:BP GO:0034641 cellular nitrogen compound metabolic process 1.32808962673179e-06 6563 19 18 0.947368421052632 0.00274264817918635
GO:BP GO:0060255 regulation of macromolecule metabolic process 1.45884282192328e-06 6603 19 18 0.947368421052632 0.00272603362108133
GO:BP GO:0048519 negative regulation of biological process 2.58813088012413e-06 5757 19 17 0.894736842105263 0.00295292687163453
GO:BP GO:0019538 protein metabolic process 2.94868811875712e-06 5808 19 17 0.894736842105263 0.00292699724517906
GO:BP GO:0051179 localization 3.04270751582067e-06 6901 19 18 0.947368421052632 0.00260831763512534
GO:BP GO:0019222 regulation of metabolic process 5.5525440315943e-06 7148 19 18 0.947368421052632 0.00251818690542809
GO:BP GO:1901798 positive regulation of signal transduction by p53 class mediator 6.40507264066133e-06 24 14 3 0.214285714285714 0.125
GO:BP GO:0034470 ncRNA processing 1.3614439921859e-05 397 18 6 0.333333333333333 0.0151133501259446
GO:BP GO:1901564 organonitrogen compound metabolic process 3.42747423695585e-05 6792 19 17 0.894736842105263 0.00250294464075383
GO:BP GO:0034660 ncRNA metabolic process 4.60015708462097e-05 493 18 6 0.333333333333333 0.0121703853955375
GO:BP GO:0044260 cellular macromolecule metabolic process 8.33843879406912e-05 8390 19 18 0.947368421052632 0.00214541120381406
GO:BP GO:0006396 RNA processing 0.000182188793444294 964 18 7 0.388888888888889 0.00726141078838174
GO:BP GO:0042255 ribosome assembly 0.000262863057431075 64 18 3 0.166666666666667 0.046875
GO:BP GO:0042273 ribosomal large subunit biogenesis 0.000277625834651514 74 16 3 0.1875 0.0405405405405405
GO:BP GO:0002181 cytoplasmic translation 0.000381564701039876 103 13 3 0.230769230769231 0.029126213592233
GO:BP GO:0043170 macromolecule metabolic process 0.00109703054916566 9796 19 18 0.947368421052632 0.0018374846876276
GO:BP GO:0006807 nitrogen compound metabolic process 0.00170435836260067 10078 19 18 0.947368421052632 0.00178606866441754
GO:BP GO:0006417 regulation of translation 0.00180497588561077 462 13 4 0.307692307692308 0.00865800865800866
GO:BP GO:0010608 posttranscriptional regulation of gene expression 0.00194146160855705 896 13 5 0.384615384615385 0.00558035714285714
GO:BP GO:1901796 regulation of signal transduction by p53 class mediator 0.0023073446176543 180 14 3 0.214285714285714 0.0166666666666667
GO:BP GO:0034248 regulation of cellular amide metabolic process 0.00306786940176499 535 13 4 0.307692307692308 0.00747663551401869
GO:BP GO:0044238 primary metabolic process 0.00370722108580829 10584 19 18 0.947368421052632 0.00170068027210884
GO:BP GO:0044237 cellular metabolic process 0.00530539361819145 10871 19 18 0.947368421052632 0.00165578143685034
GO:BP GO:0022618 ribonucleoprotein complex assembly 0.00575786501357599 197 18 3 0.166666666666667 0.0152284263959391
GO:BP GO:0071826 ribonucleoprotein complex subunit organization 0.00631623937905395 204 18 3 0.166666666666667 0.0147058823529412
GO:BP GO:0072331 signal transduction by p53 class mediator 0.00638319133015526 268 14 3 0.214285714285714 0.0111940298507463
GO:BP GO:0065007 biological regulation 0.00821185740683089 12809 19 19 1 0.00148333203216488
GO:BP GO:0032268 regulation of cellular protein metabolic process 0.00871465603098141 2541 14 7 0.5 0.00275482093663912
GO:BP GO:0071704 organic substance metabolic process 0.00951597863616642 11326 19 18 0.947368421052632 0.00158926364117959
GO:BP GO:0044085 cellular component biogenesis 0.0111360517778837 3257 18 9 0.5 0.00276327909118821
GO:BP GO:0043065 positive regulation of apoptotic process 0.0114067326582914 604 17 4 0.235294117647059 0.00662251655629139
GO:BP GO:0051246 regulation of protein metabolic process 0.0114938141920017 2704 14 7 0.5 0.0025887573964497
GO:BP GO:0043068 positive regulation of programmed cell death 0.0120870289008962 621 17 4 0.235294117647059 0.00644122383252818
GO:BP GO:0010942 positive regulation of cell death 0.0163530783564143 684 17 4 0.235294117647059 0.00584795321637427
GO:BP GO:0008152 metabolic process 0.0168122469883446 11827 19 18 0.947368421052632 0.00152194132070686
GO:BP GO:0034622 cellular protein-containing complex assembly 0.0189724220254877 1107 6 3 0.5 0.002710027100271
GO:BP GO:0050789 regulation of biological process 0.0223192246127016 12091 19 18 0.947368421052632 0.00148871061119841
GO:BP GO:1902533 positive regulation of intracellular signal transduction 0.02892318018097 1037 14 4 0.285714285714286 0.0038572806171649
GO:BP GO:0045787 positive regulation of cell cycle 0.0330228256688996 403 19 3 0.157894736842105 0.00744416873449132
GO:BP GO:0010628 positive regulation of gene expression 0.0384324480104418 1160 14 4 0.285714285714286 0.00344827586206897
GO:BP GO:0042981 regulation of apoptotic process 0.0392860984911189 1549 6 3 0.5 0.00193673337637185
GO:BP GO:0043067 regulation of programmed cell death 0.041248249183856 1582 6 3 0.5 0.00189633375474083
GO:BP GO:0065003 protein-containing complex assembly 0.0453333809967262 1680 6 3 0.5 0.00178571428571429
GO:BP GO:0006511 ubiquitin-dependent protein catabolic process 0.0453333809967262 655 14 3 0.214285714285714 0.00458015267175573
GO:BP GO:0019941 modification-dependent protein catabolic process 0.0456284471536516 662 14 3 0.214285714285714 0.00453172205438067
GO:BP GO:0043632 modification-dependent macromolecule catabolic process 0.0466203428858217 673 14 3 0.214285714285714 0.00445765230312036
GO:BP GO:0010941 regulation of cell death 0.0466203428858217 1720 6 3 0.5 0.00174418604651163
GO:BP GO:0051171 regulation of nitrogen compound metabolic process 0.0468603398326249 5848 14 9 0.642857142857143 0.0015389876880985
GO:CC GO:0022626 cytosolic ribosome 4.19609378011357e-35 109 19 17 0.894736842105263 0.155963302752294
GO:CC GO:0044391 ribosomal subunit 4.69960476242569e-31 190 19 17 0.894736842105263 0.0894736842105263
GO:CC GO:0005840 ribosome 2.7808081680935e-29 245 19 17 0.894736842105263 0.0693877551020408
GO:CC GO:1990904 ribonucleoprotein complex 1.21038700680318e-21 688 19 17 0.894736842105263 0.0247093023255814
GO:CC GO:0022627 cytosolic small ribosomal subunit 6.38924998728732e-21 47 19 10 0.526315789473684 0.212765957446809
GO:CC GO:0015935 small ribosomal subunit 8.42085341222626e-19 75 19 10 0.526315789473684 0.133333333333333
GO:CC GO:0022625 cytosolic large ribosomal subunit 2.71515219648912e-13 57 16 7 0.4375 0.12280701754386
GO:CC GO:0015934 large ribosomal subunit 4.61863029791761e-11 118 16 7 0.4375 0.0593220338983051
GO:CC GO:0005925 focal adhesion 5.98186553190528e-10 420 18 9 0.5 0.0214285714285714
GO:CC GO:0030055 cell-substrate junction 6.23708192352805e-10 427 18 9 0.5 0.0210772833723653
GO:CC GO:0005829 cytosol 1.52941755471253e-08 5303 19 18 0.947368421052632 0.00339430511031492
GO:CC GO:0032991 protein-containing complex 3.11217722020003e-08 5548 19 18 0.947368421052632 0.00324441240086518
GO:CC GO:0070161 anchoring junction 1.76640270956725e-07 836 18 9 0.5 0.0107655502392345
GO:CC GO:0043232 intracellular non-membrane-bounded organelle 3.04332539241495e-07 5338 19 17 0.894736842105263 0.00318471337579618
GO:CC GO:0043228 non-membrane-bounded organelle 3.04332539241495e-07 5346 19 17 0.894736842105263 0.00317994762439207
GO:CC GO:0070062 extracellular exosome 8.23446561944911e-07 2176 19 12 0.631578947368421 0.00551470588235294
GO:CC GO:1903561 extracellular vesicle 1.13483185051136e-06 2261 19 12 0.631578947368421 0.00530738611233967
GO:CC GO:0043230 extracellular organelle 1.13483185051136e-06 2263 19 12 0.631578947368421 0.00530269553689792
GO:CC GO:0005730 nucleolus 6.60541271275297e-06 955 18 8 0.444444444444444 0.00837696335078534
GO:CC GO:0005615 extracellular space 1.91988237166099e-05 3594 19 13 0.684210526315789 0.00361713967723984
GO:CC GO:0005844 polysome 0.000183292585190479 72 17 3 0.176470588235294 0.0416666666666667
GO:CC GO:0031981 nuclear lumen 0.000203345702859701 4444 19 13 0.684210526315789 0.00292529252925293
GO:CC GO:0030054 cell junction 0.000233622938500011 2105 18 9 0.5 0.00427553444180523
GO:CC GO:0005576 extracellular region 0.00025400708280071 4567 19 13 0.684210526315789 0.00284650755419312
GO:CC GO:0070013 intracellular organelle lumen 0.000257216377442145 5402 19 14 0.736842105263158 0.00259163272861903
GO:CC GO:0043233 organelle lumen 0.000342132764090643 5565 19 14 0.736842105263158 0.00251572327044025
GO:CC GO:0031974 membrane-enclosed lumen 0.000342132764090643 5565 19 14 0.736842105263158 0.00251572327044025
GO:CC GO:0005634 nucleus 0.00039417305139613 7592 19 16 0.842105263157895 0.00210748155953635
GO:CC GO:0031982 vesicle 0.00039417305139613 4055 19 12 0.631578947368421 0.00295930949445129
GO:CC GO:0005654 nucleoplasm 0.000415654727425397 4102 19 12 0.631578947368421 0.00292540224280839
GO:CC GO:0005737 cytoplasm 0.000507967570655859 11911 19 19 1 0.00159516413399379
GO:CC GO:0045202 synapse 0.000507967570655859 1349 18 7 0.388888888888889 0.00518902891030393
GO:CC GO:0014069 postsynaptic density 0.00076181162111332 334 18 4 0.222222222222222 0.0119760479041916
GO:CC GO:0032279 asymmetric synapse 0.000792742326967925 340 18 4 0.222222222222222 0.0117647058823529
GO:CC GO:0099572 postsynaptic specialization 0.000938831472753282 358 18 4 0.222222222222222 0.0111731843575419
GO:CC GO:0098984 neuron to neuron synapse 0.000994239910502653 366 18 4 0.222222222222222 0.0109289617486339
GO:CC GO:0043229 intracellular organelle 0.00102929971335066 12491 19 19 1 0.00152109518853575
GO:CC GO:0043231 intracellular membrane-bounded organelle 0.0020630660141997 11296 19 18 0.947368421052632 0.00159348441926346
GO:CC GO:0098794 postsynapse 0.0068274225325503 639 18 4 0.222222222222222 0.00625978090766823
GO:CC GO:0043226 organelle 0.00788565873738861 14008 19 19 1 0.00135636778983438
GO:CC GO:0016020 membrane 0.00877723101732923 9838 19 16 0.842105263157895 0.00162634681845904
GO:CC GO:0005783 endoplasmic reticulum 0.0137540982363693 1982 8 4 0.5 0.00201816347124117
GO:CC GO:0043227 membrane-bounded organelle 0.0142496744444536 12858 19 18 0.947368421052632 0.00139990667288847
GO:CC GO:0005622 intracellular anatomical structure 0.0195438286768638 14790 19 19 1 0.00128465179175118
GO:CC GO:0012505 endomembrane system 0.0465068176768293 4640 8 5 0.625 0.00107758620689655
GO:MF GO:0003735 structural constituent of ribosome 8.65749193747349e-32 171 19 17 0.894736842105263 0.0994152046783626
GO:MF GO:0005198 structural molecule activity 1.85818350948541e-21 698 19 17 0.894736842105263 0.0243553008595989
GO:MF GO:0003723 RNA binding 4.4431356086296e-14 1943 19 17 0.894736842105263 0.00874935666495111
GO:MF GO:0003676 nucleic acid binding 1.74295944312273e-08 4276 19 17 0.894736842105263 0.00397567820392891
GO:MF GO:0019843 rRNA binding 1.19315162182252e-06 63 14 4 0.285714285714286 0.0634920634920635
GO:MF GO:0097159 organic cyclic compound binding 4.96119901223592e-06 6309 19 17 0.894736842105263 0.00269456332223807
GO:MF GO:0048027 mRNA 5'-UTR binding 4.96119901223592e-06 27 13 3 0.230769230769231 0.111111111111111
GO:MF GO:1901363 heterocyclic compound binding 4.96119901223592e-06 6228 19 17 0.894736842105263 0.0027296082209377
GO:MF GO:0003729 mRNA binding 0.000349012403282577 552 16 5 0.3125 0.00905797101449275
GO:MF GO:0019901 protein kinase binding 0.0471504882041287 673 18 3 0.166666666666667 0.00445765230312036
HP HP:0030270 Elevated red cell adenosine deaminase level 0.000350638329867866 22 19 4 0.210526315789474 0.181818181818182
HP HP:0005532 Macrocytic dyserythropoietic anemia 0.000350638329867866 23 19 4 0.210526315789474 0.173913043478261
HP HP:0031640 Abnormal radial artery morphology 0.000350638329867866 22 19 4 0.210526315789474 0.181818181818182
HP HP:0012133 Erythroid hypoplasia 0.000350638329867866 25 19 4 0.210526315789474 0.16
HP HP:0012410 Pure red cell aplasia 0.000350638329867866 25 19 4 0.210526315789474 0.16
HP HP:0020118 Radial artery aplasia 0.000350638329867866 22 19 4 0.210526315789474 0.181818181818182
HP HP:0006758 Malignant genitourinary tract tumor 0.000354240272343647 26 19 4 0.210526315789474 0.153846153846154
HP HP:0040276 Adenocarcinoma of the colon 0.000362891250386334 27 19 4 0.210526315789474 0.148148148148148
HP HP:0011904 Persistence of hemoglobin F 0.000374749594513437 30 19 4 0.210526315789474 0.133333333333333
HP HP:0001227 Abnormality of the thenar eminence 0.000374749594513437 29 19 4 0.210526315789474 0.137931034482759
HP HP:0030272 Abnormal erythrocyte enzyme level 0.000374749594513437 29 19 4 0.210526315789474 0.137931034482759
HP HP:0040275 Adenocarcinoma of the large intestine 0.000374749594513437 30 19 4 0.210526315789474 0.133333333333333
HP HP:0001895 Normochromic anemia 0.000396105839113466 31 19 4 0.210526315789474 0.129032258064516
HP HP:0002669 Osteosarcoma 0.000444057773159171 33 19 4 0.210526315789474 0.121212121212121
HP HP:0001896 Reticulocytopenia 0.000444057773159171 33 19 4 0.210526315789474 0.121212121212121
HP HP:0040273 Adenocarcinoma of the intestines 0.000529837490148175 35 19 4 0.210526315789474 0.114285714285714
HP HP:0009944 Partial duplication of thumb phalanx 0.00059087832285468 37 19 4 0.210526315789474 0.108108108108108
HP HP:0100273 Neoplasm of the colon 0.00059087832285468 78 19 5 0.263157894736842 0.0641025641025641
HP HP:0012131 Abnormal number of erythroid precursors 0.000623957935067754 38 19 4 0.210526315789474 0.105263157894737
HP HP:0009999 Partial duplication of the phalanx of hand 0.000627364253805896 39 19 4 0.210526315789474 0.102564102564103
HP HP:0005518 Increased mean corpuscular volume 0.000627364253805896 39 19 4 0.210526315789474 0.102564102564103
HP HP:0001790 Nonimmune hydrops fetalis 0.000733369658481958 41 19 4 0.210526315789474 0.0975609756097561
HP HP:0009777 Absent thumb 0.000932781220632482 44 19 4 0.210526315789474 0.0909090909090909
HP HP:0010622 Neoplasm of the skeletal system 0.00101201427557231 93 19 5 0.263157894736842 0.0537634408602151
HP HP:0025065 Abnormal mean corpuscular volume 0.00132151174848962 49 19 4 0.210526315789474 0.0816326530612245
HP HP:0001894 Thrombocytosis 0.00137747128664504 50 19 4 0.210526315789474 0.08
HP HP:0000912 Sprengel anomaly 0.00143547974552822 51 19 4 0.210526315789474 0.0784313725490196
HP HP:0100834 Neoplasm of the large intestine 0.0015781700102879 106 19 5 0.263157894736842 0.0471698113207547
HP HP:0009942 Duplication of thumb phalanx 0.0015781700102879 53 19 4 0.210526315789474 0.0754716981132075
HP HP:0011902 Abnormal hemoglobin 0.00162181974663703 54 19 4 0.210526315789474 0.0740740740740741
HP HP:0001972 Macrocytic anemia 0.002381319423311 60 19 4 0.210526315789474 0.0666666666666667
HP HP:0001087 Developmental glaucoma 0.0029736652789933 64 19 4 0.210526315789474 0.0625
HP HP:0006749 Malignant gastrointestinal tract tumors 0.00306741613454786 66 19 4 0.210526315789474 0.0606060606060606
HP HP:0009380 Aplasia of the fingers 0.00306741613454786 66 19 4 0.210526315789474 0.0606060606060606
HP HP:0002672 Gastrointestinal carcinoma 0.00306741613454786 66 19 4 0.210526315789474 0.0606060606060606
HP HP:0001199 Triphalangeal thumb 0.00307754640487628 67 19 4 0.210526315789474 0.0597014925373134
HP HP:0004808 Acute myeloid leukemia 0.00307754640487628 67 19 4 0.210526315789474 0.0597014925373134
HP HP:0004312 Abnormal reticulocyte morphology 0.00396829696825454 72 19 4 0.210526315789474 0.0555555555555556
HP HP:0000085 Horseshoe kidney 0.00639891512313031 82 19 4 0.210526315789474 0.0487804878048781
HP HP:0001421 Abnormality of the musculature of the hand 0.00813963996048615 89 19 4 0.210526315789474 0.0449438202247191
HP HP:0001789 Hydrops fetalis 0.0101998587920357 95 19 4 0.210526315789474 0.0421052631578947
HP HP:0009778 Short thumb 0.0112193444066312 98 19 4 0.210526315789474 0.0408163265306122
HP HP:0002863 Myelodysplasia 0.0122994048702826 101 19 4 0.210526315789474 0.0396039603960396
HP HP:0002488 Acute leukemia 0.0129590204711607 103 19 4 0.210526315789474 0.0388349514563107
HP HP:0000294 Low anterior hairline 0.0131550957478418 104 19 4 0.210526315789474 0.0384615384615385
HP HP:0000465 Webbed neck 0.0154950550949692 111 19 4 0.210526315789474 0.036036036036036
HP HP:0001680 Coarctation of aorta 0.0162503222947863 113 19 4 0.210526315789474 0.0353982300884956
HP HP:0007379 Neoplasm of the genitourinary tract 0.0216122280208058 214 19 5 0.263157894736842 0.0233644859813084
HP HP:0000519 Developmental cataract 0.0218669555617432 126 19 4 0.210526315789474 0.0317460317460317
HP HP:0009601 Aplasia/Hypoplasia of the thumb 0.0218669555617432 126 19 4 0.210526315789474 0.0317460317460317
HP HP:0008551 Microtia 0.0261032028781332 134 19 4 0.210526315789474 0.0298507462686567
HP HP:0000980 Pallor 0.0281616818042304 138 19 4 0.210526315789474 0.0289855072463768
HP HP:0008772 Aplasia/Hypoplasia of the external ear 0.028232077080832 139 19 4 0.210526315789474 0.0287769784172662
HP HP:0002250 Abnormal large intestine morphology 0.028232077080832 235 19 5 0.263157894736842 0.0212765957446809
HP HP:0001909 Leukemia 0.0304915206471961 143 19 4 0.210526315789474 0.027972027972028
HP HP:0008771 Aplasia/Hypoplasia of the ear 0.0304915206471961 144 19 4 0.210526315789474 0.0277777777777778
HP HP:0000782 Abnormal scapula morphology 0.0319345897071339 147 19 4 0.210526315789474 0.0272108843537415
HP HP:0000599 Abnormality of the frontal hairline 0.0319345897071339 147 19 4 0.210526315789474 0.0272108843537415
HP HP:0000185 Cleft soft palate 0.0388524771271349 161 19 4 0.210526315789474 0.0248447204968944
HP HP:0007378 Neoplasm of the gastrointestinal tract 0.0388524771271349 262 19 5 0.263157894736842 0.0190839694656489
HP HP:0001875 Neutropenia 0.0396270912590526 163 19 4 0.210526315789474 0.0245398773006135
HP HP:0100542 Abnormal localization of kidney 0.0396270912590526 163 19 4 0.210526315789474 0.0245398773006135
HP HP:0100242 Sarcoma 0.040162538450743 165 19 4 0.210526315789474 0.0242424242424242
HP HP:0010972 Anemia of inadequate production 0.040162538450743 165 19 4 0.210526315789474 0.0242424242424242
HP HP:0000104 Renal agenesis 0.0428695827798301 171 19 4 0.210526315789474 0.0233918128654971
HP HP:0011991 Abnormal neutrophil count 0.0446225329331804 174 19 4 0.210526315789474 0.0229885057471264
HP HP:0009381 Short finger 0.0470043952050192 287 19 5 0.263157894736842 0.0174216027874564
HPA HPA:0330223 oral mucosa; squamous epithelial cells[High] 0.00471182363069636 1112 17 9 0.529411764705882 0.00809352517985612
HPA HPA:0091003 cerebellum; molecular layer cells - cytoplasm/membrane[High] 0.00495943040386503 182 5 3 0.6 0.0164835164835165
HPA HPA:0190223 esophagus; squamous epithelial cells[High] 0.00495943040386503 1596 17 10 0.588235294117647 0.006265664160401
HPA HPA:0470683 skin 2; epidermal cells[High] 0.00555771355516703 1346 17 9 0.529411764705882 0.00668647845468053
HPA HPA:0620223 vagina; squamous epithelial cells[High] 0.00735649232180166 1091 17 8 0.470588235294118 0.0073327222731439
HPA HPA:0091002 cerebellum; molecular layer cells - cytoplasm/membrane[≥Medium] 0.00950088196921747 309 5 3 0.6 0.00970873786407767
HPA HPA:0160053 endometrium 1; glandular cells[High] 0.00950088196921747 1413 15 8 0.533333333333333 0.0056617126680821
HPA HPA:0100123 cerebral cortex; glial cells[High] 0.00950088196921747 683 6 4 0.666666666666667 0.00585651537335286
HPA HPA:0091001 cerebellum; molecular layer cells - cytoplasm/membrane[≥Low] 0.0109003431840076 343 5 3 0.6 0.0087463556851312
HPA HPA:0090942 cerebellum; Purkinje cells - cytoplasm/membrane[≥Medium] 0.0120796062730831 368 5 3 0.6 0.00815217391304348
HPA HPA:0110223 cervix, uterine; squamous epithelial cells[High] 0.0132327298760511 986 17 7 0.411764705882353 0.00709939148073022
HPA HPA:0350473 pancreas; exocrine glandular cells[High] 0.0137388359385273 1879 19 10 0.526315789473684 0.00532197977647685
HPA HPA:0090941 cerebellum; Purkinje cells - cytoplasm/membrane[≥Low] 0.0161049863608855 448 5 3 0.6 0.00669642857142857
HPA HPA:0080133 caudate; neuronal cells[High] 0.0161049863608855 1059 17 7 0.411764705882353 0.00661000944287063
HPA HPA:0320103 nasopharynx; respiratory epithelial cells[High] 0.0173582206164817 1844 17 9 0.529411764705882 0.00488069414316703
HPA HPA:0600433 tonsil; germinal center cells[High] 0.0318640475076165 1179 14 6 0.428571428571429 0.00508905852417303
HPA HPA:0050053 breast; glandular cells[High] 0.0318640475076165 1299 17 7 0.411764705882353 0.00538876058506543
HPA HPA:0550053 stomach 2; glandular cells[High] 0.0367371883232335 2350 19 10 0.526315789473684 0.00425531914893617
HPA HPA:0310432 lymph node; germinal center cells[≥Medium] 0.0367371883232335 3209 15 10 0.666666666666667 0.00311623558741041
HPA HPA:0100133 cerebral cortex; neuronal cells[High] 0.0367371883232335 1785 17 8 0.470588235294118 0.00448179271708683
HPA HPA:0050093 breast; myoepithelial cells[High] 0.0367371883232335 798 15 5 0.333333333333333 0.006265664160401
HPA HPA:0610833 urinary bladder; urothelial cells[High] 0.0399456908538369 1969 10 6 0.6 0.00304723209751143
HPA HPA:0600223 tonsil; squamous epithelial cells[High] 0.0424164369959507 1442 17 7 0.411764705882353 0.00485436893203883
HPA HPA:0620222 vagina; squamous epithelial cells[≥Medium] 0.0441876033460837 3945 17 12 0.705882352941177 0.00304182509505703
HPA HPA:0060103 bronchus; respiratory epithelial cells[High] 0.0442471887710781 1890 17 8 0.470588235294118 0.00423280423280423
HPA HPA:0170251 endometrium 2; cells in endometrial stroma[≥Low] 0.0462039103266476 3410 17 11 0.647058823529412 0.0032258064516129
KEGG KEGG:03010 Ribosome 8.18296737759851e-27 153 19 17 0.894736842105263 0.111111111111111
KEGG KEGG:05171 Coronavirus disease - COVID-19 6.08218414960797e-24 231 19 17 0.894736842105263 0.0735930735930736
MIRNA MIRNA:hsa-miR-100-5p hsa-miR-100-5p 0.000156381019537718 250 19 6 0.315789473684211 0.024
MIRNA MIRNA:hsa-miR-652-3p hsa-miR-652-3p 0.00597387466697551 162 18 4 0.222222222222222 0.0246913580246914
MIRNA MIRNA:hsa-miR-324-3p hsa-miR-324-3p 0.0403126526385927 336 7 3 0.428571428571429 0.00892857142857143
MIRNA MIRNA:hsa-miR-4477a hsa-miR-4477a 0.0475592505449001 139 18 3 0.166666666666667 0.0215827338129496
REAC REAC:R-HSA-72764 Eukaryotic Translation Termination 4.06202083639672e-32 94 19 17 0.894736842105263 0.180851063829787
REAC REAC:R-HSA-192823 Viral mRNA Translation 4.06202083639672e-32 90 19 17 0.894736842105263 0.188888888888889
REAC REAC:R-HSA-156842 Eukaryotic Translation Elongation 4.06202083639672e-32 94 19 17 0.894736842105263 0.180851063829787
REAC REAC:R-HSA-2408557 Selenocysteine synthesis 4.06202083639672e-32 94 19 17 0.894736842105263 0.180851063829787
REAC REAC:R-HSA-156902 Peptide chain elongation 4.06202083639672e-32 90 19 17 0.894736842105263 0.188888888888889
REAC REAC:R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 5.00814707958699e-32 96 19 17 0.894736842105263 0.177083333333333
REAC REAC:R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 1.15519857662242e-31 102 19 17 0.894736842105263 0.166666666666667
REAC REAC:R-HSA-72689 Formation of a pool of free 40S subunits 1.15519857662242e-31 102 19 17 0.894736842105263 0.166666666666667
REAC REAC:R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 5.52756392970341e-31 113 19 17 0.894736842105263 0.150442477876106
REAC REAC:R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 5.52756392970341e-31 112 19 17 0.894736842105263 0.151785714285714
REAC REAC:R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 5.52756392970341e-31 113 19 17 0.894736842105263 0.150442477876106
REAC REAC:R-HSA-927802 Nonsense-Mediated Decay (NMD) 7.55396404868992e-31 116 19 17 0.894736842105263 0.146551724137931
REAC REAC:R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 7.55396404868992e-31 116 19 17 0.894736842105263 0.146551724137931
REAC REAC:R-HSA-2408522 Selenoamino acid metabolism 8.20535649622024e-31 117 19 17 0.894736842105263 0.145299145299145
REAC REAC:R-HSA-72737 Cap-dependent Translation Initiation 1.13951749436373e-30 120 19 17 0.894736842105263 0.141666666666667
REAC REAC:R-HSA-72613 Eukaryotic Translation Initiation 1.13951749436373e-30 120 19 17 0.894736842105263 0.141666666666667
REAC REAC:R-HSA-168273 Influenza Viral RNA Transcription and Replication 6.94272045241964e-30 133 19 17 0.894736842105263 0.12781954887218
REAC REAC:R-HSA-168255 Influenza Infection 7.26610335305108e-29 152 19 17 0.894736842105263 0.111842105263158
REAC REAC:R-HSA-9711097 Cellular response to starvation 1.22945500003044e-28 157 19 17 0.894736842105263 0.10828025477707
REAC REAC:R-HSA-9010553 Regulation of expression of SLITs and ROBOs 5.37044814875749e-28 171 19 17 0.894736842105263 0.0994152046783626
REAC REAC:R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 1.70911880500455e-27 183 19 17 0.894736842105263 0.092896174863388
REAC REAC:R-HSA-8868773 rRNA processing in the nucleus and cytosol 4.19135689019286e-27 193 19 17 0.894736842105263 0.0880829015544041
REAC REAC:R-HSA-72312 rRNA processing 9.79907989406749e-27 203 19 17 0.894736842105263 0.083743842364532
REAC REAC:R-HSA-376176 Signaling by ROBO receptors 3.04643615295395e-26 217 19 17 0.894736842105263 0.0783410138248848
REAC REAC:R-HSA-72766 Translation 5.30819093113548e-24 292 19 17 0.894736842105263 0.0582191780821918
REAC REAC:R-HSA-71291 Metabolism of amino acids and derivatives 2.83769071153555e-22 368 19 17 0.894736842105263 0.046195652173913
REAC REAC:R-HSA-2262752 Cellular responses to stress 2.44718555936637e-19 546 19 17 0.894736842105263 0.0311355311355311
REAC REAC:R-HSA-422475 Axon guidance 2.59230072630833e-19 549 19 17 0.894736842105263 0.0309653916211293
REAC REAC:R-HSA-8953897 Cellular responses to external stimuli 3.5169611250801e-19 560 19 17 0.894736842105263 0.0303571428571429
REAC REAC:R-HSA-9675108 Nervous system development 5.19070027719757e-19 574 19 17 0.894736842105263 0.029616724738676
REAC REAC:R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 3.8216956615803e-18 52 19 10 0.526315789473684 0.192307692307692
REAC REAC:R-HSA-8953854 Metabolism of RNA 5.03494192440442e-18 658 19 17 0.894736842105263 0.0258358662613982
REAC REAC:R-HSA-72702 Ribosomal scanning and start codon recognition 1.37631062235464e-17 59 19 10 0.526315789473684 0.169491525423729
REAC REAC:R-HSA-72649 Translation initiation complex formation 1.37631062235464e-17 59 19 10 0.526315789473684 0.169491525423729
REAC REAC:R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 1.6031337649805e-17 60 19 10 0.526315789473684 0.166666666666667
REAC REAC:R-HSA-5663205 Infectious disease 1.71854413800706e-16 815 19 17 0.894736842105263 0.0208588957055215
REAC REAC:R-HSA-1266738 Developmental Biology 1.66743083104788e-14 1069 19 17 0.894736842105263 0.0159027128157156
REAC REAC:R-HSA-1643685 Disease 5.40898664394465e-12 1509 19 17 0.894736842105263 0.0112657388999337
REAC REAC:R-HSA-392499 Metabolism of proteins 1.04430148065903e-11 1961 19 18 0.947368421052632 0.00917899031106578
REAC REAC:R-HSA-1430728 Metabolism 1.00767943884595e-09 2070 19 17 0.894736842105263 0.00821256038647343
TF TF:M09966_1 Factor: Kaiso; motif: SARNYCTCGCGAGAN; match class: 1 0.00849608155228317 449 18 6 0.333333333333333 0.0133630289532294
TF TF:M03970 Factor: ELK1; motif: ACCGGAAGTN 0.011101672785964 4782 19 14 0.736842105263158 0.00292764533667921
TF TF:M12238_1 Factor: DREF; motif: MTRTCGCGAYAK; match class: 1 0.011101672785964 293 19 5 0.263157894736842 0.0170648464163823
TF TF:M11432 Factor: Elk-1; motif: NACMGGAAGTN 0.0115563208907324 6140 19 15 0.789473684210526 0.00244299674267101
TF TF:M01660 Factor: GABP-alpha; motif: CTTCCK 0.0115563208907324 11116 19 19 1 0.0017092479309104
TF TF:M07140_1 Factor: Kaiso; motif: NTCTCGCGAGANYTN; match class: 1 0.0115563208907324 189 18 4 0.222222222222222 0.0211640211640212
TF TF:M11448 Factor: Elf-1; motif: NANGCGGAAGTN 0.0115563208907324 7600 18 16 0.888888888888889 0.00210526315789474
TF TF:M08910_1 Factor: C/EBPBETA; motif: KRTTGCGYAAY; match class: 1 0.0115563208907324 3194 18 11 0.611111111111111 0.00344395742016281
TF TF:M12238 Factor: DREF; motif: MTRTCGCGAYAK 0.0115563208907324 350 19 5 0.263157894736842 0.0142857142857143
TF TF:M03975_1 Factor: ERG; motif: ACCGGAARTN; match class: 1 0.011786759003867 4024 18 12 0.666666666666667 0.00298210735586481
TF TF:M08510 Factor: TEF-3:Fli-1; motif: ACCGGAAATGCC 0.0142781662432385 7360 19 16 0.842105263157895 0.00217391304347826
TF TF:M11316_1 Factor: C/EBPbeta; motif: NRTTGCGYAAYN; match class: 1 0.0142781662432385 2743 18 10 0.555555555555556 0.00364564345607
TF TF:M11420 Factor: ER81; motif: NACCGGAAGTN 0.0144703051086593 3210 19 11 0.578947368421053 0.00342679127725857
TF TF:M11435 Factor: Elk-1; motif: NNCCGGAAGTN 0.0156546614412005 11728 19 19 1 0.00162005457025921
TF TF:M02068 Factor: etv3; motif: ACCGGAAGYN 0.0193601319382651 3443 19 11 0.578947368421053 0.00319488817891374
TF TF:M01165 Factor: Elk-1; motif: RACCGGAAGTR 0.0193601319382651 7773 19 16 0.842105263157895 0.00205840730734594
TF TF:M11433 Factor: Elk-1; motif: NRCCGGAAGTN 0.0193601319382651 7679 19 16 0.842105263157895 0.00208360463602032
TF TF:M11452 Factor: Elf-1; motif: NANGCGGAAGTR 0.0193601319382651 6276 18 14 0.777777777777778 0.00223072020395156
TF TF:M11382 Factor: ESE-1; motif: NWTRCGGAWGCN 0.0193601319382651 10339 19 18 0.947368421052632 0.00174098075249057
TF TF:M02073 Factor: Fli-1; motif: ACCGGAAGYN 0.0196447233885771 5839 19 14 0.736842105263158 0.00239767083404693
TF TF:M01078_1 Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN; match class: 1 0.0202023594976066 2448 18 9 0.5 0.00367647058823529
TF TF:M02067 Factor: ER71; motif: ACCGGAARYN 0.0202023594976066 5930 19 14 0.736842105263158 0.00236087689713322
TF TF:M11414 Factor: GABP-alpha; motif: NACCGGAAGTN 0.0202023594976066 2907 19 10 0.526315789473684 0.00343997248022016
TF TF:M08377_1 Factor: meis1:Elf-1; motif: NTGCCGGAAGTN; match class: 1 0.0202023594976066 5051 19 13 0.684210526315789 0.00257374777271827
TF TF:M11427_1 Factor: PEA3; motif: NACCGGAAGTN; match class: 1 0.0202023594976066 4606 18 12 0.666666666666667 0.00260529743812419
TF TF:M00025_1 Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1 0.0202023594976066 4639 18 12 0.666666666666667 0.00258676438887691
TF TF:M02062 Factor: Erg; motif: ACCGGAAGTN 0.021502038169505 8056 19 16 0.842105263157895 0.00198609731876862
TF TF:M09966 Factor: Kaiso; motif: SARNYCTCGCGAGAN 0.0216340875724834 2356 19 9 0.473684210526316 0.00382003395585739
TF TF:M07140 Factor: Kaiso; motif: NTCTCGCGAGANYTN 0.0216340875724834 552 19 5 0.263157894736842 0.00905797101449275
TF TF:M03990 Factor: GABPA; motif: ACCGGAAGTN 0.02270485024139 5258 19 13 0.684210526315789 0.00247242297451502
TF TF:M11396 Factor: Erg; motif: NACCGGAARTN 0.02270485024139 10765 19 18 0.947368421052632 0.00167208546214584
TF TF:M09608 Factor: Erg; motif: NNACCGGAARTSN 0.02270485024139 8152 19 16 0.842105263157895 0.00196270853778214
TF TF:M02070_1 Factor: TEL1; motif: CNCGGAANNN; match class: 1 0.0247143427879833 4841 18 12 0.666666666666667 0.00247882668870068
TF TF:M02065_1 Factor: ER81; motif: RCCGGAARYN; match class: 1 0.0248424529531932 6749 18 14 0.777777777777778 0.00207438138983553
TF TF:M08759 Factor: c-Ets-2; motif: NCCGGAAGTG 0.0253705179819476 8319 19 16 0.842105263157895 0.00192330808991465
TF TF:M02064 Factor: c-ets-2; motif: ACCGGAWRTN 0.0256505609401532 10939 19 18 0.947368421052632 0.00164548861870372
TF TF:M03983 Factor: ETV5; motif: NCCGGAWGYN 0.0259394240200199 3129 19 10 0.526315789473684 0.00319590923617769
TF TF:M01167 Factor: SAP-1a; motif: NACCGGAAGTV 0.0273180114371673 1948 19 8 0.421052631578947 0.00410677618069815
TF TF:M09632_1 Factor: Kaiso; motif: GNTCTCGCGAGRNNNNGGN; match class: 1 0.030131461546092 679 18 5 0.277777777777778 0.00736377025036819
TF TF:M11425 Factor: PEA3; motif: NACCGGAAGTN 0.0309290627593553 7428 19 15 0.789473684210526 0.00201938610662359
TF TF:M11415 Factor: GABP-alpha; motif: NRCCGGAAGTN 0.0329767452366428 3257 19 10 0.526315789473684 0.00307031010132023
TF TF:M08226_1 Factor: Elk-1:Pax-9; motif: ACCGGAACYACGCWYSANTG; match class: 1 0.0332429650924424 5604 19 13 0.684210526315789 0.0023197715917202
TF TF:M01256 Factor: REST; motif: NNNNGGNGCTGTCCATGGTGCT 0.0332429650924424 2681 4 4 1 0.00149198060425214
TF TF:M11449 Factor: Elf-1; motif: NANCCGGAAGTN 0.0341564268341323 4305 18 11 0.611111111111111 0.00255516840882695
TF TF:M11392 Factor: Erg; motif: NACCGGAARYN 0.0365430871366242 8690 19 16 0.842105263157895 0.00184119677790564
TF TF:M11419 Factor: ER81; motif: NNCCGGAWGYN 0.0365806464021565 5699 19 13 0.684210526315789 0.00228110194771012
TF TF:M01082 Factor: BRCA1:USF2; motif: KTNNGTTG 0.0365806464021565 7155 18 14 0.777777777777778 0.00195667365478686
TF TF:M04818_1 Factor: IRF-4; motif: RGGAASWGR; match class: 1 0.0372990569291548 3038 6 5 0.833333333333333 0.00164581961816985
TF TF:M08222 Factor: Elk-1:HOXB13; motif: ACCGGAAGTNGTAAAN 0.0372990569291548 7653 19 15 0.789473684210526 0.00196001568012544
TF TF:M03975 Factor: ERG; motif: ACCGGAARTN 0.0372990569291548 10002 19 17 0.894736842105263 0.0016996600679864
TF TF:M11382_1 Factor: ESE-1; motif: NWTRCGGAWGCN; match class: 1 0.0372990569291548 4112 19 11 0.578947368421053 0.00267509727626459
TF TF:M11447 Factor: Elf-1; motif: NAMCCGGAAGTN 0.0380915691853005 7703 19 15 0.789473684210526 0.00194729326236531
TF TF:M08224_1 Factor: Elk-1:Pax-1; motif: ACCGGAACTACGCWTSANTG; match class: 1 0.0381058149079098 2748 19 9 0.473684210526316 0.00327510917030568
TF TF:M02071 Factor: ETV7; motif: NCCGGAANNN 0.0408789629461164 10116 19 17 0.894736842105263 0.00168050612890471
TF TF:M02052 Factor: EHF; motif: CSCGGAARTN 0.0408789629461164 10107 19 17 0.894736842105263 0.00168200257247452
TF TF:M00225 Factor: STAT3; motif: NGNNATTTCCSGGAARTGNNN 0.042990916673366 3188 6 5 0.833333333333333 0.00156838143036386
TF TF:M11451 Factor: Elf-1; motif: NANCCGGAAGTN 0.0465293341168456 6886 19 14 0.736842105263158 0.00203311065930874
TF TF:M00025 Factor: Elk-1; motif: NNNNCCGGAARTNN 0.0466060444166021 10262 19 17 0.894736842105263 0.00165659715455077
TF TF:M11397_1 Factor: Erg; motif: NACCGGATATCCGGTN; match class: 1 0.0478380046988541 11731 14 14 1 0.00119341914585287
TF TF:M02011_1 Factor: HES-1; motif: GSCACGMGMC; match class: 1 0.0499818476037446 845 5 3 0.6 0.00355029585798817
WP WP:WP477 Cytoplasmic Ribosomal Proteins 2.14084212249425e-30 90 19 17 0.894736842105263 0.188888888888889

pEpi25 transcription factor target enrichment of top program genes

TF enrichment of pEpi25
Possible regulators of activation of pEpi25 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.