pM07 program activity among Myeloid cells

Activation of pM07
pM07 gene program activation in Myeloid cells.
Gene program activation of pM07 by different cell subtypes
pM07 gene program activation among cells of different subtypes (Myeloid cells).

pM07 top program genes

Top genes of pM07 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pM07 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pM07
pM07 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0002520 immune system development 0.00012260896699607 1020 125 24 0.192 0.0235294117647059
GO:BP GO:0046649 lymphocyte activation 0.00012260896699607 771 129 21 0.162790697674419 0.0272373540856031
GO:BP GO:0045321 leukocyte activation 0.00012260896699607 1332 129 29 0.224806201550388 0.0217717717717718
GO:BP GO:0048534 hematopoietic or lymphoid organ development 0.000131167580369604 966 125 23 0.184 0.0238095238095238
GO:BP GO:0030097 hemopoiesis 0.000218433693115427 928 125 22 0.176 0.0237068965517241
GO:BP GO:0001775 cell activation 0.000272388396533217 1495 129 29 0.224806201550388 0.0193979933110368
GO:BP GO:0002376 immune system process 0.00033069317353197 3278 130 47 0.361538461538462 0.0143380109823063
GO:BP GO:0034155 regulation of toll-like receptor 7 signaling pathway 0.00127949894449843 7 87 3 0.0344827586206897 0.428571428571429
GO:BP GO:0071310 cellular response to organic substance 0.00127949894449843 2776 68 26 0.382352941176471 0.00936599423631124
GO:BP GO:1903131 mononuclear cell differentiation 0.00271653363543675 430 125 13 0.104 0.0302325581395349
GO:BP GO:0034121 regulation of toll-like receptor signaling pathway 0.00273158935371654 79 31 4 0.129032258064516 0.0506329113924051
GO:BP GO:0045047 protein targeting to ER 0.00376835824893509 113 52 5 0.0961538461538462 0.0442477876106195
GO:BP GO:0098542 defense response to other organism 0.00376835824893509 1218 31 10 0.32258064516129 0.00821018062397373
GO:BP GO:0006952 defense response 0.00376835824893509 1818 31 12 0.387096774193548 0.0066006600660066
GO:BP GO:0042113 B cell activation 0.00376835824893509 330 125 11 0.088 0.0333333333333333
GO:BP GO:0034154 toll-like receptor 7 signaling pathway 0.00376835824893509 12 87 3 0.0344827586206897 0.25
GO:BP GO:1903513 endoplasmic reticulum to cytosol transport 0.00376835824893509 28 109 4 0.036697247706422 0.142857142857143
GO:BP GO:0030970 retrograde protein transport, ER to cytosol 0.00376835824893509 28 109 4 0.036697247706422 0.142857142857143
GO:BP GO:0072599 establishment of protein localization to endoplasmic reticulum 0.00376835824893509 117 52 5 0.0961538461538462 0.0427350427350427
GO:BP GO:0010033 response to organic substance 0.00395895901521516 3412 73 29 0.397260273972603 0.00849941383352872
GO:BP GO:0002521 leukocyte differentiation 0.00395895901521516 550 125 14 0.112 0.0254545454545455
GO:BP GO:0045087 innate immune response 0.0042819963025175 998 31 9 0.290322580645161 0.00901803607214429
GO:BP GO:0062207 regulation of pattern recognition receptor signaling pathway 0.00450126992499342 108 31 4 0.129032258064516 0.037037037037037
GO:BP GO:0070887 cellular response to chemical stimulus 0.00568421602601239 3393 68 27 0.397058823529412 0.00795755968169761
GO:BP GO:0006955 immune response 0.00568421602601239 2311 31 13 0.419354838709677 0.0056252704456945
GO:BP GO:0060255 regulation of macromolecule metabolic process 0.00568421602601239 6603 32 23 0.71875 0.00348326518249281
GO:BP GO:0019222 regulation of metabolic process 0.00568421602601239 7148 32 24 0.75 0.00335758254057079
GO:BP GO:0045944 positive regulation of transcription by RNA polymerase II 0.00568421602601239 1197 28 9 0.321428571428571 0.0075187969924812
GO:BP GO:0070972 protein localization to endoplasmic reticulum 0.00632118762486843 146 52 5 0.0961538461538462 0.0342465753424658
GO:BP GO:0030098 lymphocyte differentiation 0.00632118762486843 376 125 11 0.088 0.0292553191489362
GO:BP GO:0042592 homeostatic process 0.008573999310786 1981 42 14 0.333333333333333 0.00706713780918728
GO:BP GO:0071345 cellular response to cytokine stimulus 0.010210612928344 1132 64 13 0.203125 0.0114840989399293
GO:BP GO:0051707 response to other organism 0.010210612928344 1592 15 7 0.466666666666667 0.00439698492462312
GO:BP GO:0051234 establishment of localization 0.010210612928344 5372 73 37 0.506849315068493 0.00688756515264334
GO:BP GO:0001504 neurotransmitter uptake 0.010210612928344 41 114 4 0.0350877192982456 0.0975609756097561
GO:BP GO:0006672 ceramide metabolic process 0.010210612928344 104 84 5 0.0595238095238095 0.0480769230769231
GO:BP GO:0019221 cytokine-mediated signaling pathway 0.010210612928344 810 64 11 0.171875 0.0135802469135802
GO:BP GO:0043207 response to external biotic stimulus 0.010210612928344 1594 15 7 0.466666666666667 0.00439146800501882
GO:BP GO:0051248 negative regulation of protein metabolic process 0.0104670626134596 1151 26 8 0.307692307692308 0.00695047784535187
GO:BP GO:0009607 response to biotic stimulus 0.010630542974728 1626 15 7 0.466666666666667 0.0043050430504305
GO:BP GO:0002224 toll-like receptor signaling pathway 0.010630542974728 161 31 4 0.129032258064516 0.0248447204968944
GO:BP GO:0071705 nitrogen compound transport 0.0111183060012589 2322 130 32 0.246153846153846 0.0137812230835487
GO:BP GO:0009743 response to carbohydrate 0.0111183060012589 243 117 8 0.0683760683760684 0.0329218106995885
GO:BP GO:0051240 positive regulation of multicellular organismal process 0.0111183060012589 1455 27 9 0.333333333333333 0.00618556701030928
GO:BP GO:0001816 cytokine production 0.0111183060012589 844 27 7 0.259259259259259 0.00829383886255924
GO:BP GO:0006810 transport 0.0111183060012589 5224 73 36 0.493150684931507 0.00689127105666156
GO:BP GO:0032527 protein exit from endoplasmic reticulum 0.0118008662843117 48 109 4 0.036697247706422 0.0833333333333333
GO:BP GO:0002312 B cell activation involved in immune response 0.0118032914193109 79 123 5 0.040650406504065 0.0632911392405063
GO:BP GO:0046513 ceramide biosynthetic process 0.0125362537559472 71 30 3 0.1 0.0422535211267606
GO:BP GO:0006811 ion transport 0.0132988037853584 3661 52 22 0.423076923076923 0.00600928708003278
GO:BP GO:2000107 negative regulation of leukocyte apoptotic process 0.013537260036999 45 123 4 0.032520325203252 0.0888888888888889
GO:BP GO:0030433 ubiquitin-dependent ERAD pathway 0.0140909225987519 82 125 5 0.04 0.0609756097560976
GO:BP GO:0060548 negative regulation of cell death 0.0156110479804913 1038 24 7 0.291666666666667 0.00674373795761079
GO:BP GO:0034097 response to cytokine 0.0156110479804913 1226 64 13 0.203125 0.0106035889070147
GO:BP GO:0060333 interferon-gamma-mediated signaling pathway 0.0156110479804913 88 27 3 0.111111111111111 0.0340909090909091
GO:BP GO:0006950 response to stress 0.0157203104107563 4170 33 17 0.515151515151515 0.00407673860911271
GO:BP GO:0001776 leukocyte homeostasis 0.0157203104107563 86 126 5 0.0396825396825397 0.0581395348837209
GO:BP GO:0071322 cellular response to carbohydrate stimulus 0.0157203104107563 148 73 5 0.0684931506849315 0.0337837837837838
GO:BP GO:0051239 regulation of multicellular organismal process 0.0157203104107563 2861 30 13 0.433333333333333 0.00454386578119539
GO:BP GO:0008219 cell death 0.0165187372845726 2292 24 10 0.416666666666667 0.0043630017452007
GO:BP GO:0060337 type I interferon signaling pathway 0.0165187372845726 95 27 3 0.111111111111111 0.0315789473684211
GO:BP GO:0051172 negative regulation of nitrogen compound metabolic process 0.0165187372845726 2518 26 11 0.423076923076923 0.00436854646544877
GO:BP GO:0071357 cellular response to type I interferon 0.0165582803495768 96 27 3 0.111111111111111 0.03125
GO:BP GO:0051051 negative regulation of transport 0.0165582803495768 474 123 11 0.0894308943089431 0.0232067510548523
GO:BP GO:0002252 immune effector process 0.0171328984757733 1309 130 21 0.161538461538462 0.0160427807486631
GO:BP GO:0002793 positive regulation of peptide secretion 0.0182186677342179 159 73 5 0.0684931506849315 0.0314465408805031
GO:BP GO:0002221 pattern recognition receptor signaling pathway 0.0182186677342179 213 31 4 0.129032258064516 0.0187793427230047
GO:BP GO:0034340 response to type I interferon 0.0182186677342179 101 27 3 0.111111111111111 0.0297029702970297
GO:BP GO:0048872 homeostasis of number of cells 0.0188910433136695 261 126 8 0.0634920634920635 0.0306513409961686
GO:BP GO:0045893 positive regulation of transcription, DNA-templated 0.0188910433136695 1617 28 9 0.321428571428571 0.00556586270871985
GO:BP GO:0030154 cell differentiation 0.0188910433136695 4350 30 16 0.533333333333333 0.00367816091954023
GO:BP GO:1902680 positive regulation of RNA biosynthetic process 0.0188910433136695 1618 28 9 0.321428571428571 0.00556242274412855
GO:BP GO:1903508 positive regulation of nucleic acid-templated transcription 0.0188910433136695 1617 28 9 0.321428571428571 0.00556586270871985
GO:BP GO:0050857 positive regulation of antigen receptor-mediated signaling pathway 0.0188910433136695 23 123 3 0.024390243902439 0.130434782608696
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 0.0189353962095461 2255 34 12 0.352941176470588 0.00532150776053215
GO:BP GO:0007275 multicellular organism development 0.0189353962095461 5613 38 22 0.578947368421053 0.00391947265277035
GO:BP GO:0007166 cell surface receptor signaling pathway 0.0189353962095461 3210 123 37 0.300813008130081 0.0115264797507788
GO:BP GO:0042100 B cell proliferation 0.0191178728510821 98 123 5 0.040650406504065 0.0510204081632653
GO:BP GO:0050896 response to stimulus 0.0194942444536245 9407 35 28 0.8 0.00297650685659615
GO:BP GO:0032479 regulation of type I interferon production 0.0195138918885615 130 23 3 0.130434782608696 0.0230769230769231
GO:BP GO:0051179 localization 0.0195138918885615 6901 73 42 0.575342465753425 0.00608607448195914
GO:BP GO:0032606 type I interferon production 0.019740169466619 131 23 3 0.130434782608696 0.0229007633587786
GO:BP GO:0048869 cellular developmental process 0.0198644706841435 4428 30 16 0.533333333333333 0.003613369467028
GO:BP GO:0097028 dendritic cell differentiation 0.0198644706841435 48 63 3 0.0476190476190476 0.0625
GO:BP GO:0006915 apoptotic process 0.0198644706841435 1990 24 9 0.375 0.00452261306532663
GO:BP GO:0006820 anion transport 0.0198644706841435 2889 77 24 0.311688311688312 0.0083073727933541
GO:BP GO:0032269 negative regulation of cellular protein metabolic process 0.0198644706841435 1082 26 7 0.269230769230769 0.00646950092421442
GO:BP GO:0015833 peptide transport 0.0198644706841435 1971 73 18 0.246575342465753 0.0091324200913242
GO:BP GO:0009605 response to external stimulus 0.0198644706841435 2944 31 13 0.419354838709677 0.00441576086956522
GO:BP GO:0031324 negative regulation of cellular metabolic process 0.020200568470343 2719 26 11 0.423076923076923 0.00404560500183891
GO:BP GO:0032501 multicellular organismal process 0.020200568470343 7946 40 28 0.7 0.00352378555247923
GO:BP GO:0032502 developmental process 0.020200568470343 6628 38 24 0.631578947368421 0.00362100181050091
GO:BP GO:0036503 ERAD pathway 0.020200568470343 103 125 5 0.04 0.0485436893203883
GO:BP GO:0072676 lymphocyte migration 0.020200568470343 117 63 4 0.0634920634920635 0.0341880341880342
GO:BP GO:0051254 positive regulation of RNA metabolic process 0.020200568470343 1714 28 9 0.321428571428571 0.00525087514585764
GO:BP GO:0048518 positive regulation of biological process 0.020200568470343 6363 35 22 0.628571428571429 0.00345748860600346
GO:BP GO:0090277 positive regulation of peptide hormone secretion 0.0204600154993686 103 73 4 0.0547945205479452 0.0388349514563107
GO:BP GO:0090087 regulation of peptide transport 0.0206590495115072 618 73 9 0.123287671232877 0.0145631067961165
GO:BP GO:0030148 sphingolipid biosynthetic process 0.0206590495115072 112 30 3 0.1 0.0267857142857143
GO:BP GO:0042886 amide transport 0.0206590495115072 2007 73 18 0.246575342465753 0.00896860986547085
GO:BP GO:0009893 positive regulation of metabolic process 0.0208126199629534 3783 35 16 0.457142857142857 0.0042294475284166
GO:BP GO:0001817 regulation of cytokine production 0.0208126199629534 806 133 15 0.112781954887218 0.0186104218362283
GO:BP GO:0010605 negative regulation of macromolecule metabolic process 0.0208126199629534 3241 26 12 0.461538461538462 0.0037025609379821
GO:BP GO:0031328 positive regulation of cellular biosynthetic process 0.0208784316342013 1967 30 10 0.333333333333333 0.00508388408744281
GO:BP GO:0030888 regulation of B cell proliferation 0.0210683238354557 63 123 4 0.032520325203252 0.0634920634920635
GO:BP GO:0048731 system development 0.0210683238354557 5052 35 19 0.542857142857143 0.00376088677751386
GO:BP GO:0002682 regulation of immune system process 0.0215197922373208 1617 136 24 0.176470588235294 0.0148423005565863
GO:BP GO:0009891 positive regulation of biosynthetic process 0.0221137996397877 2004 30 10 0.333333333333333 0.00499001996007984
GO:BP GO:0048871 multicellular organismal homeostasis 0.0221137996397877 530 27 5 0.185185185185185 0.00943396226415094
GO:BP GO:1903532 positive regulation of secretion by cell 0.0221137996397877 285 99 7 0.0707070707070707 0.0245614035087719
GO:BP GO:1902475 L-alpha-amino acid transmembrane transport 0.022302603912961 62 130 4 0.0307692307692308 0.0645161290322581
GO:BP GO:0002250 adaptive immune response 0.022302603912961 689 126 13 0.103174603174603 0.0188679245283019
GO:BP GO:0065008 regulation of biological quality 0.0231626113297287 4131 42 19 0.452380952380952 0.00459937061244251
GO:BP GO:0009749 response to glucose 0.0232547867965481 202 70 5 0.0714285714285714 0.0247524752475248
GO:BP GO:0012501 programmed cell death 0.0232547867965481 2143 24 9 0.375 0.00419972001866542
GO:BP GO:1903792 negative regulation of anion transport 0.0234974268597832 235 123 7 0.0569105691056911 0.0297872340425532
GO:BP GO:0006665 sphingolipid metabolic process 0.0235920588043211 169 84 5 0.0595238095238095 0.029585798816568
GO:BP GO:0071549 cellular response to dexamethasone stimulus 0.0237884145672366 31 122 3 0.0245901639344262 0.0967741935483871
GO:BP GO:0009966 regulation of signal transduction 0.0237884145672366 3165 125 36 0.288 0.0113744075829384
GO:BP GO:0098810 neurotransmitter reuptake 0.0237884145672366 33 114 3 0.0263157894736842 0.0909090909090909
GO:BP GO:0050854 regulation of antigen receptor-mediated signaling pathway 0.0238181287042727 68 123 4 0.032520325203252 0.0588235294117647
GO:BP GO:0010941 regulation of cell death 0.0238181287042727 1720 24 8 0.333333333333333 0.00465116279069767
GO:BP GO:0051249 regulation of lymphocyte activation 0.0238181287042727 518 129 11 0.0852713178294574 0.0212355212355212
GO:BP GO:0085029 extracellular matrix assembly 0.0243340957702455 47 82 3 0.0365853658536585 0.0638297872340425
GO:BP GO:0010628 positive regulation of gene expression 0.0243340957702455 1160 27 7 0.259259259259259 0.00603448275862069
GO:BP GO:0010646 regulation of cell communication 0.0243901884330903 3543 125 39 0.312 0.0110076206604572
GO:BP GO:0009746 response to hexose 0.0245549086075321 209 70 5 0.0714285714285714 0.0239234449760766
GO:BP GO:0071333 cellular response to glucose stimulus 0.0250569776597678 137 63 4 0.0634920634920635 0.0291970802919708
GO:BP GO:0072594 establishment of protein localization to organelle 0.0250569776597678 584 52 7 0.134615384615385 0.011986301369863
GO:BP GO:0010557 positive regulation of macromolecule biosynthetic process 0.0254169837533211 1851 28 9 0.321428571428571 0.00486223662884927
GO:BP GO:0008284 positive regulation of cell population proliferation 0.0254892821141593 982 32 7 0.21875 0.00712830957230143
GO:BP GO:0048247 lymphocyte chemotaxis 0.0254892821141593 63 63 3 0.0476190476190476 0.0476190476190476
GO:BP GO:0071331 cellular response to hexose stimulus 0.0256912868312152 139 63 4 0.0634920634920635 0.0287769784172662
GO:BP GO:0071326 cellular response to monosaccharide stimulus 0.0259182850802803 140 63 4 0.0634920634920635 0.0285714285714286
GO:BP GO:0034284 response to monosaccharide 0.0259182850802803 215 70 5 0.0714285714285714 0.0232558139534884
GO:BP GO:0051171 regulation of nitrogen compound metabolic process 0.0259182850802803 5848 32 19 0.59375 0.00324897400820793
GO:BP GO:0050901 leukocyte tethering or rolling 0.0259182850802803 30 136 3 0.0220588235294118 0.1
GO:BP GO:0002790 peptide secretion 0.0267954405951218 421 73 7 0.0958904109589041 0.0166270783847981
GO:BP GO:0045935 positive regulation of nucleobase-containing compound metabolic process 0.0268022732816654 1887 28 9 0.321428571428571 0.00476947535771065
GO:BP GO:0023051 regulation of signaling 0.0268022732816654 3578 125 39 0.312 0.0108999441028508
GO:BP GO:0030217 T cell differentiation 0.0268022732816654 260 59 5 0.0847457627118644 0.0192307692307692
GO:BP GO:0009892 negative regulation of metabolic process 0.0270461196942456 3479 26 12 0.461538461538462 0.00344926703075596
GO:BP GO:0002684 positive regulation of immune system process 0.0270461196942456 1065 130 17 0.130769230769231 0.015962441314554
GO:BP GO:0050900 leukocyte migration 0.027262451216095 511 136 11 0.0808823529411765 0.0215264187866928
GO:BP GO:0051047 positive regulation of secretion 0.027262451216095 314 73 6 0.0821917808219178 0.0191082802547771
GO:BP GO:0048522 positive regulation of cellular process 0.0273688262759298 5757 35 20 0.571428571428571 0.00347403161368768
GO:BP GO:0048519 negative regulation of biological process 0.0273688262759298 5757 42 23 0.547619047619048 0.00399513635574084
GO:BP GO:0046879 hormone secretion 0.0277290472608283 317 73 6 0.0821917808219178 0.0189274447949527
GO:BP GO:0071702 organic substance transport 0.028246240848045 2766 130 33 0.253846153846154 0.0119305856832972
GO:BP GO:0030182 neuron differentiation 0.0282833540987211 1412 24 7 0.291666666666667 0.00495750708215297
GO:BP GO:0043270 positive regulation of ion transport 0.0282833540987211 694 73 9 0.123287671232877 0.0129682997118156
GO:BP GO:0048856 anatomical structure development 0.0285837004404386 6106 38 22 0.578947368421053 0.00360301342941369
GO:BP GO:0002285 lymphocyte activation involved in immune response 0.0286839205047237 190 123 6 0.0487804878048781 0.0315789473684211
GO:BP GO:0002791 regulation of peptide secretion 0.0289612843619273 325 73 6 0.0821917808219178 0.0184615384615385
GO:BP GO:0046467 membrane lipid biosynthetic process 0.0289612843619273 151 30 3 0.1 0.0198675496688742
GO:BP GO:0009914 hormone transport 0.0294950489756424 327 73 6 0.0821917808219178 0.018348623853211
GO:BP GO:0046887 positive regulation of hormone secretion 0.0294950489756424 133 73 4 0.0547945205479452 0.0300751879699248
GO:BP GO:0050864 regulation of B cell activation 0.0299621190209716 194 123 6 0.0487804878048781 0.0309278350515464
GO:BP GO:0051222 positive regulation of protein transport 0.0299621190209716 329 73 6 0.0821917808219178 0.0182370820668693
GO:BP GO:0051716 cellular response to stimulus 0.0304881334030926 7781 127 71 0.559055118110236 0.00912479115794885
GO:BP GO:0001678 cellular glucose homeostasis 0.0305384857556801 157 63 4 0.0634920634920635 0.0254777070063694
GO:BP GO:0071346 cellular response to interferon-gamma 0.0305609885741261 175 27 3 0.111111111111111 0.0171428571428571
GO:BP GO:0050714 positive regulation of protein secretion 0.0306406605062452 136 73 4 0.0547945205479452 0.0294117647058824
GO:BP GO:0048583 regulation of response to stimulus 0.0306406605062452 4278 125 44 0.352 0.0102851799906498
GO:BP GO:0050789 regulation of biological process 0.0306406605062452 12091 36 32 0.888888888888889 0.00264659664213051
GO:BP GO:0030100 regulation of endocytosis 0.0306406605062452 212 114 6 0.0526315789473684 0.0283018867924528
GO:BP GO:1990845 adaptive thermogenesis 0.0307558509013979 155 65 4 0.0615384615384615 0.0258064516129032
GO:BP GO:0080090 regulation of primary metabolic process 0.0307558509013979 6053 32 19 0.59375 0.00313893936890798
GO:BP GO:2000106 regulation of leukocyte apoptotic process 0.0309629485646468 82 123 4 0.032520325203252 0.0487804878048781
GO:BP GO:0051223 regulation of protein transport 0.0317059096748772 586 73 8 0.10958904109589 0.0136518771331058
GO:BP GO:0048523 negative regulation of cellular process 0.0317943070026441 5139 42 21 0.5 0.00408639813193228
GO:BP GO:0045184 establishment of protein localization 0.0317943070026441 2035 117 24 0.205128205128205 0.0117936117936118
GO:BP GO:0071548 response to dexamethasone 0.0317943070026441 40 122 3 0.0245901639344262 0.075
GO:BP GO:0048513 animal organ development 0.0322288552938644 3672 125 39 0.312 0.0106209150326797
GO:BP GO:0006614 SRP-dependent cotranslational protein targeting to membrane 0.0331834238581362 96 52 3 0.0576923076923077 0.03125
GO:BP GO:0015031 protein transport 0.0331834238581362 1929 117 23 0.196581196581197 0.0119232763089684
GO:BP GO:1904951 positive regulation of establishment of protein localization 0.0331834238581362 345 73 6 0.0821917808219178 0.0173913043478261
GO:BP GO:0042110 T cell activation 0.0331834238581362 489 129 10 0.0775193798449612 0.0204498977505112
GO:BP GO:0043367 CD4-positive, alpha-beta T cell differentiation 0.0331834238581362 85 59 3 0.0508474576271186 0.0352941176470588
GO:BP GO:0030890 positive regulation of B cell proliferation 0.0332477853352332 41 123 3 0.024390243902439 0.0731707317073171
GO:BP GO:0032940 secretion by cell 0.0345072862572004 1364 117 18 0.153846153846154 0.0131964809384164
GO:BP GO:0002244 hematopoietic progenitor cell differentiation 0.0345072862572004 172 30 3 0.1 0.0174418604651163
GO:BP GO:0030183 B cell differentiation 0.0345408407424035 140 125 5 0.04 0.0357142857142857
GO:BP GO:0051241 negative regulation of multicellular organismal process 0.0345408407424035 1160 39 8 0.205128205128205 0.00689655172413793
GO:BP GO:0050856 regulation of T cell receptor signaling pathway 0.034559074841869 42 123 3 0.024390243902439 0.0714285714285714
GO:BP GO:0023052 signaling 0.0345621724782178 6810 126 63 0.5 0.0092511013215859
GO:BP GO:0043170 macromolecule metabolic process 0.0345621724782178 9796 33 26 0.787878787878788 0.00265414454879543
GO:BP GO:0046626 regulation of insulin receptor signaling pathway 0.034630172529362 71 73 3 0.0410958904109589 0.0422535211267606
GO:BP GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 0.034630172529362 185 138 6 0.0434782608695652 0.0324324324324324
GO:BP GO:0034341 response to interferon-gamma 0.0351878845097869 196 27 3 0.111111111111111 0.0153061224489796
GO:BP GO:0009126 purine nucleoside monophosphate metabolic process 0.0354609295157452 43 123 3 0.024390243902439 0.0697674418604651
GO:BP GO:0042981 regulation of apoptotic process 0.0354609295157452 1549 24 7 0.291666666666667 0.00451904454486766
GO:BP GO:0006613 cotranslational protein targeting to membrane 0.0354609295157452 102 52 3 0.0576923076923077 0.0294117647058824
GO:BP GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 0.0354609295157452 251 138 7 0.0507246376811594 0.0278884462151394
GO:BP GO:0070201 regulation of establishment of protein localization 0.0354609295157452 611 73 8 0.10958904109589 0.0130932896890344
GO:BP GO:0007154 cell communication 0.0354609295157452 6829 126 63 0.5 0.00922536242495241
GO:BP GO:0043269 regulation of ion transport 0.0355345454231149 1379 73 13 0.178082191780822 0.00942712110224801
GO:BP GO:0048699 generation of neurons 0.0356314453143212 1559 24 7 0.291666666666667 0.00449005772931366
GO:BP GO:0030968 endoplasmic reticulum unfolded protein response 0.0356448056762132 128 42 3 0.0714285714285714 0.0234375
GO:BP GO:0010604 positive regulation of macromolecule metabolic process 0.0358927418162398 3483 28 12 0.428571428571429 0.00344530577088717
GO:BP GO:0006643 membrane lipid metabolic process 0.0358927418162398 217 84 5 0.0595238095238095 0.0230414746543779
GO:BP GO:1901701 cellular response to oxygen-containing compound 0.0358927418162398 1227 73 12 0.164383561643836 0.0097799511002445
GO:BP GO:0045806 negative regulation of endocytosis 0.0358927418162398 53 103 3 0.029126213592233 0.0566037735849057
GO:BP GO:0007165 signal transduction 0.0358927418162398 6309 68 35 0.514705882352941 0.00554763036931368
GO:BP GO:0002366 leukocyte activation involved in immune response 0.0358927418162398 717 123 12 0.0975609756097561 0.0167364016736402
GO:BP GO:0043067 regulation of programmed cell death 0.0358927418162398 1582 24 7 0.291666666666667 0.00442477876106195
GO:BP GO:0043603 cellular amide metabolic process 0.0358927418162398 1241 30 7 0.233333333333333 0.0056406124093473
GO:BP GO:0002694 regulation of leukocyte activation 0.0358927418162398 610 31 5 0.161290322580645 0.00819672131147541
GO:BP GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 0.0358927418162398 363 123 8 0.0650406504065041 0.0220385674931129
GO:BP GO:0031323 regulation of cellular metabolic process 0.0359451672055857 6269 32 19 0.59375 0.00303078640931568
GO:BP GO:0002263 cell activation involved in immune response 0.0364433695430888 721 123 12 0.0975609756097561 0.0166435506241331
GO:BP GO:0006687 glycosphingolipid metabolic process 0.0365783891053295 68 84 3 0.0357142857142857 0.0441176470588235
GO:BP GO:0051050 positive regulation of transport 0.0365783891053295 923 73 10 0.136986301369863 0.0108342361863489
GO:BP GO:0032024 positive regulation of insulin secretion 0.0365783891053295 78 73 3 0.0410958904109589 0.0384615384615385
GO:BP GO:0022008 neurogenesis 0.0365783891053295 1675 29 8 0.275862068965517 0.00477611940298507
GO:BP GO:0032879 regulation of localization 0.0365783891053295 2872 73 21 0.287671232876712 0.00731197771587744
GO:BP GO:0030072 peptide hormone secretion 0.0366016108857675 260 73 5 0.0684931506849315 0.0192307692307692
GO:BP GO:0140352 export from cell 0.0371345352109699 1418 73 13 0.178082191780822 0.00916784203102962
GO:BP GO:1903793 positive regulation of anion transport 0.0377392034623418 504 73 7 0.0958904109589041 0.0138888888888889
GO:BP GO:0051049 regulation of transport 0.0378533945574803 1809 114 21 0.184210526315789 0.0116086235489221
GO:BP GO:0043066 negative regulation of apoptotic process 0.0383153385540125 921 41 7 0.170731707317073 0.00760043431053203
GO:BP GO:0001819 positive regulation of cytokine production 0.0383693331144936 452 27 4 0.148148148148148 0.00884955752212389
GO:BP GO:0042221 response to chemical 0.0391323638793057 4781 73 30 0.410958904109589 0.00627483790002092
GO:BP GO:0071674 mononuclear cell migration 0.0392384606106529 191 63 4 0.0634920634920635 0.0209424083769634
GO:BP GO:0071356 cellular response to tumor necrosis factor 0.0397384873290542 306 64 5 0.078125 0.0163398692810458
GO:BP GO:0048878 chemical homeostasis 0.0397384873290542 1229 24 6 0.25 0.0048820179007323
GO:BP GO:0051173 positive regulation of nitrogen compound metabolic process 0.0399294410196297 3083 32 12 0.375 0.00389231268245216
GO:BP GO:0030099 myeloid cell differentiation 0.0400306632921937 428 29 4 0.137931034482759 0.00934579439252336
GO:BP GO:0002377 immunoglobulin production 0.0405022340941247 99 125 4 0.032 0.0404040404040404
GO:BP GO:0002443 leukocyte mediated immunity 0.0405022340941247 877 119 13 0.109243697478992 0.0148232611174458
GO:BP GO:0002573 myeloid leukocyte differentiation 0.0405022340941247 213 29 3 0.103448275862069 0.0140845070422535
GO:BP GO:0120162 positive regulation of cold-induced thermogenesis 0.0405022340941247 97 65 3 0.0461538461538462 0.0309278350515464
GO:BP GO:0019731 antibacterial humoral response 0.0405022340941247 62 102 3 0.0294117647058824 0.0483870967741935
GO:BP GO:0008361 regulation of cell size 0.0405022340941247 182 35 3 0.0857142857142857 0.0164835164835165
GO:BP GO:0010468 regulation of gene expression 0.0405022340941247 5196 23 13 0.565217391304348 0.00250192455735181
GO:BP GO:0050865 regulation of cell activation 0.0405022340941247 655 31 5 0.161290322580645 0.00763358778625954
GO:BP GO:0016192 vesicle-mediated transport 0.0405022340941247 2180 115 24 0.208695652173913 0.0110091743119266
GO:BP GO:0046883 regulation of hormone secretion 0.0405022340941247 275 73 5 0.0684931506849315 0.0181818181818182
GO:BP GO:0043069 negative regulation of programmed cell death 0.0405022340941247 943 41 7 0.170731707317073 0.00742311770943796
GO:BP GO:0034976 response to endoplasmic reticulum stress 0.0405022340941247 298 125 7 0.056 0.023489932885906
GO:BP GO:0003333 amino acid transmembrane transport 0.0405022340941247 96 130 4 0.0307692307692308 0.0416666666666667
GO:BP GO:0034620 cellular response to unfolded protein 0.0405022340941247 149 42 3 0.0714285714285714 0.0201342281879195
GO:BP GO:0035710 CD4-positive, alpha-beta T cell activation 0.0405022340941247 104 59 3 0.0508474576271186 0.0288461538461538
GO:BP GO:0045912 negative regulation of carbohydrate metabolic process 0.0405783093644989 52 122 3 0.0245901639344262 0.0576923076923077
GO:BP GO:0002685 regulation of leukocyte migration 0.0407920503997352 211 136 6 0.0441176470588235 0.028436018957346
GO:BP GO:0048584 positive regulation of response to stimulus 0.0408038989996159 2344 138 29 0.210144927536232 0.0123720136518771
GO:BP GO:1903828 negative regulation of cellular protein localization 0.0408038989996159 116 109 4 0.036697247706422 0.0344827586206897
GO:BP GO:0044260 cellular macromolecule metabolic process 0.0428426902939043 8390 33 23 0.696969696969697 0.00274135876042908
GO:BP GO:0002449 lymphocyte mediated immunity 0.0440509416307002 354 59 5 0.0847457627118644 0.0141242937853107
GO:BP GO:0046632 alpha-beta T cell differentiation 0.0446443729035245 113 59 3 0.0508474576271186 0.0265486725663717
GO:BP GO:0046903 secretion 0.0446443729035245 1501 123 19 0.154471544715447 0.0126582278481013
GO:BP GO:0034612 response to tumor necrosis factor 0.0465888594104495 331 64 5 0.078125 0.0151057401812689
GO:BP GO:0008152 metabolic process 0.0467086890314211 11827 35 30 0.857142857142857 0.00253656886784476
GO:BP GO:0071887 leukocyte apoptotic process 0.0467884411829109 108 123 4 0.032520325203252 0.037037037037037
GO:BP GO:0033036 macromolecule localization 0.0470542342453013 3218 73 22 0.301369863013699 0.00683654443753884
GO:BP GO:0031214 biomineral tissue development 0.0470542342453013 164 82 4 0.0487804878048781 0.024390243902439
GO:BP GO:0035967 cellular response to topologically incorrect protein 0.0470542342453013 168 42 3 0.0714285714285714 0.0178571428571429
GO:BP GO:0045861 negative regulation of proteolysis 0.0470542342453013 359 38 4 0.105263157894737 0.011142061281337
GO:BP GO:0110148 biomineralization 0.0470542342453013 166 82 4 0.0487804878048781 0.0240963855421687
GO:BP GO:0060627 regulation of vesicle-mediated transport 0.0470542342453013 536 114 9 0.0789473684210526 0.0167910447761194
GO:BP GO:0065007 biological regulation 0.0470542342453013 12809 42 37 0.880952380952381 0.00288859395737372
GO:BP GO:0050708 regulation of protein secretion 0.0470542342453013 295 73 5 0.0684931506849315 0.0169491525423729
GO:BP GO:0010975 regulation of neuron projection development 0.0470542342453013 451 16 3 0.1875 0.00665188470066519
GO:BP GO:0071385 cellular response to glucocorticoid stimulus 0.0470542342453013 57 122 3 0.0245901639344262 0.0526315789473684
GO:BP GO:0019725 cellular homeostasis 0.0470542342453013 981 42 7 0.166666666666667 0.00713557594291539
GO:BP GO:0007249 I-kappaB kinase/NF-kappaB signaling 0.0470641742337335 291 138 7 0.0507246376811594 0.0240549828178694
GO:BP GO:0098657 import into cell 0.0472878368747052 235 130 6 0.0461538461538462 0.025531914893617
GO:BP GO:0044070 regulation of anion transport 0.0475735469840376 896 82 10 0.121951219512195 0.0111607142857143
GO:BP GO:0050793 regulation of developmental process 0.0477921807197283 2605 30 10 0.333333333333333 0.00383877159309021
GO:BP GO:0031325 positive regulation of cellular metabolic process 0.0494086536476075 3274 32 12 0.375 0.00366524129505192
GO:CC GO:0140534 endoplasmic reticulum protein-containing complex 0.000296734989224296 128 47 6 0.127659574468085 0.046875
GO:CC GO:0012505 endomembrane system 0.00159042214783586 4640 125 53 0.424 0.0114224137931034
GO:CC GO:0031982 vesicle 0.00169886836871294 4055 133 50 0.37593984962406 0.0123304562268804
GO:CC GO:0005768 endosome 0.00282615006059216 987 120 18 0.15 0.0182370820668693
GO:CC GO:0005737 cytoplasm 0.00295467807188509 11911 125 99 0.792 0.00831164469817815
GO:CC GO:0016021 integral component of membrane 0.00332157451966411 5711 56 31 0.553571428571429 0.00542812116967256
GO:CC GO:0010008 endosome membrane 0.00335774111531419 505 120 12 0.1 0.0237623762376238
GO:CC GO:0031224 intrinsic component of membrane 0.00403857352830304 5868 56 31 0.553571428571429 0.00528289025221541
GO:CC GO:0098588 bounding membrane of organelle 0.00944681108494273 2158 120 27 0.225 0.0125115848007414
GO:CC GO:0031901 early endosome membrane 0.00944681108494273 159 120 6 0.05 0.0377358490566038
GO:CC GO:0031410 cytoplasmic vesicle 0.011956195453303 2424 123 29 0.235772357723577 0.011963696369637
GO:CC GO:0097708 intracellular vesicle 0.011956195453303 2428 123 29 0.235772357723577 0.0119439868204283
GO:CC GO:0005576 extracellular region 0.0128281811652143 4567 5 5 1 0.00109481059776659
GO:CC GO:0031984 organelle subcompartment 0.0155778188849255 1773 109 21 0.192660550458716 0.011844331641286
GO:CC GO:0055037 recycling endosome 0.0155778188849255 188 116 6 0.0517241379310345 0.0319148936170213
GO:CC GO:0031090 organelle membrane 0.0212972556992946 3612 125 38 0.304 0.0105204872646733
GO:CC GO:0005783 endoplasmic reticulum 0.0228816318825144 1982 65 15 0.230769230769231 0.00756811301715439
GO:CC GO:0098827 endoplasmic reticulum subcompartment 0.0228816318825144 1122 49 9 0.183673469387755 0.00802139037433155
GO:CC GO:0005789 endoplasmic reticulum membrane 0.0228816318825144 1117 49 9 0.183673469387755 0.00805729632945389
GO:CC GO:0070062 extracellular exosome 0.0228816318825144 2176 139 28 0.201438848920863 0.0128676470588235
GO:CC GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network 0.0228816318825144 1139 49 9 0.183673469387755 0.00790166812993854
GO:CC GO:0055038 recycling endosome membrane 0.0228816318825144 84 116 4 0.0344827586206897 0.0476190476190476
GO:CC GO:0005769 early endosome 0.024588660615668 378 120 8 0.0666666666666667 0.0211640211640212
GO:CC GO:0000323 lytic vacuole 0.0284422904697815 712 130 12 0.0923076923076923 0.0168539325842697
GO:CC GO:0043230 extracellular organelle 0.0284422904697815 2263 139 28 0.201438848920863 0.0123729562527618
GO:CC GO:0005764 lysosome 0.0284422904697815 712 130 12 0.0923076923076923 0.0168539325842697
GO:CC GO:1903561 extracellular vesicle 0.0284422904697815 2261 139 28 0.201438848920863 0.0123839009287926
GO:CC GO:0030176 integral component of endoplasmic reticulum membrane 0.0361126392369156 158 42 3 0.0714285714285714 0.0189873417721519
GO:CC GO:0016020 membrane 0.0361126392369156 9838 131 83 0.633587786259542 0.00843667412075625
GO:CC GO:0031227 intrinsic component of endoplasmic reticulum membrane 0.0386309963602696 166 42 3 0.0714285714285714 0.0180722891566265
TF TF:M00712_1 Factor: myogenin; motif: RGCAGSTG; match class: 1 0.00608437311601644 1875 85 23 0.270588235294118 0.0122666666666667
TF TF:M02014_1 Factor: HNF-3beta; motif: NTRTTTRYT; match class: 1 0.00608437311601644 224 3 3 1 0.0133928571428571
TF TF:M00804 Factor: E2A; motif: NCACCTGYYNCNKN 0.00608437311601644 1226 60 15 0.25 0.0122349102773246
TF TF:M09962_1 Factor: ITF-2; motif: NGCAGSTGKS; match class: 1 0.00687187455441217 768 73 13 0.178082191780822 0.0169270833333333
TF TF:M04619 Factor: MTF-1; motif: CCGNGTGCAV 0.0172393755366022 1167 28 9 0.321428571428571 0.0077120822622108
TF TF:M00927 Factor: AP-4; motif: RNCAGCTGC 0.0172393755366022 6341 73 41 0.561643835616438 0.00646585712032802
TF TF:M00931_1 Factor: Sp1; motif: GGGGCGGGGC; match class: 1 0.0172393755366022 5905 105 52 0.495238095238095 0.00880609652836579
TF TF:M00644_1 Factor: LBP-1; motif: CAGCTGS; match class: 1 0.0172393755366022 4046 73 31 0.424657534246575 0.00766188828472565
TF TF:M02088 Factor: E2A; motif: NRMCASCTGCNNN 0.0265229625999068 2871 63 22 0.349206349206349 0.00766283524904215
TF TF:M07261 Factor: LKLF; motif: GGGGTGGKSN 0.0265229625999068 9774 86 61 0.709302325581395 0.00624104767751177
TF TF:M00931 Factor: Sp1; motif: GGGGCGGGGC 0.0265229625999068 10281 105 75 0.714285714285714 0.0072950102130143
TF TF:M02089_1 Factor: E2F-3; motif: GGCGGGN; match class: 1 0.0269469421126431 9362 135 87 0.644444444444444 0.00929288613544114
TF TF:M00712 Factor: myogenin; motif: RGCAGSTG 0.0387915655371657 6982 88 49 0.556818181818182 0.00701804640504154
TF TF:M07277_1 Factor: BTEB2; motif: RGGGNGKGGN; match class: 1 0.0440693663047339 4149 105 39 0.371428571428571 0.0093998553868402
TF TF:M00196_1 Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1 0.0440693663047339 5919 105 50 0.476190476190476 0.00844737286703835
TF TF:M00747_1 Factor: IRF-1; motif: TTCACTT; match class: 1 0.0440693663047339 933 3 3 1 0.00321543408360129
TF TF:M01860 Factor: AP-4; motif: NCAGCTGYNGNCN 0.0471648697783149 5995 139 63 0.453237410071942 0.0105087572977481
TF TF:M09962 Factor: ITF-2; motif: NGCAGSTGKS 0.0471648697783149 4783 78 34 0.435897435897436 0.00710850930378424
TF TF:M09658 Factor: Sp2; motif: GGSNNGGGGGCGGGGCCNGNGS 0.0471648697783149 5262 72 34 0.472222222222222 0.0064614215127328
TF TF:M01100 Factor: LRF; motif: GGGGKYNNB 0.0471648697783149 7557 139 75 0.539568345323741 0.00992457324335054
TF TF:M01303_1 Factor: SP1; motif: GGGGYGGGGNS; match class: 1 0.0477129184666158 3507 73 26 0.356164383561644 0.00741374394069005
TF TF:M00932_1 Factor: Sp1; motif: NNGGGGCGGGGNN; match class: 1 0.0477129184666158 6047 105 50 0.476190476190476 0.00826856292376385
TF TF:M07395 Factor: Sp1; motif: NGGGGCGGGGN 0.0477129184666158 10640 133 92 0.691729323308271 0.00864661654135338
TF TF:M03831 Factor: MRF4; motif: CASCTGC 0.0477129184666158 8749 135 81 0.6 0.00925820093724997
TF TF:M00932 Factor: Sp1; motif: NNGGGGCGGGGNN 0.0477129184666158 10419 105 74 0.704761904761905 0.00710240906037048
TF TF:M10435 Factor: Sp2; motif: GGGGCGGGG 0.0477129184666158 7696 111 62 0.558558558558559 0.00805613305613306
TF TF:M07063 Factor: Sp1; motif: GGGGCGGGGC 0.0477129184666158 7696 111 62 0.558558558558559 0.00805613305613306
TF TF:M01860_1 Factor: AP-4; motif: NCAGCTGYNGNCN; match class: 1 0.0477129184666158 1669 77 17 0.220779220779221 0.0101857399640503
TF TF:M12173_1 Factor: GKLF; motif: NNCCMCRCCCN; match class: 1 0.0477129184666158 4965 80 35 0.4375 0.00704934541792548
TF TF:M02018 Factor: HTF4; motif: CASCTGB 0.0477129184666158 8749 135 81 0.6 0.00925820093724997
TF TF:M07140_1 Factor: Kaiso; motif: NTCTCGCGAGANYTN; match class: 1 0.0477129184666158 189 128 7 0.0546875 0.037037037037037
TF TF:M00644 Factor: LBP-1; motif: CAGCTGS 0.0477129184666158 8878 78 51 0.653846153846154 0.00574453705789592
WP WP:WP3892 Development of pulmonary dendritic cells and macrophage subsets 6.85406798580046e-06 13 61 5 0.0819672131147541 0.384615384615385

pM07 transcription factor target enrichment of top program genes

TF enrichment of pM07
TFs corrosponding to activation of pM07. (Left) pearson correlation of TF expression and gene expression program activatity in Myeloid cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.