pS02 program activity among Stromal cells

Activation of pS02
pS02 gene program activation in Stromal cells.
Gene program activation of pS02 by different cell subtypes
pS02 gene program activation among cells of different subtypes (Stromal cells).

pS02 top program genes

Top genes of pS02 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pS02 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pS02
pS02 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0045229 external encapsulating structure organization 5.675709678078e-06 404 85 14 0.164705882352941 0.0346534653465347
GO:BP GO:0043062 extracellular structure organization 5.675709678078e-06 402 85 14 0.164705882352941 0.0348258706467662
GO:BP GO:0030198 extracellular matrix organization 5.675709678078e-06 401 85 14 0.164705882352941 0.0349127182044888
GO:BP GO:0001503 ossification 1.22219989383459e-05 417 136 17 0.125 0.0407673860911271
GO:BP GO:0042340 keratan sulfate catabolic process 3.31498935761836e-05 12 60 4 0.0666666666666667 0.333333333333333
GO:BP GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway 7.05260649356305e-05 16 55 4 0.0727272727272727 0.25
GO:BP GO:0030282 bone mineralization 9.40769484723101e-05 116 66 7 0.106060606060606 0.0603448275862069
GO:BP GO:0006027 glycosaminoglycan catabolic process 0.000105338825028692 61 81 6 0.0740740740740741 0.0983606557377049
GO:BP GO:0006026 aminoglycan catabolic process 0.000151838476461946 67 81 6 0.0740740740740741 0.0895522388059701
GO:BP GO:2000050 regulation of non-canonical Wnt signaling pathway 0.000283206810576423 26 55 4 0.0727272727272727 0.153846153846154
GO:BP GO:0031214 biomineral tissue development 0.000456500278732507 164 66 7 0.106060606060606 0.0426829268292683
GO:BP GO:0110148 biomineralization 0.000463948821746139 166 66 7 0.106060606060606 0.0421686746987952
GO:BP GO:0030199 collagen fibril organization 0.000477023265915534 58 9 3 0.333333333333333 0.0517241379310345
GO:BP GO:0044273 sulfur compound catabolic process 0.000493061100675024 54 134 6 0.0447761194029851 0.111111111111111
GO:BP GO:0042339 keratan sulfate metabolic process 0.000631567749730404 33 60 4 0.0666666666666667 0.121212121212121
GO:BP GO:0008285 negative regulation of cell population proliferation 0.000657495838892396 790 12 6 0.5 0.00759493670886076
GO:BP GO:0009888 tissue development 0.000688566909673087 2107 121 32 0.264462809917355 0.015187470336972
GO:BP GO:0001501 skeletal system development 0.000715475861064991 504 136 15 0.110294117647059 0.0297619047619048
GO:BP GO:0030510 regulation of BMP signaling pathway 0.000960666316036139 96 137 7 0.0510948905109489 0.0729166666666667
GO:BP GO:0007155 cell adhesion 0.0010088581203929 1492 76 19 0.25 0.0127345844504021
GO:BP GO:0022610 biological adhesion 0.00104166709941535 1499 76 19 0.25 0.0126751167444963
GO:BP GO:2000052 positive regulation of non-canonical Wnt signaling pathway 0.00122985356537139 15 55 3 0.0545454545454545 0.2
GO:BP GO:0097435 supramolecular fiber organization 0.00155621560902624 734 15 6 0.4 0.00817438692098093
GO:BP GO:0043506 regulation of JUN kinase activity 0.00163481014643568 87 11 3 0.272727272727273 0.0344827586206897
GO:BP GO:0006790 sulfur compound metabolic process 0.00175344749837949 386 89 10 0.112359550561798 0.0259067357512953
GO:BP GO:0030278 regulation of ossification 0.00202588478125285 115 135 7 0.0518518518518519 0.0608695652173913
GO:BP GO:0052547 regulation of peptidase activity 0.00204663555915015 467 24 6 0.25 0.012847965738758
GO:BP GO:0043405 regulation of MAP kinase activity 0.00206189271312332 316 11 4 0.363636363636364 0.0126582278481013
GO:BP GO:1901136 carbohydrate derivative catabolic process 0.00206189271312332 196 81 7 0.0864197530864197 0.0357142857142857
GO:BP GO:0044272 sulfur compound biosynthetic process 0.00231317528420603 193 84 7 0.0833333333333333 0.0362694300518135
GO:BP GO:0018146 keratan sulfate biosynthetic process 0.00242032466379359 28 41 3 0.0731707317073171 0.107142857142857
GO:BP GO:0042119 neutrophil activation 0.00292115755255284 498 109 12 0.110091743119266 0.0240963855421687
GO:BP GO:0036230 granulocyte activation 0.00321273641969808 504 109 12 0.110091743119266 0.0238095238095238
GO:BP GO:0034103 regulation of tissue remodeling 0.00333622054934046 92 15 3 0.2 0.0326086956521739
GO:BP GO:0032502 developmental process 0.00404194065673279 6628 81 47 0.580246913580247 0.00709112854556427
GO:BP GO:0030203 glycosaminoglycan metabolic process 0.004562906876025 159 81 6 0.0740740740740741 0.0377358490566038
GO:BP GO:0051241 negative regulation of multicellular organismal process 0.0045973779716976 1160 24 8 0.333333333333333 0.00689655172413793
GO:BP GO:0010811 positive regulation of cell-substrate adhesion 0.00520356407857459 124 35 4 0.114285714285714 0.032258064516129
GO:BP GO:0010466 negative regulation of peptidase activity 0.00520356407857459 267 17 4 0.235294117647059 0.0149812734082397
GO:BP GO:0051216 cartilage development 0.00542600876398552 196 23 4 0.173913043478261 0.0204081632653061
GO:BP GO:0048856 anatomical structure development 0.00552657610947662 6106 81 44 0.54320987654321 0.00720602685882738
GO:BP GO:0045926 negative regulation of growth 0.00552657610947662 255 77 7 0.0909090909090909 0.0274509803921569
GO:BP GO:0055114 obsolete oxidation-reduction process 0.00559624092146306 745 119 15 0.126050420168067 0.0201342281879195
GO:BP GO:0006024 glycosaminoglycan biosynthetic process 0.00565580928489479 107 81 5 0.0617283950617284 0.0467289719626168
GO:BP GO:1901687 glutathione derivative biosynthetic process 0.00565580928489479 21 84 3 0.0357142857142857 0.142857142857143
GO:BP GO:0045785 positive regulation of cell adhesion 0.00565580928489479 437 136 12 0.0882352941176471 0.0274599542334096
GO:BP GO:1901685 glutathione derivative metabolic process 0.00565580928489479 21 84 3 0.0357142857142857 0.142857142857143
GO:BP GO:0061138 morphogenesis of a branching epithelium 0.00565580928489479 181 77 6 0.0779220779220779 0.0331491712707182
GO:BP GO:0006022 aminoglycan metabolic process 0.00576632182397171 173 81 6 0.0740740740740741 0.0346820809248555
GO:BP GO:0060348 bone development 0.00626069943334476 203 136 8 0.0588235294117647 0.0394088669950739
GO:BP GO:0030500 regulation of bone mineralization 0.00626069943334476 74 66 4 0.0606060606060606 0.0540540540540541
GO:BP GO:0006023 aminoglycan biosynthetic process 0.00626069943334476 114 81 5 0.0617283950617284 0.043859649122807
GO:BP GO:0030308 negative regulation of cell growth 0.00626069943334476 192 77 6 0.0779220779220779 0.03125
GO:BP GO:0006508 proteolysis 0.00626069943334476 1836 70 18 0.257142857142857 0.00980392156862745
GO:BP GO:0031589 cell-substrate adhesion 0.00626069943334476 367 141 11 0.0780141843971631 0.0299727520435967
GO:BP GO:0048705 skeletal system morphogenesis 0.00626069943334476 226 23 4 0.173913043478261 0.0176991150442478
GO:BP GO:0032268 regulation of cellular protein metabolic process 0.00626069943334476 2541 17 9 0.529411764705882 0.00354191263282172
GO:BP GO:1903510 mucopolysaccharide metabolic process 0.00626069943334476 116 81 5 0.0617283950617284 0.0431034482758621
GO:BP GO:0071900 regulation of protein serine/threonine kinase activity 0.00626069943334476 503 11 4 0.363636363636364 0.00795228628230616
GO:BP GO:0090090 negative regulation of canonical Wnt signaling pathway 0.00626069943334476 187 11 3 0.272727272727273 0.0160427807486631
GO:BP GO:0090287 regulation of cellular response to growth factor stimulus 0.00626069943334476 315 137 10 0.072992700729927 0.0317460317460317
GO:BP GO:0001763 morphogenesis of a branching structure 0.00646391468455229 195 77 6 0.0779220779220779 0.0307692307692308
GO:BP GO:0030509 BMP signaling pathway 0.00699261687286923 158 137 7 0.0510948905109489 0.0443037974683544
GO:BP GO:0042127 regulation of cell population proliferation 0.00699261687286923 1774 28 10 0.357142857142857 0.0056369785794814
GO:BP GO:0048771 tissue remodeling 0.0070330875296192 186 117 7 0.0598290598290598 0.0376344086021505
GO:BP GO:2000026 regulation of multicellular organismal development 0.0070330875296192 1447 137 24 0.175182481751825 0.0165860400829302
GO:BP GO:0001974 blood vessel remodeling 0.00722847785688979 46 117 4 0.0341880341880342 0.0869565217391304
GO:BP GO:0002576 platelet degranulation 0.00722847785688979 126 123 6 0.0487804878048781 0.0476190476190476
GO:BP GO:0043312 neutrophil degranulation 0.00754683250218172 482 22 5 0.227272727272727 0.0103734439834025
GO:BP GO:0002283 neutrophil activation involved in immune response 0.00763417545971499 485 22 5 0.227272727272727 0.0103092783505155
GO:BP GO:0051246 regulation of protein metabolic process 0.00791563235052476 2704 17 9 0.529411764705882 0.00332840236686391
GO:BP GO:0048589 developmental growth 0.00791563235052476 649 117 13 0.111111111111111 0.0200308166409861
GO:BP GO:0048869 cellular developmental process 0.00791563235052476 4428 80 34 0.425 0.00767841011743451
GO:BP GO:0045861 negative regulation of proteolysis 0.00791563235052476 359 17 4 0.235294117647059 0.011142061281337
GO:BP GO:0030178 negative regulation of Wnt signaling pathway 0.00791563235052476 218 11 3 0.272727272727273 0.0137614678899083
GO:BP GO:0002446 neutrophil mediated immunity 0.00791563235052476 497 22 5 0.227272727272727 0.0100603621730382
GO:BP GO:0006805 xenobiotic metabolic process 0.00791563235052476 122 134 6 0.0447761194029851 0.0491803278688525
GO:BP GO:0033687 osteoblast proliferation 0.00791563235052476 35 66 3 0.0454545454545455 0.0857142857142857
GO:BP GO:1901564 organonitrogen compound metabolic process 0.00791563235052476 6792 72 42 0.583333333333333 0.00618374558303887
GO:BP GO:0061448 connective tissue development 0.00791563235052476 256 23 4 0.173913043478261 0.015625
GO:BP GO:0060828 regulation of canonical Wnt signaling pathway 0.00791563235052476 298 55 6 0.109090909090909 0.0201342281879195
GO:BP GO:0060560 developmental growth involved in morphogenesis 0.00791563235052476 236 98 7 0.0714285714285714 0.0296610169491525
GO:BP GO:0022603 regulation of anatomical structure morphogenesis 0.00823407716135161 1042 137 19 0.138686131386861 0.0182341650671785
GO:BP GO:0009887 animal organ morphogenesis 0.00823407716135161 1073 55 11 0.2 0.0102516309412861
GO:BP GO:0071772 response to BMP 0.00823407716135161 171 137 7 0.0510948905109489 0.0409356725146199
GO:BP GO:0071773 cellular response to BMP stimulus 0.00823407716135161 171 137 7 0.0510948905109489 0.0409356725146199
GO:BP GO:0002062 chondrocyte differentiation 0.00834381489041051 108 23 3 0.130434782608696 0.0277777777777778
GO:BP GO:0060071 Wnt signaling pathway, planar cell polarity pathway 0.00835820307213575 110 55 4 0.0727272727272727 0.0363636363636364
GO:BP GO:0030155 regulation of cell adhesion 0.00835820307213575 748 24 6 0.25 0.00802139037433155
GO:BP GO:0030162 regulation of proteolysis 0.00835820307213575 752 33 7 0.212121212121212 0.00930851063829787
GO:BP GO:0010810 regulation of cell-substrate adhesion 0.00835820307213575 222 76 6 0.0789473684210526 0.027027027027027
GO:BP GO:0008406 gonad development 0.00841112851766527 221 28 4 0.142857142857143 0.0180995475113122
GO:BP GO:0030514 negative regulation of BMP signaling pathway 0.00845089410568655 53 115 4 0.0347826086956522 0.0754716981132075
GO:BP GO:0070167 regulation of biomineral tissue development 0.00849705303881908 93 66 4 0.0606060606060606 0.043010752688172
GO:BP GO:0071466 cellular response to xenobiotic stimulus 0.00849705303881908 127 134 6 0.0447761194029851 0.047244094488189
GO:BP GO:0002366 leukocyte activation involved in immune response 0.00851027958764319 717 109 13 0.119266055045872 0.0181311018131102
GO:BP GO:0002274 myeloid leukocyte activation 0.00851104798229442 667 117 13 0.111111111111111 0.0194902548725637
GO:BP GO:0043299 leukocyte degranulation 0.00865022333500007 535 22 5 0.227272727272727 0.00934579439252336
GO:BP GO:0050793 regulation of developmental process 0.00866928654718078 2605 137 35 0.255474452554745 0.0134357005758157
GO:BP GO:0045137 development of primary sexual characteristics 0.00866928654718078 227 28 4 0.142857142857143 0.0176211453744493
GO:BP GO:0002263 cell activation involved in immune response 0.00866928654718078 721 109 13 0.119266055045872 0.0180305131761442
GO:BP GO:0090175 regulation of establishment of planar polarity 0.00870253944181466 114 55 4 0.0727272727272727 0.0350877192982456
GO:BP GO:0110149 regulation of biomineralization 0.00870253944181466 95 66 4 0.0606060606060606 0.0421052631578947
GO:BP GO:0048588 developmental cell growth 0.00905611826337689 235 137 8 0.0583941605839416 0.0340425531914894
GO:BP GO:0001649 osteoblast differentiation 0.00905611826337689 232 12 3 0.25 0.0129310344827586
GO:BP GO:0002275 myeloid cell activation involved in immune response 0.00905611826337689 547 22 5 0.227272727272727 0.00914076782449726
GO:BP GO:0002444 myeloid leukocyte mediated immunity 0.00913070887186308 551 22 5 0.227272727272727 0.00907441016333938
GO:BP GO:2001236 regulation of extrinsic apoptotic signaling pathway 0.00913070887186308 159 111 6 0.0540540540540541 0.0377358490566038
GO:BP GO:0043567 regulation of insulin-like growth factor receptor signaling pathway 0.00958587557928445 25 111 3 0.027027027027027 0.12
GO:BP GO:0009410 response to xenobiotic stimulus 0.00988729036014925 134 134 6 0.0447761194029851 0.0447761194029851
GO:BP GO:0048846 axon extension involved in axon guidance 0.0102612757251768 37 77 3 0.038961038961039 0.0810810810810811
GO:BP GO:0045444 fat cell differentiation 0.0102612757251768 229 13 3 0.230769230769231 0.0131004366812227
GO:BP GO:1902284 neuron projection extension involved in neuron projection guidance 0.0102612757251768 37 77 3 0.038961038961039 0.0810810810810811
GO:BP GO:0048585 negative regulation of response to stimulus 0.0102612757251768 1733 137 26 0.18978102189781 0.015002885170225
GO:BP GO:0046903 secretion 0.0102612757251768 1501 49 12 0.244897959183673 0.00799467021985343
GO:BP GO:0048675 axon extension 0.0103242755380756 122 98 5 0.0510204081632653 0.040983606557377
GO:BP GO:0060070 canonical Wnt signaling pathway 0.0112254009071762 345 55 6 0.109090909090909 0.0173913043478261
GO:BP GO:0007167 enzyme linked receptor protein signaling pathway 0.0116190133895261 1103 137 19 0.138686131386861 0.0172257479601088
GO:BP GO:0007164 establishment of tissue polarity 0.0116190133895261 130 55 4 0.0727272727272727 0.0307692307692308
GO:BP GO:0008283 cell population proliferation 0.0116190133895261 2054 28 10 0.357142857142857 0.00486854917234664
GO:BP GO:0001736 establishment of planar polarity 0.0116190133895261 130 55 4 0.0727272727272727 0.0307692307692308
GO:BP GO:0008584 male gonad development 0.0116190133895261 142 22 3 0.136363636363636 0.0211267605633803
GO:BP GO:0046546 development of primary male sexual characteristics 0.0116640329397083 143 22 3 0.136363636363636 0.020979020979021
GO:BP GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 0.011839739159307 93 136 5 0.0367647058823529 0.0537634408602151
GO:BP GO:0045321 leukocyte activation 0.0124553664671499 1332 22 7 0.318181818181818 0.00525525525525526
GO:BP GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.0128595644620867 257 137 8 0.0583941605839416 0.0311284046692607
GO:BP GO:0048598 embryonic morphogenesis 0.0128595644620867 595 23 5 0.217391304347826 0.00840336134453781
GO:BP GO:0001932 regulation of protein phosphorylation 0.0129962981310008 1240 12 5 0.416666666666667 0.00403225806451613
GO:BP GO:0007548 sex differentiation 0.0131316868434875 275 28 4 0.142857142857143 0.0145454545454545
GO:BP GO:0035282 segmentation 0.0132719154115201 98 135 5 0.037037037037037 0.0510204081632653
GO:BP GO:0045596 negative regulation of cell differentiation 0.0132719154115201 697 137 14 0.102189781021898 0.0200860832137733
GO:BP GO:0051346 negative regulation of hydrolase activity 0.0132719154115201 470 17 4 0.235294117647059 0.00851063829787234
GO:BP GO:0030154 cell differentiation 0.0132761230017427 4350 79 32 0.40506329113924 0.00735632183908046
GO:BP GO:0032940 secretion by cell 0.0132761230017427 1364 22 7 0.318181818181818 0.00513196480938416
GO:BP GO:0043086 negative regulation of catalytic activity 0.0136969804456338 851 17 5 0.294117647058824 0.00587544065804935
GO:BP GO:0048736 appendage development 0.0142149459227226 176 77 5 0.0649350649350649 0.0284090909090909
GO:BP GO:0060173 limb development 0.0142149459227226 176 77 5 0.0649350649350649 0.0284090909090909
GO:BP GO:0051336 regulation of hydrolase activity 0.0142149459227226 1321 17 6 0.352941176470588 0.00454201362604088
GO:BP GO:0030111 regulation of Wnt signaling pathway 0.0144035791637337 376 55 6 0.109090909090909 0.0159574468085106
GO:BP GO:0090288 negative regulation of cellular response to growth factor stimulus 0.0146722764092804 119 115 5 0.0434782608695652 0.0420168067226891
GO:BP GO:0046661 male sex differentiation 0.0146722764092804 163 22 3 0.136363636363636 0.0184049079754601
GO:BP GO:0043408 regulation of MAPK cascade 0.0150186920351766 730 12 4 0.333333333333333 0.00547945205479452
GO:BP GO:0040007 growth 0.0150797670063676 967 137 17 0.124087591240876 0.0175801447776629
GO:BP GO:0045859 regulation of protein kinase activity 0.0150797670063676 809 11 4 0.363636363636364 0.00494437577255871
GO:BP GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.0155779064011884 136 27 3 0.111111111111111 0.0220588235294118
GO:BP GO:0140352 export from cell 0.0155779064011884 1418 22 7 0.318181818181818 0.00493653032440056
GO:BP GO:0050919 negative chemotaxis 0.0161286917801693 48 77 3 0.038961038961039 0.0625
GO:BP GO:0050790 regulation of catalytic activity 0.0161286917801693 2545 17 8 0.470588235294118 0.0031434184675835
GO:BP GO:0090263 positive regulation of canonical Wnt signaling pathway 0.0162417740354173 151 55 4 0.0727272727272727 0.0264900662251656
GO:BP GO:0035567 non-canonical Wnt signaling pathway 0.0162417740354173 151 55 4 0.0727272727272727 0.0264900662251656
GO:BP GO:0035116 embryonic hindlimb morphogenesis 0.0164105983778101 28 135 3 0.0222222222222222 0.107142857142857
GO:BP GO:0001738 morphogenesis of a polarized epithelium 0.0164195559179527 152 55 4 0.0727272727272727 0.0263157894736842
GO:BP GO:0043171 peptide catabolic process 0.017161892929715 29 134 3 0.0223880597014925 0.103448275862069
GO:BP GO:0016049 cell growth 0.0180588967564422 495 137 11 0.0802919708029197 0.0222222222222222
GO:BP GO:0072359 circulatory system development 0.0181591526106437 1194 135 19 0.140740740740741 0.0159128978224456
GO:BP GO:0051093 negative regulation of developmental process 0.0185339365211578 977 24 6 0.25 0.00614124872057318
GO:BP GO:0001775 cell activation 0.0187175334944771 1495 22 7 0.318181818181818 0.00468227424749164
GO:BP GO:0032148 activation of protein kinase B activity 0.0187175334944771 35 116 3 0.0258620689655172 0.0857142857142857
GO:BP GO:0045765 regulation of angiogenesis 0.0189130196922751 358 12 3 0.25 0.00837988826815642
GO:BP GO:0001558 regulation of cell growth 0.0191567213992189 426 137 10 0.072992700729927 0.0234741784037559
GO:BP GO:0042325 regulation of phosphorylation 0.0191567213992189 1431 12 5 0.416666666666667 0.00349406009783368
GO:BP GO:1901342 regulation of vasculature development 0.0194412692886818 364 12 3 0.25 0.00824175824175824
GO:BP GO:0010951 negative regulation of endopeptidase activity 0.0198242314000918 253 17 3 0.176470588235294 0.0118577075098814
GO:BP GO:1901135 carbohydrate derivative metabolic process 0.0202497634843127 1145 111 16 0.144144144144144 0.0139737991266376
GO:BP GO:0043549 regulation of kinase activity 0.0203300939725121 921 11 4 0.363636363636364 0.00434310532030402
GO:BP GO:0009617 response to bacterium 0.0205188305704577 743 22 5 0.227272727272727 0.00672947510094213
GO:BP GO:0048608 reproductive structure development 0.0206020090610079 429 37 5 0.135135135135135 0.0116550116550117
GO:BP GO:0061458 reproductive system development 0.0209986145769275 432 37 5 0.135135135135135 0.0115740740740741
GO:BP GO:0048762 mesenchymal cell differentiation 0.0222582563442421 234 135 7 0.0518518518518519 0.0299145299145299
GO:BP GO:0010647 positive regulation of cell communication 0.0228145596130394 1777 61 14 0.229508196721311 0.00787844682048396
GO:BP GO:0043409 negative regulation of MAPK cascade 0.0228145596130394 190 24 3 0.125 0.0157894736842105
GO:BP GO:0040008 regulation of growth 0.0230296090671141 681 137 13 0.0948905109489051 0.0190895741556534
GO:BP GO:0045055 regulated exocytosis 0.0231207786886371 785 42 7 0.166666666666667 0.0089171974522293
GO:BP GO:0023056 positive regulation of signaling 0.0231704530156141 1782 61 14 0.229508196721311 0.00785634118967452
GO:BP GO:0032963 collagen metabolic process 0.0233399768847646 114 85 4 0.0470588235294118 0.0350877192982456
GO:BP GO:0048731 system development 0.0245322309321472 5052 122 49 0.401639344262295 0.00969912905779889
GO:BP GO:0035137 hindlimb morphogenesis 0.0245322309321472 35 135 3 0.0222222222222222 0.0857142857142857
GO:BP GO:0051239 regulation of multicellular organismal process 0.0245322309321472 2861 24 10 0.416666666666667 0.0034952813701503
GO:BP GO:0009967 positive regulation of signal transduction 0.0245322309321472 1598 61 13 0.213114754098361 0.0081351689612015
GO:BP GO:0016477 cell migration 0.0245322309321472 1649 88 17 0.193181818181818 0.0103092783505155
GO:BP GO:1990138 neuron projection extension 0.0252283633799684 170 98 5 0.0510204081632653 0.0294117647058824
GO:BP GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation 0.0252283633799684 38 126 3 0.0238095238095238 0.0789473684210526
GO:BP GO:0030177 positive regulation of Wnt signaling pathway 0.0253296078297713 184 55 4 0.0727272727272727 0.0217391304347826
GO:BP GO:2000027 regulation of animal organ morphogenesis 0.0253296078297713 184 55 4 0.0727272727272727 0.0217391304347826
GO:BP GO:0051094 positive regulation of developmental process 0.0253933888640789 1341 136 20 0.147058823529412 0.0149142431021626
GO:BP GO:0032269 negative regulation of cellular protein metabolic process 0.0253933888640789 1082 24 6 0.25 0.0055452865064695
GO:BP GO:0048513 animal organ development 0.0253933888640789 3672 117 37 0.316239316239316 0.0100762527233115
GO:BP GO:0097191 extrinsic apoptotic signaling pathway 0.0253933888640789 223 46 4 0.0869565217391304 0.0179372197309417
GO:BP GO:0007160 cell-matrix adhesion 0.0253933888640789 235 141 7 0.049645390070922 0.0297872340425532
GO:BP GO:0010952 positive regulation of peptidase activity 0.0253933888640789 205 24 3 0.125 0.0146341463414634
GO:BP GO:0033993 response to lipid 0.0253933888640789 918 28 6 0.214285714285714 0.0065359477124183
GO:BP GO:0000165 MAPK cascade 0.0254569829706607 935 12 4 0.333333333333333 0.00427807486631016
GO:BP GO:0043009 chordate embryonic development 0.0254569829706607 616 137 12 0.0875912408759124 0.0194805194805195
GO:BP GO:0051338 regulation of transferase activity 0.0256278315196417 1035 11 4 0.363636363636364 0.00386473429951691
GO:BP GO:0007275 multicellular organism development 0.0264039499603388 5613 77 36 0.467532467532468 0.00641368252271513
GO:BP GO:0009968 negative regulation of signal transduction 0.0272372250712135 1364 126 19 0.150793650793651 0.0139296187683284
GO:BP GO:0009653 anatomical structure morphogenesis 0.0273375350645474 2797 137 34 0.248175182481752 0.0121558813013944
GO:BP GO:0019220 regulation of phosphate metabolic process 0.0273375350645474 1645 12 5 0.416666666666667 0.00303951367781155
GO:BP GO:0051174 regulation of phosphorus metabolic process 0.0273375350645474 1645 12 5 0.416666666666667 0.00303951367781155
GO:BP GO:0061383 trabecula morphogenesis 0.0276390707866871 44 117 3 0.0256410256410256 0.0681818181818182
GO:BP GO:0006468 protein phosphorylation 0.0282521969971968 1668 12 5 0.416666666666667 0.00299760191846523
GO:BP GO:1901661 quinone metabolic process 0.0282521969971968 37 143 3 0.020979020979021 0.0810810810810811
GO:BP GO:0030501 positive regulation of bone mineralization 0.0282521969971968 39 135 3 0.0222222222222222 0.0769230769230769
GO:BP GO:0031399 regulation of protein modification process 0.0282521969971968 1671 12 5 0.416666666666667 0.00299222022740874
GO:BP GO:0035107 appendage morphogenesis 0.0282521969971968 141 77 4 0.051948051948052 0.0283687943262411
GO:BP GO:0035108 limb morphogenesis 0.0282521969971968 141 77 4 0.051948051948052 0.0283687943262411
GO:BP GO:0009792 embryo development ending in birth or egg hatching 0.028920369863801 635 137 12 0.0875912408759124 0.0188976377952756
GO:BP GO:0001823 mesonephros development 0.028920369863801 97 55 3 0.0545454545454545 0.0309278350515464
GO:BP GO:0030334 regulation of cell migration 0.028920369863801 999 88 12 0.136363636363636 0.012012012012012
GO:BP GO:0051248 negative regulation of protein metabolic process 0.0291930573218427 1151 24 6 0.25 0.0052128583840139
GO:BP GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 0.0293211496166974 133 136 5 0.0367647058823529 0.037593984962406
GO:BP GO:0051270 regulation of cellular component movement 0.0295255541009069 1141 88 13 0.147727272727273 0.0113935144609991
GO:BP GO:0040013 negative regulation of locomotion 0.0295360468859127 401 88 7 0.0795454545454545 0.0174563591022444
GO:BP GO:0018212 peptidyl-tyrosine modification 0.0295360468859127 388 141 9 0.0638297872340425 0.0231958762886598
GO:BP GO:0016055 Wnt signaling pathway 0.0298486866914064 529 11 3 0.272727272727273 0.0056710775047259
GO:BP GO:0002443 leukocyte mediated immunity 0.029986880057348 877 22 5 0.227272727272727 0.00570125427594071
GO:BP GO:1901137 carbohydrate derivative biosynthetic process 0.029986880057348 686 81 9 0.111111111111111 0.0131195335276968
GO:BP GO:0198738 cell-cell signaling by wnt 0.029986880057348 531 11 3 0.272727272727273 0.00564971751412429
GO:BP GO:0009966 regulation of signal transduction 0.0303292269631495 3165 46 16 0.347826086956522 0.00505529225908373
GO:BP GO:0001944 vasculature development 0.0303292269631495 830 135 14 0.103703703703704 0.0168674698795181
GO:BP GO:0045595 regulation of cell differentiation 0.030486384857988 1679 137 23 0.167883211678832 0.0136986301369863
GO:BP GO:0006887 exocytosis 0.0322350332692034 904 22 5 0.227272727272727 0.00553097345132743
GO:BP GO:0044092 negative regulation of molecular function 0.033773300606123 1219 17 5 0.294117647058824 0.00410172272354389
GO:BP GO:0090596 sensory organ morphogenesis 0.033773300606123 262 23 3 0.130434782608696 0.0114503816793893
GO:BP GO:0048523 negative regulation of cellular process 0.0339827938603999 5139 28 15 0.535714285714286 0.00291885580852306
GO:BP GO:0009605 response to external stimulus 0.0353076813788171 2944 18 8 0.444444444444444 0.00271739130434783
GO:BP GO:0048584 positive regulation of response to stimulus 0.0354852423081808 2344 62 16 0.258064516129032 0.0068259385665529
GO:BP GO:1901565 organonitrogen compound catabolic process 0.0354852423081808 1358 95 15 0.157894736842105 0.0110456553755523
GO:BP GO:0071398 cellular response to fatty acid 0.0361636365354728 43 143 3 0.020979020979021 0.0697674418604651
GO:BP GO:0045862 positive regulation of proteolysis 0.036184059406933 378 33 4 0.121212121212121 0.0105820105820106
GO:BP GO:0048519 negative regulation of biological process 0.0367793832789514 5757 28 16 0.571428571428571 0.00277922529095015
GO:BP GO:0009952 anterior/posterior pattern specification 0.0378650249675027 211 135 6 0.0444444444444444 0.028436018957346
GO:BP GO:2000145 regulation of cell motility 0.038396964496576 1061 88 12 0.136363636363636 0.0113100848256362
GO:BP GO:0070169 positive regulation of biomineral tissue development 0.0384609576536589 47 135 3 0.0222222222222222 0.0638297872340425
GO:BP GO:0007267 cell-cell signaling 0.0384609576536589 1722 13 5 0.384615384615385 0.00290360046457607
GO:BP GO:0065009 regulation of molecular function 0.0385642041823278 3221 17 8 0.470588235294118 0.00248370071406396
GO:BP GO:0071363 cellular response to growth factor stimulus 0.0387553304081262 731 81 9 0.111111111111111 0.012311901504788
GO:BP GO:1902532 negative regulation of intracellular signal transduction 0.0392286780569767 549 24 4 0.166666666666667 0.00728597449908925
GO:BP GO:0110151 positive regulation of biomineralization 0.0392286780569767 48 135 3 0.0222222222222222 0.0625
GO:BP GO:0048583 regulation of response to stimulus 0.0396946793902071 4278 62 24 0.387096774193548 0.00561009817671809
GO:BP GO:0030326 embryonic limb morphogenesis 0.0396946793902071 119 55 3 0.0545454545454545 0.0252100840336134
GO:BP GO:0045664 regulation of neuron differentiation 0.0396946793902071 202 64 4 0.0625 0.0198019801980198
GO:BP GO:0035113 embryonic appendage morphogenesis 0.0396946793902071 119 55 3 0.0545454545454545 0.0252100840336134
GO:BP GO:0010629 negative regulation of gene expression 0.0398473311810943 1460 28 7 0.25 0.00479452054794521
GO:BP GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling 0.0399180512884934 636 11 3 0.272727272727273 0.00471698113207547
GO:BP GO:0048562 embryonic organ morphogenesis 0.0399463430439344 292 23 3 0.130434782608696 0.0102739726027397
GO:BP GO:0045778 positive regulation of ossification 0.0400126536869361 49 135 3 0.0222222222222222 0.0612244897959184
GO:BP GO:0010648 negative regulation of cell communication 0.0402496812199485 1468 28 7 0.25 0.00476839237057221
GO:BP GO:0023057 negative regulation of signaling 0.0404564064341274 1471 28 7 0.25 0.00475866757307954
GO:BP GO:0006959 humoral immune response 0.0406930171237342 384 18 3 0.166666666666667 0.0078125
GO:BP GO:0010769 regulation of cell morphogenesis involved in differentiation 0.0407378723472983 97 136 4 0.0294117647058824 0.0412371134020619
GO:BP GO:0060485 mesenchyme development 0.0410332676170888 291 135 7 0.0518518518518519 0.0240549828178694
GO:BP GO:0046324 regulation of glucose import 0.0410988435672232 61 111 3 0.027027027027027 0.0491803278688525
GO:BP GO:0001568 blood vessel development 0.0412270773987099 792 135 13 0.0962962962962963 0.0164141414141414
GO:BP GO:0051674 localization of cell 0.0415288021475623 1828 88 17 0.193181818181818 0.00929978118161926
GO:BP GO:0010605 negative regulation of macromolecule metabolic process 0.0415288021475623 3241 28 11 0.392857142857143 0.00339401419315026
GO:BP GO:0048870 cell motility 0.0415288021475623 1828 88 17 0.193181818181818 0.00929978118161926
GO:BP GO:0045597 positive regulation of cell differentiation 0.0415288021475623 879 136 14 0.102941176470588 0.0159271899886234
GO:BP GO:1903018 regulation of glycoprotein metabolic process 0.0419411263860951 62 111 3 0.027027027027027 0.0483870967741935
GO:BP GO:0035265 organ growth 0.0421758966538232 182 117 5 0.0427350427350427 0.0274725274725275
GO:BP GO:0014033 neural crest cell differentiation 0.0423296351968575 90 77 3 0.038961038961039 0.0333333333333333
GO:BP GO:0070848 response to growth factor 0.0424809875734369 759 81 9 0.111111111111111 0.0118577075098814
GO:BP GO:0034308 primary alcohol metabolic process 0.0428553103657357 95 143 4 0.027972027972028 0.0421052631578947
GO:BP GO:0001525 angiogenesis 0.0431054943629558 617 12 3 0.25 0.00486223662884927
GO:BP GO:1902531 regulation of intracellular signal transduction 0.0432835290344178 1842 13 5 0.384615384615385 0.00271444082519001
GO:BP GO:0040012 regulation of locomotion 0.0435647334593506 1104 88 12 0.136363636363636 0.0108695652173913
GO:BP GO:2001233 regulation of apoptotic signaling pathway 0.0436579906823449 363 111 7 0.0630630630630631 0.0192837465564738
GO:BP GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 0.0438434638594699 369 137 8 0.0583941605839416 0.021680216802168
GO:BP GO:0006693 prostaglandin metabolic process 0.0445345080151619 50 143 3 0.020979020979021 0.06
GO:BP GO:0006692 prostanoid metabolic process 0.0445345080151619 50 143 3 0.020979020979021 0.06
GO:BP GO:0050678 regulation of epithelial cell proliferation 0.044726206739526 401 55 5 0.0909090909090909 0.0124688279301746
GO:BP GO:0014065 phosphatidylinositol 3-kinase signaling 0.0447699273717283 161 136 5 0.0367647058823529 0.031055900621118
GO:BP GO:0052548 regulation of endopeptidase activity 0.0447699273717283 437 17 3 0.176470588235294 0.0068649885583524
GO:BP GO:0040011 locomotion 0.0448606913670723 2028 81 17 0.209876543209877 0.00838264299802761
GO:BP GO:0032496 response to lipopolysaccharide 0.0452694797721708 338 22 3 0.136363636363636 0.00887573964497041
GO:BP GO:0060429 epithelium development 0.0457631839223343 1325 84 13 0.154761904761905 0.00981132075471698
GO:BP GO:0002683 negative regulation of immune system process 0.0458572191021273 420 18 3 0.166666666666667 0.00714285714285714
GO:BP GO:0008284 positive regulation of cell population proliferation 0.0477529980392127 982 24 5 0.208333333333333 0.00509164969450102
GO:BP GO:0018108 peptidyl-tyrosine phosphorylation 0.0477529980392127 385 20 3 0.15 0.00779220779220779
GO:BP GO:0044255 cellular lipid metabolic process 0.0484275969467611 1075 60 9 0.15 0.00837209302325581
GO:BP GO:0016310 phosphorylation 0.049970711553776 2138 12 5 0.416666666666667 0.00233863423760524
GO:CC GO:0005576 extracellular region 2.00575124144443e-24 4567 123 86 0.699186991869919 0.0188307422815853
GO:CC GO:0062023 collagen-containing extracellular matrix 6.55604713998197e-23 421 88 28 0.318181818181818 0.0665083135391924
GO:CC GO:0030312 external encapsulating structure 6.49504580071929e-20 563 112 31 0.276785714285714 0.0550621669626998
GO:CC GO:0031012 extracellular matrix 6.49504580071929e-20 562 112 31 0.276785714285714 0.0551601423487545
GO:CC GO:0005615 extracellular space 1.98736703080043e-15 3594 123 65 0.528455284552846 0.0180856983861992
GO:CC GO:0043230 extracellular organelle 7.00048009655507e-12 2263 84 37 0.44047619047619 0.0163499779054353
GO:CC GO:1903561 extracellular vesicle 7.00048009655507e-12 2261 84 37 0.44047619047619 0.0163644405130473
GO:CC GO:0070062 extracellular exosome 6.34003916289957e-11 2176 84 35 0.416666666666667 0.0160845588235294
GO:CC GO:0031982 vesicle 9.73163596981208e-09 4055 67 38 0.567164179104478 0.0093711467324291
GO:CC GO:0043202 lysosomal lumen 7.50923660104421e-08 97 140 10 0.0714285714285714 0.103092783505155
GO:CC GO:0005775 vacuolar lumen 1.85707825549043e-06 174 140 11 0.0785714285714286 0.0632183908045977
GO:CC GO:0005614 interstitial matrix 1.8992783783978e-06 11 76 4 0.0526315789473684 0.363636363636364
GO:CC GO:0071944 cell periphery 2.53883876606135e-06 6169 82 50 0.609756097560976 0.00810504133571081
GO:CC GO:0005773 vacuole 7.60721321774854e-05 810 66 13 0.196969696969697 0.0160493827160494
GO:CC GO:0005796 Golgi lumen 8.11868787167282e-05 99 81 6 0.0740740740740741 0.0606060606060606
GO:CC GO:0000323 lytic vacuole 9.55059349131372e-05 712 66 12 0.181818181818182 0.0168539325842697
GO:CC GO:0005764 lysosome 9.55059349131372e-05 712 66 12 0.181818181818182 0.0168539325842697
GO:CC GO:0012505 endomembrane system 0.00107737024486102 4640 93 40 0.43010752688172 0.00862068965517241
GO:CC GO:0005788 endoplasmic reticulum lumen 0.00182849467550898 307 92 8 0.0869565217391304 0.0260586319218241
GO:CC GO:0030141 secretory granule 0.00388716466624666 851 49 9 0.183673469387755 0.0105757931844888
GO:CC GO:0099503 secretory vesicle 0.00646398857437887 1020 64 11 0.171875 0.0107843137254902
GO:CC GO:0005794 Golgi apparatus 0.00660996136519664 1623 55 13 0.236363636363636 0.00800985828712261
GO:CC GO:0101002 ficolin-1-rich granule 0.00696700616405955 184 18 3 0.166666666666667 0.016304347826087
GO:CC GO:0005783 endoplasmic reticulum 0.00931465667410552 1982 97 21 0.216494845360825 0.0105953582240161
GO:CC GO:0005766 primary lysosome 0.0147729351410196 154 104 5 0.0480769230769231 0.0324675324675325
GO:CC GO:0042582 azurophil granule 0.0147729351410196 154 104 5 0.0480769230769231 0.0324675324675325
GO:CC GO:0035577 azurophil granule membrane 0.0325617842073574 57 104 3 0.0288461538461538 0.0526315789473684
GO:CC GO:0009986 cell surface 0.0337094535852327 899 55 8 0.145454545454545 0.00889877641824249
GO:CC GO:0097708 intracellular vesicle 0.0359820234469275 2428 52 14 0.269230769230769 0.0057660626029654
GO:CC GO:0031410 cytoplasmic vesicle 0.0359820234469275 2424 52 14 0.269230769230769 0.00577557755775578
GO:MF GO:0005201 extracellular matrix structural constituent 4.40606821734832e-14 171 88 16 0.181818181818182 0.0935672514619883
GO:MF GO:0008201 heparin binding 1.83835519192779e-09 168 46 10 0.217391304347826 0.0595238095238095
GO:MF GO:1901681 sulfur compound binding 4.72554240057268e-09 264 46 11 0.239130434782609 0.0416666666666667
GO:MF GO:0005539 glycosaminoglycan binding 2.6025234684458e-08 238 115 14 0.121739130434783 0.0588235294117647
GO:MF GO:0005198 structural molecule activity 2.89001904078443e-07 698 131 22 0.16793893129771 0.0315186246418338
GO:MF GO:0001968 fibronectin binding 9.04478532636312e-07 28 4 3 0.75 0.107142857142857
GO:MF GO:0061134 peptidase regulator activity 2.01111031417552e-05 224 24 6 0.25 0.0267857142857143
GO:MF GO:0005518 collagen binding 5.33305424023429e-05 70 88 6 0.0681818181818182 0.0857142857142857
GO:MF GO:0030021 extracellular matrix structural constituent conferring compression resistance 0.000157742355828073 22 88 4 0.0454545454545455 0.181818181818182
GO:MF GO:0016504 peptidase activator activity 0.000932064274409559 42 24 3 0.125 0.0714285714285714
GO:MF GO:0005178 integrin binding 0.00141684717341262 147 24 4 0.166666666666667 0.0272108843537415
GO:MF GO:0005509 calcium ion binding 0.00311214974478604 721 38 8 0.210526315789474 0.0110957004160888
GO:MF GO:0016491 oxidoreductase activity 0.0039703415394464 771 119 15 0.126050420168067 0.0194552529182879
GO:MF GO:0004364 glutathione transferase activity 0.00528606631355565 25 84 3 0.0357142857142857 0.12
GO:MF GO:0042802 identical protein binding 0.00569705788796572 2067 89 22 0.247191011235955 0.0106434446057088
GO:MF GO:0008233 peptidase activity 0.00569909278606714 646 134 14 0.104477611940299 0.021671826625387
GO:MF GO:0005102 signaling receptor binding 0.00660088565446293 1672 12 6 0.5 0.00358851674641148
GO:MF GO:0030414 peptidase inhibitor activity 0.00814714977363036 182 64 5 0.078125 0.0274725274725275
GO:MF GO:0008238 exopeptidase activity 0.0101940787847857 95 132 5 0.0378787878787879 0.0526315789473684
GO:MF GO:0061135 endopeptidase regulator activity 0.0102536199570528 188 17 3 0.176470588235294 0.0159574468085106
GO:MF GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 0.0105335011588712 137 143 6 0.041958041958042 0.0437956204379562
GO:MF GO:0002020 protease binding 0.013333175666413 133 104 5 0.0480769230769231 0.037593984962406
GO:MF GO:0048018 receptor ligand activity 0.013880540865319 494 115 10 0.0869565217391304 0.0202429149797571
GO:MF GO:0030546 signaling receptor activator activity 0.0147427848113454 501 115 10 0.0869565217391304 0.0199600798403194
GO:MF GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor 0.0148721973098967 27 143 3 0.020979020979021 0.111111111111111
GO:MF GO:0004497 monooxygenase activity 0.0167260031201518 106 143 5 0.034965034965035 0.0471698113207547
GO:MF GO:0098772 molecular function regulator 0.0192035933265411 2363 24 9 0.375 0.003808717731697
GO:MF GO:0030545 receptor regulator activity 0.0207730218245921 545 115 10 0.0869565217391304 0.018348623853211
GO:MF GO:0008237 metallopeptidase activity 0.021121489506498 188 132 6 0.0454545454545455 0.0319148936170213
GO:MF GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 0.0212441154987005 58 84 3 0.0357142857142857 0.0517241379310345
GO:MF GO:0004177 aminopeptidase activity 0.0227049936570179 39 132 3 0.0227272727272727 0.0769230769230769
GO:MF GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.0231803291202158 125 143 5 0.034965034965035 0.04
GO:MF GO:0008236 serine-type peptidase activity 0.0271069822231714 189 102 5 0.0490196078431373 0.0264550264550265
GO:MF GO:0030234 enzyme regulator activity 0.0278930045049574 1248 17 5 0.294117647058824 0.00400641025641026
GO:MF GO:0017171 serine hydrolase activity 0.0278930045049574 193 102 5 0.0490196078431373 0.0259067357512953
GO:MF GO:0004175 endopeptidase activity 0.0280003723527856 450 85 7 0.0823529411764706 0.0155555555555556
GO:MF GO:0050839 cell adhesion molecule binding 0.0280562135056506 546 12 3 0.25 0.00549450549450549
GO:MF GO:0004857 enzyme inhibitor activity 0.0289141143713858 385 17 3 0.176470588235294 0.00779220779220779
GO:MF GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 0.0405998481117674 167 91 4 0.043956043956044 0.0239520958083832
GO:MF GO:0008235 metalloexopeptidase activity 0.0434119958101612 63 132 3 0.0227272727272727 0.0476190476190476
GO:MF GO:0044877 protein-containing complex binding 0.0486008032801745 1287 14 4 0.285714285714286 0.00310800310800311
REAC REAC:R-HSA-2022857 Keratan sulfate degradation 0.000109563984326911 13 60 4 0.0666666666666667 0.307692307692308
REAC REAC:R-HSA-3560782 Diseases associated with glycosaminoglycan metabolism 0.000109563984326911 41 81 6 0.0740740740740741 0.146341463414634
REAC REAC:R-HSA-2129379 Molecules associated with elastic fibres 0.0001689029105808 37 62 5 0.0806451612903226 0.135135135135135
REAC REAC:R-HSA-3656243 Defective ST3GAL3 causes MCT12 and EIEE15 0.0001689029105808 8 41 3 0.0731707317073171 0.375
REAC REAC:R-HSA-3656225 Defective CHST6 causes MCDC1 0.0001689029105808 8 41 3 0.0731707317073171 0.375
REAC REAC:R-HSA-3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) 0.0001689029105808 8 41 3 0.0731707317073171 0.375
REAC REAC:R-HSA-1566948 Elastic fibre formation 0.000260839120038881 44 62 5 0.0806451612903226 0.113636363636364
REAC REAC:R-HSA-1638074 Keratan sulfate/keratin metabolism 0.00162486934631871 34 60 4 0.0666666666666667 0.117647058823529
REAC REAC:R-HSA-3781865 Diseases of glycosylation 0.00346592764219306 140 81 7 0.0864197530864197 0.05
REAC REAC:R-HSA-2022854 Keratan sulfate biosynthesis 0.00510586718430541 28 41 3 0.0731707317073171 0.107142857142857
REAC REAC:R-HSA-211859 Biological oxidations 0.00977197734364411 215 134 10 0.0746268656716418 0.0465116279069767
REAC REAC:R-HSA-1474244 Extracellular matrix organization 0.00977197734364411 298 35 6 0.171428571428571 0.0201342281879195
REAC REAC:R-HSA-1630316 Glycosaminoglycan metabolism 0.00977197734364411 123 81 6 0.0740740740740741 0.0487804878048781
REAC REAC:R-HSA-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol 0.0178541192076942 14 143 3 0.020979020979021 0.214285714285714
REAC REAC:R-HSA-156590 Glutathione conjugation 0.0180778971970357 34 134 4 0.0298507462686567 0.117647058823529
REAC REAC:R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol 0.0194971732059708 15 143 3 0.020979020979021 0.2
REAC REAC:R-HSA-6798695 Neutrophil degranulation 0.0421222758085702 474 22 5 0.227272727272727 0.0105485232067511
REAC REAC:R-HSA-5668914 Diseases of metabolism 0.0421222758085702 241 81 7 0.0864197530864197 0.029045643153527

pS02 transcription factor target enrichment of top program genes

TF enrichment of pS02
TFs corrosponding to activation of pS02. (Left) pearson correlation of TF expression and gene expression program activatity in Stromal cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.