pEpiTp15 program activity among Epithelial cells

Activation of pEpiTp15
pEpiTp15 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpiTp15 by different cell subtypes
pEpiTp15 gene program activation among cells of different subtypes (Epithelial cells).

pEpiTp15 top program genes

Top genes of pEpiTp15 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpiTp15 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpiTp15
pEpiTp15 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0002376 immune system process 1.94139854877663e-13 3278 39 31 0.794871794871795 0.00945698596705308
GO:BP GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent 4.65481802438502e-11 8 5 4 0.8 0.5
GO:BP GO:0002682 regulation of immune system process 4.65481802438502e-11 1617 39 22 0.564102564102564 0.0136054421768707
GO:BP GO:0006955 immune response 8.74559309921323e-11 2311 37 24 0.648648648648649 0.0103851146689745
GO:BP GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I 2.70446274313914e-10 13 5 4 0.8 0.307692307692308
GO:BP GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent 5.27803926382397e-10 75 11 6 0.545454545454545 0.08
GO:BP GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I 6.74346121225484e-10 80 11 6 0.545454545454545 0.075
GO:BP GO:0002483 antigen processing and presentation of endogenous peptide antigen 7.91609975092484e-10 19 5 4 0.8 0.210526315789474
GO:BP GO:0098542 defense response to other organism 7.91609975092484e-10 1218 29 16 0.551724137931034 0.013136288998358
GO:BP GO:0045087 innate immune response 7.91609975092484e-10 998 29 15 0.517241379310345 0.0150300601202405
GO:BP GO:0019882 antigen processing and presentation 8.27714503141374e-10 234 32 10 0.3125 0.0427350427350427
GO:BP GO:0009605 response to external stimulus 8.83057837731649e-10 2944 30 22 0.733333333333333 0.00747282608695652
GO:BP GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 1.16817570455078e-09 99 11 6 0.545454545454545 0.0606060606060606
GO:BP GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent 1.16817570455078e-09 3 5 3 0.6 1
GO:BP GO:0002484 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway 1.16817570455078e-09 3 5 3 0.6 1
GO:BP GO:0002478 antigen processing and presentation of exogenous peptide antigen 1.39054607282962e-09 174 32 9 0.28125 0.0517241379310345
GO:BP GO:0019883 antigen processing and presentation of endogenous antigen 1.66221694642152e-09 26 5 4 0.8 0.153846153846154
GO:BP GO:0019884 antigen processing and presentation of exogenous antigen 1.66745796950338e-09 182 32 9 0.28125 0.0494505494505494
GO:BP GO:0051707 response to other organism 1.66745796950338e-09 1592 29 17 0.586206896551724 0.010678391959799
GO:BP GO:0043207 response to external biotic stimulus 1.66745796950338e-09 1594 29 17 0.586206896551724 0.0106649937264743
GO:BP GO:0009607 response to biotic stimulus 2.16208050571275e-09 1626 29 17 0.586206896551724 0.0104551045510455
GO:BP GO:0048002 antigen processing and presentation of peptide antigen 2.45100340851445e-09 192 32 9 0.28125 0.046875
GO:BP GO:0001775 cell activation 8.12424917666031e-09 1495 37 18 0.486486486486487 0.0120401337792642
GO:BP GO:0006952 defense response 2.33427615523848e-08 1818 30 17 0.566666666666667 0.00935093509350935
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 2.89975565486894e-08 2255 29 18 0.620689655172414 0.00798226164079823
GO:BP GO:0002684 positive regulation of immune system process 5.64573061178306e-08 1065 37 15 0.405405405405405 0.0140845070422535
GO:BP GO:0002252 immune effector process 9.54005840116694e-08 1309 37 16 0.432432432432432 0.0122230710466005
GO:BP GO:0045321 leukocyte activation 1.18534295411985e-07 1332 37 16 0.432432432432432 0.012012012012012
GO:BP GO:0060333 interferon-gamma-mediated signaling pathway 1.51570069115007e-07 88 5 4 0.8 0.0454545454545455
GO:BP GO:0019221 cytokine-mediated signaling pathway 1.92949654198703e-07 810 37 13 0.351351351351351 0.0160493827160494
GO:BP GO:0050776 regulation of immune response 2.14456023690922e-07 996 37 14 0.378378378378378 0.0140562248995984
GO:BP GO:0002250 adaptive immune response 3.41424142987531e-07 689 37 12 0.324324324324324 0.0174165457184325
GO:BP GO:0001906 cell killing 4.67041299337458e-07 175 29 7 0.241379310344828 0.04
GO:BP GO:0001916 positive regulation of T cell mediated cytotoxicity 5.02250445778629e-07 26 18 4 0.222222222222222 0.153846153846154
GO:BP GO:0034341 response to interferon-gamma 5.58892894915307e-07 196 27 7 0.259259259259259 0.0357142857142857
GO:BP GO:0050896 response to stimulus 5.88079064805837e-07 9407 33 32 0.96969696969697 0.00340172212182417
GO:BP GO:0050778 positive regulation of immune response 7.94624047956402e-07 753 37 12 0.324324324324324 0.0159362549800797
GO:BP GO:0048583 regulation of response to stimulus 1.18361393548244e-06 4278 33 23 0.696969696969697 0.00537634408602151
GO:BP GO:0001914 regulation of T cell mediated cytotoxicity 1.525015278268e-06 35 18 4 0.222222222222222 0.114285714285714
GO:BP GO:0034097 response to cytokine 1.62505603526684e-06 1226 31 13 0.419354838709677 0.0106035889070147
GO:BP GO:0071346 cellular response to interferon-gamma 1.72898763190789e-06 175 5 4 0.8 0.0228571428571429
GO:BP GO:0002697 regulation of immune effector process 2.78861650099117e-06 461 32 9 0.28125 0.0195227765726681
GO:BP GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 2.8253708520171e-06 96 21 5 0.238095238095238 0.0520833333333333
GO:BP GO:0001913 T cell mediated cytotoxicity 2.87707596558583e-06 42 18 4 0.222222222222222 0.0952380952380952
GO:BP GO:0002821 positive regulation of adaptive immune response 3.48569425174291e-06 101 21 5 0.238095238095238 0.0495049504950495
GO:BP GO:0002708 positive regulation of lymphocyte mediated immunity 3.94820422255935e-06 104 21 5 0.238095238095238 0.0480769230769231
GO:BP GO:0031347 regulation of defense response 3.94820422255935e-06 704 30 10 0.333333333333333 0.0142045454545455
GO:BP GO:0048584 positive regulation of response to stimulus 3.97109542351111e-06 2344 33 17 0.515151515151515 0.00725255972696246
GO:BP GO:0002366 leukocyte activation involved in immune response 3.9945110474605e-06 717 37 11 0.297297297297297 0.0153417015341702
GO:BP GO:0002263 cell activation involved in immune response 4.140924159167e-06 721 37 11 0.297297297297297 0.0152565880721221
GO:BP GO:0002711 positive regulation of T cell mediated immunity 4.29904965781799e-06 48 18 4 0.222222222222222 0.0833333333333333
GO:BP GO:0071345 cellular response to cytokine stimulus 5.0711744272759e-06 1132 31 12 0.387096774193548 0.0106007067137809
GO:BP GO:0001912 positive regulation of leukocyte mediated cytotoxicity 5.30308051695117e-06 51 18 4 0.222222222222222 0.0784313725490196
GO:BP GO:0002573 myeloid leukocyte differentiation 6.7511217582846e-06 213 37 7 0.189189189189189 0.0328638497652582
GO:BP GO:0030099 myeloid cell differentiation 7.22299383845418e-06 428 39 9 0.230769230769231 0.0210280373831776
GO:BP GO:0002705 positive regulation of leukocyte mediated immunity 7.22299383845418e-06 122 21 5 0.238095238095238 0.040983606557377
GO:BP GO:0002443 leukocyte mediated immunity 7.24797470363829e-06 877 21 9 0.428571428571429 0.0102622576966933
GO:BP GO:0031343 positive regulation of cell killing 8.78193678735328e-06 59 18 4 0.222222222222222 0.0677966101694915
GO:BP GO:0030097 hemopoiesis 9.47431633883082e-06 928 39 12 0.307692307692308 0.0129310344827586
GO:BP GO:0048534 hematopoietic or lymphoid organ development 1.43206196488459e-05 966 39 12 0.307692307692308 0.0124223602484472
GO:BP GO:0016045 detection of bacterium 1.52030940958107e-05 17 18 3 0.166666666666667 0.176470588235294
GO:BP GO:0010033 response to organic substance 1.52030940958107e-05 3412 27 17 0.62962962962963 0.00498241500586166
GO:BP GO:0001816 cytokine production 1.57912931215271e-05 844 30 10 0.333333333333333 0.0118483412322275
GO:BP GO:0002274 myeloid leukocyte activation 1.60601527408264e-05 667 37 10 0.27027027027027 0.0149925037481259
GO:BP GO:0002709 regulation of T cell mediated immunity 1.67315787750836e-05 74 5 3 0.6 0.0405405405405405
GO:BP GO:0001910 regulation of leukocyte mediated cytotoxicity 1.67315787750836e-05 74 5 3 0.6 0.0405405405405405
GO:BP GO:0001909 leukocyte mediated cytotoxicity 1.73243817946857e-05 107 29 5 0.172413793103448 0.0467289719626168
GO:BP GO:0002706 regulation of lymphocyte mediated immunity 1.73243817946857e-05 151 21 5 0.238095238095238 0.033112582781457
GO:BP GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 1.7486201416504e-05 152 21 5 0.238095238095238 0.0328947368421053
GO:BP GO:0043312 neutrophil degranulation 1.84377439206792e-05 482 21 7 0.333333333333333 0.0145228215767635
GO:BP GO:0098543 detection of other organism 1.86877308258993e-05 19 18 3 0.166666666666667 0.157894736842105
GO:BP GO:0002283 neutrophil activation involved in immune response 1.86877308258993e-05 485 21 7 0.333333333333333 0.0144329896907217
GO:BP GO:0002520 immune system development 2.09646111528008e-05 1020 39 12 0.307692307692308 0.0117647058823529
GO:BP GO:0002446 neutrophil mediated immunity 2.11347148207766e-05 497 21 7 0.333333333333333 0.0140845070422535
GO:BP GO:0042119 neutrophil activation 2.11393925371834e-05 498 21 7 0.333333333333333 0.0140562248995984
GO:BP GO:0036230 granulocyte activation 2.2607208914935e-05 504 21 7 0.333333333333333 0.0138888888888889
GO:BP GO:0002819 regulation of adaptive immune response 2.46384580437344e-05 167 21 5 0.238095238095238 0.029940119760479
GO:BP GO:0002521 leukocyte differentiation 2.56778806799889e-05 550 37 9 0.243243243243243 0.0163636363636364
GO:BP GO:0080134 regulation of response to stress 2.61601883889277e-05 1443 25 11 0.44 0.00762300762300762
GO:BP GO:0031341 regulation of cell killing 2.72480532172701e-05 93 5 3 0.6 0.032258064516129
GO:BP GO:0060337 type I interferon signaling pathway 2.87049438918753e-05 95 5 3 0.6 0.0315789473684211
GO:BP GO:0032101 regulation of response to external stimulus 2.88414169413862e-05 1051 33 11 0.333333333333333 0.0104662226450999
GO:BP GO:0071357 cellular response to type I interferon 2.89230081464389e-05 96 5 3 0.6 0.03125
GO:BP GO:0002456 T cell mediated immunity 3.01626736800086e-05 98 5 3 0.6 0.0306122448979592
GO:BP GO:0043299 leukocyte degranulation 3.01626736800086e-05 535 21 7 0.333333333333333 0.0130841121495327
GO:BP GO:0098581 detection of external biotic stimulus 3.21082964403274e-05 24 18 3 0.166666666666667 0.125
GO:BP GO:0034340 response to type I interferon 3.21879607598358e-05 101 5 3 0.6 0.0297029702970297
GO:BP GO:0002275 myeloid cell activation involved in immune response 3.37902367884001e-05 547 21 7 0.333333333333333 0.0127970749542962
GO:BP GO:0002699 positive regulation of immune effector process 3.44200100083674e-05 215 32 6 0.1875 0.027906976744186
GO:BP GO:0002444 myeloid leukocyte mediated immunity 3.46905973611184e-05 551 21 7 0.333333333333333 0.0127041742286751
GO:BP GO:0071310 cellular response to organic substance 3.47806529199155e-05 2776 11 9 0.818181818181818 0.00324207492795389
GO:BP GO:0032940 secretion by cell 4.76288070602916e-05 1364 23 10 0.434782608695652 0.00733137829912024
GO:BP GO:0031348 negative regulation of defense response 4.81286998478558e-05 246 30 6 0.2 0.024390243902439
GO:BP GO:0006950 response to stress 4.8462831138503e-05 4170 30 19 0.633333333333333 0.00455635491606715
GO:BP GO:0002703 regulation of leukocyte mediated immunity 5.48673626458068e-05 205 21 5 0.238095238095238 0.024390243902439
GO:BP GO:0050852 T cell receptor signaling pathway 5.59962082063879e-05 203 37 6 0.162162162162162 0.0295566502463054
GO:BP GO:0045055 regulated exocytosis 5.70293511432809e-05 785 23 8 0.347826086956522 0.0101910828025478
GO:BP GO:0140352 export from cell 6.36167180444667e-05 1418 23 10 0.434782608695652 0.00705218617771509
GO:BP GO:0001817 regulation of cytokine production 6.82258169458993e-05 806 30 9 0.3 0.011166253101737
GO:BP GO:0070887 cellular response to chemical stimulus 7.41322741204027e-05 3393 33 18 0.545454545454545 0.00530503978779841
GO:BP GO:0006959 humoral immune response 8.04258955164599e-05 384 33 7 0.212121212121212 0.0182291666666667
GO:BP GO:0042221 response to chemical 8.34585893102256e-05 4781 37 23 0.621621621621622 0.0048107090566827
GO:BP GO:0071621 granulocyte chemotaxis 8.94573752684146e-05 126 37 5 0.135135135135135 0.0396825396825397
GO:BP GO:0009595 detection of biotic stimulus 9.31530296294699e-05 36 18 3 0.166666666666667 0.0833333333333333
GO:BP GO:0030595 leukocyte chemotaxis 9.74764163681312e-05 227 37 6 0.162162162162162 0.026431718061674
GO:BP GO:0046903 secretion 9.82831665743914e-05 1501 23 10 0.434782608695652 0.00666222518321119
GO:BP GO:0050900 leukocyte migration 0.000109911069880575 511 37 8 0.216216216216216 0.0156555772994129
GO:BP GO:0001819 positive regulation of cytokine production 0.000109911069880575 452 30 7 0.233333333333333 0.0154867256637168
GO:BP GO:0006887 exocytosis 0.000140383688031229 904 23 8 0.347826086956522 0.00884955752212389
GO:BP GO:0097530 granulocyte migration 0.000195349499841974 151 37 5 0.135135135135135 0.033112582781457
GO:BP GO:0002253 activation of immune response 0.000215963349510357 568 27 7 0.259259259259259 0.0123239436619718
GO:BP GO:0002831 regulation of response to biotic stimulus 0.000245410091051094 415 25 6 0.24 0.0144578313253012
GO:BP GO:0002449 lymphocyte mediated immunity 0.000247258167544785 354 29 6 0.206896551724138 0.0169491525423729
GO:BP GO:0002698 negative regulation of immune effector process 0.000247744599552994 125 8 3 0.375 0.024
GO:BP GO:0046649 lymphocyte activation 0.000256440011626947 771 37 9 0.243243243243243 0.0116731517509728
GO:BP GO:0045637 regulation of myeloid cell differentiation 0.000262088126618893 263 39 6 0.153846153846154 0.0228136882129278
GO:BP GO:1903131 mononuclear cell differentiation 0.000300444863614363 430 37 7 0.189189189189189 0.0162790697674419
GO:BP GO:0045088 regulation of innate immune response 0.000327992688580052 309 11 4 0.363636363636364 0.0129449838187702
GO:BP GO:0009617 response to bacterium 0.000341519034497239 743 23 7 0.304347826086957 0.00942126514131898
GO:BP GO:0002700 regulation of production of molecular mediator of immune response 0.000376298747705693 148 8 3 0.375 0.0202702702702703
GO:BP GO:1903706 regulation of hemopoiesis 0.000378975176656479 424 39 7 0.179487179487179 0.0165094339622642
GO:BP GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 0.00039721193718609 103 32 4 0.125 0.0388349514563107
GO:BP GO:0002440 production of molecular mediator of immune response 0.00039721193718609 189 18 4 0.222222222222222 0.0211640211640212
GO:BP GO:0048260 positive regulation of receptor-mediated endocytosis 0.000403116547318002 54 21 3 0.142857142857143 0.0555555555555556
GO:BP GO:0016032 viral process 0.000434736223907841 942 5 4 0.8 0.00424628450106157
GO:BP GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 0.000438470835503806 111 11 3 0.272727272727273 0.027027027027027
GO:BP GO:0060326 cell chemotaxis 0.000438470835503806 310 37 6 0.162162162162162 0.0193548387096774
GO:BP GO:0002683 negative regulation of immune system process 0.000447116261719168 420 28 6 0.214285714285714 0.0142857142857143
GO:BP GO:0043620 regulation of DNA-templated transcription in response to stress 0.000505854868017727 117 11 3 0.272727272727273 0.0256410256410256
GO:BP GO:0044403 biological process involved in symbiotic interaction 0.00052965160929157 1001 5 4 0.8 0.003996003996004
GO:BP GO:0050851 antigen receptor-mediated signaling pathway 0.000531007331363514 323 37 6 0.162162162162162 0.0185758513931889
GO:BP GO:0032102 negative regulation of response to external stimulus 0.00053790649092539 406 30 6 0.2 0.0147783251231527
GO:BP GO:0009967 positive regulation of signal transduction 0.000566642733971952 1598 37 12 0.324324324324324 0.00750938673341677
GO:BP GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 0.000566846096635724 363 21 5 0.238095238095238 0.0137741046831956
GO:BP GO:0048585 negative regulation of response to stimulus 0.000601331766892499 1733 25 10 0.4 0.00577034045008656
GO:BP GO:0030593 neutrophil chemotaxis 0.000621084980991577 103 37 4 0.108108108108108 0.0388349514563107
GO:BP GO:0050670 regulation of lymphocyte proliferation 0.000621084980991577 230 33 5 0.151515151515152 0.0217391304347826
GO:BP GO:0032944 regulation of mononuclear cell proliferation 0.000639962643494745 232 33 5 0.151515151515152 0.021551724137931
GO:BP GO:0050777 negative regulation of immune response 0.000648468268508138 157 25 4 0.16 0.0254777070063694
GO:BP GO:0030225 macrophage differentiation 0.000790322052625313 48 31 3 0.0967741935483871 0.0625
GO:BP GO:0097028 dendritic cell differentiation 0.000790322052625313 48 31 3 0.0967741935483871 0.0625
GO:BP GO:0097529 myeloid leukocyte migration 0.000858057665239584 221 37 5 0.135135135135135 0.0226244343891403
GO:BP GO:0070663 regulation of leukocyte proliferation 0.000883086308049273 251 33 5 0.151515151515152 0.0199203187250996
GO:BP GO:0007155 cell adhesion 0.00102651775256114 1492 36 11 0.305555555555556 0.00737265415549598
GO:BP GO:0045824 negative regulation of innate immune response 0.00103207459926878 66 25 3 0.12 0.0454545454545455
GO:BP GO:0022610 biological adhesion 0.00105789998583203 1499 36 11 0.305555555555556 0.00733822548365577
GO:BP GO:0051179 localization 0.00109987790266097 6901 18 15 0.833333333333333 0.00217359802927112
GO:BP GO:1990266 neutrophil migration 0.00113124597275789 124 37 4 0.108108108108108 0.032258064516129
GO:BP GO:0031349 positive regulation of defense response 0.00114240521133308 362 25 5 0.2 0.0138121546961326
GO:BP GO:0052548 regulation of endopeptidase activity 0.00114240521133308 437 21 5 0.238095238095238 0.011441647597254
GO:BP GO:0006508 proteolysis 0.00122840839689402 1836 26 10 0.384615384615385 0.00544662309368192
GO:BP GO:0010647 positive regulation of cell communication 0.00129101089711405 1777 37 12 0.324324324324324 0.00675295441755768
GO:BP GO:0023056 positive regulation of signaling 0.00131893459103177 1782 37 12 0.324324324324324 0.00673400673400673
GO:BP GO:0009966 regulation of signal transduction 0.00137689883544834 3165 26 13 0.5 0.00410742496050553
GO:BP GO:0030154 cell differentiation 0.00142209980236129 4350 33 18 0.545454545454545 0.00413793103448276
GO:BP GO:0007166 cell surface receptor signaling pathway 0.00142209980236129 3210 39 17 0.435897435897436 0.00529595015576324
GO:BP GO:0052547 regulation of peptidase activity 0.00147026734257635 467 21 5 0.238095238095238 0.0107066381156317
GO:BP GO:0032103 positive regulation of response to external stimulus 0.00149682627434969 513 30 6 0.2 0.0116959064327485
GO:BP GO:0007165 signal transduction 0.00156470415616812 6309 27 19 0.703703703703704 0.00301157077191314
GO:BP GO:0046651 lymphocyte proliferation 0.00156470415616812 294 33 5 0.151515151515152 0.0170068027210884
GO:BP GO:0032943 mononuclear cell proliferation 0.00162355744677857 297 33 5 0.151515151515152 0.0168350168350168
GO:BP GO:0048869 cellular developmental process 0.00170139106053964 4428 33 18 0.545454545454545 0.0040650406504065
GO:BP GO:0045807 positive regulation of endocytosis 0.00179213399472045 101 21 3 0.142857142857143 0.0297029702970297
GO:BP GO:0048878 chemical homeostasis 0.00196038097757447 1229 20 7 0.35 0.00569568755085435
GO:BP GO:0050789 regulation of biological process 0.00200017823108231 12091 33 31 0.939393939393939 0.00256389049706393
GO:BP GO:0071456 cellular response to hypoxia 0.00205464754775391 212 11 3 0.272727272727273 0.0141509433962264
GO:BP GO:0051716 cellular response to stimulus 0.0020697051860003 7781 27 21 0.777777777777778 0.00269888189178769
GO:BP GO:0036294 cellular response to decreased oxygen levels 0.00230708913374276 222 11 3 0.272727272727273 0.0135135135135135
GO:BP GO:0048259 regulation of receptor-mediated endocytosis 0.0023212582336541 112 21 3 0.142857142857143 0.0267857142857143
GO:BP GO:0070661 leukocyte proliferation 0.0023212582336541 325 33 5 0.151515151515152 0.0153846153846154
GO:BP GO:0048247 lymphocyte chemotaxis 0.00233623719458807 63 37 3 0.0810810810810811 0.0476190476190476
GO:BP GO:0016477 cell migration 0.00254473157324031 1649 37 11 0.297297297297297 0.00667070952092177
GO:BP GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 0.0026400498158931 95 26 3 0.115384615384615 0.0315789473684211
GO:BP GO:0071453 cellular response to oxygen levels 0.00275283397614831 240 11 3 0.272727272727273 0.0125
GO:BP GO:0002833 positive regulation of response to biotic stimulus 0.00278895198391568 250 25 4 0.16 0.016
GO:BP GO:0050727 regulation of inflammatory response 0.00287026228164035 381 30 5 0.166666666666667 0.0131233595800525
GO:BP GO:0002757 immune response-activating signal transduction 0.0028822319546269 477 37 6 0.162162162162162 0.0125786163522013
GO:BP GO:0002429 immune response-activating cell surface receptor signaling pathway 0.0028822319546269 477 37 6 0.162162162162162 0.0125786163522013
GO:BP GO:0042110 T cell activation 0.00325980572606838 489 37 6 0.162162162162162 0.0122699386503067
GO:BP GO:1902105 regulation of leukocyte differentiation 0.00330725964413015 288 23 4 0.173913043478261 0.0138888888888889
GO:BP GO:0010646 regulation of cell communication 0.00355814444607681 3543 26 13 0.5 0.00366920688681908
GO:BP GO:0002761 regulation of myeloid leukocyte differentiation 0.0036202452300382 123 23 3 0.130434782608696 0.024390243902439
GO:BP GO:0006898 receptor-mediated endocytosis 0.00379856186892399 333 21 4 0.19047619047619 0.012012012012012
GO:BP GO:0023051 regulation of signaling 0.00379856186892399 3578 26 13 0.5 0.00363331470095025
GO:BP GO:0002768 immune response-regulating cell surface receptor signaling pathway 0.00392810298275705 512 37 6 0.162162162162162 0.01171875
GO:BP GO:0010950 positive regulation of endopeptidase activity 0.00393244203320935 187 16 3 0.1875 0.0160427807486631
GO:BP GO:0023052 signaling 0.00395847907755674 6810 27 19 0.703703703703704 0.00279001468428781
GO:BP GO:0002764 immune response-regulating signaling pathway 0.0040000763020278 515 37 6 0.162162162162162 0.0116504854368932
GO:BP GO:0048863 stem cell differentiation 0.00403998347236386 258 12 3 0.25 0.0116279069767442
GO:BP GO:0007154 cell communication 0.00407204054826066 6829 27 19 0.703703703703704 0.00278225215990628
GO:BP GO:0071674 mononuclear cell migration 0.00420827945756368 191 37 4 0.108108108108108 0.0209424083769634
GO:BP GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II 0.00445166265182335 96 32 3 0.09375 0.03125
GO:BP GO:0043269 regulation of ion transport 0.00452153604440521 1379 21 7 0.333333333333333 0.0050761421319797
GO:BP GO:0051649 establishment of localization in cell 0.00452153604440521 2813 25 11 0.44 0.00391041592605759
GO:BP GO:0010952 positive regulation of peptidase activity 0.00485423762805961 205 16 3 0.1875 0.0146341463414634
GO:BP GO:0002495 antigen processing and presentation of peptide antigen via MHC class II 0.00485478954005731 100 32 3 0.09375 0.03
GO:BP GO:0045595 regulation of cell differentiation 0.00493802712574569 1679 23 8 0.347826086956522 0.00476474091721263
GO:BP GO:0048870 cell motility 0.0050969344842862 1828 37 11 0.297297297297297 0.00601750547045952
GO:BP GO:0051674 localization of cell 0.0050969344842862 1828 37 11 0.297297297297297 0.00601750547045952
GO:BP GO:0048518 positive regulation of biological process 0.0051489696248018 6363 33 21 0.636363636363636 0.0033003300330033
GO:BP GO:0019730 antimicrobial humoral response 0.00520439197992491 145 23 3 0.130434782608696 0.0206896551724138
GO:BP GO:0010604 positive regulation of macromolecule metabolic process 0.00563681101960224 3483 31 14 0.451612903225806 0.00401952339936836
GO:BP GO:0043687 post-translational protein modification 0.00563681101960224 362 22 4 0.181818181818182 0.0110497237569061
GO:BP GO:0048523 negative regulation of cellular process 0.00563681101960224 5139 8 7 0.875 0.00136213271064409
GO:BP GO:0016192 vesicle-mediated transport 0.00563681101960224 2180 23 9 0.391304347826087 0.00412844036697248
GO:BP GO:0030098 lymphocyte differentiation 0.00597305810207157 376 37 5 0.135135135135135 0.0132978723404255
GO:BP GO:0006810 transport 0.00606349718912072 5224 18 12 0.666666666666667 0.00229709035222052
GO:BP GO:0006954 inflammatory response 0.00611109341022294 794 37 7 0.189189189189189 0.00881612090680101
GO:BP GO:0002286 T cell activation involved in immune response 0.00669583458624596 112 33 3 0.0909090909090909 0.0267857142857143
GO:BP GO:0065007 biological regulation 0.00681097492834722 12809 33 31 0.939393939393939 0.00242017331563744
GO:BP GO:0001666 response to hypoxia 0.00720755836421981 367 11 3 0.272727272727273 0.00817438692098093
GO:BP GO:0050790 regulation of catalytic activity 0.00737165687561976 2545 21 9 0.428571428571429 0.00353634577603143
GO:BP GO:0051234 establishment of localization 0.00741523757349929 5372 18 12 0.666666666666667 0.00223380491437081
GO:BP GO:0009628 response to abiotic stimulus 0.00753486435701281 1261 13 5 0.384615384615385 0.00396510705789056
GO:BP GO:0032502 developmental process 0.00771358615001802 6628 23 16 0.695652173913043 0.0024140012070006
GO:BP GO:0036293 response to decreased oxygen levels 0.00778808699839607 382 11 3 0.272727272727273 0.00785340314136126
GO:BP GO:0030162 regulation of proteolysis 0.00814966713948797 752 21 5 0.238095238095238 0.00664893617021277
GO:BP GO:0098609 cell-cell adhesion 0.00821747654089755 894 18 5 0.277777777777778 0.00559284116331096
GO:BP GO:0065009 regulation of molecular function 0.00910551866158972 3221 21 10 0.476190476190476 0.00310462589257994
GO:BP GO:0070482 response to oxygen levels 0.00913304275227401 408 11 3 0.272727272727273 0.00735294117647059
GO:BP GO:0050794 regulation of cellular process 0.00915517051704269 11473 33 29 0.878787878787879 0.00252767366861327
GO:BP GO:0072676 lymphocyte migration 0.00944341174009764 117 37 3 0.0810810810810811 0.0256410256410256
GO:BP GO:0030155 regulation of cell adhesion 0.00944341174009764 748 32 6 0.1875 0.00802139037433155
GO:BP GO:0030100 regulation of endocytosis 0.00957245978080968 212 21 3 0.142857142857143 0.0141509433962264
GO:BP GO:0040011 locomotion 0.00960339333302297 2028 37 11 0.297297297297297 0.00542406311637081
GO:BP GO:0030217 T cell differentiation 0.00988008232492328 260 37 4 0.108108108108108 0.0153846153846154
GO:BP GO:0048519 negative regulation of biological process 0.00988008232492328 5757 8 7 0.875 0.00121591106479069
GO:BP GO:0048522 positive regulation of cellular process 0.00988008232492328 5757 33 19 0.575757575757576 0.0033003300330033
GO:BP GO:0006935 chemotaxis 0.00988008232492328 653 37 6 0.162162162162162 0.00918836140888208
GO:BP GO:0048872 homeostasis of number of cells 0.00988008232492328 261 37 4 0.108108108108108 0.0153256704980843
GO:BP GO:0042330 taxis 0.00997776759318632 656 37 6 0.162162162162162 0.00914634146341463
GO:BP GO:0051240 positive regulation of multicellular organismal process 0.0100026019277861 1455 30 8 0.266666666666667 0.00549828178694158
GO:BP GO:0010628 positive regulation of gene expression 0.0100026019277861 1160 37 8 0.216216216216216 0.00689655172413793
GO:BP GO:0065008 regulation of biological quality 0.0100413803237158 4131 23 12 0.521739130434783 0.00290486564996369
GO:BP GO:0009893 positive regulation of metabolic process 0.0101571806977083 3783 31 14 0.451612903225806 0.00370076658736453
GO:BP GO:0050671 positive regulation of lymphocyte proliferation 0.0103543737558095 141 33 3 0.0909090909090909 0.0212765957446809
GO:BP GO:0032946 positive regulation of mononuclear cell proliferation 0.0105044151173769 142 33 3 0.0909090909090909 0.0211267605633803
GO:BP GO:0050793 regulation of developmental process 0.0109066332914823 2605 39 13 0.333333333333333 0.00499040307101727
GO:BP GO:0042127 regulation of cell population proliferation 0.0109263980972512 1774 37 10 0.27027027027027 0.0056369785794814
GO:BP GO:0051249 regulation of lymphocyte activation 0.0109263980972512 518 33 5 0.151515151515152 0.00965250965250965
GO:BP GO:0042981 regulation of apoptotic process 0.0111315087954865 1549 23 7 0.304347826086957 0.00451904454486766
GO:BP GO:0043067 regulation of programmed cell death 0.0123907016056595 1582 23 7 0.304347826086957 0.00442477876106195
GO:BP GO:0070665 positive regulation of leukocyte proliferation 0.0126962190923976 155 33 3 0.0909090909090909 0.0193548387096774
GO:BP GO:0050728 negative regulation of inflammatory response 0.0126962190923976 171 30 3 0.1 0.0175438596491228
GO:BP GO:0046631 alpha-beta T cell activation 0.0126962190923976 155 33 3 0.0909090909090909 0.0193548387096774
GO:BP GO:0006812 cation transport 0.0131289416465159 1197 10 4 0.4 0.00334168755221387
GO:BP GO:0055065 metal ion homeostasis 0.0133410365671388 667 17 4 0.235294117647059 0.00599700149925037
GO:BP GO:0032879 regulation of localization 0.013379552899006 2872 21 9 0.428571428571429 0.00313370473537604
GO:BP GO:2000026 regulation of multicellular organismal development 0.0136366919466943 1447 39 9 0.230769230769231 0.00621976503109883
GO:BP GO:1902531 regulation of intracellular signal transduction 0.0136412821497054 1842 37 10 0.27027027027027 0.00542888165038002
GO:BP GO:0002244 hematopoietic progenitor cell differentiation 0.0136412821497054 172 31 3 0.0967741935483871 0.0174418604651163
GO:BP GO:0051336 regulation of hydrolase activity 0.0136412821497054 1321 21 6 0.285714285714286 0.00454201362604088
GO:BP GO:0045089 positive regulation of innate immune response 0.0138616403137196 216 25 3 0.12 0.0138888888888889
GO:BP GO:0051049 regulation of transport 0.0140040560363081 1809 21 7 0.333333333333333 0.00386954118297402
GO:BP GO:0032501 multicellular organismal process 0.0145992662615218 7946 23 17 0.739130434782609 0.00213944122829096
GO:BP GO:0002262 myeloid cell homeostasis 0.0150050941458511 151 37 3 0.0810810810810811 0.0198675496688742
GO:BP GO:0042129 regulation of T cell proliferation 0.0150372970204531 176 32 3 0.09375 0.0170454545454545
GO:BP GO:0021700 developmental maturation 0.015449343239001 275 21 3 0.142857142857143 0.0109090909090909
GO:BP GO:0042592 homeostatic process 0.0160443906031667 1981 20 7 0.35 0.00353356890459364
GO:BP GO:0007159 leukocyte cell-cell adhesion 0.0165264363403434 375 32 4 0.125 0.0106666666666667
GO:BP GO:0048856 anatomical structure development 0.0165264363403434 6106 33 19 0.575757575757576 0.00311169341631182
GO:BP GO:0045862 positive regulation of proteolysis 0.0165264363403434 378 16 3 0.1875 0.00793650793650794
GO:BP GO:0051251 positive regulation of lymphocyte activation 0.0166048460327527 365 33 4 0.121212121212121 0.010958904109589
GO:BP GO:0010941 regulation of cell death 0.0169394129680574 1720 23 7 0.304347826086957 0.00406976744186047
GO:BP GO:1902533 positive regulation of intracellular signal transduction 0.0173804804095255 1037 37 7 0.189189189189189 0.00675024108003857
GO:BP GO:0055080 cation homeostasis 0.0174216153698634 750 17 4 0.235294117647059 0.00533333333333333
GO:BP GO:0051641 cellular localization 0.0175441928162529 3541 25 11 0.44 0.00310646709968935
GO:BP GO:0002694 regulation of leukocyte activation 0.0175441928162529 610 33 5 0.151515151515152 0.00819672131147541
GO:BP GO:0008152 metabolic process 0.0175526892008695 11827 23 21 0.91304347826087 0.00177559820749133
GO:BP GO:0098771 inorganic ion homeostasis 0.017714889846037 761 17 4 0.235294117647059 0.00525624178712221
GO:BP GO:0002285 lymphocyte activation involved in immune response 0.0181843505052722 190 33 3 0.0909090909090909 0.0157894736842105
GO:BP GO:0019222 regulation of metabolic process 0.0182409838464207 7148 18 13 0.722222222222222 0.00181869054280918
GO:BP GO:0006928 movement of cell or subcellular component 0.0185863027007305 2311 37 11 0.297297297297297 0.00475984422327997
GO:BP GO:0051239 regulation of multicellular organismal process 0.0189804621010539 2861 39 13 0.333333333333333 0.00454386578119539
GO:BP GO:0043066 negative regulation of apoptotic process 0.0189804621010539 921 23 5 0.217391304347826 0.00542888165038002
GO:BP GO:0032270 positive regulation of cellular protein metabolic process 0.0192164876817344 1477 21 6 0.285714285714286 0.004062288422478
GO:BP GO:0042098 T cell proliferation 0.0194304429713582 205 32 3 0.09375 0.0146341463414634
GO:BP GO:0031325 positive regulation of cellular metabolic process 0.0194304429713582 3274 31 12 0.387096774193548 0.00366524129505192
GO:BP GO:0044093 positive regulation of molecular function 0.0198108963487439 1771 18 6 0.333333333333333 0.00338791643139469
GO:BP GO:0043069 negative regulation of programmed cell death 0.0199114030378229 943 23 5 0.217391304347826 0.00530222693531283
GO:BP GO:0050801 ion homeostasis 0.0200751957427526 808 17 4 0.235294117647059 0.00495049504950495
GO:BP GO:0019538 protein metabolic process 0.0206623564517899 5808 26 15 0.576923076923077 0.00258264462809917
GO:BP GO:0000165 MAPK cascade 0.0208299074507458 935 33 6 0.181818181818182 0.00641711229946524
GO:BP GO:0050865 regulation of cell activation 0.0208477646056284 655 33 5 0.151515151515152 0.00763358778625954
GO:BP GO:0002696 positive regulation of leukocyte activation 0.0212760254864144 412 33 4 0.121212121212121 0.00970873786407767
GO:BP GO:0050870 positive regulation of T cell activation 0.0217600509221065 219 32 3 0.09375 0.0136986301369863
GO:BP GO:0008283 cell population proliferation 0.0218508780616198 2054 37 10 0.27027027027027 0.00486854917234664
GO:BP GO:0009968 negative regulation of signal transduction 0.0222164167258029 1364 11 4 0.363636363636364 0.00293255131964809
GO:BP GO:0045785 positive regulation of cell adhesion 0.0225640955953028 437 32 4 0.125 0.0091533180778032
GO:BP GO:0050867 positive regulation of cell activation 0.0225844437069491 424 33 4 0.121212121212121 0.00943396226415094
GO:BP GO:0035556 intracellular signal transduction 0.0225989015325617 2772 37 12 0.324324324324324 0.00432900432900433
GO:BP GO:0051247 positive regulation of protein metabolic process 0.0226800456436145 1564 21 6 0.285714285714286 0.00383631713554987
GO:BP GO:0034612 response to tumor necrosis factor 0.0227042836890896 331 22 3 0.136363636363636 0.00906344410876133
GO:BP GO:0022407 regulation of cell-cell adhesion 0.0234741705056659 445 32 4 0.125 0.00898876404494382
GO:BP GO:0060255 regulation of macromolecule metabolic process 0.0237063360082648 6603 12 9 0.75 0.00136301681054066
GO:BP GO:0006897 endocytosis 0.0238042055792543 696 21 4 0.19047619047619 0.00574712643678161
GO:BP GO:0035295 tube development 0.0238042055792543 1146 37 7 0.189189189189189 0.00610820244328098
GO:BP GO:0016567 protein ubiquitination 0.0242819386493139 892 26 5 0.192307692307692 0.00560538116591928
GO:BP GO:0007162 negative regulation of cell adhesion 0.0248079268822259 304 25 3 0.12 0.00986842105263158
GO:BP GO:0055082 cellular chemical homeostasis 0.0250380208160378 841 18 4 0.222222222222222 0.00475624256837099
GO:BP GO:0060548 negative regulation of cell death 0.0257993931960343 1038 23 5 0.217391304347826 0.00481695568400771
GO:BP GO:1903039 positive regulation of leukocyte cell-cell adhesion 0.0257993931960343 241 32 3 0.09375 0.012448132780083
GO:BP GO:0010648 negative regulation of cell communication 0.0260955060074424 1468 11 4 0.363636363636364 0.00272479564032698
GO:BP GO:0023057 negative regulation of signaling 0.0262388730103694 1471 11 4 0.363636363636364 0.00271923861318831
GO:BP GO:0048731 system development 0.027332265387533 5052 33 16 0.484848484848485 0.00316706254948535
GO:BP GO:0006915 apoptotic process 0.0276708441649711 1990 23 7 0.304347826086957 0.00351758793969849
GO:BP GO:0071704 organic substance metabolic process 0.028300628369233 11326 23 20 0.869565217391304 0.00176584849019954
GO:BP GO:0002237 response to molecule of bacterial origin 0.0292245586808063 361 23 3 0.130434782608696 0.00831024930747922
GO:BP GO:0051173 positive regulation of nitrogen compound metabolic process 0.0292245586808063 3083 31 11 0.354838709677419 0.00356795329224781
GO:BP GO:2001233 regulation of apoptotic signaling pathway 0.0293556305420681 363 23 3 0.130434782608696 0.00826446280991736
GO:BP GO:0072503 cellular divalent inorganic cation homeostasis 0.0293556305420681 497 17 3 0.176470588235294 0.00603621730382294
GO:BP GO:0043085 positive regulation of catalytic activity 0.0294179373345718 1418 18 5 0.277777777777778 0.00352609308885755
GO:BP GO:0007275 multicellular organism development 0.030205952613825 5613 33 17 0.515151515151515 0.00302868341350436
GO:BP GO:0032446 protein modification by small protein conjugation 0.0308388403499986 973 26 5 0.192307692307692 0.00513874614594039
GO:BP GO:0006464 cellular protein modification process 0.0308388403499986 4041 31 13 0.419354838709677 0.00321702548874041
GO:BP GO:0036211 protein modification process 0.0308388403499986 4041 31 13 0.419354838709677 0.00321702548874041
GO:BP GO:0030163 protein catabolic process 0.0308928482633939 974 26 5 0.192307692307692 0.00513347022587269
GO:BP GO:0072507 divalent inorganic cation homeostasis 0.0311640893399107 516 17 3 0.176470588235294 0.00581395348837209
GO:BP GO:0010468 regulation of gene expression 0.0315426516074428 5196 25 13 0.52 0.00250192455735181
GO:BP GO:0006511 ubiquitin-dependent protein catabolic process 0.0344373912692546 655 26 4 0.153846153846154 0.00610687022900763
GO:BP GO:0022409 positive regulation of cell-cell adhesion 0.0345624812516918 284 32 3 0.09375 0.0105633802816901
GO:BP GO:0008284 positive regulation of cell population proliferation 0.0348302213668594 982 37 6 0.162162162162162 0.00610997963340122
GO:BP GO:0019941 modification-dependent protein catabolic process 0.0349353146308668 662 26 4 0.153846153846154 0.00604229607250755
GO:BP GO:0012501 programmed cell death 0.0352027676287274 2143 23 7 0.304347826086957 0.00326644890340644
GO:BP GO:0048514 blood vessel morphogenesis 0.0352027676287274 711 37 5 0.135135135135135 0.0070323488045007
GO:BP GO:0019725 cellular homeostasis 0.0352027676287274 981 18 4 0.222222222222222 0.00407747196738022
GO:BP GO:0043170 macromolecule metabolic process 0.0352027676287274 9796 26 20 0.769230769230769 0.00204164965291956
GO:BP GO:0043632 modification-dependent macromolecule catabolic process 0.0358647444314779 673 26 4 0.153846153846154 0.00594353640416048
GO:BP GO:0031667 response to nutrient levels 0.0368512559177302 482 20 3 0.15 0.00622406639004149
GO:BP GO:0043410 positive regulation of MAPK cascade 0.0384509889380951 539 33 4 0.121212121212121 0.00742115027829314
GO:BP GO:0051346 negative regulation of hydrolase activity 0.0386613834509002 470 21 3 0.142857142857143 0.00638297872340425
GO:BP GO:1901990 regulation of mitotic cell cycle phase transition 0.0389401205387061 451 22 3 0.136363636363636 0.00665188470066519
GO:BP GO:0006875 cellular metal ion homeostasis 0.0390827638792935 593 17 3 0.176470588235294 0.00505902192242833
GO:BP GO:0048513 animal organ development 0.0395395919509919 3672 39 14 0.358974358974359 0.00381263616557734
GO:BP GO:0043412 macromolecule modification 0.0399888803790163 4257 31 13 0.419354838709677 0.00305379375146817
GO:BP GO:0009991 response to extracellular stimulus 0.0405499307774021 512 20 3 0.15 0.005859375
GO:BP GO:0022603 regulation of anatomical structure morphogenesis 0.0405898800756786 1042 37 6 0.162162162162162 0.00575815738963532
GO:BP GO:0008219 cell death 0.0444623074241664 2292 23 7 0.304347826086957 0.00305410122164049
GO:BP GO:0051050 positive regulation of transport 0.0444623074241664 923 21 4 0.19047619047619 0.00433369447453954
GO:BP GO:0032268 regulation of cellular protein metabolic process 0.0450165287494348 2541 21 7 0.333333333333333 0.00275482093663912
GO:BP GO:1901987 regulation of cell cycle phase transition 0.045772950217503 493 22 3 0.136363636363636 0.00608519269776876
GO:BP GO:0051603 proteolysis involved in cellular protein catabolic process 0.0459068734650526 750 26 4 0.153846153846154 0.00533333333333333
GO:BP GO:0050863 regulation of T cell activation 0.0461429523104083 337 32 3 0.09375 0.00890207715133531
GO:BP GO:1903037 regulation of leukocyte cell-cell adhesion 0.0464223574630266 338 32 3 0.09375 0.00887573964497041
GO:BP GO:0001568 blood vessel development 0.046707361958761 792 37 5 0.135135135135135 0.00631313131313131
GO:BP GO:0060627 regulation of vesicle-mediated transport 0.0491532708299508 536 21 3 0.142857142857143 0.00559701492537313
GO:CC GO:0042611 MHC protein complex 4.00492804702259e-15 24 32 8 0.25 0.333333333333333
GO:CC GO:0042612 MHC class I protein complex 7.08625171509327e-12 8 5 4 0.8 0.5
GO:CC GO:0043230 extracellular organelle 2.30256248484982e-11 2263 23 18 0.782608695652174 0.00795404330534688
GO:CC GO:0070062 extracellular exosome 2.30256248484982e-11 2176 21 17 0.80952380952381 0.0078125
GO:CC GO:1903561 extracellular vesicle 3.07141303007132e-11 2261 21 17 0.80952380952381 0.0075187969924812
GO:CC GO:0012507 ER to Golgi transport vesicle membrane 5.61763411924011e-09 57 27 6 0.222222222222222 0.105263157894737
GO:CC GO:0098553 lumenal side of endoplasmic reticulum membrane 5.61763411924011e-09 25 27 5 0.185185185185185 0.2
GO:CC GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane 5.61763411924011e-09 25 27 5 0.185185185185185 0.2
GO:CC GO:0005615 extracellular space 1.85125816824851e-08 3594 27 20 0.740740740740741 0.00556483027267668
GO:CC GO:0098576 lumenal side of membrane 1.99206646934636e-08 33 27 5 0.185185185185185 0.151515151515152
GO:CC GO:0030670 phagocytic vesicle membrane 2.35464639341608e-08 76 5 4 0.8 0.0526315789473684
GO:CC GO:0055038 recycling endosome membrane 3.24501605523221e-08 84 5 4 0.8 0.0476190476190476
GO:CC GO:0031982 vesicle 3.87919828356104e-08 4055 24 19 0.791666666666667 0.00468557336621455
GO:CC GO:0030134 COPII-coated ER to Golgi transport vesicle 3.87919828356104e-08 90 5 4 0.8 0.0444444444444444
GO:CC GO:0009986 cell surface 1.63328168286301e-07 899 21 10 0.476190476190476 0.0111234705228031
GO:CC GO:0042613 MHC class II protein complex 1.63328168286301e-07 16 32 4 0.125 0.25
GO:CC GO:0045335 phagocytic vesicle 1.66347075083882e-07 137 5 4 0.8 0.0291970802919708
GO:CC GO:0031901 early endosome membrane 2.57874750742327e-07 159 5 4 0.8 0.0251572327044025
GO:CC GO:0030666 endocytic vesicle membrane 2.57874750742327e-07 159 5 4 0.8 0.0251572327044025
GO:CC GO:0030176 integral component of endoplasmic reticulum membrane 2.57874750742327e-07 158 5 4 0.8 0.0253164556962025
GO:CC GO:0031227 intrinsic component of endoplasmic reticulum membrane 2.92169838907064e-07 166 5 4 0.8 0.0240963855421687
GO:CC GO:0030662 coated vesicle membrane 3.61142576640984e-07 177 5 4 0.8 0.0225988700564972
GO:CC GO:0055037 recycling endosome 4.40333056855156e-07 188 5 4 0.8 0.0212765957446809
GO:CC GO:0005576 extracellular region 5.14041066769126e-07 4567 19 16 0.842105263157895 0.00350339391285308
GO:CC GO:0030658 transport vesicle membrane 6.20217607443755e-07 209 5 4 0.8 0.0191387559808612
GO:CC GO:0010008 endosome membrane 8.56240107209727e-07 505 32 9 0.28125 0.0178217821782178
GO:CC GO:0030139 endocytic vesicle 1.44756370448407e-06 306 27 7 0.259259259259259 0.0228758169934641
GO:CC GO:0098552 side of membrane 1.65967429172812e-06 619 6 5 0.833333333333333 0.00807754442649435
GO:CC GO:0030135 coated vesicle 2.13238591903993e-06 295 5 4 0.8 0.0135593220338983
GO:CC GO:0005769 early endosome 5.56201394320527e-06 378 5 4 0.8 0.0105820105820106
GO:CC GO:0031301 integral component of organelle membrane 5.61404669228389e-06 382 5 4 0.8 0.0104712041884817
GO:CC GO:0031300 intrinsic component of organelle membrane 7.06058445556143e-06 413 5 4 0.8 0.00968523002421308
GO:CC GO:0030133 transport vesicle 7.06058445556143e-06 414 5 4 0.8 0.00966183574879227
GO:CC GO:0030141 secretory granule 2.59282793010304e-05 851 23 8 0.347826086956522 0.00940070505287897
GO:CC GO:0097708 intracellular vesicle 4.817791050144e-05 2428 27 13 0.481481481481481 0.00535420098846788
GO:CC GO:0031410 cytoplasmic vesicle 4.817791050144e-05 2424 27 13 0.481481481481481 0.00536303630363036
GO:CC GO:0098797 plasma membrane protein complex 4.83045870564573e-05 694 5 4 0.8 0.00576368876080692
GO:CC GO:0000139 Golgi membrane 7.15636925267207e-05 771 5 4 0.8 0.00518806744487678
GO:CC GO:0030659 cytoplasmic vesicle membrane 7.27418676879032e-05 779 5 4 0.8 0.00513478818998716
GO:CC GO:0012506 vesicle membrane 7.89258198876992e-05 800 5 4 0.8 0.005
GO:CC GO:0099503 secretory vesicle 8.2190382763328e-05 1020 23 8 0.347826086956522 0.00784313725490196
GO:CC GO:0098791 Golgi apparatus subcompartment 0.000112493513549683 885 5 4 0.8 0.00451977401129944
GO:CC GO:0005768 endosome 0.00012412726201546 987 32 9 0.28125 0.00911854103343465
GO:CC GO:0098796 membrane protein complex 0.000135738207310381 1322 37 11 0.297297297297297 0.00832072617246596
GO:CC GO:0034774 secretory granule lumen 0.000154777323202592 320 23 5 0.217391304347826 0.015625
GO:CC GO:0098827 endoplasmic reticulum subcompartment 0.000154777323202592 1122 8 5 0.625 0.00445632798573975
GO:CC GO:0005789 endoplasmic reticulum membrane 0.000154777323202592 1117 8 5 0.625 0.0044762757385855
GO:CC GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network 0.000159360966802422 1139 8 5 0.625 0.00438981562774363
GO:CC GO:0060205 cytoplasmic vesicle lumen 0.000159360966802422 324 23 5 0.217391304347826 0.0154320987654321
GO:CC GO:0031983 vesicle lumen 0.000159372413189568 326 23 5 0.217391304347826 0.0153374233128834
GO:CC GO:0071944 cell periphery 0.000212275002464978 6169 39 25 0.641025641025641 0.00405252066785541
GO:CC GO:0043227 membrane-bounded organelle 0.000243318622962363 12858 25 25 1 0.00194431482345621
GO:CC GO:0005887 integral component of plasma membrane 0.000258952137907284 1645 10 6 0.6 0.00364741641337386
GO:CC GO:0031226 intrinsic component of plasma membrane 0.000333519344629519 1726 10 6 0.6 0.00347624565469293
GO:CC GO:0031902 late endosome membrane 0.000333519344629519 140 32 4 0.125 0.0285714285714286
GO:CC GO:0005783 endoplasmic reticulum 0.000338568201925801 1982 29 11 0.379310344827586 0.00554994954591322
GO:CC GO:0140534 endoplasmic reticulum protein-containing complex 0.000468229666350407 128 15 3 0.2 0.0234375
GO:CC GO:0000323 lytic vacuole 0.000523989499929379 712 32 7 0.21875 0.0098314606741573
GO:CC GO:0005764 lysosome 0.000523989499929379 712 32 7 0.21875 0.0098314606741573
GO:CC GO:0005794 Golgi apparatus 0.000836042440158488 1623 5 4 0.8 0.00246457178065311
GO:CC GO:0031984 organelle subcompartment 0.00102966181749589 1773 8 5 0.625 0.00282007896221094
GO:CC GO:0005773 vacuole 0.00107054269969384 810 32 7 0.21875 0.00864197530864197
GO:CC GO:0012505 endomembrane system 0.00119996258798369 4640 29 16 0.551724137931034 0.00344827586206897
GO:CC GO:0098852 lytic vacuole membrane 0.00127754336615142 383 32 5 0.15625 0.0130548302872063
GO:CC GO:0005765 lysosomal membrane 0.00127754336615142 383 32 5 0.15625 0.0130548302872063
GO:CC GO:0030667 secretory granule membrane 0.00133250846001271 303 10 3 0.3 0.0099009900990099
GO:CC GO:0005886 plasma membrane 0.00150725483901993 5681 39 22 0.564102564102564 0.00387255764830136
GO:CC GO:0043226 organelle 0.00150725483901993 14008 25 25 1 0.0017846944603084
GO:CC GO:0042582 azurophil granule 0.00176404170070088 154 21 3 0.142857142857143 0.0194805194805195
GO:CC GO:0005766 primary lysosome 0.00176404170070088 154 21 3 0.142857142857143 0.0194805194805195
GO:CC GO:0031090 organelle membrane 0.00176404170070088 3612 10 7 0.7 0.00193798449612403
GO:CC GO:0098588 bounding membrane of organelle 0.0020589619490444 2158 5 4 0.8 0.00185356811862836
GO:CC GO:0005774 vacuolar membrane 0.00212147980543746 441 32 5 0.15625 0.0113378684807256
GO:CC GO:0005770 late endosome 0.00297010979293577 275 32 4 0.125 0.0145454545454545
GO:CC GO:0031224 intrinsic component of membrane 0.0030244164656195 5868 35 20 0.571428571428571 0.00340831629175187
GO:CC GO:0016021 integral component of membrane 0.00409263855261691 5711 10 8 0.8 0.00140080546314131
GO:CC GO:0030312 external encapsulating structure 0.00879458052863436 563 36 5 0.138888888888889 0.0088809946714032
GO:CC GO:0031012 extracellular matrix 0.00879458052863436 562 36 5 0.138888888888889 0.00889679715302491
GO:CC GO:0009897 external side of plasma membrane 0.0135657086346703 408 18 3 0.166666666666667 0.00735294117647059
GO:CC GO:0016020 membrane 0.0151220476000337 9838 37 27 0.72972972972973 0.00274446025614962
GO:CC GO:0032991 protein-containing complex 0.0194700129738381 5548 37 18 0.486486486486487 0.00324441240086518
GO:CC GO:0005737 cytoplasm 0.0312215007362155 11911 29 24 0.827586206896552 0.00201494416925531
GO:CC GO:1902494 catalytic complex 0.0398313172855448 1441 15 4 0.266666666666667 0.00277585010409438
GO:MF GO:0046977 TAP binding 7.8119729536674e-08 9 5 3 0.6 0.333333333333333
GO:MF GO:0042605 peptide antigen binding 7.8119729536674e-08 30 27 5 0.185185185185185 0.166666666666667
GO:MF GO:0003823 antigen binding 0.00022162622676789 163 27 5 0.185185185185185 0.0306748466257669
GO:MF GO:0061135 endopeptidase regulator activity 0.00150212950985277 188 21 4 0.19047619047619 0.0212765957446809
GO:MF GO:0042277 peptide binding 0.00150212950985277 314 5 3 0.6 0.00955414012738853
GO:MF GO:0033218 amide binding 0.00219486057319544 389 5 3 0.6 0.0077120822622108
GO:MF GO:0061134 peptidase regulator activity 0.00230544184159597 224 21 4 0.19047619047619 0.0178571428571429
GO:MF GO:0008201 heparin binding 0.0126186906546731 168 23 3 0.130434782608696 0.0178571428571429
GO:MF GO:0030234 enzyme regulator activity 0.0192045307883147 1248 21 6 0.285714285714286 0.00480769230769231
GO:MF GO:0005102 signaling receptor binding 0.0259320476296016 1672 23 7 0.304347826086957 0.0041866028708134
GO:MF GO:0005539 glycosaminoglycan binding 0.0259320476296016 238 23 3 0.130434782608696 0.0126050420168067
GO:MF GO:1901681 sulfur compound binding 0.0289431180151943 264 23 3 0.130434782608696 0.0113636363636364
GO:MF GO:0001664 G protein-coupled receptor binding 0.0355253458329942 292 23 3 0.130434782608696 0.0102739726027397
GO:MF GO:0008047 enzyme activator activity 0.0412216297198969 540 15 3 0.2 0.00555555555555556
GO:MF GO:0004857 enzyme inhibitor activity 0.0412216297198969 385 21 3 0.142857142857143 0.00779220779220779
GO:MF GO:0008289 lipid binding 0.0412216297198969 776 20 4 0.2 0.00515463917525773
GO:MF GO:0044877 protein-containing complex binding 0.0431517230484016 1287 36 7 0.194444444444444 0.00543900543900544
HP HP:0003765 Psoriasiform dermatitis 0.00170196108291716 25 37 5 0.135135135135135 0.2
HP HP:0002524 Cataplexy 0.0179678327573259 12 24 3 0.125 0.25
HP HP:0002024 Malabsorption 0.0311938891269 195 18 6 0.333333333333333 0.0307692307692308
HP HP:0011037 Decreased urine output 0.0348918559554841 21 21 3 0.142857142857143 0.142857142857143
KEGG KEGG:04612 Antigen processing and presentation 9.6943186190873e-12 69 32 10 0.3125 0.144927536231884
KEGG KEGG:05330 Allograft rejection 3.05629445975883e-09 34 32 7 0.21875 0.205882352941176
KEGG KEGG:05332 Graft-versus-host disease 3.86742632831995e-09 37 32 7 0.21875 0.189189189189189
KEGG KEGG:04940 Type I diabetes mellitus 5.20940720880367e-09 40 32 7 0.21875 0.175
KEGG KEGG:05320 Autoimmune thyroid disease 1.87330501637312e-08 49 32 7 0.21875 0.142857142857143
KEGG KEGG:05416 Viral myocarditis 4.13436639375352e-08 56 32 7 0.21875 0.125
KEGG KEGG:05166 Human T-cell leukemia virus 1 infection 4.28812792501159e-08 216 37 11 0.297297297297297 0.0509259259259259
KEGG KEGG:04145 Phagosome 1.46676046351304e-06 147 32 8 0.25 0.054421768707483
KEGG KEGG:05169 Epstein-Barr virus infection 3.32573891829169e-06 198 37 9 0.243243243243243 0.0454545454545455
KEGG KEGG:05150 Staphylococcus aureus infection 1.51482729456325e-05 87 32 6 0.1875 0.0689655172413793
KEGG KEGG:04514 Cell adhesion molecules 1.83945048536115e-05 146 32 7 0.21875 0.0479452054794521
KEGG KEGG:05170 Human immunodeficiency virus 1 infection 2.84361165609171e-05 210 5 4 0.8 0.019047619047619
KEGG KEGG:05163 Human cytomegalovirus infection 3.33890950424092e-05 223 5 4 0.8 0.0179372197309417
KEGG KEGG:05310 Asthma 3.74017142333522e-05 27 32 4 0.125 0.148148148148148
KEGG KEGG:05140 Leishmaniasis 8.60399769029177e-05 72 32 5 0.15625 0.0694444444444444
KEGG KEGG:04672 Intestinal immune network for IgA production 0.000264165981917606 45 32 4 0.125 0.0888888888888889
KEGG KEGG:04650 Natural killer cell mediated cytotoxicity 0.000307951386218837 123 5 3 0.6 0.024390243902439
KEGG KEGG:05168 Herpes simplex virus 1 infection 0.000471701516049522 494 37 10 0.27027027027027 0.0202429149797571
KEGG KEGG:04218 Cellular senescence 0.00056154390028622 156 5 3 0.6 0.0192307692307692
KEGG KEGG:05321 Inflammatory bowel disease 0.000754423863914856 62 32 4 0.125 0.0645161290322581
KEGG KEGG:05167 Kaposi sarcoma-associated herpesvirus infection 0.000958899768166605 193 5 3 0.6 0.0155440414507772
KEGG KEGG:05203 Viral carcinogenesis 0.00104716295816641 202 5 3 0.6 0.0148514851485149
KEGG KEGG:05322 Systemic lupus erythematosus 0.00104716295816641 132 32 5 0.15625 0.0378787878787879
KEGG KEGG:04144 Endocytosis 0.00185354791174344 252 5 3 0.6 0.0119047619047619
KEGG KEGG:05323 Rheumatoid arthritis 0.00234565859489542 88 32 4 0.125 0.0454545454545455
KEGG KEGG:04658 Th1 and Th2 cell differentiation 0.00235497424695798 89 32 4 0.125 0.0449438202247191
KEGG KEGG:04640 Hematopoietic cell lineage 0.00290756809928218 95 32 4 0.125 0.0421052631578947
KEGG KEGG:05152 Tuberculosis 0.00317954885338504 175 32 5 0.15625 0.0285714285714286
KEGG KEGG:05165 Human papillomavirus infection 0.00343351814485815 331 5 3 0.6 0.00906344410876133
KEGG KEGG:04659 Th17 cell differentiation 0.00368551054036309 104 32 4 0.125 0.0384615384615385
KEGG KEGG:05145 Toxoplasmosis 0.00425525603694872 109 32 4 0.125 0.036697247706422
KEGG KEGG:05164 Influenza A 0.00471505876559232 169 37 5 0.135135135135135 0.029585798816568
MIRNA MIRNA:hsa-miR-4524a-3p hsa-miR-4524a-3p 0.0244132225311117 316 4 3 0.75 0.00949367088607595
MIRNA MIRNA:hsa-miR-148a-3p hsa-miR-148a-3p 0.0490193913190849 212 13 3 0.230769230769231 0.0141509433962264
REAC REAC:R-HSA-1236977 Endosomal/Vacuolar pathway 9.19891513199825e-10 11 5 4 0.8 0.363636363636364
REAC REAC:R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 1.17416713103291e-08 25 5 4 0.8 0.16
REAC REAC:R-HSA-1236974 ER-Phagosome pathway 1.17416713103291e-08 83 11 6 0.545454545454545 0.072289156626506
REAC REAC:R-HSA-1236975 Antigen processing-Cross presentation 1.87743464010112e-08 99 11 6 0.545454545454545 0.0606060606060606
REAC REAC:R-HSA-877300 Interferon gamma signaling 1.23379578224904e-06 87 5 4 0.8 0.0459770114942529
REAC REAC:R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 1.98353774408348e-05 181 5 4 0.8 0.0220994475138122
REAC REAC:R-HSA-913531 Interferon Signaling 2.11028884296621e-05 191 5 4 0.8 0.0209424083769634
REAC REAC:R-HSA-983169 Class I MHC mediated antigen processing & presentation 2.56205265161754e-05 370 11 6 0.545454545454545 0.0162162162162162
REAC REAC:R-HSA-168249 Innate Immune System 4.95534267654848e-05 1073 21 11 0.523809523809524 0.0102516309412861
REAC REAC:R-HSA-909733 Interferon alpha/beta signaling 6.66573431303854e-05 66 5 3 0.6 0.0454545454545455
REAC REAC:R-HSA-1280218 Adaptive Immune System 0.000274877342077099 800 37 12 0.324324324324324 0.015
REAC REAC:R-HSA-6798695 Neutrophil degranulation 0.000569972761477732 474 21 7 0.333333333333333 0.0147679324894515
REAC REAC:R-HSA-1280215 Cytokine Signaling in Immune system 0.000720420850148262 842 18 8 0.444444444444444 0.00950118764845606
REAC REAC:R-HSA-168256 Immune System 0.000720420850148262 2139 21 13 0.619047619047619 0.00607760635811127
REAC REAC:R-HSA-202424 Downstream TCR signaling 0.0017649848515143 98 27 4 0.148148148148148 0.0408163265306122
REAC REAC:R-HSA-202403 TCR signaling 0.00364769444637855 120 27 4 0.148148148148148 0.0333333333333333
REAC REAC:R-HSA-162909 Host Interactions of HIV factors 0.00378304147974683 125 11 3 0.272727272727273 0.024
REAC REAC:R-HSA-9020702 Interleukin-1 signaling 0.00755284185284662 101 17 3 0.176470588235294 0.0297029702970297
REAC REAC:R-HSA-1442490 Collagen degradation 0.00853383232990291 64 36 3 0.0833333333333333 0.046875
REAC REAC:R-HSA-446652 Interleukin-1 family signaling 0.00853383232990291 138 17 3 0.176470588235294 0.0217391304347826
REAC REAC:R-HSA-162906 HIV Infection 0.00853383232990291 226 11 3 0.272727272727273 0.0132743362831858
REAC REAC:R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.00912325063496326 94 31 3 0.0967741935483871 0.0319148936170213
REAC REAC:R-HSA-8878171 Transcriptional regulation by RUNX1 0.00915329486981538 200 31 4 0.129032258064516 0.02
REAC REAC:R-HSA-2132295 MHC class II antigen presentation 0.0155471115908581 123 32 3 0.09375 0.024390243902439
REAC REAC:R-HSA-418594 G alpha (i) signalling events 0.0190928301494131 401 33 5 0.151515151515152 0.0124688279301746
REAC REAC:R-HSA-202733 Cell surface interactions at the vascular wall 0.0192083424400916 190 23 3 0.130434782608696 0.0157894736842105
REAC REAC:R-HSA-375276 Peptide ligand-binding receptors 0.0199669754174827 195 23 3 0.130434782608696 0.0153846153846154
REAC REAC:R-HSA-8951664 Neddylation 0.0260305198843459 233 22 3 0.136363636363636 0.0128755364806867
REAC REAC:R-HSA-1474228 Degradation of the extracellular matrix 0.0260305198843459 140 36 3 0.0833333333333333 0.0214285714285714
REAC REAC:R-HSA-392499 Metabolism of proteins 0.0267980150204914 1961 22 9 0.409090909090909 0.00458949515553289
REAC REAC:R-HSA-597592 Post-translational protein modification 0.0353459706096002 1377 22 7 0.318181818181818 0.00508351488743646
REAC REAC:R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 0.0353654518901618 328 33 4 0.121212121212121 0.0121951219512195
TF TF:M07216 Factor: IRF1; motif: NNNYASTTTCACTTTCNNTTT 4.33757100371286e-06 440 7 6 0.857142857142857 0.0136363636363636
TF TF:M08887 Factor: IRF; motif: NNGAAANTGAAANN 9.13933947844612e-06 1267 19 11 0.578947368421053 0.00868192580899763
TF TF:M09957 Factor: IRF-2; motif: NAAANNGAAAGTGAAASTRN 1.74359025141934e-05 272 7 5 0.714285714285714 0.0183823529411765
TF TF:M04788 Factor: IRF-1; motif: STTTCACTTTCNNT 2.17212814854008e-05 536 19 8 0.421052631578947 0.0149253731343284
TF TF:M11664 Factor: IRF-2; motif: NGAAASYGAAAS 5.83146187425561e-05 1651 19 11 0.578947368421053 0.0066626287098728
TF TF:M11686 Factor: IRF-4; motif: NYGAAASYGAAACYN 8.30179474641989e-05 3391 19 14 0.736842105263158 0.00412857564140372
TF TF:M00258 Factor: ISGF-3; motif: CAGTTTCWCTTTYCC 8.36921325185407e-05 823 5 5 1 0.00607533414337789
TF TF:M00699_1 Factor: ICSBP; motif: RAARTGAAACTG; match class: 1 8.36921325185407e-05 47 5 3 0.6 0.0638297872340425
TF TF:M11665 Factor: IRF-2; motif: NGAAASYGAAAS 0.000130873149991646 2396 19 12 0.631578947368421 0.00500834724540901
TF TF:M09956 Factor: IRF-1; motif: NAAANNGAAASTGAAASNRN 0.000171270432432237 317 5 4 0.8 0.0126182965299685
TF TF:M11682 Factor: IRF-8; motif: NYGAAASYGAAACYN 0.00019576923048129 3795 19 14 0.736842105263158 0.00368906455862978
TF TF:M11683 Factor: IRF-8; motif: NCGAAACCGAAACYN 0.000270958918281185 4690 19 15 0.789473684210526 0.00319829424307036
TF TF:M00699 Factor: ICSBP; motif: RAARTGAAACTG 0.000315178007137492 1184 5 5 1 0.00422297297297297
TF TF:M08775 Factor: IRF-2; motif: NAANYGAAASYR 0.00079249197402682 8370 19 18 0.947368421052632 0.0021505376344086
TF TF:M11687 Factor: IRF-4; motif: NCGAAACCGAAACYN 0.00079249197402682 3595 19 13 0.684210526315789 0.00361613351877608
TF TF:M04849_1 Factor: RelA-p65; motif: AAASTCCC; match class: 1 0.000843956565902747 1170 28 10 0.357142857142857 0.00854700854700855
TF TF:M09629 Factor: IRF-1; motif: NAAANNGAAAGTGAAASTRN 0.000866583804043354 336 7 4 0.571428571428571 0.0119047619047619
TF TF:M08775_1 Factor: IRF-2; motif: NAANYGAAASYR; match class: 1 0.000884286790799542 2761 12 9 0.75 0.00325968851865266
TF TF:M00453 Factor: IRF-7; motif: TNSGAAWNCGAAANTNNN 0.000990521711947395 3082 19 12 0.631578947368421 0.00389357560025957
TF TF:M11684 Factor: IRF-8; motif: NYGAAACYGAAACTN 0.00136542967615556 4664 19 14 0.736842105263158 0.00300171526586621
TF TF:M01223_1 Factor: P50:P50; motif: NRGGGAMTNCCCN; match class: 1 0.00136542967615556 161 5 3 0.6 0.0186335403726708
TF TF:M00772 Factor: IRF; motif: RRAANTGAAASYGNV 0.00136542967615556 1029 27 9 0.333333333333333 0.0087463556851312
TF TF:M11685 Factor: IRF-8; motif: NCGAAACYGAAACYN 0.0016322826959274 1617 19 9 0.473684210526316 0.00556586270871985
TF TF:M09733 Factor: STAT2; motif: NRGAAANNGAAACTNA 0.00197873792983033 2842 8 7 0.875 0.00246305418719212
TF TF:M04706 Factor: RelA; motif: GGGRAWTYC 0.00210801423032789 2278 22 11 0.5 0.004828797190518
TF TF:M00972 Factor: IRF; motif: RAAANTGAAAN 0.00420989089417987 1979 22 10 0.454545454545455 0.00505305709954523
TF TF:M00772_1 Factor: IRF; motif: RRAANTGAAASYGNV; match class: 1 0.00420989089417987 57 19 3 0.157894736842105 0.0526315789473684
TF TF:M10046 Factor: c-Rel; motif: NRNRGGGRAATKCCA 0.0043099224281174 4696 12 10 0.833333333333333 0.00212947189097104
TF TF:M07323 Factor: IRF-4; motif: KRAAMNGAAANYN 0.0043189453924977 938 5 4 0.8 0.00426439232409382
TF TF:M00063 Factor: IRF-2; motif: GAAAAGYGAAASY 0.00534306411814926 685 12 5 0.416666666666667 0.0072992700729927
TF TF:M00287 Factor: NF-Y; motif: NNNRRCCAATSRGNNN 0.0054241952767674 1635 27 10 0.37037037037037 0.00611620795107034
TF TF:M03821_1 Factor: ER-beta; motif: ANNSTGACCYRGNN; match class: 1 0.00585184372852814 1368 11 6 0.545454545454545 0.0043859649122807
TF TF:M03852_1 Factor: SREBP-2; motif: NTCACCYNNNN; match class: 1 0.00654492733903308 2246 14 8 0.571428571428571 0.00356188780053428
TF TF:M11677 Factor: IRF-3; motif: NGGAAACNGAAACCGAAACN 0.00756402065044309 470 4 3 0.75 0.00638297872340425
TF TF:M10046_1 Factor: c-Rel; motif: NRNRGGGRAATKCCA; match class: 1 0.00848529544971747 734 7 4 0.571428571428571 0.00544959128065395
TF TF:M07429 Factor: SMAD3; motif: CAGACAS 0.00903758810302903 6273 16 13 0.8125 0.00207237366491312
TF TF:M07045 Factor: IRF-1; motif: NNRAAANNGAAASN 0.00934365207728702 535 27 6 0.222222222222222 0.011214953271028
TF TF:M00687 Factor: alpha-CP1; motif: CAGCCAATGAG 0.0137815623564747 2326 31 12 0.387096774193548 0.00515907136715391
TF TF:M09959 Factor: IRF-4; motif: NAANGRGGAASTGAAASN 0.0137815623564747 3386 9 7 0.777777777777778 0.00206733608978145
TF TF:M00775 Factor: NF-Y; motif: NNNNRRCCAATSR 0.0151801180724604 1428 5 4 0.8 0.00280112044817927
TF TF:M01224 Factor: P50:RELA-P65; motif: GGANTTYCCCWN 0.0153942739194511 2329 19 9 0.473684210526316 0.0038643194504079
TF TF:M02106 Factor: NF-YA; motif: CRGCCAATCAGNRN 0.0156793728234267 1741 15 7 0.466666666666667 0.00402067777139575
TF TF:M10006 Factor: NF-YC; motif: NNRRCCAATCAGNR 0.0156793728234267 2510 18 9 0.5 0.00358565737051793
TF TF:M11816_1 Factor: T3R-beta; motif: NRGGTCAAAGGTCAN; match class: 1 0.0187586965954874 4798 18 12 0.666666666666667 0.00250104210087536
TF TF:M07302 Factor: NF-Y; motif: RGCCAATCRGN 0.0196802877357155 1576 5 4 0.8 0.00253807106598985
TF TF:M08241_1 Factor: ERF:FOXO1A; motif: RTMAACAGGAARNS; match class: 1 0.0196802877357155 2010 7 5 0.714285714285714 0.00248756218905473
TF TF:M11800_1 Factor: NR1B2; motif: RAGGTCRTGACCTY; match class: 1 0.0196802877357155 987 7 4 0.571428571428571 0.00405268490374873
TF TF:M04683 Factor: NF-YA; motif: YTCTSATTGGYYRN 0.0227206093818109 1657 5 4 0.8 0.0024140012070006
TF TF:M07204 Factor: AR; motif: ARGAACANNNTGTNC 0.0227639080567655 4906 6 6 1 0.00122299225438239
TF TF:M00208_1 Factor: NF-kappaB; motif: NGGGACTTTCCA; match class: 1 0.0250892407362347 604 5 3 0.6 0.00496688741721854
TF TF:M04014 Factor: IRF3; motif: NNRRAANGGAAACCGAAACYR 0.0250892407362347 278 23 4 0.173913043478261 0.0143884892086331
TF TF:M04706_1 Factor: RelA; motif: GGGRAWTYC; match class: 1 0.0250892407362347 344 19 4 0.210526315789474 0.0116279069767442
TF TF:M00088_1 Factor: Ik-3; motif: TNYTGGGAATACC; match class: 1 0.0250892407362347 1019 19 6 0.315789473684211 0.00588812561334642
TF TF:M11579_1 Factor: foxl2; motif: NNYGTAAACAN; match class: 1 0.0250892407362347 1157 38 9 0.236842105263158 0.00777873811581677
TF TF:M07429_1 Factor: SMAD3; motif: CAGACAS; match class: 1 0.0260351054534421 1381 10 5 0.5 0.00362056480811007
TF TF:M12286 Factor: ZNF647; motif: NYAGGCCYAC 0.0267933516608986 6231 12 10 0.833333333333333 0.00160487883164821
TF TF:M09733_1 Factor: STAT2; motif: NRGAAANNGAAACTNA; match class: 1 0.0267933516608986 367 8 3 0.375 0.00817438692098093
TF TF:M09975_1 Factor: LEF-1; motif: NCCTTTSWNNTNYN; match class: 1 0.0272793274896215 542 35 6 0.171428571428571 0.011070110701107
TF TF:M09784 Factor: RELB; motif: NNATTCCCCNN 0.0283230635908155 5356 22 14 0.636363636363636 0.00261389096340553
TF TF:M10005 Factor: NF-YA; motif: NYRRCCAATCAGAR 0.0287042944208289 2225 14 7 0.5 0.00314606741573034
TF TF:M01223 Factor: P50:P50; motif: NRGGGAMTNCCCN 0.0287042944208289 1283 11 5 0.454545454545455 0.00389711613406079
TF TF:M11679 Factor: IRF-7; motif: NCGAAANCGAAANYN 0.0291483507199173 622 12 4 0.333333333333333 0.00643086816720257
TF TF:M09816 Factor: NFYA; motif: RRCCAATCAGN 0.0330750236497944 1969 5 4 0.8 0.00203148806500762
TF TF:M08473 Factor: FOXJ2:HOXB13; motif: TTTTATNDGNMAACA 0.0393132181763039 1653 30 9 0.3 0.00544464609800363
TF TF:M09630 Factor: IRF-4; motif: RRRGRGGAASTGARAS 0.0393132181763039 954 9 4 0.444444444444444 0.00419287211740042
TF TF:M08501 Factor: HOXB2:pitx1; motif: TAATKANGGGATTA 0.0485528139423189 302 12 3 0.25 0.00993377483443709
WP WP:WP2328 Allograft Rejection 1.75979519952998e-07 88 32 8 0.25 0.0909090909090909
WP WP:WP4217 Ebola Virus Pathway on Host 3.5419362127472e-07 130 37 9 0.243243243243243 0.0692307692307692
WP WP:WP183 Proteasome Degradation 4.76841831002166e-07 64 11 5 0.454545454545455 0.078125
WP WP:WP3945 TYROBP Causal Network 0.0325814675824041 63 35 3 0.0857142857142857 0.0476190476190476

pEpiTp15 transcription factor target enrichment of top program genes

TF enrichment of pEpiTp15
Possible regulators of activation of pEpiTp15 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.