pB04 program activity among B cells

Activation of pB04
pB04 gene program activation in B cells.
Gene program activation of pB04 by different cell subtypes
pB04 gene program activation among cells of different subtypes (B cells).

pB04 top program genes

Top genes of pB04 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pB04 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pB04
pB04 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0046649 lymphocyte activation 2.29378700170824e-06 771 138 25 0.181159420289855 0.0324254215304799
GO:BP GO:0042113 B cell activation 3.49209706597031e-06 330 138 16 0.115942028985507 0.0484848484848485
GO:BP GO:0001775 cell activation 3.49209706597031e-06 1495 144 35 0.243055555555556 0.0234113712374582
GO:BP GO:0045321 leukocyte activation 3.49209706597031e-06 1332 138 32 0.231884057971014 0.024024024024024
GO:BP GO:0050853 B cell receptor signaling pathway 0.000337745265312704 135 41 6 0.146341463414634 0.0444444444444444
GO:BP GO:0042100 B cell proliferation 0.000413911456956166 98 138 8 0.0579710144927536 0.0816326530612245
GO:BP GO:0002376 immune system process 0.000531252703453431 3278 113 42 0.371681415929204 0.0128126906650397
GO:BP GO:0050778 positive regulation of immune response 0.000697277893422495 753 56 12 0.214285714285714 0.0159362549800797
GO:BP GO:0051716 cellular response to stimulus 0.000697277893422495 7781 116 75 0.646551724137931 0.00963886389924174
GO:BP GO:0050864 regulation of B cell activation 0.000697277893422495 194 138 10 0.072463768115942 0.0515463917525773
GO:BP GO:0051249 regulation of lymphocyte activation 0.000697277893422495 518 138 16 0.115942028985507 0.0308880308880309
GO:BP GO:0002764 immune response-regulating signaling pathway 0.000811845951197967 515 56 10 0.178571428571429 0.0194174757281553
GO:BP GO:0002768 immune response-regulating cell surface receptor signaling pathway 0.000811845951197967 512 56 10 0.178571428571429 0.01953125
GO:BP GO:0050865 regulation of cell activation 0.000997194036656784 655 144 18 0.125 0.0274809160305344
GO:BP GO:0002684 positive regulation of immune system process 0.00109509659721527 1065 138 23 0.166666666666667 0.0215962441314554
GO:BP GO:0050851 antigen receptor-mediated signaling pathway 0.00136120992568029 323 41 7 0.170731707317073 0.021671826625387
GO:BP GO:0002429 immune response-activating cell surface receptor signaling pathway 0.0013885842614274 477 113 13 0.115044247787611 0.0272536687631027
GO:BP GO:0002757 immune response-activating signal transduction 0.0013885842614274 477 113 13 0.115044247787611 0.0272536687631027
GO:BP GO:0030888 regulation of B cell proliferation 0.0013885842614274 63 138 6 0.0434782608695652 0.0952380952380952
GO:BP GO:0002285 lymphocyte activation involved in immune response 0.00156019609273583 190 133 9 0.0676691729323308 0.0473684210526316
GO:BP GO:0002694 regulation of leukocyte activation 0.00220759940987477 610 138 16 0.115942028985507 0.0262295081967213
GO:BP GO:0002366 leukocyte activation involved in immune response 0.00230887276158495 717 119 16 0.134453781512605 0.0223152022315202
GO:BP GO:0002263 cell activation involved in immune response 0.00230887276158495 721 119 16 0.134453781512605 0.0221914008321775
GO:BP GO:0002250 adaptive immune response 0.00230887276158495 689 138 17 0.123188405797101 0.0246734397677794
GO:BP GO:0042110 T cell activation 0.0025225493527331 489 138 14 0.101449275362319 0.0286298568507157
GO:BP GO:0002312 B cell activation involved in immune response 0.00263516314005496 79 133 6 0.0451127819548872 0.0759493670886076
GO:BP GO:0000018 regulation of DNA recombination 0.00279063374672435 103 31 4 0.129032258064516 0.0388349514563107
GO:BP GO:0033632 regulation of cell-cell adhesion mediated by integrin 0.00356986404736957 11 113 3 0.0265486725663717 0.272727272727273
GO:BP GO:0050896 response to stimulus 0.00361143090700787 9407 102 73 0.715686274509804 0.0077601785904114
GO:BP GO:0050776 regulation of immune response 0.00376534996268478 996 56 12 0.214285714285714 0.0120481927710843
GO:BP GO:0048584 positive regulation of response to stimulus 0.00386617535871621 2344 56 19 0.339285714285714 0.00810580204778157
GO:BP GO:0002253 activation of immune response 0.00454085303476756 568 113 13 0.115044247787611 0.022887323943662
GO:BP GO:0006955 immune response 0.00476731228327847 2311 87 25 0.28735632183908 0.0108178277801817
GO:BP GO:0045911 positive regulation of DNA recombination 0.00490319713038908 45 31 3 0.0967741935483871 0.0666666666666667
GO:BP GO:0050790 regulation of catalytic activity 0.00561040963785944 2545 76 24 0.315789473684211 0.00943025540275049
GO:BP GO:0002682 regulation of immune system process 0.00592866510695779 1617 138 27 0.195652173913043 0.0166975881261596
GO:BP GO:0007166 cell surface receptor signaling pathway 0.00608615116769851 3210 138 43 0.311594202898551 0.0133956386292835
GO:BP GO:0050867 positive regulation of cell activation 0.00714231549294113 424 138 12 0.0869565217391304 0.0283018867924528
GO:BP GO:0051251 positive regulation of lymphocyte activation 0.00792502927686726 365 138 11 0.0797101449275362 0.0301369863013699
GO:BP GO:0002252 immune effector process 0.00793132314751603 1309 119 21 0.176470588235294 0.0160427807486631
GO:BP GO:0007165 signal transduction 0.00803436207019315 6309 118 61 0.516949152542373 0.00966872721508955
GO:BP GO:0002467 germinal center formation 0.00858029030700461 14 133 3 0.0225563909774436 0.214285714285714
GO:BP GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 0.00858029030700461 760 132 16 0.121212121212121 0.0210526315789474
GO:BP GO:0007015 actin filament organization 0.00931539823265739 445 98 10 0.102040816326531 0.0224719101123595
GO:BP GO:0033631 cell-cell adhesion mediated by integrin 0.00934906957769525 17 113 3 0.0265486725663717 0.176470588235294
GO:BP GO:0044089 positive regulation of cellular component biogenesis 0.00955800203611522 540 98 11 0.112244897959184 0.0203703703703704
GO:BP GO:0050871 positive regulation of B cell activation 0.00955800203611522 151 138 7 0.0507246376811594 0.0463576158940397
GO:BP GO:0052548 regulation of endopeptidase activity 0.0105934742371955 437 36 6 0.166666666666667 0.0137299771167048
GO:BP GO:0007154 cell communication 0.0105934742371955 6829 118 64 0.542372881355932 0.009371796749158
GO:BP GO:0002377 immunoglobulin production 0.0105934742371955 99 52 4 0.0769230769230769 0.0404040404040404
GO:BP GO:0002637 regulation of immunoglobulin production 0.0105934742371955 67 31 3 0.0967741935483871 0.0447761194029851
GO:BP GO:0048583 regulation of response to stimulus 0.0105934742371955 4278 113 44 0.389380530973451 0.0102851799906498
GO:BP GO:1901698 response to nitrogen compound 0.0106660897761611 1172 128 20 0.15625 0.0170648464163823
GO:BP GO:0010243 response to organonitrogen compound 0.0108218305881651 1085 128 19 0.1484375 0.0175115207373272
GO:BP GO:0045454 cell redox homeostasis 0.0116901382063506 58 95 4 0.0421052631578947 0.0689655172413793
GO:BP GO:0050863 regulation of T cell activation 0.0122613994316705 337 138 10 0.072463768115942 0.029673590504451
GO:BP GO:0030890 positive regulation of B cell proliferation 0.0122613994316705 41 138 4 0.0289855072463768 0.0975609756097561
GO:BP GO:0052547 regulation of peptidase activity 0.0132098257876529 467 36 6 0.166666666666667 0.012847965738758
GO:BP GO:0002696 positive regulation of leukocyte activation 0.0142814635640284 412 138 11 0.0797101449275362 0.0266990291262136
GO:BP GO:0023052 signaling 0.0146584142619224 6810 118 63 0.533898305084746 0.0092511013215859
GO:BP GO:0008277 regulation of G protein-coupled receptor signaling pathway 0.0146588910464427 149 113 6 0.0530973451327434 0.0402684563758389
GO:BP GO:0045190 isotype switching 0.0146588910464427 48 52 3 0.0576923076923077 0.0625
GO:BP GO:0002208 somatic diversification of immunoglobulins involved in immune response 0.0146588910464427 48 52 3 0.0576923076923077 0.0625
GO:BP GO:0002204 somatic recombination of immunoglobulin genes involved in immune response 0.0146588910464427 48 52 3 0.0576923076923077 0.0625
GO:BP GO:0046651 lymphocyte proliferation 0.0174954242551588 294 138 9 0.0652173913043478 0.0306122448979592
GO:BP GO:0030036 actin cytoskeleton organization 0.0183340160959697 709 142 15 0.105633802816901 0.0211565585331453
GO:BP GO:0032943 mononuclear cell proliferation 0.0183340160959697 297 138 9 0.0652173913043478 0.0303030303030303
GO:BP GO:0002520 immune system development 0.01836400451496 1020 144 19 0.131944444444444 0.0186274509803922
GO:BP GO:0002381 immunoglobulin production involved in immunoglobulin-mediated immune response 0.0183946369383854 53 52 3 0.0576923076923077 0.0566037735849057
GO:BP GO:0009264 deoxyribonucleotide catabolic process 0.018676986611445 25 113 3 0.0265486725663717 0.12
GO:BP GO:0016447 somatic recombination of immunoglobulin gene segments 0.0187174429398157 54 52 3 0.0576923076923077 0.0555555555555556
GO:BP GO:0046386 deoxyribose phosphate catabolic process 0.0200166820463908 26 113 3 0.0265486725663717 0.115384615384615
GO:BP GO:0048518 positive regulation of biological process 0.0200669052862473 6363 113 57 0.504424778761062 0.00895803866100896
GO:BP GO:0032869 cellular response to insulin stimulus 0.0200669052862473 235 143 8 0.0559440559440559 0.0340425531914894
GO:BP GO:0030029 actin filament-based process 0.0210493247187782 808 142 16 0.112676056338028 0.0198019801980198
GO:BP GO:0035556 intracellular signal transduction 0.0233018248678241 2772 76 23 0.302631578947368 0.0082972582972583
GO:BP GO:0016445 somatic diversification of immunoglobulins 0.0233018248678241 61 52 3 0.0576923076923077 0.0491803278688525
GO:BP GO:0010563 negative regulation of phosphorus metabolic process 0.0255680811476982 544 136 12 0.0882352941176471 0.0220588235294118
GO:BP GO:0016444 somatic cell DNA recombination 0.0255680811476982 64 52 3 0.0576923076923077 0.046875
GO:BP GO:0045936 negative regulation of phosphate metabolic process 0.0255680811476982 543 136 12 0.0882352941176471 0.0220994475138122
GO:BP GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus 0.0255680811476982 64 52 3 0.0576923076923077 0.046875
GO:BP GO:0065009 regulation of molecular function 0.025940671136503 3221 63 22 0.349206349206349 0.00683017696367588
GO:BP GO:0070661 leukocyte proliferation 0.0260571656401814 325 138 9 0.0652173913043478 0.0276923076923077
GO:BP GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.0260571656401814 217 36 4 0.111111111111111 0.0184331797235023
GO:BP GO:0065003 protein-containing complex assembly 0.0276431929942469 1680 35 10 0.285714285714286 0.00595238095238095
GO:BP GO:0001824 blastocyst development 0.0279238842150564 104 132 5 0.0378787878787879 0.0480769230769231
GO:BP GO:0002200 somatic diversification of immune receptors 0.0316692183538122 72 52 3 0.0576923076923077 0.0416666666666667
GO:BP GO:0002431 Fc receptor mediated stimulatory signaling pathway 0.032538231913459 141 102 5 0.0490196078431373 0.0354609929078014
GO:BP GO:2000116 regulation of cysteine-type endopeptidase activity 0.0338071346528803 240 36 4 0.111111111111111 0.0166666666666667
GO:BP GO:0009394 2'-deoxyribonucleotide metabolic process 0.0347302258258772 35 113 3 0.0265486725663717 0.0857142857142857
GO:BP GO:0051336 regulation of hydrolase activity 0.0366937820831251 1321 62 12 0.193548387096774 0.00908402725208176
GO:BP GO:0010951 negative regulation of endopeptidase activity 0.0366937820831251 253 36 4 0.111111111111111 0.0158102766798419
GO:BP GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 0.0366937820831251 363 133 9 0.0676691729323308 0.0247933884297521
GO:BP GO:0046632 alpha-beta T cell differentiation 0.0366937820831251 113 133 5 0.037593984962406 0.0442477876106195
GO:BP GO:0006310 DNA recombination 0.0366937820831251 294 31 4 0.129032258064516 0.0136054421768707
GO:BP GO:0071375 cellular response to peptide hormone stimulus 0.0366937820831251 340 143 9 0.0629370629370629 0.0264705882352941
GO:BP GO:0019692 deoxyribose phosphate metabolic process 0.0370582215173862 37 113 3 0.0265486725663717 0.0810810810810811
GO:BP GO:2000779 regulation of double-strand break repair 0.0379564461172689 87 49 3 0.0612244897959184 0.0344827586206897
GO:BP GO:0009262 deoxyribonucleotide metabolic process 0.0381234099564925 39 113 3 0.0265486725663717 0.0769230769230769
GO:BP GO:0008154 actin polymerization or depolymerization 0.0381234099564925 223 142 7 0.0492957746478873 0.031390134529148
GO:BP GO:0010466 negative regulation of peptidase activity 0.0381234099564925 267 36 4 0.111111111111111 0.0149812734082397
GO:BP GO:0050670 regulation of lymphocyte proliferation 0.0381234099564925 230 138 7 0.0507246376811594 0.0304347826086957
GO:BP GO:0030098 lymphocyte differentiation 0.0381234099564925 376 133 9 0.0676691729323308 0.023936170212766
GO:BP GO:0032527 protein exit from endoplasmic reticulum 0.0381234099564925 48 90 3 0.0333333333333333 0.0625
GO:BP GO:0032944 regulation of mononuclear cell proliferation 0.0393043677601561 232 138 7 0.0507246376811594 0.0301724137931034
GO:BP GO:0002700 regulation of production of molecular mediator of immune response 0.0393043677601561 148 31 3 0.0967741935483871 0.0202702702702703
GO:BP GO:0044093 positive regulation of molecular function 0.039831653991326 1771 110 21 0.190909090909091 0.0118577075098814
GO:BP GO:0002440 production of molecular mediator of immune response 0.0399137733722721 189 52 4 0.0769230769230769 0.0211640211640212
GO:BP GO:0022407 regulation of cell-cell adhesion 0.0401556979389042 445 138 10 0.072463768115942 0.0224719101123595
GO:BP GO:1902117 positive regulation of organelle assembly 0.0401556979389042 68 69 3 0.0434782608695652 0.0441176470588235
GO:BP GO:2001242 regulation of intrinsic apoptotic signaling pathway 0.0401556979389042 167 28 3 0.107142857142857 0.0179640718562874
GO:BP GO:0007159 leukocyte cell-cell adhesion 0.0407349733379248 375 138 9 0.0652173913043478 0.024
GO:BP GO:0061842 microtubule organizing center localization 0.0407349733379248 34 141 3 0.0212765957446809 0.0882352941176471
GO:BP GO:0048585 negative regulation of response to stimulus 0.0407349733379248 1733 136 24 0.176470588235294 0.0138488170802077
GO:BP GO:0032868 response to insulin 0.040748133121356 295 143 8 0.0559440559440559 0.0271186440677966
GO:BP GO:0008286 insulin receptor signaling pathway 0.0410542612418964 148 114 5 0.043859649122807 0.0337837837837838
GO:BP GO:0065008 regulation of biological quality 0.0418260808771626 4131 98 35 0.357142857142857 0.00847252481239409
GO:BP GO:0050794 regulation of cellular process 0.042647556180483 11473 116 88 0.758620689655172 0.00767018216682646
GO:BP GO:0001825 blastocyst formation 0.042647556180483 38 132 3 0.0227272727272727 0.0789473684210526
GO:BP GO:0007167 enzyme linked receptor protein signaling pathway 0.0431353752285119 1103 132 17 0.128787878787879 0.0154125113327289
GO:BP GO:0034314 Arp2/3 complex-mediated actin nucleation 0.043948898146177 41 126 3 0.0238095238095238 0.0731707317073171
GO:BP GO:0051052 regulation of DNA metabolic process 0.043948898146177 363 49 5 0.102040816326531 0.0137741046831956
GO:BP GO:0070663 regulation of leukocyte proliferation 0.043948898146177 251 21 3 0.142857142857143 0.0119521912350598
GO:BP GO:0009968 negative regulation of signal transduction 0.0439653721731396 1364 136 20 0.147058823529412 0.0146627565982405
GO:BP GO:0050852 T cell receptor signaling pathway 0.0439653721731396 203 26 3 0.115384615384615 0.0147783251231527
GO:BP GO:0032870 cellular response to hormone stimulus 0.0439653721731396 645 84 9 0.107142857142857 0.013953488372093
GO:BP GO:0050801 ion homeostasis 0.0444862944020919 808 33 6 0.181818181818182 0.00742574257425743
GO:BP GO:0071900 regulation of protein serine/threonine kinase activity 0.0444862944020919 503 128 10 0.078125 0.0198807157057654
GO:BP GO:0051130 positive regulation of cellular component organization 0.0445222474291382 1153 107 15 0.14018691588785 0.013009540329575
GO:BP GO:0030217 T cell differentiation 0.0445222474291382 260 133 7 0.0526315789473684 0.0269230769230769
GO:BP GO:0043933 protein-containing complex subunit organization 0.0445222474291382 1963 35 10 0.285714285714286 0.00509424350483953
GO:BP GO:0006289 nucleotide-excision repair 0.0454505847090465 110 49 3 0.0612244897959184 0.0272727272727273
GO:BP GO:0016192 vesicle-mediated transport 0.0455146688192958 2180 106 23 0.216981132075472 0.0105504587155963
GO:BP GO:0030097 hemopoiesis 0.0455146688192958 928 133 15 0.112781954887218 0.0161637931034483
GO:BP GO:0098609 cell-cell adhesion 0.0455146688192958 894 138 15 0.108695652173913 0.0167785234899329
GO:BP GO:0033628 regulation of cell adhesion mediated by integrin 0.0455146688192958 48 113 3 0.0265486725663717 0.0625
GO:BP GO:0030162 regulation of proteolysis 0.0455146688192958 752 36 6 0.166666666666667 0.00797872340425532
GO:BP GO:0006892 post-Golgi vesicle-mediated transport 0.0455146688192958 108 103 4 0.0388349514563107 0.037037037037037
GO:BP GO:0022604 regulation of cell morphogenesis 0.0455765570563336 309 114 7 0.0614035087719298 0.0226537216828479
GO:BP GO:0050789 regulation of biological process 0.0456875240894577 12091 14 14 1 0.0011578860309321
GO:BP GO:0030183 B cell differentiation 0.0476869577212384 140 133 5 0.037593984962406 0.0357142857142857
GO:BP GO:1902905 positive regulation of supramolecular fiber organization 0.0476869577212384 214 126 6 0.0476190476190476 0.0280373831775701
GO:BP GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 0.0476869577212384 63 90 3 0.0333333333333333 0.0476190476190476
GO:BP GO:0019882 antigen processing and presentation 0.0481825929644369 234 81 5 0.0617283950617284 0.0213675213675214
GO:BP GO:0065007 biological regulation 0.0481825929644369 12809 116 95 0.818965517241379 0.00741666016082442
GO:BP GO:1900076 regulation of cellular response to insulin stimulus 0.0487397657900511 69 84 3 0.0357142857142857 0.0434782608695652
GO:BP GO:0006875 cellular metal ion homeostasis 0.0492943149622039 593 33 5 0.151515151515152 0.00843170320404722
GO:BP GO:0038127 ERBB signaling pathway 0.0495471649444659 145 132 5 0.0378787878787879 0.0344827586206897
GO:BP GO:0002443 leukocyte mediated immunity 0.0495471649444659 877 54 8 0.148148148148148 0.00912200684150513
GO:BP GO:0008064 regulation of actin polymerization or depolymerization 0.0495471649444659 193 142 6 0.0422535211267606 0.0310880829015544
GO:BP GO:0055086 nucleobase-containing small molecule metabolic process 0.0495471649444659 629 59 7 0.11864406779661 0.0111287758346582
GO:BP GO:0030832 regulation of actin filament length 0.0496802527443869 194 142 6 0.0422535211267606 0.0309278350515464
GO:BP GO:0048534 hematopoietic or lymphoid organ development 0.0496802527443869 966 144 16 0.111111111111111 0.0165631469979296
GO:BP GO:0046626 regulation of insulin receptor signaling pathway 0.0499798318528738 71 84 3 0.0357142857142857 0.0422535211267606
GO:BP GO:1903037 regulation of leukocyte cell-cell adhesion 0.0499798318528738 338 138 8 0.0579710144927536 0.0236686390532544
GO:BP GO:0006304 DNA modification 0.0499798318528738 122 49 3 0.0612244897959184 0.0245901639344262
GO:BP GO:0006281 DNA repair 0.0499798318528738 576 49 6 0.122448979591837 0.0104166666666667
GO:CC GO:1903561 extracellular vesicle 1.15387881263573e-05 2261 106 33 0.311320754716981 0.0145953118089341
GO:CC GO:0031982 vesicle 1.15387881263573e-05 4055 121 52 0.429752066115702 0.0128236744759556
GO:CC GO:0070062 extracellular exosome 1.15387881263573e-05 2176 106 33 0.311320754716981 0.0151654411764706
GO:CC GO:0043230 extracellular organelle 1.15387881263573e-05 2263 106 33 0.311320754716981 0.0145824127264693
GO:CC GO:0005886 plasma membrane 5.40730732361215e-05 5681 106 56 0.528301886792453 0.00985741946840345
GO:CC GO:0031252 cell leading edge 0.000230809134874159 422 144 14 0.0972222222222222 0.033175355450237
GO:CC GO:0030055 cell-substrate junction 0.000230809134874159 427 142 14 0.0985915492957746 0.0327868852459016
GO:CC GO:0071944 cell periphery 0.000511502124902955 6169 106 56 0.528301886792453 0.00907764629599611
GO:CC GO:0005737 cytoplasm 0.000511502124902955 11911 99 82 0.828282828282828 0.00688439257828898
GO:CC GO:0005925 focal adhesion 0.00061367959952776 420 142 13 0.0915492957746479 0.030952380952381
GO:CC GO:0005615 extracellular space 0.00061367959952776 3594 21 13 0.619047619047619 0.00361713967723984
GO:CC GO:0031410 cytoplasmic vesicle 0.000768704559898496 2424 140 36 0.257142857142857 0.0148514851485149
GO:CC GO:0097708 intracellular vesicle 0.000768704559898496 2428 140 36 0.257142857142857 0.014827018121911
GO:CC GO:0042613 MHC class II protein complex 0.00111133310534587 16 81 3 0.037037037037037 0.1875
GO:CC GO:0070161 anchoring junction 0.001242311551151 836 92 14 0.152173913043478 0.0167464114832536
GO:CC GO:0005885 Arp2/3 protein complex 0.00187847068310891 13 126 3 0.0238095238095238 0.230769230769231
GO:CC GO:0016020 membrane 0.00242589688833922 9838 104 73 0.701923076923077 0.00742020735921935
GO:CC GO:0042611 MHC protein complex 0.00304798943269571 24 81 3 0.037037037037037 0.125
GO:CC GO:0005576 extracellular region 0.00502086456222668 4567 21 13 0.619047619047619 0.00284650755419312
GO:CC GO:0001726 ruffle 0.00780178948371415 179 142 7 0.0492957746478873 0.0391061452513966
GO:CC GO:0098857 membrane microdomain 0.0130039443897124 335 41 5 0.121951219512195 0.0149253731343284
GO:CC GO:0045121 membrane raft 0.0130039443897124 335 41 5 0.121951219512195 0.0149253731343284
GO:CC GO:0009986 cell surface 0.0177054685447679 899 35 7 0.2 0.00778642936596218
GO:CC GO:0012505 endomembrane system 0.0187391578819502 4640 95 37 0.389473684210526 0.00797413793103448
GO:CC GO:0031965 nuclear membrane 0.0286111862890988 298 143 8 0.0559440559440559 0.0268456375838926
GO:CC GO:0031902 late endosome membrane 0.0291162127355837 140 35 3 0.0857142857142857 0.0214285714285714
GO:CC GO:0030054 cell junction 0.0291162127355837 2105 92 20 0.217391304347826 0.00950118764845606
GO:CC GO:0030027 lamellipodium 0.0291162127355837 200 87 5 0.0574712643678161 0.025
GO:CC GO:0005622 intracellular anatomical structure 0.0291162127355837 14790 64 59 0.921875 0.00398918187964841
GO:CC GO:0005635 nuclear envelope 0.0318374231114858 467 143 10 0.0699300699300699 0.0214132762312634
GO:CC GO:0015629 actin cytoskeleton 0.0346735249058121 513 91 8 0.0879120879120879 0.0155945419103314
GO:CC GO:0035861 site of double-strand break 0.0363038625482229 68 87 3 0.0344827586206897 0.0441176470588235
GO:CC GO:0098552 side of membrane 0.0381351016691796 619 33 5 0.151515151515152 0.00807754442649435
GO:CC GO:0031983 vesicle lumen 0.0395708400403806 326 119 7 0.0588235294117647 0.0214723926380368
GO:CC GO:0060205 cytoplasmic vesicle lumen 0.0395708400403806 324 119 7 0.0588235294117647 0.0216049382716049
GO:CC GO:0043227 membrane-bounded organelle 0.0420816810119595 12858 141 110 0.780141843971631 0.00855498522320734
GO:CC GO:0009897 external side of plasma membrane 0.0441799215210342 408 33 4 0.121212121212121 0.00980392156862745
GO:CC GO:0005769 early endosome 0.0453406934066432 378 36 4 0.111111111111111 0.0105820105820106
GO:MF GO:0042169 SH2 domain binding 0.000216638674175439 37 96 5 0.0520833333333333 0.135135135135135
GO:MF GO:0023026 MHC class II protein complex binding 0.000216638674175439 17 81 4 0.0493827160493827 0.235294117647059
GO:MF GO:0044877 protein-containing complex binding 0.000216638674175439 1287 142 27 0.190140845070423 0.020979020979021
GO:MF GO:0023023 MHC protein complex binding 0.000503761890568291 25 81 4 0.0493827160493827 0.16
GO:MF GO:0019899 enzyme binding 0.00175806820998709 2074 76 22 0.289473684210526 0.0106075216972035
GO:MF GO:0005515 protein binding 0.0101812704018318 14767 135 123 0.911111111111111 0.0083293830839033
GO:MF GO:0051015 actin filament binding 0.0143449992898355 212 142 8 0.0563380281690141 0.0377358490566038
GO:MF GO:0051117 ATPase binding 0.0316889009971465 86 90 4 0.0444444444444444 0.0465116279069767
HPA HPA:0310433 lymph node; germinal center cells[High] 3.16930285915263e-09 908 98 32 0.326530612244898 0.0352422907488987
HPA HPA:0600433 tonsil; germinal center cells[High] 5.45141428781641e-07 1179 95 32 0.336842105263158 0.0271416454622561
HPA HPA:0030073 appendix; lymphoid tissue[High] 8.82512288209806e-07 803 139 32 0.23021582733813 0.0398505603985056
HPA HPA:0310432 lymph node; germinal center cells[≥Medium] 1.54296601997787e-05 3209 98 54 0.551020408163265 0.0168276721720162
HPA HPA:0530723 spleen; cells in white pulp[High] 1.75164188863633e-05 811 92 23 0.25 0.0283600493218249
HPA HPA:0310442 lymph node; non-germinal center cells[≥Medium] 0.000164957210752412 3875 98 58 0.591836734693878 0.0149677419354839
HPA HPA:0600442 tonsil; non-germinal center cells[≥Medium] 0.000517663901127381 4079 101 60 0.594059405940594 0.0147094876195146
HPA HPA:0600432 tonsil; germinal center cells[≥Medium] 0.000517663901127381 3988 101 59 0.584158415841584 0.0147943831494483
HPA HPA:0310431 lymph node; germinal center cells[≥Low] 0.00056261535221352 4935 96 65 0.677083333333333 0.0131712259371834
HPA HPA:0530721 spleen; cells in white pulp[≥Low] 0.000610271548977914 4249 43 31 0.720930232558139 0.00729583431395622
HPA HPA:0530712 spleen; cells in red pulp[≥Medium] 0.000999581784733458 3049 82 41 0.5 0.0134470318137094
HPA HPA:0030072 appendix; lymphoid tissue[≥Medium] 0.0016641533544254 3131 100 48 0.48 0.015330565314596
HPA HPA:0530722 spleen; cells in white pulp[≥Medium] 0.00296269506148368 2645 100 42 0.42 0.0158790170132325
HPA HPA:0600441 tonsil; non-germinal center cells[≥Low] 0.00387262097592006 5966 96 71 0.739583333333333 0.0119007710358699
HPA HPA:0600443 tonsil; non-germinal center cells[High] 0.00387262097592006 1271 139 32 0.23021582733813 0.025177025963808
HPA HPA:0030071 appendix; lymphoid tissue[≥Low] 0.0046897210792594 4976 101 65 0.643564356435644 0.0130627009646302
HPA HPA:0600431 tonsil; germinal center cells[≥Low] 0.00757546021423103 5845 96 69 0.71875 0.0118049615055603
HPA HPA:0530711 spleen; cells in red pulp[≥Low] 0.0162240913373721 5195 83 55 0.662650602409639 0.0105871029836381
HPA HPA:0530000 spleen 0.0172072165423704 5756 83 59 0.710843373493976 0.0102501737317582
HPA HPA:0040083 bone marrow; hematopoietic cells[High] 0.0351146436363603 1376 28 10 0.357142857142857 0.00726744186046512
HPA HPA:0250123 hippocampus; glial cells[High] 0.0357672104685176 508 6 3 0.5 0.00590551181102362
HPA HPA:0310000 lymph node 0.0357672104685176 6374 87 65 0.747126436781609 0.0101976780671478
HPA HPA:0530713 spleen; cells in red pulp[High] 0.0410640765869916 778 20 6 0.3 0.0077120822622108
KEGG KEGG:05310 Asthma 0.00985974780170544 27 24 3 0.125 0.111111111111111
KEGG KEGG:05330 Allograft rejection 0.00994750891832997 34 24 3 0.125 0.0882352941176471
KEGG KEGG:04672 Intestinal immune network for IgA production 0.0147091464361312 45 24 3 0.125 0.0666666666666667
KEGG KEGG:05320 Autoimmune thyroid disease 0.0147091464361312 49 24 3 0.125 0.0612244897959184
KEGG KEGG:04640 Hematopoietic cell lineage 0.0147091464361312 95 33 4 0.121212121212121 0.0421052631578947
KEGG KEGG:05416 Viral myocarditis 0.0147091464361312 56 24 3 0.125 0.0535714285714286
KEGG KEGG:04514 Cell adhesion molecules 0.0181117871710827 146 24 4 0.166666666666667 0.0273972602739726
KEGG KEGG:03410 Base excision repair 0.0192784053113416 33 49 3 0.0612244897959184 0.0909090909090909
KEGG KEGG:05140 Leishmaniasis 0.0204442981481255 72 24 3 0.125 0.0416666666666667
KEGG KEGG:05323 Rheumatoid arthritis 0.0308043253313187 88 24 3 0.125 0.0340909090909091
KEGG KEGG:04658 Th1 and Th2 cell differentiation 0.0308043253313187 89 24 3 0.125 0.0337078651685393
KEGG KEGG:05340 Primary immunodeficiency 0.038300630972231 37 138 4 0.0289855072463768 0.108108108108108
KEGG KEGG:04659 Th17 cell differentiation 0.038300630972231 104 24 3 0.125 0.0288461538461538
KEGG KEGG:05166 Human T-cell leukemia virus 1 infection 0.038300630972231 216 24 4 0.166666666666667 0.0185185185185185
KEGG KEGG:05145 Toxoplasmosis 0.0401507410269297 109 24 3 0.125 0.0275229357798165
KEGG KEGG:04064 NF-kappa B signaling pathway 0.0472155991900215 102 28 3 0.107142857142857 0.0294117647058824
MIRNA MIRNA:hsa-miR-590-3p hsa-miR-590-3p 0.0453849635618787 389 92 11 0.119565217391304 0.0282776349614396
REAC REAC:R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine 0.0400199868445487 37 49 3 0.0612244897959184 0.0810810810810811
REAC REAC:R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains 0.0400199868445487 23 74 3 0.0405405405405405 0.130434782608696
REAC REAC:R-HSA-73928 Depyrimidination 0.0400199868445487 37 49 3 0.0612244897959184 0.0810810810810811
REAC REAC:R-HSA-110329 Cleavage of the damaged pyrimidine 0.0400199868445487 37 49 3 0.0612244897959184 0.0810810810810811
REAC REAC:R-HSA-73929 Base-Excision Repair, AP Site Formation 0.0400199868445487 38 49 3 0.0612244897959184 0.0789473684210526
REAC REAC:R-HSA-73884 Base Excision Repair 0.0400199868445487 66 49 4 0.0816326530612245 0.0606060606060606
REAC REAC:R-HSA-73933 Resolution of Abasic Sites (AP sites) 0.0400199868445487 36 49 3 0.0612244897959184 0.0833333333333333
TF TF:M11376 Factor: Spi-B; motif: RAAWGRGGAAGTN 1.8686032541117e-05 729 51 14 0.274509803921569 0.0192043895747599
TF TF:M00971 Factor: Ets; motif: ACTTCCTS 0.00475387086558714 2349 114 32 0.280701754385965 0.0136228182205194
TF TF:M01203 Factor: SPI1; motif: NNAAWGNGGAASTNNNN 0.00475387086558714 2643 67 24 0.358208955223881 0.00908059023836549
TF TF:M00655_1 Factor: PEA3; motif: ACWTCCK; match class: 1 0.00475387086558714 2934 114 37 0.324561403508772 0.0126107702794819
TF TF:M09659 Factor: PU.1; motif: NRAAAGAGGAAGTGARA 0.00532511513766523 2523 26 13 0.5 0.00515259611573524
TF TF:M10073 Factor: PU.1; motif: NRAAAGAGGAAGTGRNN 0.00532511513766523 2416 120 33 0.275 0.013658940397351
TF TF:M00746 Factor: Elf-1; motif: RNWMBAGGAART 0.00629936679491575 3365 98 35 0.357142857142857 0.0104011887072808
TF TF:M01172 Factor: PU.1; motif: NNNNYYYACTTCCTCTTTY 0.00896744890802968 4281 84 36 0.428571428571429 0.00840925017519271
TF TF:M10074 Factor: Spi-B; motif: NRAAAGAGGAAGTGARA 0.0100424016699912 1611 16 8 0.5 0.00496585971446307
TF TF:M09903 Factor: elf5; motif: NNNANSAGGAAGTNN 0.0104265708771816 1243 110 20 0.181818181818182 0.0160901045856798
TF TF:M03995 Factor: SPIB; motif: NAAAAGMGGAAGTN 0.0105586179504268 759 51 10 0.196078431372549 0.0131752305665349
TF TF:M02078 Factor: SPI1; motif: NGRGGAAGTN 0.0105586179504268 3506 110 38 0.345454545454545 0.0108385624643468
TF TF:M11374 Factor: Spi-B; motif: NAWGRGGAAGTR 0.0105586179504268 2512 68 22 0.323529411764706 0.00875796178343949
TF TF:M03994 Factor: SPI1; motif: AAAAAGCGGAAGTW 0.0247986534537541 2182 76 21 0.276315789473684 0.00962419798350138
TF TF:M11445 Factor: Elf-1; motif: NANCAGGAAGTR 0.0432602048456381 1689 30 10 0.333333333333333 0.0059206631142688
TF TF:M02278_1 Factor: SPI1; motif: AGGAAGT; match class: 1 0.0432602048456381 1496 114 21 0.184210526315789 0.0140374331550802
TF TF:M03579_1 Factor: PEA3; motif: AGGAAGT; match class: 1 0.0432602048456381 1496 114 21 0.184210526315789 0.0140374331550802
TF TF:M07382_1 Factor: Fli-1; motif: MGGAAGT; match class: 1 0.0432602048456381 1496 114 21 0.184210526315789 0.0140374331550802
TF TF:M01870_1 Factor: C-ets-1; motif: AGGAAGN; match class: 1 0.0432602048456381 1496 114 21 0.184210526315789 0.0140374331550802

pB04 transcription factor target enrichment of top program genes

TF enrichment of pB04
TFs corrosponding to activation of pB04. (Left) pearson correlation of TF expression and gene expression program activatity in B cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.