pEpiTp28 program activity among Epithelial cells

Activation of pEpiTp28
pEpiTp28 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpiTp28 by different cell subtypes
pEpiTp28 gene program activation among cells of different subtypes (Epithelial cells).

pEpiTp28 top program genes

Top genes of pEpiTp28 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpiTp28 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpiTp28
pEpiTp28 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0016266 O-glycan processing 1.27967310320693e-05 58 78 7 0.0897435897435897 0.120689655172414
GO:BP GO:0006493 protein O-linked glycosylation 0.000337860855937448 102 78 7 0.0897435897435897 0.0686274509803922
GO:BP GO:0043413 macromolecule glycosylation 0.000891478669057931 251 129 11 0.0852713178294574 0.0438247011952191
GO:BP GO:0009101 glycoprotein biosynthetic process 0.000891478669057931 347 129 13 0.10077519379845 0.037463976945245
GO:BP GO:0006486 protein glycosylation 0.000891478669057931 251 129 11 0.0852713178294574 0.0438247011952191
GO:BP GO:0070085 glycosylation 0.00121093363731294 264 129 11 0.0852713178294574 0.0416666666666667
GO:BP GO:0009100 glycoprotein metabolic process 0.00346024322360176 424 129 13 0.10077519379845 0.0306603773584906
GO:BP GO:1901137 carbohydrate derivative biosynthetic process 0.00346024322360176 686 133 17 0.12781954887218 0.0247813411078717
GO:BP GO:0034976 response to endoplasmic reticulum stress 0.00436759487556749 298 138 11 0.0797101449275362 0.0369127516778524
GO:BP GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 0.00436759487556749 63 92 5 0.0543478260869565 0.0793650793650794
GO:BP GO:0010951 negative regulation of endopeptidase activity 0.0110469078980842 253 6 3 0.5 0.0118577075098814
GO:BP GO:0010466 negative regulation of peptidase activity 0.0114837588820213 267 6 3 0.5 0.0112359550561798
GO:BP GO:0008643 carbohydrate transport 0.0218974019201336 154 91 6 0.0659340659340659 0.038961038961039
GO:BP GO:0045861 negative regulation of proteolysis 0.0237461883085707 359 6 3 0.5 0.00835654596100279
GO:BP GO:0035459 vesicle cargo loading 0.0271234248390858 26 80 3 0.0375 0.115384615384615
GO:BP GO:0070293 renal absorption 0.0271234248390858 18 116 3 0.0258620689655172 0.166666666666667
GO:BP GO:0090114 COPII-coated vesicle budding 0.0284145828285604 72 138 5 0.036231884057971 0.0694444444444444
GO:BP GO:0048199 vesicle targeting, to, from or within Golgi 0.028488125267422 73 138 5 0.036231884057971 0.0684931506849315
GO:BP GO:0052548 regulation of endopeptidase activity 0.0288184548344861 437 6 3 0.5 0.0068649885583524
GO:BP GO:0006986 response to unfolded protein 0.0288184548344861 184 124 7 0.0564516129032258 0.0380434782608696
GO:BP GO:0048193 Golgi vesicle transport 0.0288184548344861 382 101 9 0.0891089108910891 0.0235602094240838
GO:BP GO:0018146 keratan sulfate biosynthetic process 0.028854155875047 28 86 3 0.0348837209302326 0.107142857142857
GO:BP GO:0052547 regulation of peptidase activity 0.028854155875047 467 6 3 0.5 0.00642398286937901
GO:BP GO:0051346 negative regulation of hydrolase activity 0.028854155875047 470 6 3 0.5 0.00638297872340425
GO:BP GO:0051047 positive regulation of secretion 0.028854155875047 314 54 6 0.111111111111111 0.0191082802547771
GO:BP GO:0050878 regulation of body fluid levels 0.0363561905969072 514 116 11 0.0948275862068965 0.0214007782101167
GO:BP GO:0006508 proteolysis 0.0363561905969072 1836 8 5 0.625 0.00272331154684096
GO:BP GO:0006811 ion transport 0.037471339347839 3661 94 33 0.351063829787234 0.00901393062004917
GO:BP GO:0042339 keratan sulfate metabolic process 0.037471339347839 33 86 3 0.0348837209302326 0.0909090909090909
GO:BP GO:0035966 response to topologically incorrect protein 0.037471339347839 205 124 7 0.0564516129032258 0.0341463414634146
GO:BP GO:0034220 ion transmembrane transport 0.037471339347839 1397 116 20 0.172413793103448 0.0143163922691482
GO:BP GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 0.0383092964174898 206 90 6 0.0666666666666667 0.029126213592233
GO:BP GO:0034620 cellular response to unfolded protein 0.0392171849297296 149 47 4 0.0851063829787234 0.0268456375838926
GO:BP GO:1901135 carbohydrate derivative metabolic process 0.0447609156686523 1145 133 19 0.142857142857143 0.0165938864628821
GO:BP GO:0006903 vesicle targeting 0.047517337959042 94 138 5 0.036231884057971 0.0531914893617021
GO:CC GO:0012505 endomembrane system 5.19550193107906e-12 4640 101 61 0.603960396039604 0.0131465517241379
GO:CC GO:0005794 Golgi apparatus 1.03004559111925e-09 1623 118 36 0.305084745762712 0.022181146025878
GO:CC GO:0000139 Golgi membrane 3.65583166516937e-09 771 106 23 0.216981132075472 0.0298313878080415
GO:CC GO:0098791 Golgi apparatus subcompartment 4.15441847254006e-08 885 106 23 0.216981132075472 0.0259887005649717
GO:CC GO:0031984 organelle subcompartment 2.00620443833341e-07 1773 139 37 0.266187050359712 0.020868584320361
GO:CC GO:0098588 bounding membrane of organelle 1.75093771419374e-06 2158 106 33 0.311320754716981 0.015291936978684
GO:CC GO:0070701 mucus layer 1.75093771419374e-06 3 64 3 0.046875 1
GO:CC GO:0031982 vesicle 6.09639918426891e-06 4055 101 45 0.445544554455446 0.0110974106041924
GO:CC GO:0099503 secretory vesicle 4.82249466900158e-05 1020 100 19 0.19 0.0186274509803922
GO:CC GO:0005576 extracellular region 6.07786096023802e-05 4567 56 30 0.535714285714286 0.00656886358659952
GO:CC GO:0042589 zymogen granule membrane 6.9450396898696e-05 10 54 3 0.0555555555555556 0.3
GO:CC GO:0005615 extracellular space 6.9450396898696e-05 3594 56 26 0.464285714285714 0.00723427935447969
GO:CC GO:0031410 cytoplasmic vesicle 0.000132152320801358 2424 101 30 0.297029702970297 0.0123762376237624
GO:CC GO:0097708 intracellular vesicle 0.000132152320801358 2428 101 30 0.297029702970297 0.0123558484349259
GO:CC GO:0030133 transport vesicle 0.000151464262416151 414 95 11 0.115789473684211 0.0265700483091787
GO:CC GO:0042588 zymogen granule 0.000155494011980705 14 54 3 0.0555555555555556 0.214285714285714
GO:CC GO:0005783 endoplasmic reticulum 0.000250333588813049 1982 139 32 0.23021582733813 0.0161453077699294
GO:CC GO:0031090 organelle membrane 0.000450269969292272 3612 101 37 0.366336633663366 0.0102436323366556
GO:CC GO:0030141 secretory granule 0.000467247744286386 851 65 12 0.184615384615385 0.0141010575793184
GO:CC GO:0005788 endoplasmic reticulum lumen 0.000548722507595873 307 124 10 0.0806451612903226 0.0325732899022801
GO:CC GO:0070062 extracellular exosome 0.00139467984651268 2176 55 17 0.309090909090909 0.0078125
GO:CC GO:1903561 extracellular vesicle 0.00198641405154343 2261 55 17 0.309090909090909 0.0075187969924812
GO:CC GO:0043230 extracellular organelle 0.00198641405154343 2263 55 17 0.309090909090909 0.00751215201060539
GO:CC GO:0016020 membrane 0.00437675745639538 9838 135 90 0.666666666666667 0.00914820085383208
GO:CC GO:0031985 Golgi cisterna 0.00440638610275009 115 100 5 0.05 0.0434782608695652
GO:CC GO:0005793 endoplasmic reticulum-Golgi intermediate compartment 0.00474867378780939 131 90 5 0.0555555555555556 0.0381679389312977
GO:CC GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane 0.00484430317705758 74 90 4 0.0444444444444444 0.0540540540540541
GO:CC GO:0030134 COPII-coated ER to Golgi transport vesicle 0.0056106934222256 90 138 5 0.036231884057971 0.0555555555555556
GO:CC GO:0030667 secretory granule membrane 0.00633023373780992 303 65 6 0.0923076923076923 0.0198019801980198
GO:CC GO:0044322 endoplasmic reticulum quality control compartment 0.00735021802736924 27 124 3 0.0241935483870968 0.111111111111111
GO:CC GO:0031224 intrinsic component of membrane 0.00846646785507624 5868 131 58 0.442748091603053 0.00988411724608044
GO:CC GO:0005796 Golgi lumen 0.00846646785507624 99 81 4 0.0493827160493827 0.0404040404040404
GO:CC GO:0031983 vesicle lumen 0.00847523552235249 326 118 8 0.0677966101694915 0.0245398773006135
GO:CC GO:0070382 exocytic vesicle 0.00847523552235249 229 95 6 0.0631578947368421 0.0262008733624454
GO:CC GO:0030135 coated vesicle 0.00847523552235249 295 101 7 0.0693069306930693 0.023728813559322
GO:CC GO:0048770 pigment granule 0.00847523552235249 105 135 5 0.037037037037037 0.0476190476190476
GO:CC GO:0060205 cytoplasmic vesicle lumen 0.00847523552235249 324 118 8 0.0677966101694915 0.0246913580246914
GO:CC GO:0042470 melanosome 0.00847523552235249 105 135 5 0.037037037037037 0.0476190476190476
GO:CC GO:0005795 Golgi stack 0.00927061701734539 149 100 5 0.05 0.0335570469798658
GO:CC GO:0016528 sarcoplasm 0.00962423030114992 79 112 4 0.0357142857142857 0.0506329113924051
GO:CC GO:0005789 endoplasmic reticulum membrane 0.00994566837792591 1117 139 18 0.129496402877698 0.0161145926589078
GO:CC GO:0005737 cytoplasm 0.00994566837792591 11911 101 78 0.772277227722772 0.00654856855007976
GO:CC GO:0032580 Golgi cisterna membrane 0.00994566837792591 90 100 4 0.04 0.0444444444444444
GO:CC GO:0070971 endoplasmic reticulum exit site 0.00994566837792591 31 138 3 0.0217391304347826 0.0967741935483871
GO:CC GO:0098827 endoplasmic reticulum subcompartment 0.00994566837792591 1122 139 18 0.129496402877698 0.0160427807486631
GO:CC GO:0016021 integral component of membrane 0.00994566837792591 5711 131 56 0.427480916030534 0.00980563824198914
GO:CC GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network 0.0112645354760451 1139 139 18 0.129496402877698 0.0158033362598771
GO:CC GO:0030312 external encapsulating structure 0.0176843645663862 563 81 8 0.0987654320987654 0.0142095914742451
GO:CC GO:0031012 extracellular matrix 0.0176843645663862 562 81 8 0.0987654320987654 0.0142348754448399
GO:CC GO:0034774 secretory granule lumen 0.0231334149520433 320 118 7 0.0593220338983051 0.021875
GO:CC GO:0030658 transport vesicle membrane 0.0234469087997434 209 95 5 0.0526315789473684 0.0239234449760766
GO:CC GO:0071944 cell periphery 0.0283785006489493 6169 94 43 0.457446808510638 0.0069703355487113
GO:CC GO:0030659 cytoplasmic vesicle membrane 0.0295790129066377 779 80 9 0.1125 0.0115532734274711
GO:CC GO:0034703 cation channel complex 0.0295790129066377 227 94 5 0.0531914893617021 0.0220264317180617
GO:CC GO:0035580 specific granule lumen 0.0337676435102189 61 118 3 0.0254237288135593 0.0491803278688525
GO:CC GO:0012506 vesicle membrane 0.0337676435102189 800 80 9 0.1125 0.01125
GO:CC GO:0048471 perinuclear region of cytoplasm 0.0337676435102189 735 119 11 0.092436974789916 0.0149659863945578
GO:CC GO:0030173 integral component of Golgi membrane 0.0345684358583419 62 118 3 0.0254237288135593 0.0483870967741935
GO:CC GO:0031253 cell projection membrane 0.0366936149083358 343 43 4 0.0930232558139535 0.0116618075801749
GO:CC GO:0031228 intrinsic component of Golgi membrane 0.0389259955619445 67 118 3 0.0254237288135593 0.0447761194029851
GO:CC GO:0012507 ER to Golgi transport vesicle membrane 0.0389259955619445 57 138 3 0.0217391304347826 0.0526315789473684
GO:CC GO:0016529 sarcoplasmic reticulum 0.0389259955619445 70 112 3 0.0267857142857143 0.0428571428571429
GO:CC GO:0045177 apical part of cell 0.0389259955619445 431 77 6 0.0779220779220779 0.0139211136890951
GO:CC GO:0034702 ion channel complex 0.0393064985706596 302 111 6 0.0540540540540541 0.0198675496688742
GO:CC GO:0062023 collagen-containing extracellular matrix 0.0411597761338783 421 81 6 0.0740740740740741 0.0142517814726841
GO:CC GO:0008076 voltage-gated potassium channel complex 0.0439304197790348 90 94 3 0.0319148936170213 0.0333333333333333
GO:MF GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity 0.000534733885799073 20 76 4 0.0526315789473684 0.2
GO:MF GO:0004867 serine-type endopeptidase inhibitor activity 0.00063441416379552 98 6 3 0.5 0.0306122448979592
GO:MF GO:0030414 peptidase inhibitor activity 0.00179863587563853 182 6 3 0.5 0.0164835164835165
GO:MF GO:0061135 endopeptidase regulator activity 0.00179863587563853 188 6 3 0.5 0.0159574468085106
GO:MF GO:0004866 endopeptidase inhibitor activity 0.00179863587563853 176 6 3 0.5 0.0170454545454545
GO:MF GO:0061134 peptidase regulator activity 0.00253080162939311 224 6 3 0.5 0.0133928571428571
GO:MF GO:0008376 acetylgalactosaminyltransferase activity 0.00258772144129721 47 76 4 0.0526315789473684 0.0851063829787234
GO:MF GO:0030246 carbohydrate binding 0.00731515878567794 275 76 7 0.0921052631578947 0.0254545454545455
GO:MF GO:0004857 enzyme inhibitor activity 0.00760290436124785 385 6 3 0.5 0.00779220779220779
GO:MF GO:0004252 serine-type endopeptidase activity 0.00760290436124785 171 56 5 0.0892857142857143 0.0292397660818713
GO:MF GO:0008236 serine-type peptidase activity 0.0105374543211013 189 56 5 0.0892857142857143 0.0264550264550265
GO:MF GO:0017171 serine hydrolase activity 0.0106406177391945 193 56 5 0.0892857142857143 0.0259067357512953
GO:MF GO:0016757 transferase activity, transferring glycosyl groups 0.0116152084884551 283 86 7 0.0813953488372093 0.0247349823321555
GO:MF GO:0008194 UDP-glycosyltransferase activity 0.0174337477023742 146 86 5 0.0581395348837209 0.0342465753424658
GO:MF GO:0015144 carbohydrate transmembrane transporter activity 0.0218324725360644 38 91 3 0.032967032967033 0.0789473684210526
GO:MF GO:0015075 ion transmembrane transporter activity 0.0346090523940473 956 111 14 0.126126126126126 0.0146443514644351
GO:MF GO:0022839 ion gated channel activity 0.0346090523940473 43 99 3 0.0303030303030303 0.0697674418604651
GO:MF GO:0005504 fatty acid binding 0.0404598084347245 40 137 3 0.0218978102189781 0.075
GO:MF GO:0002020 protease binding 0.0404598084347245 133 40 3 0.075 0.0225563909774436
GO:MF GO:0016758 transferase activity, transferring hexosyl groups 0.0404598084347245 205 86 5 0.0581395348837209 0.024390243902439
GO:MF GO:0022857 transmembrane transporter activity 0.0467656537179935 1075 99 13 0.131313131313131 0.012093023255814
GO:MF GO:0015459 potassium channel regulator activity 0.0478776455671707 54 116 3 0.0258620689655172 0.0555555555555556
GO:MF GO:0030234 enzyme regulator activity 0.0498965263895375 1248 6 3 0.5 0.00240384615384615
KEGG KEGG:00512 Mucin type O-glycan biosynthesis 0.00129444726304316 32 76 5 0.0657894736842105 0.15625
REAC REAC:R-HSA-913709 O-linked glycosylation of mucins 0.00120934613802128 61 78 6 0.0769230769230769 0.0983606557377049
REAC REAC:R-HSA-446219 Synthesis of substrates in N-glycan biosythesis 0.00120934613802128 63 133 7 0.0526315789473684 0.111111111111111
REAC REAC:R-HSA-446203 Asparagine N-linked glycosylation 0.00120934613802128 304 138 15 0.108695652173913 0.0493421052631579
REAC REAC:R-HSA-5694530 Cargo concentration in the ER 0.00334646333227069 33 80 4 0.05 0.121212121212121
REAC REAC:R-HSA-400508 Incretin synthesis, secretion, and inactivation 0.00334646333227069 23 42 3 0.0714285714285714 0.130434782608696
REAC REAC:R-HSA-5083636 Defective GALNT12 causes colorectal cancer 1 (CRCS1) 0.00334646333227069 16 67 3 0.0447761194029851 0.1875
REAC REAC:R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 0.00334646333227069 78 133 7 0.0526315789473684 0.0897435897435897
REAC REAC:R-HSA-5083625 Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) 0.00334646333227069 16 68 3 0.0441176470588235 0.1875
REAC REAC:R-HSA-4085001 Sialic acid metabolism 0.00334646333227069 33 82 4 0.0487804878048781 0.121212121212121
REAC REAC:R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 0.00334646333227069 20 42 3 0.0714285714285714 0.15
REAC REAC:R-HSA-5173105 O-linked glycosylation 0.00334646333227069 107 78 6 0.0769230769230769 0.0560747663551402
REAC REAC:R-HSA-977068 Termination of O-glycan biosynthesis 0.0140566972055769 23 78 3 0.0384615384615385 0.130434782608696
REAC REAC:R-HSA-3906995 Diseases associated with O-glycosylation of proteins 0.0142601489433971 65 68 4 0.0588235294117647 0.0615384615384615
REAC REAC:R-HSA-2980736 Peptide hormone metabolism 0.0142601489433971 86 53 4 0.0754716981132075 0.0465116279069767
REAC REAC:R-HSA-983712 Ion channel transport 0.0142601489433971 182 116 8 0.0689655172413793 0.043956043956044
REAC REAC:R-HSA-948021 Transport to the Golgi and subsequent modification 0.0142601489433971 185 86 7 0.0813953488372093 0.0378378378378378
REAC REAC:R-HSA-3781865 Diseases of glycosylation 0.0142601489433971 140 81 6 0.0740740740740741 0.0428571428571429
REAC REAC:R-HSA-2672351 Stimuli-sensing channels 0.0148173568612845 105 116 6 0.0517241379310345 0.0571428571428571
REAC REAC:R-HSA-2022854 Keratan sulfate biosynthesis 0.0201487372079232 28 86 3 0.0348837209302326 0.107142857142857
REAC REAC:R-HSA-1638074 Keratan sulfate/keratin metabolism 0.0323003694897785 34 86 3 0.0348837209302326 0.0882352941176471
TF TF:M11227 Factor: ATF-6; motif: TGRTGACGTGGCAN 0.00113605017858786 201 138 11 0.0797101449275362 0.054726368159204
TF TF:M11250 Factor: Luman; motif: NGCCACGTCAYN 0.0016072424227676 223 138 11 0.0797101449275362 0.0493273542600897
TF TF:M00733_1 Factor: SMAD4; motif: GKSRKKCAGMCANCY; match class: 1 0.00366218268561569 2823 127 39 0.307086614173228 0.0138150903294368
TF TF:M09762 Factor: NF1B; motif: CYTGGCNYNCWGCCAN 0.00488820328271503 5659 125 60 0.48 0.0106025799611239
TF TF:M11229 Factor: ATF-6; motif: TGRTGACGTGGCAN 0.00488820328271503 342 138 12 0.0869565217391304 0.0350877192982456
TF TF:M11247 Factor: Luman; motif: YGCCACGTCAYC 0.00488820328271503 174 138 9 0.0652173913043478 0.0517241379310345
TF TF:M04228 Factor: XBP1; motif: WNNGMCACGTCATC 0.00488820328271503 57 86 5 0.0581395348837209 0.087719298245614
TF TF:M11276 Factor: XBP-1; motif: NNMCACGTCANN 0.00612871827558529 551 138 15 0.108695652173913 0.0272232304900181
TF TF:M04207 Factor: CREB3; motif: NTGCCACGTCAYCN 0.0069036706454315 41 138 5 0.036231884057971 0.121951219512195
TF TF:M09729 Factor: LUMAN; motif: CYCAGCYYCY 0.00969188371499459 10686 35 31 0.885714285714286 0.00290099195208684
TF TF:M11729 Factor: NF-1C; motif: NTTGGCNNNNTGCCARN 0.0127843865410506 1738 109 24 0.220183486238532 0.0138089758342923
TF TF:M09746_1 Factor: HNRPUL1; motif: NCNCAGN; match class: 1 0.0187695331870486 7619 74 46 0.621621621621622 0.00603753773461084
TF TF:M00413 Factor: AREB6; motif: WNWCACCTGWNN 0.0207968044007704 1311 47 12 0.25531914893617 0.0091533180778032
TF TF:M11230 Factor: CREBL1; motif: YGCCACGTCAYC 0.0207968044007704 56 138 5 0.036231884057971 0.0892857142857143
TF TF:M10172_1 Factor: HKR2; motif: NGNCNGAGGGMGGAGG; match class: 1 0.0251304008371684 165 117 7 0.0598290598290598 0.0424242424242424
TF TF:M07338 Factor: Sox-10; motif: ACAAWGNN 0.0251918498064555 1695 10 6 0.6 0.00353982300884956
TF TF:M09762_1 Factor: NF1B; motif: CYTGGCNYNCWGCCAN; match class: 1 0.0372220375112282 1514 21 8 0.380952380952381 0.00528401585204756
TF TF:M01808_1 Factor: NMYC; motif: CAYCTG; match class: 1 0.038597359007824 6149 44 26 0.590909090909091 0.00422832980972516
TF TF:M11745 Factor: COUP-TF1; motif: RAGGTCANTGACCTY 0.038597359007824 5058 88 39 0.443181818181818 0.00771055753262159
TF TF:M03906 Factor: HIC2; motif: RTGCCCRNN 0.0418424684412993 3458 39 17 0.435897435897436 0.00491613649508386
TF TF:M06667 Factor: ZNF599; motif: KGGTTCAGGAGM 0.0453387614717735 25 84 3 0.0357142857142857 0.12
TF TF:M00532 Factor: RP58; motif: NNAACATCTGGA 0.0453387614717735 405 40 6 0.15 0.0148148148148148
TF TF:M11741 Factor: COUP-TF1; motif: RRGGTCRNTGACCYY 0.0471750962904991 3249 99 31 0.313131313131313 0.0095413973530317
TF TF:M07608 Factor: NFAT; motif: NNGGAAAAN 0.0471750962904991 714 9 4 0.444444444444444 0.00560224089635854
TF TF:M08957_1 Factor: NURR1:RXR-ALPHA; motif: NRGGTCRTTGACCYN; match class: 1 0.0488300990027049 3226 88 28 0.318181818181818 0.00867947923124613
TF TF:M09640 Factor: NF-1C; motif: NYYTGGCWNNNNKCCMN 0.0488300990027049 2807 28 12 0.428571428571429 0.00427502671891699
TF TF:M07051_1 Factor: NF-1B; motif: CTGGCASGV; match class: 1 0.0488300990027049 567 21 5 0.238095238095238 0.00881834215167548
TF TF:M11235 Factor: OASIS; motif: YGCCACGTCANC 0.0488300990027049 368 138 10 0.072463768115942 0.0271739130434783
TF TF:M11831_1 Factor: LRH-1; motif: TCAAGGTCRTGACCTTGA; match class: 1 0.0488300990027049 1082 76 13 0.171052631578947 0.0120147874306839
TF TF:M11253 Factor: AIBZIP; motif: YGCCACGTCACC 0.0488300990027049 229 138 8 0.0579710144927536 0.0349344978165939
TF TF:M10134_1 Factor: FPM315; motif: GGGAGGAGGRRGRGGRGGRR; match class: 1 0.0488300990027049 585 121 12 0.0991735537190083 0.0205128205128205
TF TF:M02265 Factor: NFATc2; motif: TTTTCCA 0.0488300990027049 7752 9 9 1 0.0011609907120743
WP WP:WP2291 Deregulation of Rab and Rab Effector Genes in Bladder Cancer 0.0133420898862307 16 135 4 0.0296296296296296 0.25

pEpiTp28 transcription factor target enrichment of top program genes

TF enrichment of pEpiTp28
Possible regulators of activation of pEpiTp28 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.